The Rebirth of Matrix Metalloproteinase Inhibitors: Moving Beyond the Dogma

Targeting a Designer TIMP-1 to the Cell Surface for Effective MT1-MMP Inhibition: A Potential Role for the Prion Protein in Renal Carcinoma Therapy

(2019) Bingjie Jiang et al.   MOLECULES

Matrix metalloproteinases and inhibitors in dentistry

(2019) Gerd-Jan Boelen et al.   Clinical Oral Investigations

A clinical dose of angiotensin-converting enzyme (ACE) inhibitor and heterozygous ACE deletion exacerbate Alzheimer’s disease pathology in mice

(2019) Shuyu Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Directed evolution of the metalloproteinase inhibitor TIMP-1 reveals that its N- and C-terminal domains cooperate in matrix metalloproteinase recognition

(2019) Maryam Raeeszadeh-Sarmazdeh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Macrophages‐Triggered Sequential Remodeling of Endothelium‐Interstitial Matrix to Form Pre‐Metastatic Niche in Microfluidic Tumor Microenvironment

(2019) Hyunho Kim et al.   Advanced Science

Matrix metalloproteinases in the CNS: interferons get nervous

(2019) Sameeksha Chopra et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Matrix metalloproteinases and ADAMs in stroke

(2019) Joan Montaner et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

MMPs and ADAMs in neurological infectious diseases and multiple sclerosis

(2019) Lukas Muri et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Mechanisms of Action of Novel Drugs Targeting Angiogenesis-Promoting Matrix Metalloproteinases

(2019) Gregg B. Fields   Frontiers in Immunology

Monoclonal antibodies against metzincin targets

(2018) Salvatore Santamaria et al.   BRITISH JOURNAL OF PHARMACOLOGY

Andecaliximab/GS-5745 Alone and Combined with mFOLFOX6 in Advanced Gastric and Gastroesophageal Junction Adenocarcinoma: Results from a Phase I Study

(2018) Manish A. Shah et al.   CLINICAL CANCER RESEARCH

Phase 1b Study of the Safety, Pharmacokinetics, and Disease-related Outcomes of the Matrix Metalloproteinase-9 Inhibitor Andecaliximab in Patients With Rheumatoid Arthritis

(2018) David L. Gossage et al.   CLINICAL THERAPEUTICS

Simultaneous Inhibition of Tumor Necrosis Factor Receptor 1 and Matrix Metalloproteinase 8 Completely Protects Against Acute Inflammation and Sepsis

(2018) Sophie Steeland et al.   CRITICAL CARE MEDICINE

Development of a carboplatin derivative conjugated with a collagen-like triple-helical peptide

(2018) Ryo Masuda et al.   Future Medicinal Chemistry

Targeting the MMP-14/MMP-2/integrin αvβ3 axis with multispecific N-TIMP2-based antagonists for cancer therapy

(2018) Gal Yosef et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Andecaliximab [Anti-matrix Metalloproteinase-9] Induction Therapy for Ulcerative Colitis: A Randomised, Double-Blind, Placebo-Controlled, Phase 2/3 Study in Patients With Moderate to Severe Disease

(2018) William J Sandborn et al.   Journal of Crohns & Colitis

Matrix Metalloproteinase Inhibitors in Cancer Therapy: Turning Past Failures Into Future Successes

(2018) Arthur Winer et al.   MOLECULAR CANCER THERAPEUTICS

Antibody-mediated inhibition of MICA and MICB shedding promotes NK cell–driven tumor immunity

(2018) Lucas Ferrari de Andrade et al.   SCIENCE

Development of matrix metalloproteinase-13 inhibitors – A structure-activity/structure-property relationship study

(2018) Rita Fuerst et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Validation of Matrix Metalloproteinase-9 (MMP-9) as a Novel Target for Treatment of Diabetic Foot Ulcers in Humans and Discovery of a Potent and Selective Small-Molecule MMP-9 Inhibitor That Accelerates Healing

(2018) Trung T. Nguyen et al.   JOURNAL OF MEDICINAL CHEMISTRY

Combinatorial engineering of N-TIMP2 variants that selectively inhibit MMP9 and MMP14 function in the cell

(2018) Valeria Arkadash et al.   Oncotarget

MMP-9 inhibition promotes anti-tumor immunity through disruption of biochemical and physical barriers to T-cell trafficking to tumors

(2018) Vladi Juric et al.   PLoS One

Improving potency and metabolic stability by introducing an alkenyl linker to pyridine-based histone deacetylase inhibitors for orally available RUNX3 modulators

(2017) Doona Song et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Biochemical characterization and structure determination of a potent, selective antibody inhibitor of human MMP9

(2017) Todd C. Appleby et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Discovery of a highly selective chemical inhibitor of matrix metalloproteinase-9 (MMP-9) that allosterically inhibits zymogen activation

(2017) Robert H. Scannevin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Riding the metalloproteinase roller coaster

(2017) Gillian Murphy   JOURNAL OF BIOLOGICAL CHEMISTRY

Development of High Affinity and High Specificity Inhibitors of Matrix Metalloproteinase 14 through Computational Design and Directed Evolution

(2017) Valeria Arkadash et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Therapeutic Potential of Matrix Metalloproteinase Inhibition in Breast Cancer

(2017) Evette S. Radisky et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Rationalized Computer-Aided Design of Matrix-Metalloprotease-Selective Prodrugs

(2017) Mohit Jain et al.   JOURNAL OF MEDICINAL CHEMISTRY

Controlling Plasma Stability of Hydroxamic Acids: A MedChem Toolbox

(2017) Paul Hermant et al.   JOURNAL OF MEDICINAL CHEMISTRY

Second Generation Triple-Helical Peptide Inhibitors of Matrix Metalloproteinases

(2017) Manishabrata Bhowmick et al.   JOURNAL OF MEDICINAL CHEMISTRY

Structure-Based Design and Synthesis of Potent and Selective Matrix Metalloproteinase 13 Inhibitors

(2017) Jun Yong Choi et al.   JOURNAL OF MEDICINAL CHEMISTRY

A Novel Theranostic Strategy for MMP-14 –Expressing Glioblastomas Impacts Survival

(2017) Suchismita Mohanty et al.   MOLECULAR CANCER THERAPEUTICS

Trial of Minocycline in a Clinically Isolated Syndrome of Multiple Sclerosis

(2017) Luanne M. Metz et al.   NEW ENGLAND JOURNAL OF MEDICINE

Clinical Implications of Compounds Designed to Inhibit ECM-Modifying Metalloproteinases

(2017) Sabrina Amar et al.   PROTEOMICS

Inhibition of gelatinase B/MMP-9 does not attenuate colitis in murine models of inflammatory bowel disease

(2017) Magali de Bruyn et al.   Nature Communications

A novel immunotherapy targeting MMP-14 limits hypoxia, immune suppression and metastasis in triple-negative breast cancer models

(2017) Binbing Ling et al.   Oncotarget

Rethinking Brain Cancer Therapy: Tumor Enzyme Activatable Theranostic Nanoparticles

(2017) Heike E. Daldrup-Link   Molecular Imaging

Proteases in cancer drug delivery

(2016) Jennifer Vandooren et al.   ADVANCED DRUG DELIVERY REVIEWS

Randomised clinical trial: a phase 1, dose-ranging study of the anti-matrix metalloproteinase-9 monoclonal antibody GS-5745 versus placebo for ulcerative colitis

(2016) W. J. Sandborn et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Fecal Excretion of Orally Administered Collagen-Like Peptides in Rats: Contribution of the Triple-Helical Conformation to Their Stability

(2016) Takaki Koide et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Design, synthesis, and biological activity of novel, potent, and highly selective fused pyrimidine-2-carboxamide-4-one-based matrix metalloproteinase (MMP)-13 zinc-binding inhibitors

(2016) Hiroshi Nara et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Extracellular Matrix Proteolysis by MT1-MMP Contributes to Influenza-Related Tissue Damage and Mortality

(2016) Dalit Talmi-Frank et al.   Cell Host & Microbe

Matrix metalloproteinases in the brain and blood–brain barrier: Versatile breakers and makers

(2016) Ralf G Rempe et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Early matrix metalloproteinase-9 inhibition post-myocardial infarction worsens cardiac dysfunction by delaying inflammation resolution

(2016) Rugmani Padmanabhan Iyer et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Systemic Ablation of MMP-9 Triggers Invasive Growth and Metastasis of Pancreatic Cancer via Deregulation of IL6 Expression in the Bone Marrow

(2016) B. Gru nwald et al.   MOLECULAR CANCER RESEARCH

Inhibition of Breast Cancer Metastasis by Presurgical Treatment with an Oral Matrix Metalloproteinase Inhibitor: A Preclinical Proof-of-Principle Study

(2016) A. Winer et al.   MOLECULAR CANCER THERAPEUTICS

Active-site MMP-selective antibody inhibitors discovered from convex paratope synthetic libraries

(2016) Dong Hyun Nam et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Generation of inhibitory monoclonal antibodies targeting matrix metalloproteinase-14 by motif grafting and CDR optimization

(2016) Dong Hyun Nam et al.   PROTEIN ENGINEERING DESIGN & SELECTION

Selective function-blocking monoclonal human antibody highlights the important role of membrane type-1 matrix metalloproteinase (MT1-MMP) in metastasis

(2016) Albert G. Remacle et al.   Oncotarget

Development of a specific affinity-matured exosite inhibitor to MT1-MMP that efficiently inhibits tumor cell invasion in vitro and metastasis in vivo

(2016) Kenneth A. Botkjaer et al.   Oncotarget

Matrix Metalloproteinase Inhibition by Heterotrimeric Triple-Helical Peptide Transition State Analogues

(2015) Manishabrata Bhowmick et al.   CHEMBIOCHEM

Intestine-Derived Matrix Metalloproteinase-8 Is a Critical Mediator of Polymicrobial Peritonitis

(2015) Sarah J. Atkinson et al.   CRITICAL CARE MEDICINE

Potential clinical implications of recent matrix metalloproteinase inhibitor design strategies

(2015) Sabrina Amar et al.   Expert Review of Proteomics

Passenger Mutations Confound Interpretation of All Genetically Modified Congenic Mice

(2015) Tom Vanden Berghe et al.   IMMUNITY

Phosphoramidate-based peptidomimetic inhibitors of membrane type-1 matrix metalloproteinase

(2015) Desiree E. Mendes et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Discovery of N-(4-Fluoro-3-methoxybenzyl)-6-(2-(((2S,5R)-5-(hydroxymethyl)-1,4-dioxan-2-yl)methyl)-2H-tetrazol-5-yl)-2-methylpyrimidine-4-carboxamide. A Highly Selective and Orally Bioavailable Matrix Metalloproteinase-13 Inhibitor for the Potential Treatment of Osteoarthritis

(2015) Peter G. Ruminski et al.   JOURNAL OF MEDICINAL CHEMISTRY

Blockade of MMP14 Activity in Murine Breast Carcinomas: Implications for Macrophages, Vessels, and Radiotherapy

(2015) Eleanor I. Ager et al.   JNCI-Journal of the National Cancer Institute

Expanding the Activity of Tissue Inhibitors of Metalloproteinase (TIMP)-1 against Surface-Anchored Metalloproteinases by the Replacement of Its C-Terminal Domain: Implications for Anti-Cancer Effects

(2015) Jing Xian Duan et al.   PLoS One

Acceleration of diabetic wound healing using a novel protease–anti-protease combination therapy

(2015) Ming Gao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inhibition Mechanism of Membrane Metalloprotease by an Exosite-Swiveling Conformational Antibody

(2015) Yael Udi et al.   STRUCTURE

Blockade of MMP14 Activity in Murine Breast Carcinomas: Implications for Macrophages, Vessels, and Radiotherapy

(2015) Eleanor I. Ager et al.   JNCI-Journal of the National Cancer Institute

Metalloproteinases and Wound Healing

(2015) Matthew P. Caley et al.   Advances in Wound Care

Selective Allosteric Inhibition of MMP9 Is Efficacious in Preclinical Models of Ulcerative Colitis and Colorectal Cancer

(2015) Derek C. Marshall et al.   PLoS One

Citrate Synthase Is a Novel In Vivo Matrix Metalloproteinase-9 Substrate That Regulates Mitochondrial Function in the Postmyocardial Infarction Left Ventricle

(2014) Lisandra E. de Castro Brás et al.   ANTIOXIDANTS & REDOX SIGNALING

Thieno[2,3-d]pyrimidine-2-carboxamides bearing a carboxybenzene group at 5-position: Highly potent, selective, and orally available MMP-13 inhibitors interacting with the S1″ binding site

(2014) Hiroshi Nara et al.   BIOORGANIC & MEDICINAL CHEMISTRY

New approaches to selectively target cancer-associated matrix metalloproteinase activity

(2014) Marilena Tauro et al.   CANCER AND METASTASIS REVIEWS

Characterization of Selective Exosite-Binding Inhibitors of Matrix Metalloproteinase 13 That Prevent Articular Cartilage Degradation in Vitro

(2014) Timothy P. Spicer et al.   JOURNAL OF MEDICINAL CHEMISTRY

Peptide internalization enabled by folding: triple helical cell-penetrating peptides

(2014) Aparna Shinde et al.   JOURNAL OF PEPTIDE SCIENCE

Tumor-Targeted Prodrug ICT2588 Demonstrates Therapeutic Activity against Solid Tumors and Reduced Potential for Cardiovascular Toxicity

(2014) Jason H. Gill et al.   MOLECULAR PHARMACEUTICS

Is there new hope for therapeutic matrix metalloproteinase inhibition?

(2014) Roosmarijn E. Vandenbroucke et al.   NATURE REVIEWS DRUG DISCOVERY

Affinity- and Specificity-Enhancing Mutations Are Frequent in Multispecific Interactions between TIMP2 and MMPs

(2014) Oz Sharabi et al.   PLoS One

Rapid Lead Discovery Through Iterative Screening of One Bead One Compound Libraries

(2014) Yu Gao et al.   ACS Combinatorial Science

Collagen-like Cell-Penetrating Peptides

(2013) Chisato M. Yamazaki et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Potential of collagen-like triple helical peptides as drug carriers: Their in vivo distribution, metabolism, and excretion profiles in rodents

(2013) Hiroyuki Yasui et al.   BIOPOLYMERS

Biochemistry and molecular biology of gelatinase B or matrix metalloproteinase-9 (MMP-9): The next decade

(2013) Jennifer Vandooren et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

Matrix metalloproteinase 13 modulates intestinal epithelial barrier integrity in inflammatory diseases by activating TNF

(2013) Roosmarijn E. Vandenbroucke et al.   EMBO Molecular Medicine

MT-LOOP-dependent Localization of Membrane Type I Matrix Metalloproteinase (MT1-MMP) to the Cell Adhesion Complexes Promotes Cancer Cell Invasion

(2013) Anna M. Woskowicz et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Targeting a Single Function of the Multifunctional Matrix Metalloprotease MT1-MMP

(2013) Signe Ingvarsen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pro-inflammatory effects of matrix metalloproteinase 7 in acute inflammation

(2013) R E Vandenbroucke et al.   Mucosal Immunology

Development of Novel Tumor-Targeted Theranostic Nanoparticles Activated by Membrane-Type Matrix Metalloproteinases for Combined Cancer Magnetic Resonance Imaging and Therapy

(2013) Celina Ansari et al.   Small

Matrix metalloproteinases in cancer: their value as diagnostic and prognostic markers and therapeutic targets

(2013) Elin Hadler-Olsen et al.   TUMOR BIOLOGY

Novel MT1-MMP Small-Molecule Inhibitors Based on Insights into Hemopexin Domain Function in Tumor Growth

(2012) A. G. Remacle et al.   CANCER RESEARCH

A 17-residue Sequence from the Matrix Metalloproteinase-9 (MMP-9) Hemopexin Domain Binds α4β1 Integrin and Inhibits MMP-9-induced Functions in Chronic Lymphocytic Leukemia B Cells

(2012) Estefanía Ugarte-Berzal et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Matrix Metalloprotease-1a Promotes Tumorigenesis and Metastasis

(2012) Caitlin J. Foley et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Matrix Metalloprotease 8-Dependent Extracellular Matrix Cleavage at the Blood-CSF Barrier Contributes to Lethality during Systemic Inflammatory Diseases

(2012) R. E. Vandenbroucke et al.   JOURNAL OF NEUROSCIENCE

PEGylation Extends Circulation Half-Life While Preserving In Vitro and In Vivo Activity of Tissue Inhibitor of Metalloproteinases-1 (TIMP-1)

(2012) Jyotica Batra et al.   PLoS One

Identification of novel, exosite-binding matrix metalloproteinase-13 inhibitor scaffolds

(2011) Joshua Roth et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Orally Active, Antimetastatic, Nontoxic Diphenyl Ether-Derived Carbamoylphosphonate Matrix Metalloproteinase Inhibitors

(2011) Julia Frant et al.   ChemMedChem

A novel role for matrix metalloproteinase-8 in sepsis*

(2011) Patrick D. Solan et al.   CRITICAL CARE MEDICINE

New opportunities in drug design of metalloproteinase inhibitors: combination between structure–function experimental approaches and systems biology

(2011) Netta Sela-Passwell et al.   Expert Opinion on Drug Discovery

Inhibition of MT1-MMP activity using functional antibody fragments selected against its hemopexin domain

(2011) B. Basu et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Phage Display of Tissue Inhibitor of Metalloproteinases-2 (TIMP-2)

(2011) Harinath Bahudhanapati et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Antibodies targeting the catalytic zinc complex of activated matrix metalloproteinases show therapeutic potential

(2011) Netta Sela-Passwell et al.   NATURE MEDICINE

Serum MMP-8, -9 and TIMP-1 in sepsis: High serum levels of MMP-8 and TIMP-1 are associated with fatal outcome in a multicentre, prospective cohort study. Hypothetical impact of tetracyclines

(2011) Anneli Lauhio et al.   PHARMACOLOGICAL RESEARCH

Matrix Metalloproteinase-9 in an Exploratory Trial of Intravenous Minocycline for Acute Ischemic Stroke

(2011) Jeffrey A. Switzer et al.   STROKE

MT-MMPS as Regulators of Vessel Stability Associated with Angiogenesis

(2011) Nor Eddine Sounni et al.   Frontiers in Pharmacology

An Autocrine Linkage Between Matrix Metalloproteinase-14 and Tie-2 Via Ectodomain Shedding Modulates Angiopoietin-1–Dependent Function in Endothelial Cells

(2010) Mitsuho Onimaru et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Endothelial lumen signaling complexes control 3D matrix-specific tubulogenesis through interdependent Cdc42- and MT1-MMP-mediated events

(2010) A. Sacharidou et al.   BLOOD

A novel and selective membrane type-1 matrix metalloproteinase (MT1-MMP) inhibitor reduces cancer cell motility and tumor growth

(2010) Juho Suojanen et al.   CANCER BIOLOGY & THERAPY

Development of a Novel Tumor-Targeted Vascular Disrupting Agent Activated by Membrane-Type Matrix Metalloproteinases

(2010) J. M. Atkinson et al.   CANCER RESEARCH

Cutting Edge: The Membrane Type Matrix Metalloproteinase MMP14 Mediates Constitutive Shedding of MHC Class I Chain-Related Molecule A Independent of A Disintegrin and Metalloproteinases

(2010) G. Liu et al.   JOURNAL OF IMMUNOLOGY

Orally Active MMP-1 Sparing α-Tetrahydropyranyl and α-Piperidinyl Sulfone Matrix Metalloproteinase (MMP) Inhibitors with Efficacy in Cancer, Arthritis, and Cardiovascular Disease

(2010) Daniel P. Becker et al.   JOURNAL OF MEDICINAL CHEMISTRY

Minocycline to Improve Neurologic Outcome in Stroke (MINOS)

(2010) Susan C. Fagan et al.   STROKE

A new class of potent matrix metalloproteinase 13 inhibitors for potential treatment of osteoarthritis: Evidence of histologic and clinical efficacy without musculoskeletal toxicity in rat models

(2009) Vijaykumar M. Baragi et al.   ARTHRITIS AND RHEUMATISM

Updated Biological Roles for Matrix Metalloproteinases and New “Intracellular” Substrates Revealed by Degradomics

(2009) Georgina S. Butler et al.   BIOCHEMISTRY

Structural and functional bases for allosteric control of MMP activities: Can it pave the path for selective inhibition?

(2009) Netta Sela-Passwell et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

To bind zinc or not to bind zinc: An examination of innovative approaches to improved metalloproteinase inhibition

(2009) Jennifer A. Jacobsen et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Endothelial cell lumen and vascular guidance tunnel formation requires MT1-MMP-dependent proteolysis in 3-dimensional collagen matrices

(2009) A. N. Stratman et al.   BLOOD

Selective Inhibition of Matrix Metalloproteinase-14 Blocks Tumor Growth, Invasion, and Angiogenesis

(2009) Laetitia Devy et al.   CANCER RESEARCH

Selective Matrix Metalloproteinase Inhibitors for Cancer

(2009) Nian-Guang Li et al.   CURRENT MEDICINAL CHEMISTRY

Identification of Specific Hemopexin-like Domain Residues That Facilitate Matrix Metalloproteinase Collagenolytic Activity

(2009) Janelle L. Lauer-Fields et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hydroxamates: Relationships between Structure and Plasma Stability

(2009) Marion Flipo et al.   JOURNAL OF MEDICINAL CHEMISTRY

Glatiramer acetate in combination with minocycline in patients with relapsing—remitting multiple sclerosis: results of a Canadian, multicenter, double-blind, placebo-controlled trial

(2009) LM Metz et al.   Multiple Sclerosis Journal

High throughput screening of potentially selective MMP-13 exosite inhibitors utilizing a triple-helical FRET substrate

(2008) Janelle L. Lauer-Fields et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Tumour endoproteases: the cutting edge of cancer drug delivery?

(2008) J M Atkinson et al.   BRITISH JOURNAL OF PHARMACOLOGY

Zinc-Binding Groups Modulate Selective Inhibition of MMPs

(2008) Arpita Agrawal et al.   ChemMedChem

Production of multivalent protein binders using a self-trimerizing collagen-like peptide scaffold

(2008) Chia-Yu Fan et al.   FASEB JOURNAL

Selective Modulation of Matrix Metalloproteinase 9 (MMP-9) Functions via Exosite Inhibition

(2008) Janelle L. Lauer-Fields et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Carbamoylphosphonate Matrix Metalloproteinase Inhibitors 6:cis-2-Aminocyclohexylcarbamoylphosphonic Acid, A Novel Orally Active Antimetastatic Matrix Metalloproteinase-2 Selective InhibitorSynthesis and Pharmacodynamic and Pharmacokinetic Analysis

(2008) Amnon Hoffman et al.   JOURNAL OF MEDICINAL CHEMISTRY

Progress in matrix metalloproteinase research

(2008) G MURPHY et al.   MOLECULAR ASPECTS OF MEDICINE

Diverse roles of matrix metalloproteinases and tissue inhibitors of metalloproteinases in neuroinflammation and cerebral ischemia

(2008) E. Candelario-Jalil et al.   NEUROSCIENCE

Combination Therapy With Interferon Beta-1a and Doxycycline in Multiple Sclerosis

(2007) Alireza Minagar et al.   ARCHIVES OF NEUROLOGY

MMPs as therapeutic targets—Still a viable option?

(2007) B FINGLETON   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY