Development of High Affinity and High Specificity Inhibitors of Matrix Metalloproteinase 14 through Computational Design and Directed Evolution

Protein Engineering by Combined Computational and In Vitro Evolution Approaches

(2016) Lior Rosenfeld et al.   TRENDS IN BIOCHEMICAL SCIENCES

Inhibition Mechanism of Membrane Metalloprotease by an Exosite-Swiveling Conformational Antibody

(2015) Yael Udi et al.   STRUCTURE

Tumor cell-produced matrix metalloproteinase 9 (MMP-9) drives malignant progression and metastasis of basal-like triple negative breast cancer

(2015) Christine Mehner et al.   Oncotarget

Is there new hope for therapeutic matrix metalloproteinase inhibition?

(2014) Roosmarijn E. Vandenbroucke et al.   NATURE REVIEWS DRUG DISCOVERY

Affinity- and Specificity-Enhancing Mutations Are Frequent in Multispecific Interactions between TIMP2 and MMPs

(2014) Oz Sharabi et al.   PLoS One

Crystallization and preliminary X-ray crystallographic analysis of the catalytic domain of membrane type 1 matrix metalloproteinase

(2014) Hideaki Ogata et al.   Acta Crystallographica Section F-Structural Biology Communications

Single domain antibody–quantum dot conjugates for ricin detection by both fluoroimmunoassay and surface plasmon resonance

(2013) George P. Anderson et al.   ANALYTICA CHIMICA ACTA

Predicting affinity- and specificity-enhancing mutations at protein–protein interfaces

(2013) Oz Sharabi et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Matrix Metalloproteinase-10/TIMP-2 Structure and Analyses Define Conserved Core Interactions and Diverse Exosite Interactions in MMP/TIMP Complexes

(2013) Jyotica Batra et al.   PLoS One

Matrix Metalloproteinase-10 (MMP-10) Interaction with Tissue Inhibitors of Metalloproteinases TIMP-1 and TIMP-2

(2012) Jyotica Batra et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Rapid Conformational Epitope Mapping of Anti-gp120 Antibodies with a Designed Mutant Panel Displayed on Yeast

(2012) Jordi Mata-Fink et al.   JOURNAL OF MOLECULAR BIOLOGY

An Alternate Perspective on the Roles of TIMPs and MMPs in Pathology

(2011) Craig S. Moore et al.   AMERICAN JOURNAL OF PATHOLOGY

Engineering antibodies and proteins for molecular in vivo imaging

(2011) Tina Romer et al.   CURRENT OPINION IN BIOTECHNOLOGY

Phage Display of Tissue Inhibitor of Metalloproteinases-2 (TIMP-2)

(2011) Harinath Bahudhanapati et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Matrix metalloproteinases: protective roles in cancer

(2011) Julie Decock et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Worldwide experience with biosimilar development

(2011) Mark McCamish et al.   mAbs

Antibodies targeting the catalytic zinc complex of activated matrix metalloproteinases show therapeutic potential

(2011) Netta Sela-Passwell et al.   NATURE MEDICINE

Tissue inhibitors of metalloproteinases

(2011) Gillian Murphy   GENOME BIOLOGY

Selective inhibition of ADAM12 catalytic activity through engineering of tissue inhibitor of metalloproteinase 2 (TIMP-2)

(2010) Marie Kveiborg et al.   BIOCHEMICAL JOURNAL

The Intrinsic Protein Flexibility of Endogenous Protease Inhibitor TIMP-1 Controls Its Binding Interface and Affects Its Function

(2010) Moran Grossman et al.   BIOCHEMISTRY

The tissue inhibitors of metalloproteinases (TIMPs): An ancient family with structural and functional diversity

(2010) Keith Brew et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

A novel and selective membrane type-1 matrix metalloproteinase (MT1-MMP) inhibitor reduces cancer cell motility and tumor growth

(2010) Juho Suojanen et al.   CANCER BIOLOGY & THERAPY

The Chemokine Receptor CXCR4 and the Metalloproteinase MT1-MMP Are Mutually Required during Melanoma Metastasis to Lungs

(2009) Rubén A. Bartolomé et al.   AMERICAN JOURNAL OF PATHOLOGY

Selective Inhibition of Matrix Metalloproteinase-14 Blocks Tumor Growth, Invasion, and Angiogenesis

(2009) Laetitia Devy et al.   CANCER RESEARCH

MMP-14 can serve as a prognostic marker in patients with supraglottic cancer

(2009) Huiyan Zhang et al.   EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY

TIMPs and cardiac remodeling: ‘Embracing the MMP-independent-side of the family’

(2009) Davy Vanhoutte et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Tradeoff Between Stability and Multispecificity in the Design of Promiscuous Proteins

(2009) Menachem Fromer et al.   PLoS Computational Biology

Additional MDA-MB-231 breast cancer cell matrix metalloproteinases promote invasiveness

(2008) Luca Hegedüs et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Structural Determinants of the ADAM Inhibition by TIMP-3: Crystal Structure of the TACE-N-TIMP-3 Complex

(2008) Magdalena Wisniewska et al.   JOURNAL OF MOLECULAR BIOLOGY

Tissue Inhibitors of Metalloproteinases in Cell Signaling: Metalloproteinase-Independent Biological Activities

(2008) W. G. Stetler-Stevenson   Science Signaling

Reappraising metalloproteinases in rheumatoid arthritis and osteoarthritis: destruction or repair?

(2008) Gillian Murphy et al.   Nature clinical practice. Rheumatology

Matrix metalloproteinases and their inhibitors in vascular remodeling and vascular disease

(2007) Joseph D. Raffetto et al.   BIOCHEMICAL PHARMACOLOGY