Metalloproteinases and Their Inhibitors: Potential for the Development of New Therapeutics

Elevated circulating metalloproteinase 7 predicts recurrent cardiovascular events in patients with carotid stenosis: a prospective cohort study

(2020) David Moreno-Ajona et al.   BMC Cardiovascular Disorders

MMP-10 is Increased in Early Stage Diabetic Kidney Disease and can be Reduced by Renin-Angiotensin System Blockade

(2020) José María Mora-Gutiérrez et al.   Scientific Reports

Structural Microangiopathies in Skeletal Muscle Related to Systemic Vascular Pathologies in Humans

(2020) Oliver Baum et al.   Frontiers in Physiology

Matrix Metalloproteinases in Diabetic Kidney Disease

(2020) Garcia-Fernandez et al.   Journal of Clinical Medicine

Matrix Metalloproteinases Retain Soluble FasL-mediated Resistance to Cell Death in Fibrotic-Lung Myofibroblasts

(2020) David Nareznoi et al.   Cells

The Association of Matrix Metalloproteinases with Chronic Kidney Disease and Peripheral Vascular Disease: A Light at the End of the Tunnel?

(2020) Michele Provenzano et al.   Biomolecules

Injectable MMP-Responsive Nanotube-Modified Gelatin Hydrogel for Dental Infection Ablation

(2020) Juliana S. Ribeiro et al.   ACS Applied Materials & Interfaces

Haemonchus contortus: siRNA mediated knockdown of matrix metalloproteinase 12A (MMP-12) results in reduction of infectivity

(2020) Muhammad Ali-ul-Husnain Naqvi et al.   Parasites & Vectors

Matrix metalloproteinase family gene polymorphisms and lung cancer susceptibility: an updated meta-analysis

(2020) Xiaoliang Li et al.   Journal of Thoracic Disease

Dynamic changes of MMP-9 plasma levels correlate with JCV reactivation and immune activation in natalizumab-treated multiple sclerosis patients

(2019) Marco Iannetta et al.   Scientific Reports

Health benefits of resveratrol: Evidence from clinical studies

(2019) Akhand Pratap Singh et al.   MEDICINAL RESEARCH REVIEWS

MMP-8-Responsive Polyethylene Glycol Hydrogel for Intraoral Drug Delivery

(2019) J. Guo et al.   JOURNAL OF DENTAL RESEARCH

Inhibition of MMPs and ADAM/ADAMTS

(2019) Charles J. Malemud   BIOCHEMICAL PHARMACOLOGY

ADAM10 in Alzheimer's disease: Pharmacological modulation by natural compounds and its role as a peripheral marker

(2019) Patricia Regina Manzine et al.   BIOMEDICINE & PHARMACOTHERAPY

Cardiovascular organ damage in type 2 diabetes mellitus: the role of lipids and inflammation

(2019) Michaela Kozakova et al.   Cardiovascular Diabetology

Directed evolution of the metalloproteinase inhibitor TIMP-1 reveals that its N- and C-terminal domains cooperate in matrix metalloproteinase recognition

(2019) Maryam Raeeszadeh-Sarmazdeh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Urine Levels of Matrix Metalloproteinases and Tissue Inhibitor of Metalloproteinases in Children with Type 1 Diabetes Mellitus

(2019) Zeynep Yürük Yıldırım et al.   Journal of Clinical Research in Pediatric Endocrinology

Metalloproteinases and their tissue inhibitors in Alzheimer’s disease and other neurodegenerative disorders

(2019) Santiago Rivera et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Development of Capsular Fibrosis beneath the Liver Surface in Humans and Mice

(2019) Steven Balog et al.   HEPATOLOGY

Matrix metalloproteinases as target genes for gene regulatory networks driving molecular and cellular pathways related to a multistep pathogenesis of cerebrovascular disease

(2019) Alexey Polonikov et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Matrix metalloproteinase-3 predicts clinical cardiovascular outcomes in patients with coronary artery disease: a 5 years cohort study

(2019) Imen Guizani et al.   MOLECULAR BIOLOGY REPORTS

Influence of Matrix Metallopeptidase 9 on Beta-Amyloid Elimination Across the Blood-Brain Barrier

(2019) Ben Shackleton et al.   MOLECULAR NEUROBIOLOGY

Inhibitory Antibodies Designed for Matrix Metalloproteinase Modulation

(2019) Thomas Fischer et al.   MOLECULES

Matrix metalloproteinase activity in the lung is increased in Hermansky-Pudlak syndrome

(2019) Ross Summer et al.   Orphanet Journal of Rare Diseases

Mechanisms of Action of Novel Drugs Targeting Angiogenesis-Promoting Matrix Metalloproteinases

(2019) Gregg B. Fields   Frontiers in Immunology

Serum Matrix Metalloproteinase-9 Is Associated With Depression After Acute Ischemic Stroke

(2019) Bizhong Che et al.   CIRCULATION JOURNAL

Tissue inhibitor metalloproteinase-1 and clinical outcomes after acute ischemic stroke

(2019) Chongke Zhong et al.   NEUROLOGY

Understanding the complexity of the matrix metalloproteinase system and its relevance to age-related diseases: Age-related macular degeneration and Alzheimer's disease

(2019) Ali A. Hussain et al.   PROGRESS IN RETINAL AND EYE RESEARCH

The Rebirth of Matrix Metalloproteinase Inhibitors: Moving Beyond the Dogma

(2019) Gregg B. Fields   Cells

Matrix metalloproteinase-13 in atherosclerotic plaque is increased by influenza A virus infection

(2019) Han Sol Lee et al.   JOURNAL OF INFECTIOUS DISEASES

Dynamic features of liver fibrogenesis and fibrosis resolution in the absence of matrix metalloproteinase‑9

(2019) Quanrongzi Wang et al.   Molecular Medicine Reports

Effect of MMP-9 gene knockout on retinal vascular form and function

(2019) Akash K. George et al.   PHYSIOLOGICAL GENOMICS

The Role of Matrix Metalloproteinases in the Epithelial-Mesenchymal Transition of Hepatocellular Carcinoma

(2019) Cristian Scheau et al.   Analytical Cellular Pathology

Matrix metalloproteinase: An upcoming therapeutic approach for idiopathic pulmonary fibrosis

(2019) Sushweta Mahalanobish et al.   PHARMACOLOGICAL RESEARCH

The past, present and future perspectives of matrix metalloproteinase inhibitors

(2019) Kang Li et al.   PHARMACOLOGY & THERAPEUTICS

MMP-2 salivary activity in type 2 diabetes mellitus patients

(2019) Juan Antonio Arreguin-Cano et al.   Diabetology & Metabolic Syndrome

Circulating proteomic signature of early death in heart failure patients with reduced ejection fraction

(2019) Marie Cuvelliez et al.   Scientific Reports

Hispidulin inhibits hepatocellular carcinoma growth and metastasis through AMPK and ERK signaling mediated activation of PPARγ

(2018) Mei Han et al.   BIOMEDICINE & PHARMACOTHERAPY

Phase 1b Study of the Safety, Pharmacokinetics, and Disease-related Outcomes of the Matrix Metalloproteinase-9 Inhibitor Andecaliximab in Patients With Rheumatoid Arthritis

(2018) David L. Gossage et al.   CLINICAL THERAPEUTICS

Converting a broad matrix metalloproteinase family inhibitor into a specific inhibitor of MMP-9 and MMP-14

(2018) Jason Shirian et al.   FEBS LETTERS

Targeting the MMP-14/MMP-2/integrin αvβ3 axis with multispecific N-TIMP2-based antagonists for cancer therapy

(2018) Gal Yosef et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Andecaliximab [Anti-matrix Metalloproteinase-9] Induction Therapy for Ulcerative Colitis: A Randomised, Double-Blind, Placebo-Controlled, Phase 2/3 Study in Patients With Moderate to Severe Disease

(2018) William J Sandborn et al.   Journal of Crohns & Colitis

A Phase 2, Randomized, Placebo-Controlled Study Evaluating Matrix Metalloproteinase-9 Inhibitor, Andecaliximab, in Patients With Moderately to Severely Active Crohn’s Disease

(2018) Stefan Schreiber et al.   Journal of Crohns & Colitis

Urinary metalloproteinases and tissue inhibitors of metalloproteinases as potential early biomarkers for renal fibrosis in children with nephrotic syndrome

(2018) Beata Bieniaś et al.   MEDICINE

Protein kinase D3 modulates MMP1 and MMP13 expression in human chondrocytes

(2018) Jonathan Baker et al.   PLoS One

MMP-Responsive ‘Smart’ Drug Delivery and Tumor Targeting

(2018) Qing Yao et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Upregulating MMP‑1 in carcinoma‑associated fibroblasts reduces the efficacy of Taxotere on breast cancer synergized by Collagen IV

(2018) Qingyu Cui et al.   Oncology Letters

A bi-specific inhibitor targeting IL-17A and MMP-9 reduces invasion and motility in MDA-MB-231 cells

(2018) Dana Koslawsky et al.   Oncotarget

Insulin-like growth factor binding protein related protein 1 knockdown attenuates hepatic fibrosis via the regulation of MMPs/TIMPs in mice

(2018) Jun-Jie Ren et al.   Hepatobiliary & Pancreatic Diseases International

Cerebroprotective effects of hydrogen sulfide in homocysteine-induced neurovascular permeability: Involvement of oxidative stress, arginase, and matrix metalloproteinase-9

(2018) Nibendu Nath et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Amyloid-β and Parkinson’s disease

(2018) Ee Wei Lim et al.   JOURNAL OF NEUROLOGY

MMP-9 inhibition promotes anti-tumor immunity through disruption of biochemical and physical barriers to T-cell trafficking to tumors

(2018) Vladi Juric et al.   PLoS One

MMP‑1 is overexpressed in triple‑negative breast cancer tissues and the knockdown of MMP‑1 expression inhibits tumor cell malignant behaviors in�vitro

(2018) Qi‑Min Wang et al.   Oncology Letters

Association between matrix-metalloproteinase polymorphisms and prostate cancer risk: a meta-analysis and systematic review

(2018) Hongxing Zhou et al.   Cancer Management and Research

Synaptic dysfunction in Alzheimer's disease: From the role of amyloid β-peptide to the α-secretase ADAM10

(2017) Stefano Musardo et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

The Role of ADAM10 in Alzheimer’s Disease

(2017) Xiang-Zhen Yuan et al.   JOURNAL OF ALZHEIMERS DISEASE

Biochemical characterization and structure determination of a potent, selective antibody inhibitor of human MMP9

(2017) Todd C. Appleby et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Discovery of a highly selective chemical inhibitor of matrix metalloproteinase-9 (MMP-9) that allosterically inhibits zymogen activation

(2017) Robert H. Scannevin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Syndecan-2 cytoplasmic domain up-regulates matrix metalloproteinase-7 expression via the protein kinase Cγ–mediated FAK/ERK signaling pathway in colon cancer

(2017) Bohee Jang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Development of High Affinity and High Specificity Inhibitors of Matrix Metalloproteinase 14 through Computational Design and Directed Evolution

(2017) Valeria Arkadash et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Therapeutic Potential of Matrix Metalloproteinase Inhibition in Breast Cancer

(2017) Evette S. Radisky et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Leptin induces matrix metalloproteinase 7 expression to promote ovarian cancer cell invasion by activating ERK and JNK pathways

(2017) Ahmad Ghasemi et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Discovery of Novel, Highly Potent, and Selective Matrix Metalloproteinase (MMP)-13 Inhibitors with a 1,2,4-Triazol-3-yl Moiety as a Zinc Binding Group Using a Structure-Based Design Approach

(2017) Hiroshi Nara et al.   JOURNAL OF MEDICINAL CHEMISTRY

Metalloprotease-disintegrin ADAM12 actively promotes the stem cell-like phenotype in claudin-low breast cancer

(2017) Sara Duhachek-Muggy et al.   Molecular Cancer

Gelatin-albumin hybrid nanoparticles as matrix metalloproteinases-degradable delivery systems for breast cancer therapy

(2017) Vahid Heravi Shargh et al.   Nanomedicine

Endothelial LRP1 – A Potential Target for the Treatment of Alzheimer’s Disease

(2017) Steffen E. Storck et al.   PHARMACEUTICAL RESEARCH

Multifaceted Roles of Metzincins in CNS Physiology and Pathology: From Synaptic Plasticity and Cognition to Neurodegenerative Disorders

(2017) Patrycja Brzdak et al.   Frontiers in Cellular Neuroscience

Correlations of MMP-1, MMP-3, and MMP-12 with the degree of atherosclerosis, plaque stability and cardiovascular and cerebrovascular events

(2017) Wei Hu et al.   Experimental and Therapeutic Medicine

Membranous type matrix metalloproteinase 16 induces human prostate cancer metastasis

(2017) Chunwa Jiang et al.   Oncology Letters

Matrix Metalloproteinases-7 and Kidney Fibrosis

(2017) Ben Ke et al.   Frontiers in Physiology

Randomised clinical trial: a phase 1, dose-ranging study of the anti-matrix metalloproteinase-9 monoclonal antibody GS-5745 versus placebo for ulcerative colitis

(2016) W. J. Sandborn et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

ESAT-6 Drives MMP-10 Gene Expression and Secretion in Tuberculosis

(2016) Sara Brilha et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

The Intracellular Effect of Relaxin on Female Anterior Cruciate Ligament Cells

(2016) Jaclyn A. Konopka et al.   AMERICAN JOURNAL OF SPORTS MEDICINE

KISS1R signaling promotes invadopodia formation in human breast cancer cell via β-arrestin2/ERK

(2016) Cameron G. Goertzen et al.   CELLULAR SIGNALLING

Tumor-Triggered Drug Release with Tumor-Targeted Accumulation and Elevated Drug Retention To Overcome Multidrug Resistance

(2016) Wei-Hai Chen et al.   CHEMISTRY OF MATERIALS

Regulation and involvement of matrix metalloproteinases in vascular diseases

(2016) Utpal Sen   Frontiers in Bioscience-Landmark

Matrix metalloproteinases in the brain and blood–brain barrier: Versatile breakers and makers

(2016) Ralf G Rempe et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Radiolabeled Selective Matrix Metalloproteinase 13 (MMP-13) Inhibitors: (Radio)Syntheses and in Vitro and First in Vivo Evaluation

(2016) Verena Hugenberg et al.   JOURNAL OF MEDICINAL CHEMISTRY

Active site specificity profiling of the matrix metalloproteinase family: Proteomic identification of 4300 cleavage sites by nine MMPs explored with structural and synthetic peptide cleavage analyses

(2016) Ulrich Eckhard et al.   MATRIX BIOLOGY

Generation of inhibitory monoclonal antibodies targeting matrix metalloproteinase-14 by motif grafting and CDR optimization

(2016) Dong Hyun Nam et al.   PROTEIN ENGINEERING DESIGN & SELECTION

Hypoxia and tissue destruction in pulmonary TB

(2016) Moerida Belton et al.   THORAX

MT1-MMP sheds LYVE-1 on lymphatic endothelial cells and suppresses VEGF-C production to inhibit lymphangiogenesis

(2016) Hoi Leong Xavier Wong et al.   Nature Communications

ECM-Regulator timp Is Required for Stem Cell Niche Organization and Cyst Production in the Drosophila Ovary

(2016) John R. Pearson et al.   PLoS Genetics

Human iPSC-Derived Neuronal Model of Tau-A152T Frontotemporal Dementia Reveals Tau-Mediated Mechanisms of Neuronal Vulnerability

(2016) M. Catarina Silva et al.   Stem Cell Reports

Matrix Metalloproteinases as Therapeutic Targets for Idiopathic Pulmonary Fibrosis

(2015) Vanessa J. Craig et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Tissue inhibitor of metalloproteinase-3 (TIMP3) promotes endothelial apoptosis via a caspase-independent mechanism

(2015) Jian Hua Qi et al.   APOPTOSIS

Antibody-drug conjugates as novel anti-cancer chemotherapeutics

(2015) C. Peters et al.   BIOSCIENCE REPORTS

Targeting ADAM-17 with an inhibitory monoclonal antibody has antitumour effects in triple-negative breast cancer cells

(2015) F Caiazza et al.   BRITISH JOURNAL OF CANCER

Inhibition of bleomycin-induced pulmonary fibrosis by bone marrow-derived mesenchymal stem cells might be mediated by decreasing MMP9, TIMP-1, INF-γand TGF-β

(2015) Shi-huan Yu et al.   CELL BIOCHEMISTRY AND FUNCTION

Matrix Metalloproteinase Inhibition by Heterotrimeric Triple-Helical Peptide Transition State Analogues

(2015) Manishabrata Bhowmick et al.   CHEMBIOCHEM

Tumor necrosis factor-α-accelerated degradation of type I collagen in human skin is associated with elevated matrix metalloproteinase (MMP)-1 and MMP-3 ex vivo

(2015) Magnus S. Ågren et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

Matrix metalloproteinases as drivers and therapeutic targets in breast cancer

(2015) Evette S. Radisky   Frontiers in Bioscience-Landmark

Evaluation in pre-diagnosis samples discounts ICAM-1 and TIMP-1 as biomarkers for earlier diagnosis of pancreatic cancer

(2015) C. Jenkinson et al.   Journal of Proteomics

Matrix metalloproteinases in liver injury, repair and fibrosis

(2015) Sergio Duarte et al.   MATRIX BIOLOGY

Friends or Foes: Matrix Metalloproteinases and Their Multifaceted Roles in Neurodegenerative Diseases

(2015) Marjana Brkic et al.   MEDIATORS OF INFLAMMATION

Collagen degradation and MMP9 activation by Enterococcus faecalis contribute to intestinal anastomotic leak

(2015) Benjamin D. Shogan et al.   Science Translational Medicine

Inhibition Mechanism of Membrane Metalloprotease by an Exosite-Swiveling Conformational Antibody

(2015) Yael Udi et al.   STRUCTURE

Matrix metalloproteinase-sensitive hydrogel microparticles for pulmonary drug delivery of small molecule drugs or proteins

(2015) Emilie Secret et al.   Journal of Materials Chemistry B

Stiff substrates increase YAP-signaling-mediated matrix metalloproteinase-7 expression

(2015) A Nukuda et al.   Oncogenesis

Selective Allosteric Inhibition of MMP9 Is Efficacious in Preclinical Models of Ulcerative Colitis and Colorectal Cancer

(2015) Derek C. Marshall et al.   PLoS One

Tumor cell-produced matrix metalloproteinase 9 (MMP-9) drives malignant progression and metastasis of basal-like triple negative breast cancer

(2015) Christine Mehner et al.   Oncotarget

Matrix Metalloproteinases and Cancer - Roles in Threat and Therapy

(2014) Lalita Yadav et al.   Asian Pacific Journal of Cancer Prevention

Matrix Metalloproteinases are Involved in Cardiovascular Diseases

(2014) Aline Azevedo et al.   BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY

Urinary TIMP-1 and MMP-2 levels detect the presence of pancreatic malignancies

(2014) R Roy et al.   BRITISH JOURNAL OF CANCER

The Recognition of Collagen and Triple-helical Toolkit Peptides by MMP-13

(2014) Joanna-Marie Howes et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Is there new hope for therapeutic matrix metalloproteinase inhibition?

(2014) Roosmarijn E. Vandenbroucke et al.   NATURE REVIEWS DRUG DISCOVERY

Neuroprotective role of MMP-9 overexpression in the brain of Alzheimer's 5xFAD mice

(2014) Apostolia Fragkouli et al.   NEUROBIOLOGY OF DISEASE

Tissue inhibitor of metalloproteinases-1 induces a pro-tumourigenic increase of miR-210 in lung adenocarcinoma cells and their exosomes

(2014) H Cui et al.   ONCOGENE

ADAM-12 as a Diagnostic Marker for the Proliferation, Migration and Invasion in Patients with Small Cell Lung Cancer

(2014) Shuhong Shao et al.   PLoS One

Affinity- and Specificity-Enhancing Mutations Are Frequent in Multispecific Interactions between TIMP2 and MMPs

(2014) Oz Sharabi et al.   PLoS One

Thymoquinone inhibits proliferation and invasion of human nonsmall-cell lung cancer cells via ERK pathway

(2014) Jing Yang et al.   TUMOR BIOLOGY

Monitoring and Inhibiting MT1-MMP during Cancer Initiation and Progression

(2014) Sonia Pahwa et al.   Cancers

ADAM and ADAMTS family proteins and their role in the colorectal cancer etiopathogenesis

(2013) Leszczynski Przemyslaw et al.   BMB Reports

Therapeutic antibody engineering by high efficiency cell screening

(2013) Achim Doerner et al.   FEBS LETTERS

Targeting a Single Function of the Multifunctional Matrix Metalloprotease MT1-MMP

(2013) Signe Ingvarsen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Molecular Determinants of a Selective Matrix Metalloprotease-12 Inhibitor: Insights from Crystallography and Thermodynamic Studies

(2013) Bertrand Czarny et al.   JOURNAL OF MEDICINAL CHEMISTRY

Unraveling Hidden Regulatory Sites in Structurally Homologous Metalloproteases

(2013) Yael Udi et al.   JOURNAL OF MOLECULAR BIOLOGY

Enzyme-Directed Assembly of Nanoparticles in Tumors Monitored by in Vivo Whole Animal Imaging and ex Vivo Super-Resolution Fluorescence Imaging

(2013) Miao-Ping Chien et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Genetics of dementia

(2013) Clement T Loy et al.   LANCET

Pro-inflammatory effects of matrix metalloproteinase 7 in acute inflammation

(2013) R E Vandenbroucke et al.   Mucosal Immunology

Tissue Inhibitor of Metalloproteinases-3 Peptides Inhibit Angiogenesis and Choroidal Neovascularization in Mice

(2013) Jian Hua Qi et al.   PLoS One

TIMP-1 Promotes Accumulation of Cancer Associated Fibroblasts and Cancer Progression

(2013) Yixuan Gong et al.   PLoS One

Matrix metalloproteinases in cancer: their value as diagnostic and prognostic markers and therapeutic targets

(2013) Elin Hadler-Olsen et al.   TUMOR BIOLOGY

A monoclonal antibody interferes with TIMP-2 binding and incapacitates the MMP-2-activating function of multifunctional, pro-tumorigenic MMP-14/MT1–MMP

(2013) S A Shiryaev et al.   Oncogenesis

Matrix Metalloproteinase-19 Is a Key Regulator of Lung Fibrosis in Mice and Humans

(2012) Guoying Yu et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Engineering antibodies by yeast display

(2012) Eric T. Boder et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Novel MT1-MMP Small-Molecule Inhibitors Based on Insights into Hemopexin Domain Function in Tumor Growth

(2012) A. G. Remacle et al.   CANCER RESEARCH

Knockdown of MMP-7 inhibits cell proliferation and enhances sensitivity to 5-fluorouracil and X-ray irradiation in colon cancer cells

(2012) Wei Zhang et al.   CLINICAL AND EXPERIMENTAL MEDICINE

Molecular Link Mechanisms between Inflammation and Cancer

(2012) D. B. Vendramini-Costa et al.   CURRENT PHARMACEUTICAL DESIGN

The nuclear factor- B pathway is involved in matrix metalloproteinase-9 expression in RU486-induced endometrium breakdown in mice

(2012) Y.-F. Li et al.   HUMAN REPRODUCTION

Simple Pseudo-dipeptides with a P2′ Glutamate

(2012) Laurent Devel et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Peptide-Based Selective Inhibitors of Matrix Metalloproteinase-Mediated Activities

(2012) Margaret Ndinguri et al.   MOLECULES

Matrix Metalloproteinase-10 Is Required for Lung Cancer Stem Cell Maintenance, Tumor Initiation and Metastatic Potential

(2012) Verline Justilien et al.   PLoS One

PEGylation Extends Circulation Half-Life While Preserving In Vitro and In Vivo Activity of Tissue Inhibitor of Metalloproteinases-1 (TIMP-1)

(2012) Jyotica Batra et al.   PLoS One

Matrix Metalloproteinase Induction of Rac1b, a Key Effector of Lung Cancer Progression

(2012) M. L. Stallings-Mann et al.   Science Translational Medicine

Monitoring degradation of matrix metalloproteinases-cleavable PEG hydrogels via multiple particle tracking microrheology

(2012) Kelly M. Schultz et al.   Soft Matter

Notch Signaling

(2012) R. Kopan   Cold Spring Harbor Perspectives in Biology

New and Paradoxical Roles of Matrix Metalloproteinases in the Tumor Microenvironment

(2012) Agnès Noël et al.   Frontiers in Pharmacology

Small-Molecule Anticancer Compounds Selectively Target the Hemopexin Domain of Matrix Metalloproteinase-9

(2011) A. Dufour et al.   CANCER RESEARCH

Metalloproteinases in metabolic syndrome

(2011) Gabriela Berg et al.   CLINICA CHIMICA ACTA

Metalloproteinases in idiopathic pulmonary fibrosis

(2011) R. C. A. Dancer et al.   EUROPEAN RESPIRATORY JOURNAL

Nuclear Factor Kappa B and Matrix Metalloproteinase Induced Receptor Cleavage in the Spontaneously Hypertensive Rat

(2011) Kwan-I Sharon Wu et al.   HYPERTENSION

Phage Display of Tissue Inhibitor of Metalloproteinases-2 (TIMP-2)

(2011) Harinath Bahudhanapati et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inhibition of Matrix Metalloproteinase 14 (MMP-14)-mediated Cancer Cell Migration

(2011) Kevin Zarrabi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Antibodies targeting the catalytic zinc complex of activated matrix metalloproteinases show therapeutic potential

(2011) Netta Sela-Passwell et al.   NATURE MEDICINE

Tissue inhibitors of metalloproteinases

(2011) Gillian Murphy   GENOME BIOLOGY

An overview of the c-MET signaling pathway

(2011) Shawna Leslie Organ et al.   Therapeutic Advances in Medical Oncology

The Intrinsic Protein Flexibility of Endogenous Protease Inhibitor TIMP-1 Controls Its Binding Interface and Affects Its Function

(2010) Moran Grossman et al.   BIOCHEMISTRY

The tissue inhibitors of metalloproteinases (TIMPs): An ancient family with structural and functional diversity

(2010) Keith Brew et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Matrix Metalloproteinases: Regulators of the Tumor Microenvironment

(2010) Kai Kessenbrock et al.   CELL

JC virus-induced progressive multifocal leukoencephalopathy

(2010) A Sami Saribaş et al.   Future Virology

Insights from Selective Non-phosphinic Inhibitors of MMP-12 Tailored to Fit with an S1′ Loop Canonical Conformation

(2010) Laurent Devel et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cutting Edge: The Membrane Type Matrix Metalloproteinase MMP14 Mediates Constitutive Shedding of MHC Class I Chain-Related Molecule A Independent of A Disintegrin and Metalloproteinases

(2010) G. Liu et al.   JOURNAL OF IMMUNOLOGY

Favorable effects of MMP-9 knockdown in murine herpes simplex encephalitis using small interfering RNA

(2010) Yu Zhou et al.   NEUROLOGICAL RESEARCH

Matrix Metalloproteinases Are Modifiers of Huntingtin Proteolysis and Toxicity in Huntington's Disease

(2010) John P. Miller et al.   NEURON

Amyloid fibrils

(2010) Roma N. Rambaran et al.   Prion

Alterations of matrix metalloproteinases in the healthy elderly with increased risk of prodromal Alzheimer's disease

(2010) Erik Stomrud et al.   Alzheimers Research & Therapy

Structural and functional bases for allosteric control of MMP activities: Can it pave the path for selective inhibition?

(2009) Netta Sela-Passwell et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

To bind zinc or not to bind zinc: An examination of innovative approaches to improved metalloproteinase inhibition

(2009) Jennifer A. Jacobsen et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

The activity of a designer tissue inhibitor of metalloproteinases (TIMP)-1 against native membrane type 1 matrix metalloproteinase (MT1-MMP) in a cell-based environment

(2009) Meng-Huee Lee et al.   CANCER LETTERS

Selective Inhibition of Matrix Metalloproteinase-14 Blocks Tumor Growth, Invasion, and Angiogenesis

(2009) Laetitia Devy et al.   CANCER RESEARCH

Intra- and Interdomain Flexibility in Matrix Metalloproteinases: Functional Aspects and Drug Design

(2009) Ivano Bertini et al.   CURRENT PHARMACEUTICAL DESIGN

Neutrophil MMP-9 Proenzyme, Unencumbered by TIMP-1, Undergoes Efficient Activationin Vivoand Catalytically Induces Angiogenesis via a Basic Fibroblast Growth Factor (FGF-2)/FGFR-2 Pathway

(2009) Veronica C. Ardi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Matrix Metalloprotease-9 Inhibition Improves Amyloid  -Mediated Cognitive Impairment and Neurotoxicity in Mice

(2009) H. Mizoguchi et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Selective Use of ADAM10 and ADAM17 in Activation of Notch1 Signaling

(2009) E. C. Bozkulak et al.   MOLECULAR AND CELLULAR BIOLOGY

Selective Modulation of Matrix Metalloproteinase 9 (MMP-9) Functions via Exosite Inhibition

(2008) Janelle L. Lauer-Fields et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Serum TIMP-1 and Response to the Aromatase Inhibitor Letrozole Versus Tamoxifen in Metastatic Breast Cancer

(2008) Allan Lipton et al.   JOURNAL OF CLINICAL ONCOLOGY

Tissue Inhibitors of Metalloproteinases in Cell Signaling: Metalloproteinase-Independent Biological Activities

(2008) W. G. Stetler-Stevenson   Science Signaling

Cellular and molecular mechanisms of fibrosis

(2007) TA Wynn   JOURNAL OF PATHOLOGY

The role of collagenases in experimental pulmonary fibrosis

(2007) Hiroshi Ouchi et al.   PULMONARY PHARMACOLOGY & THERAPEUTICS

MMPs in the central nervous system: Where the good guys go bad

(2007) S AGRAWAL et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY