A central role for P2X7 receptors in human microglia

The scavenger activity of the human P2X7 receptor differs from P2X7 pore function by insensitivity to antagonists, genetic variation and sodium concentration: Relevance to inflammatory brain diseases

(2018) Amber Ou et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

The Elusive P2X7 Macropore

(2018) Francesco Di Virgilio et al.   TRENDS IN CELL BIOLOGY

Microglia in steady state

(2017) Katrin Kierdorf et al.   JOURNAL OF CLINICAL INVESTIGATION

The role of microglial P2X7: modulation of cell death and cytokine release

(2017) Yingbo He et al.   Journal of Neuroinflammation

Regulation of TMEM16A/ANO1 and TMEM16F/ANO6 ion currents and phospholipid scrambling by Ca2+ and plasma membrane lipid

(2017) Rainer Schreiber et al.   JOURNAL OF PHYSIOLOGY-LONDON

Diverse Requirements for Microglial Survival, Specification, and Function Revealed by Defined-Medium Cultures

(2017) Christopher J. Bohlen et al.   NEURON

On the permeation of large organic cations through the pore of ATP-gated P2X receptors

(2017) Mahboubi Harkat et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Recent Insights into the Molecular Mechanisms Underlying Pyroptosis and Gasdermin Family Functions

(2017) Robin A. Aglietti et al.   TRENDS IN IMMUNOLOGY

The P2X7 receptor forms a dye-permeable pore independent of its intracellular domain but dependent on membrane lipid composition

(2017) Akira Karasawa et al.   eLife

The Pathophysiological Role of Microglia in Dynamic Surveillance, Phagocytosis and Structural Remodeling of the Developing CNS

(2017) Cataldo Arcuri et al.   Frontiers in Molecular Neuroscience

P2X4 Receptor Function in the Nervous System and Current Breakthroughs in Pharmacology

(2017) Leanne Stokes et al.   Frontiers in Pharmacology

Isolation of primary microglia from the human post-mortem brain: effects of ante- and post-mortem variables

(2017) Mark R. Mizee et al.   Acta Neuropathologica Communications

Interleukin-1β has trophic effects in microglia and its release is mediated by P2X7R pore

(2016) Mastura Monif et al.   Journal of Neuroinflammation

Purinergic signaling in the immune system

(2015) Francesco Di Virgilio et al.   AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL

P2X Receptors and Inflammation

(2015) Francesco Virgilio   CURRENT MEDICINAL CHEMISTRY

IL-1β production is dependent on the activation of purinergic receptors and NLRP3 pathway in human macrophages

(2015) Thomas Gicquel et al.   FASEB JOURNAL

Quantifying Ca2+Current and Permeability in ATP-gated P2X7 Receptors

(2015) Xin Liang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Physical basis of apparent pore dilation of ATP-activated P2X receptor channels

(2015) Mufeng Li et al.   NATURE NEUROSCIENCE

Neuroinflammation: Ways in Which the Immune System Affects the Brain

(2015) Richard M. Ransohoff et al.   Neurotherapeutics

Microglia Function in Central Nervous System Development and Plasticity

(2015) Dorothy P. Schafer et al.   Cold Spring Harbor Perspectives in Biology

K+ regulates Ca2+ to drive inflammasome signaling: dynamic visualization of ion flux in live cells

(2015) J R Yaron et al.   Cell Death & Disease

Anoctamin 6 mediates effects essential for innate immunity downstream of P2X7 receptors in macrophages

(2015) Jiraporn Ousingsawat et al.   Nature Communications

P2X7-dependent, but differentially regulated release of IL-6, CCL2, and TNF-α in cultured mouse microglia

(2014) Chu-Hsin Shieh et al.   GLIA

Inflammatory caspases are innate immune receptors for intracellular LPS

(2014) Jianjin Shi et al.   NATURE

Silencing of the P2X7 receptor enhances amyloid-β phagocytosis by microglia

(2013) Jiong Ni et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

P2X7 Receptor Channels Allow Direct Permeation of Nanometer-Sized Dyes

(2013) L. E. Browne et al.   JOURNAL OF NEUROSCIENCE

P2X7 Receptor Activation Induces Reactive Oxygen Species Formation and Cell Death in Murine EOC13 Microglia

(2013) Rachael Bartlett et al.   MEDIATORS OF INFLAMMATION

Microglia and macrophages of the central nervous system: the contribution of microglia priming and systemic inflammation to chronic neurodegeneration

(2013) V. Hugh Perry et al.   Seminars in Immunopathology

Detecting adenosine triphosphate in the pericellular space

(2013) S. Falzoni et al.   Interface Focus

Positive allosteric modulation by ivermectin of human but not murine P2X7 receptors

(2012) W Nörenberg et al.   BRITISH JOURNAL OF PHARMACOLOGY

P2X4 receptor channels form large noncytolytic pores in resting and activated microglia

(2012) Louis-Philippe Bernier et al.   GLIA

Purinergic regulation of inflammasome activation after central nervous system injury

(2012) Louis-Philippe Bernier   JOURNAL OF GENERAL PHYSIOLOGY

Activation of the P2X7receptor induces migration of glial cells by inducing cathepsin B degradation of tissue inhibitor of metalloproteinase 1

(2012) Niamh Murphy et al.   JOURNAL OF NEUROCHEMISTRY

Activation of calcium-insensitive phospholipase A2 (iPLA2) by P2X7 receptors in murine peritoneal macrophages

(2012) M. El Ouaaliti et al.   PROSTAGLANDINS & OTHER LIPID MEDIATORS

A new role for the P2X7 receptor: a scavenger receptor for bacteria and apoptotic cells in the absence of serum and extracellular ATP

(2012) James S. Wiley et al.   Purinergic Signalling

Many ways to dilate the P2X7 receptor pore

(2011) Pablo Pelegrín   BRITISH JOURNAL OF PHARMACOLOGY

P2X7 Is a Scavenger Receptor for Apoptotic Cells in the Absence of Its Ligand, Extracellular ATP

(2011) B. J. Gu et al.   JOURNAL OF IMMUNOLOGY

The Inflammasomes

(2010) Kate Schroder et al.   CELL

Progressive Activation of CyclinB1-Cdk1 Coordinates Entry to Mitosis

(2010) Olivier Gavet et al.   DEVELOPMENTAL CELL

P2X4 receptors in activated C8-B4 cells of cerebellar microglial origin

(2010) Estelle Toulme et al.   JOURNAL OF GENERAL PHYSIOLOGY

Interleukin 18 in the CNS

(2010) Silvia Alboni et al.   Journal of Neuroinflammation

Experimental Characterization and Mathematical Modeling of P2X7 Receptor Channel Gating

(2010) Z. Yan et al.   JOURNAL OF NEUROSCIENCE

Extracellular ATP dissociates nonmuscle myosin from P2X7 complex: this dissociation regulates P2X7 pore formation

(2009) Ben J. Gu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

The P2X7-nonmuscle myosin membrane complex regulates phagocytosis of nonopsonized particles and bacteria by a pathway attenuated by extracellular ATP

(2009) B. J. Gu et al.   BLOOD

Expression of P2 nucleotide receptors varies with age and sex in murine brain microglia

(2009) Jessica M Crain et al.   Journal of Neuroinflammation

The P2X7 Receptor Drives Microglial Activation and Proliferation: A Trophic Role for P2X7R Pore

(2009) M. Monif et al.   JOURNAL OF NEUROSCIENCE

P2X7 Receptor Activates Multiple Selective Dye-Permeation Pathways in RAW 264.7 and Human Embryonic Kidney 293 Cells

(2009) S. Cankurtaran-Sayar et al.   MOLECULAR PHARMACOLOGY

Extracellular ATP in the Immune System: More Than Just a "Danger Signal"

(2009) A. Trautmann   Science Signaling

Signaling at Purinergic P2X Receptors

(2008) Annmarie Surprenant et al.   Annual Review of Physiology

ATP-induced P2X7-associated uptake of large molecules involves distinct mechanisms for cations and anions in macrophages

(2008) J. Schachter et al.   JOURNAL OF CELL SCIENCE

Facilitation of P2X7 Receptor Currents and Membrane Blebbing via Constitutive and Dynamic Calmodulin Binding

(2008) S. Roger et al.   JOURNAL OF NEUROSCIENCE

[3H]A-804598 ([3H]2-cyano-1-[(1S)-1-phenylethyl]-3-quinolin-5-ylguanidine) is a novel, potent, and selective antagonist radioligand for P2X7 receptors

(2008) Diana L. Donnelly-Roberts et al.   NEUROPHARMACOLOGY