Matrix Metalloproteinases are Involved in Cardiovascular Diseases

Captopril and Lisinopril Only Inhibit Matrix Metalloproteinase-2 (MMP-2) Activity at Millimolar Concentrations

(2013) Luciana B. Kuntze et al.   BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY

An important role of matrix metalloproteinase-8 in angiogenesis in vitro and in vivo

(2013) Changcun Fang et al.   CARDIOVASCULAR RESEARCH

Membrane-Associated Matrix Proteolysis and Heart Failure

(2013) Francis G. Spinale et al.   CIRCULATION RESEARCH

Nebivolol attenuates prooxidant and profibrotic mechanisms involving TGF-β and MMPs, and decreases vascular remodeling in renovascular hypertension

(2013) Carla S. Ceron et al.   FREE RADICAL BIOLOGY AND MEDICINE

Antioxidant effect of doxycycline decreases MMP activity and blood pressure in SHR

(2013) Raquel C. Antonio et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Comprehensive Evaluation of the Effects of Enalapril on Matrix Metalloproteinases Levels in Hypertension

(2012) Vanessa Fontana et al.   CARDIOVASCULAR DRUGS AND THERAPY

Regulation of the Inflammatory Response in Cardiac Repair

(2012) Nikolaos G. Frangogiannis   CIRCULATION RESEARCH

Temporal changes in cardiac matrix metalloproteinase activity, oxidative stress, and TGF-β in renovascular hypertension-induced cardiac hypertrophy

(2012) Elen Rizzi et al.   EXPERIMENTAL AND MOLECULAR PATHOLOGY

Contrasting effects of aliskiren versus losartan on hypertensive vascular remodeling

(2012) Alisson Martins-Oliveira et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Loss ofTimp3Gene Leads to Abdominal Aortic Aneurysm Formation in Response to Angiotensin II

(2012) Ratnadeep Basu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Time course involvement of matrix metalloproteinases in the vascular alterations of renovascular hypertension

(2012) Carla S. Ceron et al.   MATRIX BIOLOGY

Myofibroblasts in the Infarct Area: Concepts and Challenges

(2012) Evangelos P. Daskalopoulos et al.   MICROSCOPY AND MICROANALYSIS

Doxycycline ameliorates 2K-1C hypertension-induced vascular dysfunction in rats by attenuating oxidative stress and improving nitric oxide bioavailability

(2012) Michele M. Castro et al.   NITRIC OXIDE-BIOLOGY AND CHEMISTRY

A Novel Intracellular Isoform of Matrix Metalloproteinase-2 Induced by Oxidative Stress Activates Innate Immunity

(2012) David H. Lovett et al.   PLoS One

Matrix metalloproteinases in vascular physiology and disease

(2012) Suzanne A Siefert et al.   Vascular

Epithelial-Mesenchymal Transition: General Principles and Pathological Relevance with Special Emphasis on the Role of Matrix Metalloproteinases

(2012) P. Nistico et al.   Cold Spring Harbor Perspectives in Biology

Contribution of oxidative stress to endothelial dysfunction in hypertension

(2012) Bruno R. Silva et al.   Frontiers in Physiology

Consistent Alterations of Circulating Matrix Metalloproteinases Levels in Untreated Hypertensives and in Spontaneously Hypertensive Rats: A Relevant Pharmacological Target

(2011) Vanessa Fontana et al.   BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY

Pyrrolidine dithiocarbamate down-regulates vascular matrix metalloproteinases and ameliorates vascular dysfunction and remodelling in renovascular hypertension

(2011) SBA Cau et al.   BRITISH JOURNAL OF PHARMACOLOGY

Inhibition of matrix metalloproteinase-2 improves endothelial function and prevents hypertension in insulin-resistant rats

(2011) PR Nagareddy et al.   BRITISH JOURNAL OF PHARMACOLOGY

Doxycycline Ameliorates Vascular Endothelial and Contractile Dysfunction in the Thoracic Aorta of Diabetic Rats

(2011) Esma N. Zeydanli et al.   Cardiovascular Toxicology

Targeted Imaging of the Spatial and Temporal Variation of Matrix Metalloproteinase Activity in a Porcine Model of Postinfarct Remodeling

(2011) Zakir H. Sahul et al.   Circulation-Cardiovascular Imaging

Early measurements of plasma matrix metalloproteinase-2 predict infarct size and ventricular dysfunction in ST-elevation myocardial infarction

(2011) Lennart Nilsson et al.   HEART

Nuclear Factor Kappa B and Matrix Metalloproteinase Induced Receptor Cleavage in the Spontaneously Hypertensive Rat

(2011) Kwan-I Sharon Wu et al.   HYPERTENSION

Tempol inhibits TGF-β and MMPs upregulation and prevents cardiac hypertensive changes

(2011) Elen Rizzi et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Expression of soluble and functional full-length human matrix metalloproteinase-2 in Escherichia coli

(2011) Andrezza N. Gonçalves et al.   JOURNAL OF BIOTECHNOLOGY

Cellular/extracellular matrix cross-talk in scar evolution and control

(2011) Alan D. Widgerow   WOUND REPAIR AND REGENERATION

Matrix metalloproteinases cleave the β2-adrenergic receptor in spontaneously hypertensive rats

(2010) Stephen F. Rodrigues et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Doxycycline Dose-dependently Inhibits MMP-2-Mediated Vascular Changes in 2K1C Hypertension

(2010) Danielle A. Guimaraes et al.   BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY

Spironolactone and hydrochlorothiazide exert antioxidant effects and reduce vascular matrix metalloproteinase-2 activity and expression in a model of renovascular hypertension

(2010) CS Ceron et al.   BRITISH JOURNAL OF PHARMACOLOGY

Matrix Metalloproteinases Contribute Distinct Roles in Neuroendocrine Prostate Carcinogenesis, Metastasis, and Angiogenesis Progression

(2010) L. E. Littlepage et al.   CANCER RESEARCH

Synergism in hyperhomocysteinemia and diabetes: role of PPAR gamma and tempol

(2010) Paras K Mishra et al.   Cardiovascular Diabetology

Titin is a Target of Matrix Metalloproteinase-2

(2010) Mohammad A.M. Ali et al.   CIRCULATION

Captopril directly inhibits matrix metalloproteinase-2 activity in continuous ambulatory peritoneal dialysis therapy

(2010) Daisuke Yamamoto et al.   CLINICA CHIMICA ACTA

Transgenic expression of matrix metalloproteinase-2 induces coronary artery ectasia

(2010) Sia Dahi et al.   INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY

Combining two potential causes of metalloproteinase secretion causes abdominal aortic aneurysms in rats: a new experimental model

(2010) Karina M. Mata et al.   INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY

Cardiac Restricted Overexpression of Membrane Type-1 Matrix Metalloproteinase Causes Adverse Myocardial Remodeling following Myocardial Infarction

(2010) Francis G. Spinale et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Matrix Metalloproteinase Inhibition Improves Cardiac Dysfunction and Remodeling in 2-Kidney, 1-Clip Hypertension

(2010) Élen Rizzi et al.   JOURNAL OF CARDIAC FAILURE

Enhanced Matrix Metalloproteinase Activity in the Spontaneously Hypertensive Rat: VEGFR-2 Cleavage, Endothelial Apoptosis, and Capillary Rarefaction

(2010) Edward D. Tran et al.   JOURNAL OF VASCULAR RESEARCH

Comparative study on antioxidant effects and vascular matrix metalloproteinase-2 downregulation by dihydropyridines in renovascular hypertension

(2010) Diogo M. O. Marçal et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

A Role of Matrix Metalloproteinase-8 in Atherosclerosis

(2009) Ross C. Laxton et al.   CIRCULATION RESEARCH

Cardiac-Restricted Overexpression of Membrane Type-1 Matrix Metalloproteinase in Mice

(2009) Francis G. Spinale et al.   Circulation-Heart Failure

Circulating matrix metalloproteinase-8 (MMP-8) and MMP-9 are increased in chronic periodontal disease and decrease after non-surgical periodontal therapy

(2009) Andrea M. Marcaccini et al.   CLINICA CHIMICA ACTA

Antioxidant treatment reduces matrix metalloproteinase-2-induced vascular changes in renovascular hypertension

(2009) Michele M. Castro et al.   FREE RADICAL BIOLOGY AND MEDICINE

The extracellular matrix as a modulator of the inflammatory and reparative response following myocardial infarction

(2009) Marcin Dobaczewski et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Matrix metalloproteinase-9 and tissue inhibitor of matrix metalloproteinase-1 in blood as markers for early atherosclerosis in subjects with chronic periodontitis

(2009) P-Ö. Söder et al.   JOURNAL OF PERIODONTAL RESEARCH

Effects of Tick Control by Acaricide Self-Treatment of White-Tailed Deer on Host-Seeking Tick Infection Prevalence and Entomologic Risk for Ixodes scapularis-Borne Pathogens

(2009) Anne Gatewood Hoen et al.   VECTOR-BORNE AND ZOONOTIC DISEASES

Matrix Metalloproteinase 12 Accelerates the Initiation of Atherosclerosis and Stimulates the Progression of Fatty Streaks to Fibrous Plaques in Transgenic Rabbits

(2008) Sohsuke Yamada et al.   AMERICAN JOURNAL OF PATHOLOGY

Evidence of early involvement of matrix metalloproteinase-2 in lead-induced hypertension

(2008) Elen Rizzi et al.   ARCHIVES OF TOXICOLOGY

Activation and modulation of 72kDa matrix metalloproteinase-2 by peroxynitrite and glutathione

(2008) Serena Viappiani et al.   BIOCHEMICAL PHARMACOLOGY

Cardiac transgenic matrix metalloproteinase-2 expression induces myxomatous valve degeneration: a potential model of mitral valve prolapse disease

(2008) Rajeev Mahimkar et al.   CARDIOVASCULAR PATHOLOGY

Lercanidipine decreases vascular matrix metalloproteinase-2 activity and protects against vascular dysfunction in diabetic rats

(2008) Marcio L.L. Martinez et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Lercanidipine reduces matrix metalloproteinase-2 activity and reverses vascular dysfunction in renovascular hypertensive rats

(2008) Marcio L.L. Martinez et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Subtype specific estrogen receptor action protects against changes in MMP-2 activation in mouse retinal pigmented epithelial cells

(2008) Sharon Elliot et al.   EXPERIMENTAL EYE RESEARCH

Treatment of periodontal disease results in improvements in endothelial dysfunction and reduction of the carotid intima-media thickness

(2008) Stefania Piconi et al.   FASEB JOURNAL

The chemical biology of nitric oxide: Implications in cellular signaling

(2008) Douglas D. Thomas et al.   FREE RADICAL BIOLOGY AND MEDICINE

Proteinase Activity and Receptor Cleavage

(2008) Frank A. DeLano et al.   HYPERTENSION

Metalloproteinase Expression in Carotid Plaque and Its Correlation With Plasma Levels Before and After Carotid Endarterectomy

(2008) Maurizio Taurino et al.   Vascular and Endovascular Surgery

Metalloproteinase inhibition ameliorates hypertension and prevents vascular dysfunction and remodeling in renovascular hypertensive rats

(2007) Michele M. Castro et al.   ATHEROSCLEROSIS