Therapeutic Potential of Matrix Metalloproteinase Inhibition in Breast Cancer

Development of High Affinity and High Specificity Inhibitors of Matrix Metalloproteinase 14 through Computational Design and Directed Evolution

(2017) Valeria Arkadash et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Discovery of Novel, Highly Potent, and Selective Matrix Metalloproteinase (MMP)-13 Inhibitors with a 1,2,4-Triazol-3-yl Moiety as a Zinc Binding Group Using a Structure-Based Design Approach

(2017) Hiroshi Nara et al.   JOURNAL OF MEDICINAL CHEMISTRY

Bone-Seeking Matrix Metalloproteinase-2 Inhibitors Prevent Bone Metastatic Breast Cancer Growth

(2017) Marilena Tauro et al.   MOLECULAR CANCER THERAPEUTICS

Expression and Clinical Significance of Metalloproteases and Their Inhibitors by Endothelial Cells From Invasive Breast Carcinomas

(2016) Sandra Cid et al.   Clinical Breast Cancer

Thermodynamic Basis of Selectivity in the Interactions of Tissue Inhibitors of Metalloproteinases N-domains with Matrix Metalloproteinases-1, -3, and -14

(2016) Haiyin Zou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Zinc–Metalloproteinase Inhibitors: Evaluation of the Complex Role Played by the Zinc-Binding Group on Potency and Selectivity

(2016) Cecile Rouanet-Mehouas et al.   JOURNAL OF MEDICINAL CHEMISTRY

Radiolabeled Selective Matrix Metalloproteinase 13 (MMP-13) Inhibitors: (Radio)Syntheses and in Vitro and First in Vivo Evaluation

(2016) Verena Hugenberg et al.   JOURNAL OF MEDICINAL CHEMISTRY

Active-site MMP-selective antibody inhibitors discovered from convex paratope synthetic libraries

(2016) Dong Hyun Nam et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Generation of inhibitory monoclonal antibodies targeting matrix metalloproteinase-14 by motif grafting and CDR optimization

(2016) Dong Hyun Nam et al.   PROTEIN ENGINEERING DESIGN & SELECTION

Protein Engineering by Combined Computational and In Vitro Evolution Approaches

(2016) Lior Rosenfeld et al.   TRENDS IN BIOCHEMICAL SCIENCES

Development of a specific affinity-matured exosite inhibitor to MT1-MMP that efficiently inhibits tumor cell invasion in vitro and metastasis in vivo

(2016) Kenneth A. Botkjaer et al.   Oncotarget

Pharmacokinetics and Biodistribution of Human Serum Albumin-TIMP-2 Fusion Protein Using Near-Infrared Optical Imaging

(2016) Mi-Sook Lee et al.   JOURNAL OF PHARMACY AND PHARMACEUTICAL SCIENCES

Matrix Metalloproteinase Inhibition by Heterotrimeric Triple-Helical Peptide Transition State Analogues

(2015) Manishabrata Bhowmick et al.   CHEMBIOCHEM

Matrix metalloproteinases as drivers and therapeutic targets in breast cancer

(2015) Evette S. Radisky   Frontiers in Bioscience-Landmark

Matrix metalloproteinases in stem cell regulation and cancer

(2015) Kai Kessenbrock et al.   MATRIX BIOLOGY

p63/MT1-MMP axis is required for in situ to invasive transition in basal-like breast cancer

(2015) C Lodillinsky et al.   ONCOGENE

Inhibition Mechanism of Membrane Metalloprotease by an Exosite-Swiveling Conformational Antibody

(2015) Yael Udi et al.   STRUCTURE

Charge-Triggered Membrane Insertion of Matrix Metalloproteinase-7, Supporter of Innate Immunity and Tumors

(2015) Stephen H. Prior et al.   STRUCTURE

Presence of Insulin-Like Growth Factor Binding Proteins Correlates With Tumor-Promoting Effects of Matrix Metalloproteinase 9 in Breast Cancer

(2015) Jae-Hyun Park et al.   NEOPLASIA

ROS-induced epithelial-mesenchymal transition in mammary epithelial cells is mediated by NF-κB-dependent activation of Snail

(2015) Magdalena A. Cichon et al.   Oncotarget

Tumor cell-produced matrix metalloproteinase 9 (MMP-9) drives malignant progression and metastasis of basal-like triple negative breast cancer

(2015) Christine Mehner et al.   Oncotarget

MMP-9 expression varies according to molecular subtypes of breast cancer

(2014) Einas M Yousef et al.   BMC CANCER

Tissue inhibitor of matrix metalloproteinases-1 loaded poly(lactic-co-glycolic acid) nanoparticles for delivery across the blood–brain barrier

(2014) Mayank Chaturvedi et al.   International Journal of Nanomedicine

Protein-tyrosine Pseudokinase 7 (PTK7) Directs Cancer Cell Motility and Metastasis

(2014) Vladislav S. Golubkov et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Discovery of Novel, Highly Potent, and Selective Quinazoline-2-carboxamide-Based Matrix Metalloproteinase (MMP)-13 Inhibitors without a Zinc Binding Group Using a Structure-Based Design Approach

(2014) Hiroshi Nara et al.   JOURNAL OF MEDICINAL CHEMISTRY

Tumor Cell–Derived MMP3 Orchestrates Rac1b and Tissue Alterations That Promote Pancreatic Adenocarcinoma

(2014) Christine Mehner et al.   MOLECULAR CANCER RESEARCH

Loss of the Timp gene family is sufficient for the acquisition of the CAF-like cell state

(2014) Masayuki Shimoda et al.   NATURE CELL BIOLOGY

Is there new hope for therapeutic matrix metalloproteinase inhibition?

(2014) Roosmarijn E. Vandenbroucke et al.   NATURE REVIEWS DRUG DISCOVERY

Molecular mechanisms of epithelial–mesenchymal transition

(2014) Samy Lamouille et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Affinity- and Specificity-Enhancing Mutations Are Frequent in Multispecific Interactions between TIMP2 and MMPs

(2014) Oz Sharabi et al.   PLoS One

Ambidextrous binding of cell and membrane bilayers by soluble matrix metalloproteinase-12

(2014) Rama K. Koppisetti et al.   Nature Communications

Extracellular matrix as a contextual determinant of transforming growth factor-β signaling in epithelial-mesenchymal transition and in cancer

(2014) Magdalena A Cichon et al.   Cell Adhesion & Migration

Tissue-Infiltrating Neutrophils Constitute the Major In Vivo Source of Angiogenesis-Inducing MMP-9 in the Tumor Microenvironment

(2014) Elena I. Deryugina et al.   NEOPLASIA

Monitoring and Inhibiting MT1-MMP during Cancer Initiation and Progression

(2014) Sonia Pahwa et al.   Cancers

Plasma levels of the MMP-9:TIMP-1 complex as prognostic biomarker in breast cancer: a retrospective study

(2013) Stine B Thorsen et al.   BMC CANCER

A Role for Matrix Metalloproteinases in Regulating Mammary Stem Cell Function via the Wnt Signaling Pathway

(2013) Kai Kessenbrock et al.   Cell Stem Cell

Domain structure and function of matrix metalloprotease 23 (MMP23): role in potassium channel trafficking

(2013) Charles A. Galea et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Extracellular matrix proteins regulate epithelial–mesenchymal transition in mammary epithelial cells

(2013) Qike K. Chen et al.   DIFFERENTIATION

Crystal structure of full-length human collagenase 3 (MMP-13) with peptides in the active site defines exosites in the catalytic domain

(2013) Enrico A. Stura et al.   FASEB JOURNAL

Therapeutic antibody engineering by high efficiency cell screening

(2013) Achim Doerner et al.   FEBS LETTERS

Targeting a Single Function of the Multifunctional Matrix Metalloprotease MT1-MMP

(2013) Signe Ingvarsen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TIMP-1 Attenuates Blood–Brain Barrier Permeability in Mice with Acute Liver Failure

(2013) Feng Chen et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Unraveling Hidden Regulatory Sites in Structurally Homologous Metalloproteases

(2013) Yael Udi et al.   JOURNAL OF MOLECULAR BIOLOGY

Matrix Metalloproteinase-10/TIMP-2 Structure and Analyses Define Conserved Core Interactions and Diverse Exosite Interactions in MMP/TIMP Complexes

(2013) Jyotica Batra et al.   PLoS One

Architecture and function of metallopeptidase catalytic domains

(2013) Núria Cerdà-Costa et al.   PROTEIN SCIENCE

A monoclonal antibody interferes with TIMP-2 binding and incapacitates the MMP-2-activating function of multifunctional, pro-tumorigenic MMP-14/MT1–MMP

(2013) S A Shiryaev et al.   Oncogenesis

Diagnostic and Prognostic Relevance of MMP-11 Expression in the Stromal Fibroblast-Like Cells Adjacent to Invasive Ductal Carcinoma of the Breast

(2012) Kyueng-Whan Min et al.   ANNALS OF SURGICAL ONCOLOGY

Engineering antibodies by yeast display

(2012) Eric T. Boder et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Novel MT1-MMP Small-Molecule Inhibitors Based on Insights into Hemopexin Domain Function in Tumor Growth

(2012) A. G. Remacle et al.   CANCER RESEARCH

Targeting the Fas/FasL signaling pathway in cancer therapy

(2012) María Villa-Morales et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Matrix Metalloproteinase-10 (MMP-10) Interaction with Tissue Inhibitors of Metalloproteinases TIMP-1 and TIMP-2

(2012) Jyotica Batra et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Insights into Ectodomain Shedding and Processing of Protein-tyrosine Pseudokinase 7 (PTK7)

(2012) Vladislav S. Golubkov et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Simple Pseudo-dipeptides with a P2′ Glutamate

(2012) Laurent Devel et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Involvement of hnRNP A1 in the matrix metalloprotease-3-dependent regulation of Rac1 pre-mRNA splicing

(2012) Federico Pelisch et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Identification of collagen binding domain residues that govern catalytic activities of matrix metalloproteinase-2 (MMP-2)

(2012) Margarita Mikhailova et al.   MATRIX BIOLOGY

High expression of CD147 and MMP-9 is correlated with poor prognosis of triple-negative breast cancer (TNBC) patients

(2012) Shu Zhao et al.   MEDICAL ONCOLOGY

Matrix compliance regulates Rac1b localization, NADPH oxidase assembly, and epithelial–mesenchymal transition

(2012) KangAe Lee et al.   MOLECULAR BIOLOGY OF THE CELL

Peptide-Based Selective Inhibitors of Matrix Metalloproteinase-Mediated Activities

(2012) Margaret Ndinguri et al.   MOLECULES

TGFβ signalling in context

(2012) Joan Massagué   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Neuroprotection from Tissue Inhibitor of Metalloproteinase-1 and its nanoparticles

(2012) Mayank Chaturvedi et al.   NEUROCHEMISTRY INTERNATIONAL

Relationship between the Inflammatory Molecular Profile of Breast Carcinomas and Distant Metastasis Development

(2012) Noemí Eiró et al.   PLoS One

PEGylation Extends Circulation Half-Life While Preserving In Vitro and In Vivo Activity of Tissue Inhibitor of Metalloproteinases-1 (TIMP-1)

(2012) Jyotica Batra et al.   PLoS One

Structural insights into triple-helical collagen cleavage by matrix metalloproteinase 1

(2012) S. W. Manka et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Matrix Metalloproteinase Induction of Rac1b, a Key Effector of Lung Cancer Progression

(2012) M. L. Stallings-Mann et al.   Science Translational Medicine

Epithelial-Mesenchymal Transition: General Principles and Pathological Relevance with Special Emphasis on the Role of Matrix Metalloproteinases

(2012) P. Nistico et al.   Cold Spring Harbor Perspectives in Biology

Tumor-Recruited Neutrophils and Neutrophil TIMP-Free MMP-9 Regulate Coordinately the Levels of Tumor Angiogenesis and Efficiency of Malignant Cell Intravasation

(2011) Erin M. Bekes et al.   AMERICAN JOURNAL OF PATHOLOGY

Matrix Metalloproteinase 3 Is a Mediator of Pulmonary Fibrosis

(2011) Cory M. Yamashita et al.   AMERICAN JOURNAL OF PATHOLOGY

Cancer Cell-Associated MT1-MMP Promotes Blood Vessel Invasion and Distant Metastasis in Triple-Negative Mammary Tumors

(2011) J. Y. Perentes et al.   CANCER RESEARCH

Small-Molecule Anticancer Compounds Selectively Target the Hemopexin Domain of Matrix Metalloproteinase-9

(2011) A. Dufour et al.   CANCER RESEARCH

Epithelial–mesenchymal transition and breast cancer: Role, molecular mechanisms and clinical impact

(2011) Chiara Foroni et al.   CANCER TREATMENT REVIEWS

Entropy Increases from Different Sources Support the High-affinity Binding of the N-terminal Inhibitory Domains of Tissue Inhibitors of Metalloproteinases to the Catalytic Domains of Matrix Metalloproteinases-1 and -3

(2011) Ying Wu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Exosite Interactions Impact Matrix Metalloproteinase Collagen Specificities

(2011) Trista K. Robichaud et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Interface between Catalytic and Hemopexin Domains in Matrix Metalloproteinase-1 Conceals a Collagen Binding Exosite

(2011) Laurence H. Arnold et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Phage Display of Tissue Inhibitor of Metalloproteinases-2 (TIMP-2)

(2011) Harinath Bahudhanapati et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inhibition of Matrix Metalloproteinase 14 (MMP-14)-mediated Cancer Cell Migration

(2011) Kevin Zarrabi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Matrix metalloproteinases: protective roles in cancer

(2011) Julie Decock et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Structural Basis for Matrix Metalloproteinase 1-Catalyzed Collagenolysis

(2011) Ivano Bertini et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Antibodies targeting the catalytic zinc complex of activated matrix metalloproteinases show therapeutic potential

(2011) Netta Sela-Passwell et al.   NATURE MEDICINE

MEROPS: the database of proteolytic enzymes, their substrates and inhibitors

(2011) N. D. Rawlings et al.   NUCLEIC ACIDS RESEARCH

Matrix metalloproteinase-11 overexpressed in lobular carcinoma cells of the breast promotes anoikis resistance

(2011) Tamotsu Takeuchi et al.   VIRCHOWS ARCHIV

Macrophage Matrix Metalloproteinase-9 Mediates Epithelial-Mesenchymal Transition in Vitro in Murine Renal Tubular Cells

(2010) Thian Kui Tan et al.   AMERICAN JOURNAL OF PATHOLOGY

The Intrinsic Protein Flexibility of Endogenous Protease Inhibitor TIMP-1 Controls Its Binding Interface and Affects Its Function

(2010) Moran Grossman et al.   BIOCHEMISTRY

The tissue inhibitors of metalloproteinases (TIMPs): An ancient family with structural and functional diversity

(2010) Keith Brew et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

A novel and selective membrane type-1 matrix metalloproteinase (MT1-MMP) inhibitor reduces cancer cell motility and tumor growth

(2010) Juho Suojanen et al.   CANCER BIOLOGY & THERAPY

Matrix Metalloproteinases: Regulators of the Tumor Microenvironment

(2010) Kai Kessenbrock et al.   CELL

Localizing matrix metalloproteinase activities in the pericellular environment

(2010) Gillian Murphy et al.   FEBS Journal

Roles of matrix metalloproteinases in cancer progression and their pharmacological targeting

(2010) Chrisostomi Gialeli et al.   FEBS Journal

Role of Matrix Metalloproteinase-9 Dimers in Cell Migration

(2010) Antoine Dufour et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

NMR and Bioinformatics Discovery of Exosites That Tune Metalloelastase Specificity for Solubilized Elastin and Collagen Triple Helices

(2010) Mark O. Palmier et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Insights from Selective Non-phosphinic Inhibitors of MMP-12 Tailored to Fit with an S1′ Loop Canonical Conformation

(2010) Laurent Devel et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The 19-Amino Acid Insertion in the Tumor-associated Splice Isoform Rac1b Confers Specific Binding to p120 Catenin

(2010) Lidiya Orlichenko et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Wnt/Planar Cell Polarity Protein-tyrosine Kinase-7 (PTK7) Is a Highly Efficient Proteolytic Target of Membrane Type-1 Matrix Metalloproteinase

(2010) Vladislav S. Golubkov et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Matrix Metalloproteinase-Induced Epithelial-Mesenchymal Transition in Breast Cancer

(2010) Evette S. Radisky et al.   JOURNAL OF MAMMARY GLAND BIOLOGY AND NEOPLASIA

EMT, cancer stem cells and drug resistance: an emerging axis of evil in the war on cancer

(2010) A Singh et al.   ONCOGENE

Disruption of E-Cadherin by Matrix Metalloproteinase Directly Mediates Epithelial-Mesenchymal Transition Downstream of Transforming Growth Factor-β1 in Renal Tubular Epithelial Cells

(2009) Guoping Zheng et al.   AMERICAN JOURNAL OF PATHOLOGY

Matrix metalloproteinases: Fold and function of their catalytic domains

(2009) Cynthia Tallant et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Pleiotropic roles of matrix metalloproteinases in tumor angiogenesis: Contrasting, overlapping and compensatory functions

(2009) Elena I. Deryugina et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Structural and functional bases for allosteric control of MMP activities: Can it pave the path for selective inhibition?

(2009) Netta Sela-Passwell et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

To bind zinc or not to bind zinc: An examination of innovative approaches to improved metalloproteinase inhibition

(2009) Jennifer A. Jacobsen et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

The activity of a designer tissue inhibitor of metalloproteinases (TIMP)-1 against native membrane type 1 matrix metalloproteinase (MT1-MMP) in a cell-based environment

(2009) Meng-Huee Lee et al.   CANCER LETTERS

Selective Inhibition of Matrix Metalloproteinase-14 Blocks Tumor Growth, Invasion, and Angiogenesis

(2009) Laetitia Devy et al.   CANCER RESEARCH

Inhibition of MMP-9 transcription and suppression of tumor metastasis by pyrrole-imidazole polyamide

(2009) Xiaofei Wang et al.   CANCER SCIENCE

The clinical implications of MMP-11 and CK-20 expression in human breast cancer

(2009) Chun-Wen Cheng et al.   CLINICA CHIMICA ACTA

Intra- and Interdomain Flexibility in Matrix Metalloproteinases: Functional Aspects and Drug Design

(2009) Ivano Bertini et al.   CURRENT PHARMACEUTICAL DESIGN

Expression and prognostic significance of metalloproteases and their inhibitors in luminal A and basal-like phenotypes of breast carcinoma

(2009) Luis O. González et al.   HUMAN PATHOLOGY

Potassium Channel Modulation by a Toxin Domain in Matrix Metalloprotease 23

(2009) Srikant Rangaraju et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Neutrophil MMP-9 Proenzyme, Unencumbered by TIMP-1, Undergoes Efficient Activationin Vivoand Catalytically Induces Angiogenesis via a Basic Fibroblast Growth Factor (FGF-2)/FGFR-2 Pathway

(2009) Veronica C. Ardi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Supervised Risk Predictor of Breast Cancer Based on Intrinsic Subtypes

(2009) Joel S. Parker et al.   JOURNAL OF CLINICAL ONCOLOGY

Mammary Involution and Breast Cancer Risk: Transgenic Models and Clinical Studies

(2009) Derek C. Radisky et al.   JOURNAL OF MAMMARY GLAND BIOLOGY AND NEOPLASIA

Induction of a MT1-MMP and MT2-MMP-dependent basement membrane transmigration program in cancer cells by Snail1

(2009) I. Ota et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Matrix metalloproteinase expression and outcome in patients with breast cancer: analysis of a published database

(2008) P. M. McGowan et al.   ANNALS OF ONCOLOGY

Gene Transfer of Matrix Metalloproteinase-9 Induces Tumor Regression of Breast Cancer In vivo

(2008) C. Bendrik et al.   CANCER RESEARCH

Matrix Metalloproteinase-8 Functions as a Metastasis Suppressor through Modulation of Tumor Cell Adhesion and Invasion

(2008) A. Gutierrez-Fernandez et al.   CANCER RESEARCH

Matrix Metalloproteinase 9 Is a Mediator of Epidermal Growth Factor-Dependent E-Cadherin Loss in Ovarian Carcinoma Cells

(2008) K. D. Cowden Dahl et al.   CANCER RESEARCH

Effect of Ablation or Inhibition of Stromal Matrix Metalloproteinase-9 on Lung Metastasis in a Breast Cancer Model Is Dependent on Genetic Background

(2008) M. D. Martin et al.   CANCER RESEARCH

MT1-MMP releases latent TGF-β1 from endothelial cell extracellular matrix via proteolytic processing of LTBP-1

(2008) O TATTI et al.   EXPERIMENTAL CELL RESEARCH

Prognostic significance of MMP-9 and TIMP-1 serum and tissue expression in breast cancer

(2008) Zheng-Sheng Wu et al.   INTERNATIONAL JOURNAL OF CANCER

Membrane Type 1 Matrix Metalloproteinase Induces Epithelial-to-Mesenchymal Transition in Prostate Cancer

(2008) Jian Cao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Selective Modulation of Matrix Metalloproteinase 9 (MMP-9) Functions via Exosite Inhibition

(2008) Janelle L. Lauer-Fields et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Change in cell shape is required for matrix metalloproteinase-induced epithelial-mesenchymal transition of mammary epithelial cells

(2008) Celeste M. Nelson et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Evidence of Reciprocal Reorientation of the Catalytic and Hemopexin-Like Domains of Full-Length MMP-12

(2008) Ivano Bertini et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Tissue Inhibitors of Metalloproteinases in Cell Signaling: Metalloproteinase-Independent Biological Activities

(2008) W. G. Stetler-Stevenson   Science Signaling

MMPs as therapeutic targets—Still a viable option?

(2007) B FINGLETON   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY