Inhibitory Antibodies Designed for Matrix Metalloproteinase Modulation

Drug design inspired by Nature: Crystallographic detection of auto-tailored protease inhibitor template

(2019) Flavio M. Gall et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Design and Structural Evolution of Matrix Metalloproteinase Inhibitors

(2019) Thomas Fischer et al.   CHEMISTRY-A EUROPEAN JOURNAL

Andecaliximab/GS-5745 Alone and Combined with mFOLFOX6 in Advanced Gastric and Gastroesophageal Junction Adenocarcinoma: Results from a Phase I Study

(2018) Manish A. Shah et al.   CLINICAL CANCER RESEARCH

Matrix Metalloproteinase Inhibitors in Cancer Therapy: Turning Past Failures Into Future Successes

(2018) Arthur Winer et al.   MOLECULAR CANCER THERAPEUTICS

The promise and challenges of immune agonist antibody development in cancer

(2018) Patrick A. Mayes et al.   NATURE REVIEWS DRUG DISCOVERY

Use of a novel camelid-inspired human antibody demonstrates the importance of MMP-14 to cancer stem cell function in the metastatic process

(2018) Kuan-Hui E. Chen et al.   Oncotarget

Cutting to the Chase: How Matrix Metalloproteinase-2 Activity Controls Breast-Cancer-to-Bone Metastasis

(2018) Marilena Tauro et al.   Cancers

Epitope-specific affinity maturation improved stability of potent protease inhibitory antibodies

(2018) Tyler Lopez et al.   BIOTECHNOLOGY AND BIOENGINEERING

Reducing proteolytic liability of a MMP-14 inhibitory antibody by site-saturation mutagenesis

(2018) Ki Baek Lee et al.   PROTEIN SCIENCE

Anti-tumor effects of a ‘human & mouse cross-reactive’ anti-ADAM17 antibody in a pancreatic cancer model in vivo

(2017) Jie Ye et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Recent opportunities in matrix metalloproteinase inhibitor drug design for cancer

(2017) Yue Zhong et al.   Expert Opinion on Drug Discovery

Biochemical characterization and structure determination of a potent, selective antibody inhibitor of human MMP9

(2017) Todd C. Appleby et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Development of High Affinity and High Specificity Inhibitors of Matrix Metalloproteinase 14 through Computational Design and Directed Evolution

(2017) Valeria Arkadash et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

MMP-3 (-1171 5A/6A; Lys45Glu) variants affect serum levels of matrix metalloproteinase (MMP)-3 and correlate with severity of COPD: A study of MMP-3, MMP-7 and MMP-12 in a Tunisian population

(2017) Sarra Bchir et al.   JOURNAL OF GENE MEDICINE

Discovery of Novel, Highly Potent, and Selective Matrix Metalloproteinase (MMP)-13 Inhibitors with a 1,2,4-Triazol-3-yl Moiety as a Zinc Binding Group Using a Structure-Based Design Approach

(2017) Hiroshi Nara et al.   JOURNAL OF MEDICINAL CHEMISTRY

A novel immunotherapy targeting MMP-14 limits hypoxia, immune suppression and metastasis in triple-negative breast cancer models

(2017) Binbing Ling et al.   Oncotarget

Design and discovery of novel thiazole derivatives as potential MMP inhibitors to protect against acute lung injury in sepsis rats via attenuation of inflammation and apoptotic oxidative stress

(2017) Lingqing Ge et al.   RSC Advances

Minimalist Antibodies and Mimetics: An Update and Recent Applications

(2016) Virginia J. Bruce et al.   CHEMBIOCHEM

The molecular biology of matrix metalloproteinases and tissue inhibitors of metalloproteinases in inflammatory bowel diseases

(2016) Magali de Bruyn et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

Anti-MMP-9 Antibody

(2016) Laurence Goffin et al.   INFLAMMATORY BOWEL DISEASES

Matrix metalloproteinases (MMPs), the main extracellular matrix (ECM) enzymes in collagen degradation, as a target for anticancer drugs

(2016) Agata Jabłońska-Trypuć et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Active-site MMP-selective antibody inhibitors discovered from convex paratope synthetic libraries

(2016) Dong Hyun Nam et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Generation of inhibitory monoclonal antibodies targeting matrix metalloproteinase-14 by motif grafting and CDR optimization

(2016) Dong Hyun Nam et al.   PROTEIN ENGINEERING DESIGN & SELECTION

Selective function-blocking monoclonal human antibody highlights the important role of membrane type-1 matrix metalloproteinase (MT1-MMP) in metastasis

(2016) Albert G. Remacle et al.   Oncotarget

Development of a specific affinity-matured exosite inhibitor to MT1-MMP that efficiently inhibits tumor cell invasion in vitro and metastasis in vivo

(2016) Kenneth A. Botkjaer et al.   Oncotarget

Epitope mapping by a Wnt-blocking antibody: evidence of the Wnt binding domain in heparan sulfate

(2016) Wei Gao et al.   Scientific Reports

Structural basis for the specific inhibition of glycoprotein Ibα shedding by an inhibitory antibody

(2016) Yue Tao et al.   Scientific Reports

N-O-Isopropyl Sulfonamido-Based Hydroxamates as Matrix Metalloproteinase Inhibitors: Hit Selection and in Vivo Antiangiogenic Activity

(2015) Elisa Nuti et al.   JOURNAL OF MEDICINAL CHEMISTRY

Blockade of MMP14 Activity in Murine Breast Carcinomas: Implications for Macrophages, Vessels, and Radiotherapy

(2015) Eleanor I. Ager et al.   JNCI-Journal of the National Cancer Institute

Matrix metalloproteinases in destructive lung disease

(2015) A. McGarry Houghton   MATRIX BIOLOGY

The role of TIMPs in regulation of extracellular matrix proteolysis

(2015) Valerie Arpino et al.   MATRIX BIOLOGY

Moving targets: Emerging roles for MMPs in cancer progression and metastasis

(2015) Gemma Shay et al.   MATRIX BIOLOGY

A Monoclonal Antibody to ADAM17 Inhibits Tumor Growth by Inhibiting EGFR and Non-EGFR-Mediated Pathways

(2015) J. Rios-Doria et al.   MOLECULAR CANCER THERAPEUTICS

Cartilage damage in osteoarthritis and rheumatoid arthritis—two unequal siblings

(2015) Thomas Pap et al.   Nature Reviews Rheumatology

Renaissance of MMPs as Therapeutic Targets? Maybe

(2015) Gregory I. Goldberg   STRUCTURE

Inhibition Mechanism of Membrane Metalloprotease by an Exosite-Swiveling Conformational Antibody

(2015) Yael Udi et al.   STRUCTURE

Adverse Events of Monoclonal Antibodies Used for Cancer Therapy

(2015) Mei Guan et al.   Biomed Research International

Blockade of MMP14 Activity in Murine Breast Carcinomas: Implications for Macrophages, Vessels, and Radiotherapy

(2015) Eleanor I. Ager et al.   JNCI-Journal of the National Cancer Institute

Metalloproteinases and Wound Healing

(2015) Matthew P. Caley et al.   Advances in Wound Care

Selective Allosteric Inhibition of MMP9 Is Efficacious in Preclinical Models of Ulcerative Colitis and Colorectal Cancer

(2015) Derek C. Marshall et al.   PLoS One

Matrix metalloproteinases in inflammation

(2014) Liisa Nissinen et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Targeting Matrix Metalloproteinases: Exploring the Dynamics of the S1′ Pocket in the Design of Selective, Small Molecule Inhibitors

(2014) Benjamin Fabre et al.   JOURNAL OF MEDICINAL CHEMISTRY

The multifactorial role of neutrophils in rheumatoid arthritis

(2014) Helen L. Wright et al.   Nature Reviews Rheumatology

Association of Sepsis-Related Mortality with Early Increase of TIMP-1/MMP-9 Ratio

(2014) Leonardo Lorente et al.   PLoS One

A monoclonal antibody targeting a highly conserved epitope in influenza B neuraminidase provides protection against drug resistant strains

(2013) Tracey M. Doyle et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Selective Blockade of Matrix Metalloprotease-14 with a Monoclonal Antibody Abrogates Invasion, Angiogenesis, and Tumor Growth in Ovarian Cancer

(2013) R. Kaimal et al.   CANCER RESEARCH

Targeting a Single Function of the Multifunctional Matrix Metalloprotease MT1-MMP

(2013) Signe Ingvarsen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A monoclonal antibody interferes with TIMP-2 binding and incapacitates the MMP-2-activating function of multifunctional, pro-tumorigenic MMP-14/MT1–MMP

(2013) S A Shiryaev et al.   Oncogenesis

Matrix Metalloproteinase-10 (MMP-10) Interaction with Tissue Inhibitors of Metalloproteinases TIMP-1 and TIMP-2

(2012) Jyotica Batra et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

An Inhibitory Antibody against Dipeptidyl Peptidase IV Improves Glucose Tolerancein Vivo

(2012) Jie Tang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Discovery of MMP7 Inhibitors Exploiting a Novel Selectivity Trigger

(2011) Karl Edman et al.   ChemMedChem

The first MMP in sepsis

(2011) Roosmarijn E. Vandenbroucke et al.   EMBO Molecular Medicine

Antibodies targeting the catalytic zinc complex of activated matrix metalloproteinases show therapeutic potential

(2011) Netta Sela-Passwell et al.   NATURE MEDICINE

Serum MMP-8, -9 and TIMP-1 in sepsis: High serum levels of MMP-8 and TIMP-1 are associated with fatal outcome in a multicentre, prospective cohort study. Hypothetical impact of tetracyclines

(2011) Anneli Lauhio et al.   PHARMACOLOGICAL RESEARCH

Tissue inhibitors of metalloproteinases

(2011) Gillian Murphy   GENOME BIOLOGY

The Intrinsic Protein Flexibility of Endogenous Protease Inhibitor TIMP-1 Controls Its Binding Interface and Affects Its Function

(2010) Moran Grossman et al.   BIOCHEMISTRY

The tissue inhibitors of metalloproteinases (TIMPs): An ancient family with structural and functional diversity

(2010) Keith Brew et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

A novel and selective membrane type-1 matrix metalloproteinase (MT1-MMP) inhibitor reduces cancer cell motility and tumor growth

(2010) Juho Suojanen et al.   CANCER BIOLOGY & THERAPY

The safety and side effects of monoclonal antibodies

(2010) Trevor T. Hansel et al.   NATURE REVIEWS DRUG DISCOVERY

Selective Inhibition of Matrix Metalloproteinase-14 Blocks Tumor Growth, Invasion, and Angiogenesis

(2009) Laetitia Devy et al.   CANCER RESEARCH

Matrix metalloproteinases as modulators of inflammation

(2007) A MANICONE et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY