Article
Physiology
Jaidip Jagtap, Said Audi, Mir Hadi Razeghi-Kondelaji, Brian L. Fish, Christopher Hansen, Jayashree Narayan, Feng Gao, Gayatri Sharma, Abdul K. Parchur, Anjishnu Banerjee, Carmen Bergom, Meetha Medhora, Amit Joshi
Summary: The dynamic in vivo near-infrared fluorescence imaging method accurately tracks changes in lung vascular permeability-surface area product and lung interstitial transport in response to radiation injury. This imaging technique could replace current terminal assays for assessing lung function.
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Jiri Ferda, Matthias Frolich, Eva Ferdova, Filip Heidenreich, Radim Charvat, Hynek Mirka
Summary: Angiogenesis in healthy tissue and within malignant tumors differs, which may be due to vascular mimicry formation altering contrast material or radiopharmaceutical distribution. Changes in molecular exchange affect the behavior of contrast agents and radiopharmaceuticals. Increased permeability and faster molecular exchange are indicative signs of malignant tissue. Dynamic imaging can assess changes in the microenvironment, reflecting altered blood flow and tumor development. Understanding the vascular network and molecular distribution is crucial for image interpretation and assessment of therapies targeting neovascularization.
EUROPEAN JOURNAL OF RADIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Zhongchan Sun, Guang Tong, Yuanhui Liu, Hualin Fan, Weibin He, Bo Wang, Shuang Xia, Pengcheng He
Summary: This study used F-18-NEB probe with PET to evaluate blood perfusion and vascular permeability, and found that the F-18-NEB probe had good imaging performance and could be used to monitor the response to PAD therapy.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Biochemical Research Methods
Zhe LI, Pengbo He, Yuqing Xu, Yuxiao Deng, Yuvan Gao, Sung -liang Chen
Summary: This study demonstrates the noninvasive observation of inflammation-related vascular leakage using photoacoustic microscopy (PAM) in mice. A model combining LPS application and EB injection on mouse ears was developed for the identification and evaluation of early vascular leakage. The results show the potential of PAM in clinical sepsis diagnosis and management.
BIOMEDICAL OPTICS EXPRESS
(2022)
Article
Multidisciplinary Sciences
Magdiel Inggrid Setyawati, Qin Wang, Nengyi Ni, Jie Kai Tee, Katsuhiko Ariga, Pu Chun Ke, Han Kiat Ho, Yucai Wang, David Tai Leong
Summary: Traditional nanomedicine relies on tumor induced EPR effect for drug delivery. Here the authors show that gold nanoparticles are independently able to induce leakiness at tumor vasculature to enhance the tumor killing effect.
NATURE COMMUNICATIONS
(2023)
Article
Agriculture, Dairy & Animal Science
Kajsa Gustafsson, Amos J. Tatz, Roee Dahan, Wiessam Abu Ahmad, Malka Britzi, Gila A. Sutton, Gal Kelmer
Summary: The study aimed to investigate the safety and pharmacokinetics of trimethoprim-sulphadiazine administered via intravenous regional limb perfusion (IVRLP) into the cephalic vein. However, severe vasculitis in some horses led to low concentrations of trimethoprim-sulphadiazine in synovial fluid.
Review
Biochemistry & Molecular Biology
Alison Domingues, Alessandro Fantin
Summary: The vascular endothelium acts as a selective barrier to regulate macromolecule exchange, but its integrity is compromised in various pathological conditions, leading to increased vascular hyperpermeability. VEGFA is a potent permeability factor, and NRP1 may play a fundamental role in regulating VEGFA-induced responses in vascular endothelial cells.
Article
Instruments & Instrumentation
Pranav Shah, Kejal Chavda, Bhavin Vyas, Shailaja Patel
Summary: The development of Linagliptin solid lipid nanoparticles (LGP-SLNs) aimed to improve its oral bioavailability by using poloxamer 188 and Tween 80 as P-gp inhibitors. Experimental results showed that LGP-SLNs exhibited higher relative bioavailability and better glucose reduction effects in vivo.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Jayanarayanan Sadanandan, Monica Sathyanesan, Yutong Liu, Neeraj K. Tiwari, Samuel S. Newton
Summary: Cerebral hypoperfusion has negative effects on cognitive function and increases the risk of neuropsychiatric disorders. Erythropoietin (EPO) has been shown to improve cognitive function, but its use is limited due to its erythropoietic activity. However, carbamoylated erythropoietin (CEPO), a non-erythropoietic derivative of EPO, has similar neurotrophic and behavioral effects without affecting hematocrit levels. Our study reveals that CEPO can increase blood perfusion through neurotransmission and vasodilation, without affecting tight junction integrity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Baiyu Liu, Lei Hu, Li Wang, Dong Xing, Lin Peng, Pianpian Chen, Feifei Zeng, Weiyin Vivian Liu, Huan Liu, Yunfei Zha
Summary: The study utilized DCE-MRI and texture analysis to assess microvascular permeability and structural changes in diabetic muscles. The results indicated significant changes in permeability and texture parameters in the diabetic group at 8 weeks, followed by a decreasing trend. Muscle fiber cross-sectional area was negatively correlated with extravascular extracellular space volume fraction, while the capillary-to-fiber ratio was positively correlated with plasma volume fraction.
EUROPEAN RADIOLOGY
(2021)
Article
Engineering, Biomedical
Xin Liu, Xinhuan Wang, Liming Zhang, Lulu Sun, Heran Wang, Hao Zhao, Zhengtao Zhang, Wenli Liu, Yiming Huang, Shen Ji, Jingjinqiu Zhang, Kai Li, Biaobiao Song, Chun Li, Hui Zhang, Song Li, Shu Wang, Xiongfei Zheng, Qi Gu
Summary: This study presents a methodology for fabricating soft vascularized tissue at centimeter scale using multimaterial bioprinting with a customized multistage-temperature-control printer. The printed constructs can support 3D capillary networks to mimic mature and functional liver tissue, and also enable direct surgical anastomosis of blood vessels with the printed pressure-bearing layer. This versatile platform allows for optimal cellularization in engineered tissues through the replication of vasculature networks.
ADVANCED HEALTHCARE MATERIALS
(2021)
Article
Pharmacology & Pharmacy
Tameille Valentine, Lydia Hardowar, Jasmine Elphick-Ross, Richard P. Hulse, Mark Paul-Clark
Summary: Chemotherapy-induced neuropathies cause sensory disturbances and pain in cancer patients, and current analgesic strategies are ineffective due to a lack of understanding of the underlying causes. Research on the immune-neuronal interactions across different cancer therapy drug classes may lead to better pain management for cancer survivors.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Md Zahid Akhter, Jagdish Chandra Joshi, Vijay Avin Balaji Ragunathrao, Mark Maienschein-Cline, Richard L. Proia, Asrar B. Malik, Dolly Mehta
Summary: The study demonstrates the generation of a population of S1PR1(+) EC is crucial for mediating endothelial repair and restoring vascular homeostasis in inflammatory vascular injury states. This transition of cells is induced by S1P and involves key genes such as SPHK1 and SPNS2, which are regulated by transcription factors EGR1 and STAT3.
CIRCULATION RESEARCH
(2021)
Review
Medicine, Research & Experimental
Bart Hens, Isabel Gonzalez-Alvarez, Marival Bermejo
Summary: This review presents the applications and future perspectives of the in situ perfusion technique for studying drug absorption mechanisms. The differences in gastrointestinal anatomy and physiology between rats and humans are thoroughly discussed.
MOLECULAR PHARMACEUTICS
(2022)
Article
Biochemistry & Molecular Biology
Jin-Ho Park, Ha-Hyeon Shin, Hyun-Seung Rhyu, So-Hee Kim, Eun-Seok Jeon, Byung-Kwan Lim
Summary: Research has shown that Coxsackievirus and adenovirus receptor (CAR) plays a crucial role in vascular endothelial cell junctions, with CAR deletion leading to increased vascular permeability and inflammatory cell infiltration. However, in a mouse model, CAR deletion did not significantly increase CVB3-induced myocarditis, although tissue virus titers were higher in CAR-eKO compared to WT mice.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)