Modulation of P2X4/P2X7/Pannexin-1 sensitivity to extracellular ATP via Ivermectin induces a non-apoptotic and inflammatory form of cancer cell death

A novel mechanism of autophagic cell death in dystrophic muscle regulated by P2RX7 receptor large-pore formation and HSP90

(2015) Christopher NJ Young et al.   Autophagy

Radiation-induced autophagy potentiates immunotherapy of cancer via up-regulation of mannose 6-phosphate receptor on tumor cells in mice

(2014) Sungjune Kim et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Macrophage endocytosis of high-mobility group box 1 triggers pyroptosis

(2014) J Xu et al.   CELL DEATH AND DIFFERENTIATION

Liver X receptor β activation induces pyroptosis of human and murine colon cancer cells

(2014) V Derangère et al.   CELL DEATH AND DIFFERENTIATION

The river blindness drug Ivermectin and related macrocyclic lactones inhibit WNT-TCF pathway responses in human cancer

(2014) A. Melotti et al.   EMBO Molecular Medicine

ATP Modulates Acute Inflammation In Vivo through Dual Oxidase 1-Derived H2O2 Production and NF- B Activation

(2014) S. de Oliveira et al.   JOURNAL OF IMMUNOLOGY

The NLRP3 inflammasome is released as a particulate danger signal that amplifies the inflammatory response

(2014) Alberto Baroja-Mazo et al.   NATURE IMMUNOLOGY

Autocrine signaling via release of ATP and activation of P2X7 receptor influences motile activity of human lung cancer cells

(2014) Erina Takai et al.   Purinergic Signalling

CaMKII and stress mix it up in mitochondria

(2014) Mei-ling A. Joiner et al.   Frontiers in Pharmacology

Oxidative activation of Ca2+/calmodulin-activated kinase II mediates ER stress-induced cardiac dysfunction and apoptosis

(2013) Nathan D. Roe et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

The role of mannose-6-phosphate receptor and autophagy in influencing the outcome of combination therapy

(2013) Rupal Ramakrishnan et al.   Autophagy

P2X4 receptor regulates P2X7 receptor-dependent IL-1β and IL-18 release in mouse bone marrow-derived dendritic cells

(2013) Hayato Sakaki et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Molecular mechanisms of ATP secretion during immunogenic cell death

(2013) I Martins et al.   CELL DEATH AND DIFFERENTIATION

Immunogenic calreticulin exposure occurs through a phylogenetically conserved stress pathway involving the chemokine CXCL8

(2013) A Q Sukkurwala et al.   CELL DEATH AND DIFFERENTIATION

Autophagy and Cellular Immune Responses

(2013) Yuting Ma et al.   IMMUNITY

Role of CaMKII and ROS in rapid pacing-induced apoptosis

(2013) Marisa Sepúlveda et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

CaMKII represses transcriptionally active β-catenin to mediate acute ethanol neurodegeneration and can phosphorylate β-catenin

(2013) George R. Flentke et al.   JOURNAL OF NEUROCHEMISTRY

P2X4 Assembles with P2X7 and Pannexin-1 in Gingival Epithelial Cells and Modulates ATP-induced Reactive Oxygen Species Production and Inflammasome Activation

(2013) Shu-Chen Hung et al.   PLoS One

Purinergic signalling and cancer

(2013) Geoffrey Burnstock et al.   Purinergic Signalling

Regulation of HMGB1 release by inflammasomes

(2013) Ben Lu et al.   Protein & Cell

Immunogenic Cell Death in Cancer Therapy

(2012) Guido Kroemer et al.   Annual Review of Immunology

Regulation of P2X7-dependent inflammatory functions by P2X4 receptor in mouse macrophages

(2012) Ayumi Kawano et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Involvement of P2X4 receptor in P2X7 receptor-dependent cell death of mouse macrophages

(2012) Ayumi Kawano et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Expression of P2X7 Receptor Increases In Vivo Tumor Growth

(2012) E. Adinolfi et al.   CANCER RESEARCH

High-mobility group box 1 activates caspase-1 and promotes hepatocellular carcinoma invasiveness and metastases

(2012) Wei Yan et al.   HEPATOLOGY

Caspase-1-induced pyroptotic cell death

(2011) Edward A. Miao et al.   IMMUNOLOGICAL REVIEWS

Secretion of IL-1β triggered by dynasore in murine peritoneal macrophages

(2011) Michèle Seil et al.   Innate Immunity

Autophagy-Dependent Anticancer Immune Responses Induced by Chemotherapeutic Agents in Mice

(2011) M. Michaud et al.   SCIENCE

HMGB1 release by inflammasomes

(2011) Lieselotte Vande Walle et al.   Virulence

Salmonella Exploits Suicidal Behavior of Epithelial Cells

(2011) Sebastian E. Winter et al.   Frontiers in Microbiology

The antiparasitic agent ivermectin induces chloride-dependent membrane hyperpolarization and cell death in leukemia cells

(2010) S. Sharmeen et al.   BLOOD

Endothelin signalling regulates volume-sensitive Cl− current via NADPH oxidase and mitochondrial reactive oxygen species

(2010) Wu Deng et al.   CARDIOVASCULAR RESEARCH

P2X4 Activation Modulates Volume-sensitive Outwardly Rectifying Chloride Channels in Rat Hepatoma Cells

(2010) Diego Varela et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ivermectin-dependent release of IL-1beta in response to ATP by peritoneal macrophages from P2X7-KO mice

(2010) Michèle Seil et al.   Purinergic Signalling

Long-term (trophic) purinergic signalling: purinoceptors control cell proliferation, differentiation and death

(2010) G Burnstock et al.   Cell Death & Disease

Mechanisms of pre-apoptotic calreticulin exposure in immunogenic cell death

(2009) Theocharis Panaretakis et al.   EMBO JOURNAL

Ca2+/calmodulin-dependent kinase II signalling cascade mediates P2X7 receptor-dependent inhibition of neuritogenesis in neuroblastoma cells

(2009) Rosa Gómez-Villafuertes et al.   FEBS Journal

Constitutively Active Inflammasome in Human Melanoma Cells Mediating Autoinflammation via Caspase-1 Processing and Secretion of Interleukin-1β

(2009) Miyako Okamoto et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Activation of the NLRP3 inflammasome in dendritic cells induces IL-1β–dependent adaptive immunity against tumors

(2009) François Ghiringhelli et al.   NATURE MEDICINE

Pyroptosis: host cell death and inflammation

(2009) Tessa Bergsbaken et al.   NATURE REVIEWS MICROBIOLOGY

Increased Level of Extracellular ATP at Tumor Sites: In Vivo Imaging with Plasma Membrane Luciferase

(2008) Patrizia Pellegatti et al.   PLoS One