X-ray structures define human P2X3 receptor gating cycle and antagonist action

Molecular structure and function of P2X receptors

(2016) Chloé Habermacher et al.   NEUROPHARMACOLOGY

Conductance of P2X4purinergic receptor is determined by conformational equilibrium in the transmembrane region

(2016) Yuichi Minato et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural Insights into Divalent Cation Modulations of ATP-Gated P2X Receptor Channels

(2016) Go Kasuya et al.   Cell Reports

Photo-switchable tweezers illuminate pore-opening motions of an ATP-gated P2X ion channel

(2016) Chloé Habermacher et al.   eLife

Screening and large-scale expression of membrane proteins in mammalian cells for structural studies

(2014) April Goehring et al.   Nature Protocols

A hydrophobic residue in position 15 of the rP2X3 receptor slows desensitization and reveals properties beneficial for pharmacological analysis and high-throughput screening

(2014) Ralf Hausmann et al.   NEUROPHARMACOLOGY

Influences of Membrane Mimetic Environments on Membrane Protein Structures

(2013) Huan-Xiang Zhou et al.   Annual Review of Biophysics

P2X Receptor Chimeras Highlight Roles of the Amino Terminus to Partial Agonist Efficacy, the Carboxyl Terminus to Recovery from Desensitization, and Independent Regulation of Channel Transitions

(2013) Rebecca C. Allsopp et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Subtype-specific control of P2X receptor channel signaling by ATP and Mg2+

(2013) Mufeng Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inter- and intrasubunit interactions between transmembrane helices in the open state of P2X receptor channels

(2013) G. Heymann et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tightening of the ATP-binding sites induces the opening of P2X receptor channels

(2012) Ruotian Jiang et al.   EMBO JOURNAL

Molecular mechanism of ATP binding and ion channel activation in P2X receptors

(2012) Motoyuki Hattori et al.   NATURE

Crystal Structure of a Lipid G Protein-Coupled Receptor

(2012) M. A. Hanson et al.   SCIENCE

The Intracellular Amino Terminus Plays a Dominant Role in Desensitization of ATP-gated P2X Receptor Ion Channels

(2011) Rebecca C. Allsopp et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Improved Treatment of Ligands and Coupling Effects in Empirical Calculation and Rationalization of pKaValues

(2011) Chresten R. Søndergaard et al.   Journal of Chemical Theory and Computation

PROPKA3: Consistent Treatment of Internal and Surface Residues in Empirical pKaPredictions

(2011) Mats H. M. Olsson et al.   Journal of Chemical Theory and Computation

Ion access pathway to the transmembrane pore in P2X receptor channels

(2011) Toshimitsu Kawate et al.   JOURNAL OF GENERAL PHYSIOLOGY

Preferential use of unobstructed lateral portals as the access route to the pore of human ATP-gated ion channels (P2X receptors)

(2011) D. S. K. Samways et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

XDS

(2010) Wolfgang Kabsch   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Update of the CHARMM All-Atom Additive Force Field for Lipids: Validation on Six Lipid Types

(2010) Jeffery B. Klauda et al.   JOURNAL OF PHYSICAL CHEMISTRY B

MolProbity: all-atom structure validation for macromolecular crystallography

(2009) Vincent B. Chen et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Crystal structure of the ATP-gated P2X4 ion channel in the closed state

(2009) Toshimitsu Kawate et al.   NATURE

Signaling at Purinergic P2X Receptors

(2008) Annmarie Surprenant et al.   Annual Review of Physiology

CHARMM-GUI: A web-based graphical user interface for CHARMM

(2008) Sunhwan Jo et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

Voltage- and [ATP]-dependent Gating of the P2X2ATP Receptor Channel

(2008) Yuichiro Fujiwara et al.   JOURNAL OF GENERAL PHYSIOLOGY

ATP-gated P2X cation-channels

(2008) Michael F. Jarvis et al.   NEUROPHARMACOLOGY

An evolutionary history of P2X receptors

(2008) Samuel J. Fountain et al.   Purinergic Signalling