Converting a broad matrix metalloproteinase family inhibitor into a specific inhibitor of MMP-9 and MMP-14

Development of High Affinity and High Specificity Inhibitors of Matrix Metalloproteinase 14 through Computational Design and Directed Evolution

(2017) Valeria Arkadash et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Therapeutic Potential of Matrix Metalloproteinase Inhibition in Breast Cancer

(2017) Evette S. Radisky et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Combinatorial protein engineering of proteolytically resistant mesotrypsin inhibitors as candidates for cancer therapy

(2016) I. Cohen et al.   BIOCHEMICAL JOURNAL

Active-site MMP-selective antibody inhibitors discovered from convex paratope synthetic libraries

(2016) Dong Hyun Nam et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cold Spots in Protein Binding

(2016) Jason Shirian et al.   TRENDS IN BIOCHEMICAL SCIENCES

Is there new hope for therapeutic matrix metalloproteinase inhibition?

(2014) Roosmarijn E. Vandenbroucke et al.   NATURE REVIEWS DRUG DISCOVERY

Affinity- and Specificity-Enhancing Mutations Are Frequent in Multispecific Interactions between TIMP2 and MMPs

(2014) Oz Sharabi et al.   PLoS One

Predicting affinity- and specificity-enhancing mutations at protein–protein interfaces

(2013) Oz Sharabi et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Matrix Metalloproteinase-10/TIMP-2 Structure and Analyses Define Conserved Core Interactions and Diverse Exosite Interactions in MMP/TIMP Complexes

(2013) Jyotica Batra et al.   PLoS One

A Strategy for Modulation of Enzymes in the Ubiquitin System

(2013) A. Ernst et al.   SCIENCE

Structural insights for engineering binding proteins based on non-antibody scaffolds

(2012) Ryan N Gilbreth et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Matrix Metalloproteinase-10 (MMP-10) Interaction with Tissue Inhibitors of Metalloproteinases TIMP-1 and TIMP-2

(2012) Jyotica Batra et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Rapid Conformational Epitope Mapping of Anti-gp120 Antibodies with a Designed Mutant Panel Displayed on Yeast

(2012) Jordi Mata-Fink et al.   JOURNAL OF MOLECULAR BIOLOGY

Decreased Serum Levels of Mature Brain-Derived Neurotrophic Factor (BDNF), but Not Its Precursor proBDNF, in Patients with Major Depressive Disorder

(2012) Taisuke Yoshida et al.   PLoS One

Multispecific Recognition: Mechanism, Evolution, and Design

(2011) Ariel Erijman et al.   BIOCHEMISTRY

Phage Display of Tissue Inhibitor of Metalloproteinases-2 (TIMP-2)

(2011) Harinath Bahudhanapati et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Matrix metalloproteinases: protective roles in cancer

(2011) Julie Decock et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Transfer-PCR (TPCR): A highway for DNA cloning and protein engineering

(2011) Ariel Erijman et al.   JOURNAL OF STRUCTURAL BIOLOGY

Antibodies targeting the catalytic zinc complex of activated matrix metalloproteinases show therapeutic potential

(2011) Netta Sela-Passwell et al.   NATURE MEDICINE

Triathlon for energy functions: Who is the winner for design of protein-protein interactions?

(2011) Oz Sharabi et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

The Intrinsic Protein Flexibility of Endogenous Protease Inhibitor TIMP-1 Controls Its Binding Interface and Affects Its Function

(2010) Moran Grossman et al.   BIOCHEMISTRY

The tissue inhibitors of metalloproteinases (TIMPs): An ancient family with structural and functional diversity

(2010) Keith Brew et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

RosettaBackrub--a web server for flexible backbone protein structure modeling and design

(2010) F. Lauck et al.   NUCLEIC ACIDS RESEARCH

Matrix metalloproteinases: What do they not do? New substrates and biological roles identified by murine models and proteomics

(2009) David Rodríguez et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Selective Inhibition of Matrix Metalloproteinase-14 Blocks Tumor Growth, Invasion, and Angiogenesis

(2009) Laetitia Devy et al.   CANCER RESEARCH

Engineered protein scaffolds as next-generation antibody therapeutics

(2009) Michaela Gebauer et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Tradeoff Between Stability and Multispecificity in the Design of Promiscuous Proteins

(2009) Menachem Fromer et al.   PLoS Computational Biology

A Decade of Yeast Surface Display Technology: Where Are We Now?

(2008) Eric Shusta et al.   COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING

Computational Design of Calmodulin Mutants with up to 900-Fold Increase in Binding Specificity

(2008) Eliyahu Yosef et al.   JOURNAL OF MOLECULAR BIOLOGY