Natural Sources, Pharmacokinetics, Biological Activities and Health Benefits of Hydroxycinnamic Acids and Their Metabolites

Bioavailability and metabolism of chlorogenic acids (acyl‐quinic acids) in humans

(2020) Michael N. Clifford et al.   COMPREHENSIVE REVIEWS IN FOOD SCIENCE AND FOOD SAFETY

Chemical characterization, antioxidant evaluation, and antidiabetic potential of Pinus gerardiana (Pine nuts) extracts

(2020) Faiqa Zulfqar et al.   JOURNAL OF FOOD BIOCHEMISTRY

Identification and quantification of free, esterified, glycosylated and insoluble-bound phenolic compounds in hawthorn berry fruit (Crataegus pinnatifida) and antioxidant activity evaluation

(2020) Xinman Lou et al.   LWT-FOOD SCIENCE AND TECHNOLOGY

Evaluation of antioxidant and antimicrobial activity of phenolic lipids produced by the transesterification of 4-hydroxyphenylacetic acid and triglycerides

(2019) Mustika Sari et al.   Applied Biological Chemistry

Protective effects of p-coumaric acid against oxidant and hyperlipidemia-an in vitro and in vivo evaluation

(2019) Yingbin Shen et al.   BIOMEDICINE & PHARMACOTHERAPY

Factors affecting intake, metabolism and health benefits of phenolic acids: do we understand individual variability?

(2019) Andreia Bento-Silva et al.   EUROPEAN JOURNAL OF NUTRITION

Chemical and Pharmacological Aspects of Caffeic Acid and Its Activity in Hepatocarcinoma

(2019) Kaio Murilo Monteiro Espíndola et al.   Frontiers in Oncology

Medicinal prospects of antioxidants: A review

(2019) Kumari Neha et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Hydroxycinnamic acids and human health. Recent advances

(2019) Vasile Coman et al.   JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE

Antibiotic-Resistant Staphylococcus aureus Does Not Develop Resistance to Vanillic Acid and 2-Hydroxycinnamic Acid after Continuous Exposure in Vitro

(2019) Deniz Keman et al.   ACS Omega

p-Coumaric Acid Attenuates IL-1β-Induced Inflammatory Responses and Cellular Senescence in Rat Chondrocytes

(2019) Xiaojian Huang et al.   INFLAMMATION

Antidepressant Potential of Cinnamic Acids: Mechanisms of Action and Perspectives in Drug Development

(2019) Lúcio Ricardo Leite Diniz et al.   MOLECULES

Ferulic acid protects lipopolysaccharide-induced acute kidney injury by suppressing inflammatory events and upregulating antioxidant defenses in Balb/c mice

(2018) Salma Mukhtar Mir et al.   BIOMEDICINE & PHARMACOTHERAPY

Consumption of green coffee and the risk of chronic diseases

(2018) Nevin Sanlier et al.   CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION

Anti-Inflammatory Effects of p-Coumaric Acid, a Natural Compound of Oldenlandia diffusa, on Arthritis Model Rats

(2018) Hao Zhu et al.   Evidence-based Complementary and Alternative Medicine

Absorption and metabolism of yerba mate phenolic compounds in humans

(2018) Miren Gómez-Juaristi et al.   FOOD CHEMISTRY

Caffeic acid and chlorogenic acid: Evaluation of antioxidant effect and inhibition of key enzymes linked with hypertension

(2018) Odunayo Michael Agunloye et al.   JOURNAL OF FOOD BIOCHEMISTRY

Bioaccessibility of hydroxycinnamic acids and antioxidant capacity from sorghum bran thermally processed during simulated in vitro gastrointestinal digestion

(2018) Norma Julieta Salazar-López et al.   JOURNAL OF FOOD SCIENCE AND TECHNOLOGY-MYSORE

Pharmacokinetics and brain penetration study of chlorogenic acid in rats

(2018) Gaurav Kumar et al.   XENOBIOTICA

Oxidative stress, aging, and diseases

(2018) Ilaria Liguori et al.   Clinical Interventions in Aging

4-Hydroxyphenylacetic Acid Prevents Acute APAP-Induced Liver Injury by Increasing Phase II and Antioxidant Enzymes in Mice

(2018) Hongqiong Zhao et al.   Frontiers in Pharmacology

TNF-α-induced oxidative stress and endothelial dysfunction in EA.hy926 cells is prevented by mate and green coffee extracts, 5-caffeoylquinic acid and its microbial metabolite, dihydrocaffeic acid

(2018) Shenli Wang et al.   INTERNATIONAL JOURNAL OF FOOD SCIENCES AND NUTRITION

Antioxidant Properties of Ferulic Acid and Its Possible Application

(2018) Kamila Zduńska et al.   SKIN PHARMACOLOGY AND PHYSIOLOGY

Dietary intake of (poly)phenols in children and adults: cross-sectional analysis of UK National Diet and Nutrition Survey Rolling Programme (2008–2014)

(2018) Nida Ziauddeen et al.   EUROPEAN JOURNAL OF NUTRITION

Pharmacokinetics, Bioavailability, and Tissue Distribution Study of Angoroside C and Its Metabolite Ferulic Acid in Rat Using UPLC-MS/MS

(2018) Chenning Zhang et al.   Frontiers in Pharmacology

The potential effects of chlorogenic acid, the main phenolic components in coffee, on health: a comprehensive review of the literature

(2017) Narges Tajik et al.   EUROPEAN JOURNAL OF NUTRITION

Structural characterization of reaction products of caftaric acid and bisulfite present in a commercial wine using high resolution mass spectrometric and nuclear magnetic resonance techniques

(2017) Yoji Hayasaka et al.   FOOD CHEMISTRY

Antioxidant, Antidiabetic, and Antihypertensive Properties of Echinacea purpurea Flower Extract and Caffeic Acid Derivatives Using In Vitro Models

(2017) Shiow-Ying Chiou et al.   JOURNAL OF MEDICINAL FOOD

Ferulic acid-4- O -sulfate rather than ferulic acid relaxes arteries and lowers blood pressure in mice

(2017) Evelien Van Rymenant et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Excretion of Avenanthramides, Phenolic Acids and their Major Metabolites Following Intake of Oat Bran

(2017) Manuel Y. Schär et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Hydroxycinnamic Acids and Their Derivatives: Cosmeceutical Significance, Challenges and Future Perspectives, a Review

(2017) Oludemi Taofiq et al.   MOLECULES

Chlorogenic acids and the acyl-quinic acids: discovery, biosynthesis, bioavailability and bioactivity

(2017) Michael N. Clifford et al.   NATURAL PRODUCT REPORTS

Antioxidant activity of rosmarinic acid and its principal metabolites in chemical and cellular systems: Importance of physico-chemical characteristics

(2017) Amma G. Adomako-Bonsu et al.   TOXICOLOGY IN VITRO

The colonic metabolites dihydrocaffeic acid and dihydroferulic acid are more effective inhibitors of in vitro platelet activation than their phenolic precursors

(2017) Gema Baeza et al.   Food & Function

Cinnamic Acid and Its Derivatives: Mechanisms for Prevention and Management of Diabetes and Its Complications

(2017) Sirichai Adisakwattana   Nutrients

Biotransformation of polyphenols in a dynamic multistage gastrointestinal model

(2016) Shima Sadeghi Ekbatan et al.   FOOD CHEMISTRY

Dihydrocaffeic acid, a major microbial metabolite of chlorogenic acids, shows similar protective effect than a yerba mate phenolic extract against oxidative stress in HepG2 cells

(2016) Gema Baeza et al.   FOOD RESEARCH INTERNATIONAL

Enhanced oral bioavailability and in vivo antioxidant activity of chlorogenic acid via liposomal formulation

(2016) Yingshu Feng et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Neuroprotective Effects of Bioavailable Polyphenol-Derived Metabolites against Oxidative Stress-Induced Cytotoxicity in Human Neuroblastoma SH-SY5Y Cells

(2016) Antonio González-Sarrías et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Inhibitory mechanism against oxidative stress of caffeic acid

(2016) Farhan Ahmed Khan et al.   JOURNAL OF FOOD AND DRUG ANALYSIS

p-Coumaric acid and its conjugates: dietary sources, pharmacokinetic properties and biological activities

(2016) Kehan Pei et al.   JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE

Bioavailability of tomato polyphenols is enhanced by processing and fat addition: Evidence from a randomized feeding trial

(2016) Miriam Martínez-Huélamo et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Flavonoid metabolite 3-(3-hydroxyphenyl)propionic acid formed by human microflora decreases arterial blood pressure in rats

(2016) Iveta Najmanová et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Hydroxycinnamic acid derivatives: a potential class of natural compounds for the management of lipid metabolism and obesity

(2016) Md Ashraful Alam et al.   Nutrition & Metabolism

An overview on the role of dietary phenolics for the treatment of cancers

(2016) Preethi G. Anantharaju et al.   Nutrition Journal

Ferulic acid exerts antitumor activity and inhibits metastasis in breast cancer cells by regulating epithelial to mesenchymal transition

(2016) XIANG ZHANG et al.   ONCOLOGY REPORTS

Sinapic Acid and Its Derivatives as Medicine in Oxidative Stress-Induced Diseases and Aging

(2016) Chunye Chen   Oxidative Medicine and Cellular Longevity

Pharmacokinetics of Caffeic Acid from Methanol Seed Extract of Syzygium cumini L in Rats

(2016) Muhammad Islam et al.   TROPICAL JOURNAL OF PHARMACEUTICAL RESEARCH

Fate of Microbial Metabolites of Dietary Polyphenols in Rats: Is the Brain Their Target Destination?

(2015) Mattia Gasperotti et al.   ACS Chemical Neuroscience

Anticancer Agents Derived from Natural Cinnamic Acids

(2015) Ping Su et al.   Anti-Cancer Agents in Medicinal Chemistry

Bioactivity of phenolic acids: Metabolites versus parent compounds: A review

(2015) Sandrina A. Heleno et al.   FOOD CHEMISTRY

Ferulic acid renders protection to HEK293 cells against oxidative damage and apoptosis induced by hydrogen peroxide

(2015) Yuan-Yuan Bian et al.   IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL

Anthocyanins and their physiologically relevant metabolites alter the expression of IL-6 and VCAM-1 in CD40L and oxidized LDL challenged vascular endothelial cells

(2015) Hiren P. Amin et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Protective Effects of Dihydrocaffeic Acid, a Coffee Component Metabolite, on a Focal Cerebral Ischemia Rat Model

(2015) Kyungjin Lee et al.   MOLECULES

Breeding Vegetables with Increased Content in Bioactive Phenolic Acids

(2015) Prashant Kaushik et al.   MOLECULES

Effects of Caffeic and 5-Caffeoylquinic Acids on Cell Viability and Cellular Uptake in Human Colon Adenocarcinoma Cells

(2015) Luana Dalbem Murad et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

Role of Chlorogenic Acids in Controlling Oxidative and Inflammatory Stress Conditions

(2015) Ningjian Liang et al.   Nutrients

Pharmacokinetics and Tissue Distribution Study of Chlorogenic Acid from Lonicerae Japonicae Flos Following Oral Administrations in Rats

(2014) Yulu Zhou et al.   Evidence-based Complementary and Alternative Medicine

Determination of Phenolic Compounds in Artichoke, Garlic and Spinach by Ultra-High-Performance Liquid Chromatography Coupled to Tandem Mass Spectrometry

(2014) María Isabel Alarcón-Flores et al.   Food Analytical Methods

Pro-oxidative and Antioxidative Controls and Signaling Modification of Polyphenolic Phytochemicals: Contribution to Health Promotion and Disease Prevention?

(2014) Kai On Chu et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Analysis of phenolic constituents, antiradical and antimicrobial activity of edible mushrooms growing wild in Poland

(2014) Natalia Nowacka et al.   LWT-FOOD SCIENCE AND TECHNOLOGY

Antidepressant-like effects of ferulic acid: involvement of serotonergic and norepinergic systems

(2014) Jianliang Chen et al.   METABOLIC BRAIN DISEASE

Bioavailability of caffeic acid in rats and its absorption properties in the Caco-2 cell model

(2014) Su-Jun Wang et al.   PHARMACEUTICAL BIOLOGY

Phenolic Acid Composition, Antiatherogenic and Anticancer Potential of Honeys Derived from Various Regions in Greece

(2014) Eliana Spilioti et al.   PLoS One

Coprinopsis atramentaria extract, its organic acids, and synthesized glucuronated and methylated derivatives as antibacterial and antifungal agents

(2014) Sandrina A. Heleno et al.   Food & Function

Impact of dose on the bioavailability of coffee chlorogenic acids in humans

(2014) Angélique Stalmach et al.   Food & Function

Sinapic Acid and Its Derivatives: Natural Sources and Bioactivity

(2013) Neda Nićiforović et al.   COMPREHENSIVE REVIEWS IN FOOD SCIENCE AND FOOD SAFETY

Antioxidant Properties of Hydroxycinnamic Acids: A Review of Structure- Activity Relationships

(2013) N. Razzaghi-Asl et al.   CURRENT MEDICINAL CHEMISTRY

Antimicrobial and demelanizing activity of Ganoderma lucidum extract, p-hydroxybenzoic and cinnamic acids and their synthetic acetylated glucuronide methyl esters

(2013) Sandrina A. Heleno et al.   FOOD AND CHEMICAL TOXICOLOGY

Cytotoxicity of Coprinopsis atramentaria extract, organic acids and their synthesized methylated and glucuronate derivatives

(2013) Sandrina A. Heleno et al.   FOOD RESEARCH INTERNATIONAL

Metabolism of Nonesterified and Esterified Hydroxycinnamic Acids in Red Wines by Brettanomyces bruxellensis

(2013) Lauren M. Schopp et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Rosmarinic acid: new aspects

(2013) Maike Petersen   PHYTOCHEMISTRY REVIEWS

Hydroxycinnamic Acid Antioxidants: An Electrochemical Overview

(2013) José Teixeira et al.   Biomed Research International

Bioavailability of bioactive food compounds: a challenging journey to bioefficacy

(2012) Maarit J. Rein et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Antioxidant Therapy: Current Status and Future Prospects

(2012) O. Firuzi et al.   CURRENT MEDICINAL CHEMISTRY

Immunomodulatory and Anti-inflammatory Effect of p-Coumaric Acid, a Common Dietary Polyphenol on Experimental Inflammation in Rats

(2012) Samuel Joshua Pragasam et al.   INFLAMMATION

Antioxidant Activity of Phenolic Acids and Their Metabolites: Synthesis and Antioxidant Properties of the Sulfate Derivatives of Ferulic and Caffeic Acids and of the Acyl Glucuronide of Ferulic Acid

(2012) A. Piazzon et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Absorption, Disposition, Metabolism, and Excretion of [3-14C]Caffeic Acid in Rats

(2012) Maizatul H. Omar et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Biosynthesis, Natural Sources, Dietary Intake, Pharmacokinetic Properties, and Biological Activities of Hydroxycinnamic Acids

(2012) Hesham R. El-Seedi et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Antioxidant and Antimicrobial Activities of Cinnamic Acid Derivatives

(2012) M. Sova   MINI-REVIEWS IN MEDICINAL CHEMISTRY

Cinnamic Acid Derivatives as Anticancer Agents-A Review

(2011) P. De et al.   CURRENT MEDICINAL CHEMISTRY

Vanillic acid inhibits inflammatory mediators by suppressing NF-κB in lipopolysaccharide-stimulated mouse peritoneal macrophages

(2011) Min-Cheol Kim et al.   IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY

Increase of the Activity of Phase II Antioxidant Enzymes in Rats after a Single Dose of Coffee

(2011) Silvio José Valadão Vicente et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Effect of Simultaneous Consumption of Milk and Coffee on Chlorogenic Acids’ Bioavailability in Humans

(2011) Giselle S. Duarte et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Antidiabetic and antioxidant activity of hydroxycinnamic acids from Calamintha Officinalis Moench.

(2011) P. P. Singh et al.   MEDICINAL CHEMISTRY RESEARCH

Antiglycative and neuroprotective activity of colon-derived polyphenol catabolites

(2011) Elena Verzelloni et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Impact of Polyphenol Metabolites Produced by Colonic Microbiota on Expression of COX-2 and GSTT2 in Human Colon Cells (LT97)

(2011) Claudia Miene et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

Bioavailability of chlorogenic acids following acute ingestion of coffee by humans with an ileostomy

(2010) Angélique Stalmach et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Comparison of the Phenolic Content and Antioxidant Activities of Apocynum venetum L. (Luo-Bu-Ma) and Two of Its Alternative Species

(2010) Taigang Liang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Bioprocessing of Wheat Bran in Whole Wheat Bread Increases the Bioavailability of Phenolic Acids in Men and Exerts Antiinflammatory Effects ex Vivo

(2010) Nuria Mateo Anson et al.   JOURNAL OF NUTRITION

Dihydroxylated phenolic acids derived from microbial metabolism reduce lipopolysaccharide-stimulated cytokine secretion by human peripheral blood mononuclear cells

(2009) María Monagas et al.   BRITISH JOURNAL OF NUTRITION

Metabolite Profiling of Hydroxycinnamate Derivatives in Plasma and Urine after the Ingestion of Coffee by Humans: Identification of Biomarkers of Coffee Consumption

(2009) A. Stalmach et al.   DRUG METABOLISM AND DISPOSITION

Phenolic antioxidants – radical-scavenging and chain-breaking activity: A comparative study

(2009) Vessela D. Kancheva   EUROPEAN JOURNAL OF LIPID SCIENCE AND TECHNOLOGY

Polyphenols: food sources, properties and applications - a review

(2009) Hasna El Gharras   INTERNATIONAL JOURNAL OF FOOD SCIENCE AND TECHNOLOGY

Effect of Adlay (Coix lachryma-jobi L. var. ma-yuen Stapf) Testa and Its Phenolic Components on Cu2+-Treated Low-Density Lipoprotein (LDL) Oxidation and Lipopolysaccharide (LPS)-Induced Inflammation in RAW 264.7 Macrophages

(2009) Din-Wen Huang et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

In vitro and in vivo conjugation of dietary hydroxycinnamic acids by UDP-glucuronosyltransferases and sulfotransferases in humans

(2009) Chi Chun Wong et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Polyphenol metabolites from colonic microbiota exert anti-inflammatory activity on different inflammation models

(2009) Mar Larrosa et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Bioavailability of hydroxycinnamates: a brief review of in vivo and in vitro studies

(2009) Zhaohui Zhao et al.   PHYTOCHEMISTRY REVIEWS

Hydroxycinnamates and their in vitro and in vivo antioxidant activities

(2009) Fereidoon Shahidi et al.   PHYTOCHEMISTRY REVIEWS

Effect of dihydrocaffeic acid on UV irradiation of human keratinocyte HaCaT cells

(2008) Laure Poquet et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Synthesis of hydroxycinnamic acid glucuronides and investigation of their affinity for human serum albumin

(2008) Stéphanie Galland et al.   ORGANIC & BIOMOLECULAR CHEMISTRY