Autophagy in cancer: moving from understanding mechanism to improving therapy responses in patients

Regulation of apoptosis in health and disease: the balancing act of BCL-2 family proteins

(2019) Rumani Singh et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Protective autophagy elicited by RAF→MEK→ERK inhibition suggests a treatment strategy for RAS-driven cancers

(2019) Conan G. Kinsey et al.   NATURE MEDICINE

Combination of ERK and autophagy inhibition as a treatment approach for pancreatic cancer

(2019) Kirsten L. Bryant et al.   NATURE MEDICINE

ATG8-Binding UIM Proteins Define a New Class of Autophagy Adaptors and Receptors

(2019) Richard S. Marshall et al.   CELL

Epigenetic targeting of autophagy for cancer prevention and treatment by natural compounds

(2019) Chiara Vidoni et al.   SEMINARS IN CANCER BIOLOGY

Elevated VMP1 expression in acute myeloid leukemia amplifies autophagy and is protective against venetoclax-induced apoptosis

(2019) Hendrik Folkerts et al.   Cell Death & Disease

Autophagy Regulation of Metabolism Is Required for CD8+ T Cell Anti-tumor Immunity

(2019) Lindsay DeVorkin et al.   Cell Reports

Autophagy-Independent Functions of the Autophagy Machinery

(2019) Lorenzo Galluzzi et al.   CELL

Effect of early-stage autophagy inhibition in BRAFV600E autophagy-dependent brain tumor cells

(2019) Shadi Zahedi et al.   Cell Death & Disease

EGFRvIII expression triggers a metabolic dependency and therapeutic vulnerability sensitive to autophagy inhibition

(2018) Barry Jutten et al.   Autophagy

Chloroquine inhibits autophagic flux by decreasing autophagosome-lysosome fusion

(2018) Mario Mauthe et al.   Autophagy

FOXO3 links autophagy to apoptosis

(2018) Brent E. Fitzwalter et al.   Autophagy

Autophagy Inhibition Mediates Apoptosis Sensitization in Cancer Therapy by Relieving FOXO3a Turnover

(2018) Brent E. Fitzwalter et al.   DEVELOPMENTAL CELL

Hydroxychloroquine: A Physiologically-Based Pharmacokinetic Model in the Context of Cancer-Related Autophagy Modulation

(2018) Keagan P. Collins et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Cargo recognition and degradation by selective autophagy

(2018) Damián Gatica et al.   NATURE CELL BIOLOGY

Autophagy Sustains Pancreatic Cancer Growth through Both Cell-Autonomous and Nonautonomous Mechanisms

(2018) Annan Yang et al.   Cancer Discovery

Discovery of a small molecule targeting autophagy via ATG4B inhibition and cell death of colorectal cancer cells in vitro and in vivo

(2018) Yuanyuan Fu et al.   Autophagy

Targeting autophagy by small molecule inhibitors of vacuolar protein sorting 34 (Vps34) improves the sensitivity of breast cancer cells to Sunitinib

(2018) Matheus Dyczynski et al.   CANCER LETTERS

Curcumin sensitizes prostate cancer cells to radiation partly via epigenetic activation of miR-143 and miR-143 mediated autophagy inhibition

(2017) Jianbo Liu et al.   JOURNAL OF DRUG TARGETING

SBI0206965, a novel inhibitor of Ulk1, suppresses non-small cell lung cancer cell growth by modulating both autophagy and apoptosis pathways

(2017) Fang Tang et al.   ONCOLOGY REPORTS

Gastrin Enhances Autophagy and Promotes Gastric Carcinoma Proliferation via Inducing AMPKα

(2017) Zhuang Kun et al.   ONCOLOGY RESEARCH

A Unified Approach to Targeting the Lysosome's Degradative and Growth Signaling Roles

(2017) Vito W. Rebecca et al.   Cancer Discovery

TDP-43/HDAC6 axis promoted tumor progression and regulated nutrient deprivation-induced autophagy in glioblastoma

(2017) Tzu-Wei Lin et al.   Oncotarget

Autophagy inhibition overcomes multiple mechanisms of resistance to BRAF inhibition in brain tumors

(2017) Jean M Mulcahy Levy et al.   eLife

The presence of LC3B puncta and HMGB1 expression in malignant cells correlate with the immune infiltrate in breast cancer

(2016) Sylvain Ladoire et al.   Autophagy

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

(2016) Daniel J Klionsky et al.   Autophagy

ATG7 regulates energy metabolism, differentiation and survival of Philadelphia-chromosome-positive cells

(2016) Maria Karvela et al.   Autophagy

Caloric Restriction Mimetics Enhance Anticancer Immunosurveillance

(2016) Federico Pietrocola et al.   CANCER CELL

Recent insights into the function of autophagy in cancer: Table 1.

(2016) Ravi Amaravadi et al.   GENES & DEVELOPMENT

Antitumor adaptive immunity remains intact following inhibition of autophagy and antimalarial treatment

(2016) Hanna Starobinets et al.   JOURNAL OF CLINICAL INVESTIGATION

JNK1 Inhibition Attenuates Hypoxia-Induced Autophagy and Sensitizes to Chemotherapy

(2016) I. A. Vasilevskaya et al.   MOLECULAR CANCER RESEARCH

Pancreatic stellate cells support tumour metabolism through autophagic alanine secretion

(2016) Cristovão M. Sousa et al.   NATURE

Role of Autophagy as a Survival Mechanism for Hypoxic Cells in Tumors

(2016) Qian Tan et al.   NEOPLASIA

Therapeutic Targeting of Autophagy

(2016) Christina G. Towers et al.   EBioMedicine

Autophagy as a Survival Mechanism for Squamous Cell Carcinoma Cells in Endonuclease G-Mediated Apoptosis

(2016) Atsushi Masui et al.   PLoS One

Safety and Biologic Response of Pre-operative Autophagy Inhibition in Combination with Gemcitabine in Patients with Pancreatic Adenocarcinoma

(2015) Brian A. Boone et al.   ANNALS OF SURGICAL ONCOLOGY

SAR405, a PIK3C3/Vps34 inhibitor that prevents autophagy and synergizes with MTOR inhibition in tumor cells

(2015) Benoit Pasquier   Autophagy

Combined evaluation of LC3B puncta and HMGB1 expression predicts residual risk of relapse after adjuvant chemotherapy in breast cancer

(2015) Sylvain Ladoire et al.   Autophagy

Autophagy inhibitors

(2015) Benoit Pasquier   CELLULAR AND MOLECULAR LIFE SCIENCES

Autophagy in malignant transformation and cancer progression

(2015) L. Galluzzi et al.   EMBO JOURNAL

Recent insights into cell death and autophagy

(2015) Brent E. Fitzwalter et al.   FEBS Journal

Pharmacological inhibition of ULK1 kinase blocks mammalian target of rapamycin (mTOR)-dependent autophagy.

(2015) Katy J. Petherick et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pharmacological Inhibition of ULK1 Kinase Blocks Mammalian Target of Rapamycin (mTOR)-dependent Autophagy

(2015) Katy J. Petherick et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Limited Mitochondrial Permeabilization Causes DNA Damage and Genomic Instability in the Absence of Cell Death

(2015) Gabriel Ichim et al.   MOLECULAR CELL

Caspase-3 Promotes Genetic Instability and Carcinogenesis

(2015) Xinjian Liu et al.   MOLECULAR CELL

Small Molecule Inhibition of the Autophagy Kinase ULK1 and Identification of ULK1 Substrates

(2015) Daniel F. Egan et al.   MOLECULAR CELL

Transcriptional control of autophagy–lysosome function drives pancreatic cancer metabolism

(2015) Rushika M. Perera et al.   NATURE

Macroautophagy is dispensable for growth of KRAS mutant tumors and chloroquine efficacy

(2015) Christina H. Eng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Atg7 Overcomes Senescence and Promotes Growth of BrafV600E-Driven Melanoma

(2015) X. Xie et al.   Cancer Discovery

Therapy and pharmacological properties of hydroxychloroquine and chloroquine in treatment of systemic lupus erythematosus, rheumatoid arthritis and related diseases

(2015) K. D. Rainsford et al.   INFLAMMOPHARMACOLOGY

Phase I clinical trial and pharmacodynamic evaluation of combination hydroxychloroquine and doxorubicin treatment in pet dogs treated for spontaneously occurring lymphoma

(2014) Rebecca A Barnard et al.   Autophagy

Combined autophagy and HDAC inhibition

(2014) Devalingam Mahalingam et al.   Autophagy

Phase I trial of hydroxychloroquine with dose-intense temozolomide in patients with advanced solid tumors and melanoma

(2014) Reshma Rangwala et al.   Autophagy

Combined MTOR and autophagy inhibition

(2014) Reshma Rangwala et al.   Autophagy

A novel ATG4B antagonist inhibits autophagy and has a negative impact on osteosarcoma tumors

(2014) Debra Akin et al.   Autophagy

Acidic extracellular pH neutralizes the autophagy-inhibiting activity of chloroquine

(2014) Paola Pellegrini et al.   Autophagy

Combined autophagy and proteasome inhibition

(2014) Dan T Vogl et al.   Autophagy

A phase I/II trial of hydroxychloroquine in conjunction with radiation therapy and concurrent and adjuvant temozolomide in patients with newly diagnosed glioblastoma multiforme

(2014) Myrna R Rosenfeld et al.   Autophagy

Characterization of VPS34-IN1, a selective inhibitor of Vps34, reveals that the phosphatidylinositol 3-phosphate-binding SGK3 protein kinase is a downstream target of class III phosphoinositide 3-kinase

(2014) Ruzica Bago et al.   BIOCHEMICAL JOURNAL

Tumor Vessel Normalization by Chloroquine Independent of Autophagy

(2014) Hannelore Maes et al.   CANCER CELL

STAT3-Mediated Autophagy Dependence Identifies Subtypes of Breast Cancer Where Autophagy Inhibition Can Be Efficacious

(2014) P. Maycotte et al.   CANCER RESEARCH

Autophagy Is a Survival Mechanism of Acute Myelogenous Leukemia Precursors during Dual mTORC2/mTORC1 Targeting

(2014) J. K. Altman et al.   CLINICAL CANCER RESEARCH

Quantitative proteomics identifies NCOA4 as the cargo receptor mediating ferritinophagy

(2014) Joseph D. Mancias et al.   NATURE

Selective VPS34 inhibitor blocks autophagy and uncovers a role for NCOA4 in ferritin degradation and iron homeostasis in vivo

(2014) William E. Dowdle et al.   NATURE CELL BIOLOGY

A highly potent and selective Vps34 inhibitor alters vesicle trafficking and autophagy

(2014) Baptiste Ronan et al.   Nature Chemical Biology

Self-consumption: the interplay of autophagy and apoptosis

(2014) Guillermo Mariño et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Phase II and Pharmacodynamic Study of Autophagy Inhibition Using Hydroxychloroquine in Patients With Metastatic Pancreatic Adenocarcinoma

(2014) B. M. Wolpin et al.   ONCOLOGIST

FET-PET-based reirradiation and chloroquine in patients with recurrent glioblastoma

(2014) Angelika Bilger et al.   STRAHLENTHERAPIE UND ONKOLOGIE

Autophagy Inhibition Improves Chemosensitivity in BRAFV600E Brain Tumors

(2014) J. M. M. Levy et al.   Cancer Discovery

Autophagy Is Critical for Pancreatic Tumor Growth and Progression in Tumors with p53 Alterations

(2014) A. Yang et al.   Cancer Discovery

Autophagy Is Required for Glucose Homeostasis and Lung Tumor Maintenance

(2014) G. Karsli-Uzunbas et al.   Cancer Discovery

Autophagy Controls the Kinetics and Extent of Mitochondrial Apoptosis by Regulating PUMA Levels

(2014) Jacqueline Thorburn et al.   Cell Reports

An autophagy-dependent anticancer immune response determines the efficacy of melanoma chemotherapy

(2014) Mickaël Michaud et al.   OncoImmunology

EGFR signaling and autophagy dependence for growth, survival, and therapy resistance

(2013) Barry Jutten et al.   CELL CYCLE

Autophagy inhibition radiosensitizes in vitro, yet reduces radioresponses in vivo due to deficient immunogenic signalling

(2013) A Ko et al.   CELL DEATH AND DIFFERENTIATION

FOXO3A directs a protective autophagy program in haematopoietic stem cells

(2013) Matthew R. Warr et al.   NATURE

Control of apoptosis by the BCL-2 protein family: implications for physiology and therapy

(2013) Peter E. Czabotar et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Granzyme B degradation by autophagy decreases tumor cell susceptibility to natural killer-mediated lysis under hypoxia

(2013) J. Baginska et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Phase II randomized, double-blind, placebo-controlled study of whole-brain irradiation with concomitant chloroquine for brain metastases

(2013) Luis L Rojas-Puentes et al.   Radiation Oncology

EGFR overexpressing cells and tumors are dependent on autophagy for growth and survival

(2013) Barry Jutten et al.   RADIOTHERAPY AND ONCOLOGY

Autophagy Sustains Mitochondrial Glutamine Metabolism and Growth of BrafV600E-Driven Lung Tumors

(2013) A. M. Strohecker et al.   Cancer Discovery

Lys05

(2012) Ravi K. Amaravadi et al.   Autophagy

Chloroquine sensitizes breast cancer cells to chemotherapy independent of autophagy

(2012) Paola Maycotte et al.   Autophagy

Hypoxia, MTOR and autophagy

(2012) Mikhail V. Blagosklonny   Autophagy

Inhibiting Systemic Autophagy during Interleukin 2 Immunotherapy Promotes Long-term Tumor Regression

(2012) X. Liang et al.   CANCER RESEARCH

The Vitamin E Analogue  -TEA Stimulates Tumor Autophagy and Enhances Antigen Cross-Presentation

(2012) Y. Li et al.   CANCER RESEARCH

A Phase I Study of Erlotinib and Hydroxychloroquine in Advanced Non–Small-Cell Lung Cancer

(2012) Sarah B. Goldberg et al.   Journal of Thoracic Oncology

Autophagy inhibitor Lys05 has single-agent antitumor activity and reproduces the phenotype of a genetic autophagy deficiency

(2012) Q. McAfee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Role of Atg Proteins in Autophagosome Formation

(2011) Noboru Mizushima et al.   Annual Review of Cell and Developmental Biology

Pancreatic cancers require autophagy for tumor growth

(2011) S. Yang et al.   GENES & DEVELOPMENT

Activated Ras requires autophagy to maintain oxidative metabolism and tumorigenesis

(2011) J. Y. Guo et al.   GENES & DEVELOPMENT

Chaperone-mediated autophagy at a glance

(2011) S. Kaushik et al.   JOURNAL OF CELL SCIENCE

Suppression of Autophagy by FIP200 Deletion Impairs DNA Damage Repair and Increases Cell Death upon Treatments with Anticancer Agents

(2011) H. Bae et al.   MOLECULAR CANCER RESEARCH

Targeting autophagy during cancer therapy to improve clinical outcomes

(2011) Jean M. Mulcahy Levy et al.   PHARMACOLOGY & THERAPEUTICS

Autophagy-Dependent Anticancer Immune Responses Induced by Chemotherapeutic Agents in Mice

(2011) M. Michaud et al.   SCIENCE

Autophagic Survival in Resistance to Histone Deacetylase Inhibitors: Novel Strategies to Treat Malignant Peripheral Nerve Sheath Tumors

(2010) G. Lopez et al.   CANCER RESEARCH

Chaperone-mediated autophagy in protein quality control

(2010) Esperanza Arias et al.   CURRENT OPINION IN CELL BIOLOGY

Resistance to Caspase-Independent Cell Death Requires Persistence of Intact Mitochondria

(2010) Stephen W.G. Tait et al.   DEVELOPMENTAL CELL

Autophagy facilitates glycolysis during Ras-mediated oncogenic transformation

(2010) Rebecca Lock et al.   MOLECULAR BIOLOGY OF THE CELL

Seventy-five years of Resochin® in the fight against malaria

(2009) Markus Jensen et al.   PARASITOLOGY RESEARCH