The Positive Side of the Alzheimer’s Disease Amyloid Cross-Interactions: The Case of the Aβ 1-42 Peptide with Tau, TTR, CysC, and ApoA1

Direct Interaction between the β-Amyloid Core and Tau Facilitates Cross-Seeding: A Novel Target for Therapeutic Intervention

(2020) Timir Tripathi et al.   BIOCHEMISTRY

Transthyretin Inhibits Primary and Secondary Nucleations of Amyloid-β Peptide Aggregation and Reduces the Toxicity of Its Oligomers

(2020) Seyyed Abolghasem Ghadami et al.   BIOMACROMOLECULES

Calorimetric studies of binary and ternary molecular interactions between transthyretin, Aβ peptides and small-molecule chaperones towards an alternative strategy for Alzheimer's Disease drug discovery

(2020) Ellen Y. Cotrina et al.   JOURNAL OF MEDICINAL CHEMISTRY

Tau-tubulin kinase 1 and amyloid-β peptide induce phosphorylation of collapsin response mediator protein-2 and enhance neurite degeneration in Alzheimer disease mouse models

(2020) Seiko Ikezu et al.   Acta Neuropathologica Communications

Insulin deficiency promotes formation of toxic amyloid-β42 conformer co-aggregating with hyper-phosphorylated tau oligomer in an Alzheimer's disease model

(2020) Tomohiro Imamura et al.   NEUROBIOLOGY OF DISEASE

Intracerebral seeding of amyloid-β and tau pathology in mice: Factors underlying prion-like spreading and comparisons with α-synuclein

(2020) Brendan B. McAllister et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Amyloid-β42/40 ratio drives tau pathology in 3D human neural cell culture models of Alzheimer’s disease

(2020) Sang Su Kwak et al.   Nature Communications

Amyloid-β pathology enhances pathological fibrillary tau seeding induced by Alzheimer PHF in vivo

(2019) Cristina Vergara et al.   ACTA NEUROPATHOLOGICA

The elusive tau molecular structures: can we translate the recent breakthroughs into new targets for intervention?

(2019) Yann Fichou et al.   Acta Neuropathologica Communications

The Extent of Human Apolipoprotein A-I Lipidation Strongly Affects the β-Amyloid Efflux Across the Blood-Brain Barrier in vitro

(2019) Roberta Dal Magro et al.   Frontiers in Neuroscience

Small molecule PROTACs in targeted therapy: An emerging strategy to induce protein degradation

(2019) Meiyang Xi et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Humanization of the entire murine Mapt gene provides a murine model of pathological human tau propagation

(2019) Takashi Saito et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mechanisms of aggregation and fibril formation of the amyloidogenic N-terminal fragment of apolipoprotein A-I

(2019) Chiharu Mizuguchi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Aβ-induced acceleration of Alzheimer-related τ-pathology spreading and its association with prion protein

(2019) Luis Aragão Gomes et al.   ACTA NEUROPATHOLOGICA

Role of Tau as a Microtubule-Associated Protein: Structural and Functional Aspects

(2019) Pascale Barbier et al.   Frontiers in Aging Neuroscience

Real‐time BODIPY‐binding assay to screen inhibitors of the early oligomerization process of Aβ 1‐42 peptide

(2019) Nicolo Tonali et al.   CHEMBIOCHEM

Peptides and peptidomimetics as inhibitors of protein–protein interactions involving β-sheet secondary structures

(2019) José Laxio Arenas et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Resistance to autosomal dominant Alzheimer’s disease in an APOE3 Christchurch homozygote: a case report

(2019) Joseph F. Arboleda-Velasquez et al.   NATURE MEDICINE

Amyloid-β-independent regulators of tau pathology in Alzheimer disease

(2019) Rik van der Kant et al.   NATURE REVIEWS NEUROSCIENCE

Radiochemical examination of transthyretin (TTR) brain penetration assisted by iododiflunisal, a TTR tetramer stabilizer and a new candidate drug for AD

(2019) Xabier Rios et al.   Scientific Reports

Amyloid β-protein oligomers promote the uptake of tau fibril seeds potentiating intracellular tau aggregation

(2019) Woo Shik Shin et al.   Alzheimers Research & Therapy

Structure-based inhibitors of amyloid beta core suggest a common interface with tau

(2019) Sarah L Griner et al.   eLife

Different Amyloid-β Self-Assemblies Have Distinct Effects on Intracellular Tau Aggregation

(2019) Woo Shik Shin et al.   Frontiers in Molecular Neuroscience

Transthyretin Mimetics as Anti-β-Amyloid Agents: A Comparison of Peptide and Protein Approaches

(2018) Kayla M. Pate et al.   ChemMedChem

Inhibitors of protein–protein interactions (PPIs): an analysis of scaffold choices and buried surface area

(2018) Xu Ran et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Interfering peptides targeting protein–protein interactions: the next generation of drugs?

(2018) Heriberto Bruzzoni-Giovanelli et al.   DRUG DISCOVERY TODAY

Structure-activity relationships of β-hairpin mimics as modulators of amyloid β-peptide aggregation

(2018) Nicolo Tonali et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and physicochemical studies of amyloidogenic hexapeptides derived from human cystatin C

(2018) Emilia Iłowska et al.   JOURNAL OF PEPTIDE SCIENCE

Dependence of the Formation of Tau and Aβ Peptide Mixed Aggregates on the Secondary Structure of the N-Terminal Region of Aβ

(2018) Ana V. Rojas et al.   JOURNAL OF PHYSICAL CHEMISTRY B

The Neuronal Tau Protein Blocks in Vitro Fibrillation of the Amyloid-β (Aβ) Peptide at the Oligomeric Stage

(2018) Cecilia Wallin et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A computational examination of the binding interactions of amyloidβ and human cystatin C

(2018) Arun K. Sharma et al.   JOURNAL OF THEORETICAL & COMPUTATIONAL CHEMISTRY

Using Peptidomimetics and Constrained Peptides as Valuable Tools for Inhibiting Protein–Protein Interactions

(2018) Naomi Robertson et al.   MOLECULES

Human Serum Transthyretin Levels Correlate Inversely with Alzheimer's Disease

(2018) Sun-Ho Han et al.   JOURNAL OF ALZHEIMERS DISEASE

Gender-Dependent Transthyretin Modulation of Brain Amyloid-β Levels: Evidence from a Mouse Model of Alzheimer's Disease

(2018) Sandra Marisa Oliveira et al.   JOURNAL OF ALZHEIMERS DISEASE

Plasma Transthyretin as a Candidate Marker for Alzheimer's Disease

(2018) Latha Velayudhan et al.   JOURNAL OF ALZHEIMERS DISEASE

Abnormal Interaction of Oligomeric Amyloid-β with Phosphorylated Tau: Implications to Synaptic Dysfunction and Neuronal Damage

(2018) Maria Manczak et al.   JOURNAL OF ALZHEIMERS DISEASE

Transthyretin Stabilization by Iododiflunisal Promotes Amyloid-β Peptide Clearance, Decreases its Deposition, and Ameliorates Cognitive Deficits in an Alzheimer's Disease Mouse Model

(2018) Carlos A. Ribeiro et al.   JOURNAL OF ALZHEIMERS DISEASE

Protein misfolding, aggregation, and conformational strains in neurodegenerative diseases

(2018) Claudio Soto et al.   NATURE NEUROSCIENCE

Copper mediated amyloid-β binding to Transthyretin

(2018) Lidia Ciccone et al.   Scientific Reports

Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs

(2018) Sainan An et al.   EBioMedicine

Tau impairs neural circuits, dominating amyloid-β effects, in Alzheimer models in vivo

(2018) Marc Aurel Busche et al.   NATURE NEUROSCIENCE

Tau protein aggregation in Alzheimer's disease: An attractive target for the development of novel therapeutic agents

(2017) Marie Jouanne et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Insights on the Interaction between Transthyretin and Aβ in Solution. A Saturation Transfer Difference (STD) NMR Analysis of the Role of Iododiflunisal

(2017) Ana Gimeno et al.   JOURNAL OF MEDICINAL CHEMISTRY

Amyloid-β plaques enhance Alzheimer's brain tau-seeded pathologies by facilitating neuritic plaque tau aggregation

(2017) Zhuohao He et al.   NATURE MEDICINE

Intravenous treatment with human recombinant ApoA-I Milano reduces beta amyloid cerebral deposition in the APP23-transgenic mouse model of Alzheimer's disease

(2017) Sofía Fernández-de Retana et al.   NEUROBIOLOGY OF AGING

β-Hairpin mimics containing a piperidine–pyrrolidine scaffold modulate the β-amyloid aggregation process preserving the monomer species

(2017) S. Pellegrino et al.   Chemical Science

Complexes of Amyloid-β and Cystatin C in the Human Central Nervous System

(2017) Weiqian Mi et al.   JOURNAL OF ALZHEIMERS DISEASE

Alzheimer's Disease and the Amyloid-β Peptide

(2017) M. Paul Murphy et al.   JOURNAL OF ALZHEIMERS DISEASE

TANGO-Inspired Design of Anti-Amyloid Cyclic Peptides

(2016) Xiaomeng Lu et al.   ACS Chemical Neuroscience

Heterotypic seeding of Tau fibrillization by pre-aggregated Abeta provides potent seeds for prion-like seeding and propagation of Tau-pathology in vivo

(2016) Bruno Vasconcelos et al.   ACTA NEUROPATHOLOGICA

Cystatin C in aging and in Alzheimer’s disease

(2016) Paul M. Mathews et al.   AGEING RESEARCH REVIEWS

Reconstituted high-density lipoproteins acutely reduce soluble brain Aβ levels in symptomatic APP/PS1 mice

(2016) Jérôme Robert et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Regional profiles of the candidate tau PET ligand18F-AV-1451 recapitulate key features of Braak histopathological stages

(2016) Adam J. Schwarz et al.   BRAIN

Targeting Different Transthyretin Binding Sites with Unusual Natural Compounds

(2016) Gabriella Ortore et al.   ChemMedChem

The amyloid hypothesis of Alzheimer's disease at 25 years

(2016) Dennis J Selkoe et al.   EMBO Molecular Medicine

Cross-interactions between the Alzheimer Disease Amyloid-β Peptide and Other Amyloid Proteins: A Further Aspect of the Amyloid Cascade Hypothesis

(2016) Jinghui Luo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Synthesis and structural analysis of halogen substituted fibril formation inhibitors of Human Transthyretin (TTR)

(2016) Lidia Ciccone et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Current and future treatment of amyloid diseases

(2016) M. Ankarcrona et al.   JOURNAL OF INTERNAL MEDICINE

Designed Glycopeptidomimetics Disrupt Protein–Protein Interactions Mediating Amyloid β-Peptide Aggregation and Restore Neuroblastoma Cell Viability

(2016) Julia Kaffy et al.   JOURNAL OF MEDICINAL CHEMISTRY

Characteristics of C-terminal, β-amyloid peptide binding fragment of neuroprotective protease inhibitor, cystatin C

(2016) Marta Spodzieja et al.   JOURNAL OF MOLECULAR RECOGNITION

Human TTR conformation altered by rhenium tris-carbonyl derivatives

(2016) Lidia Ciccone et al.   JOURNAL OF STRUCTURAL BIOLOGY

Alzheimer's disease

(2016) Philip Scheltens et al.   LANCET

Resveratrol Administration Increases Transthyretin Protein Levels, Ameliorating AD Features: The Importance of Transthyretin Tetrameric Stability

(2016) Luís Miguel Santos et al.   MOLECULAR MEDICINE

Cross-talk between amyloidogenic proteins in type-2 diabetes and Parkinson’s disease

(2016) Istvan Horvath et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tau and Aβ imaging, CSF measures, and cognition in Alzheimer’s disease

(2016) Matthew R. Brier et al.   Science Translational Medicine

Transthyretin participates in beta-amyloid transport from the brain to the liver- involvement of the low-density lipoprotein receptor-related protein 1?

(2016) Mobina Alemi et al.   Scientific Reports

Tau Structures

(2016) Jesus Avila et al.   Frontiers in Aging Neuroscience

Common molecular mechanism of amyloid pore formation by Alzheimer’s β-amyloid peptide and α-synuclein

(2016) Coralie Di Scala et al.   Scientific Reports

A Cyclic Peptide Mimic of the β-Amyloid Binding Domain on Transthyretin

(2015) Patricia Y. Cho et al.   ACS Chemical Neuroscience

Beta-Amyloid and Tau-Protein: Structure, Interaction, and Prion-Like Properties

(2015) O. G. Tatarnikova et al.   BIOCHEMISTRY-MOSCOW

Opposing effects ofApoe/Apoa1double deletion on amyloid-β pathology and cognitive performance in APP mice

(2015) Nicholas F. Fitz et al.   BRAIN

The preclinical phase of the pathological process underlying sporadic Alzheimer’s disease

(2015) Heiko Braak et al.   BRAIN

Cellular factors modulating the mechanism of tau protein aggregation

(2015) Sarah N. Fontaine et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

X-ray crystal structure and activity of fluorenyl-based compounds as transthyretin fibrillogenesis inhibitors

(2015) Lidia Ciccone et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Different zinc(II) complex species and binding modes at Aβ N-terminus drive distinct long range cross-talks in the Aβ monomers

(2015) Adriana Pietropaolo et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Aβ “Stretching-and-Packing” Cross-Seeding Mechanism Can Trigger Tau Protein Aggregation

(2015) Ruxi Qi et al.   Journal of Physical Chemistry Letters

The case for rejecting the amyloid cascade hypothesis

(2015) Karl Herrup   NATURE NEUROSCIENCE

Three dimensions of the amyloid hypothesis: time, space and 'wingmen'

(2015) Erik S Musiek et al.   NATURE NEUROSCIENCE

A 3D human neural cell culture system for modeling Alzheimer's disease

(2015) Young Hye Kim et al.   Nature Protocols

Transthyretin-Derived Peptides as β-Amyloid Inhibitors

(2014) Patricia Y. Cho et al.   ACS Chemical Neuroscience

The coexistence of an equal amount of Alzheimer's amyloid-β 40 and 42 forms structurally stable and toxic oligomers through a distinct pathway

(2014) Yu-Jen Chang et al.   FEBS Journal

The hairpin conformation of the amyloid β peptide is an important structural motif along the aggregation pathway

(2014) Axel Abelein et al.   JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY

Tau pathogenesis is promoted by Aβ1-42 but not Aβ1-40

(2014) Xiaoyan Hu et al.   Molecular Neurodegeneration

Models of β-amyloid induced Tau-pathology: the long and “folded” road to understand the mechanism

(2014) Ilie-Cosmin Stancu et al.   Molecular Neurodegeneration

A three-dimensional human neural cell culture model of Alzheimer’s disease

(2014) Se Hoon Choi et al.   NATURE

HDL-targeted therapies: progress, failures and future

(2014) Bronwyn A. Kingwell et al.   NATURE REVIEWS DRUG DISCOVERY

Amyloid-clearing proteins and their epigenetic regulation as a therapeutic target in Alzheimer’s disease

(2014) Natalia N. Nalivaeva et al.   Frontiers in Aging Neuroscience

Transthyretin as both a Sensor and a Scavenger of β-Amyloid Oligomers

(2013) Dennis T. Yang et al.   BIOCHEMISTRY

Single-Molecule Imaging Reveals Aβ42:Aβ40 Ratio-Dependent Oligomer Growth on Neuronal Processes

(2013) Robin D. Johnson et al.   BIOPHYSICAL JOURNAL

Molecules That Mimic Apolipoprotein A-I: Potential Agents for Treating Atherosclerosis

(2013) Luke J. Leman et al.   JOURNAL OF MEDICINAL CHEMISTRY

Mechanisms of Transthyretin Inhibition of  -Amyloid Aggregation In Vitro

(2013) X. Li et al.   JOURNAL OF NEUROSCIENCE

Interaction of Thioflavin T with amyloid fibrils of apolipoprotein A-I N-terminal fragment: Resonance energy transfer study

(2013) Mykhailo Girych et al.   JOURNAL OF STRUCTURAL BIOLOGY

Apolipoprotein E and Alzheimer disease: risk, mechanisms and therapy

(2013) Chia-Chen Liu et al.   Nature Reviews Neurology

Transthyretin and the human placenta

(2013) K.A. Landers et al.   PLACENTA

RVX 208

(2013)   Drugs in research & development

Transthyretin is a metallopeptidase with an inducible active site

(2012) Márcia A. Liz et al.   BIOCHEMICAL JOURNAL

Effects of the Iowa and Milano Mutations on Apolipoprotein A-I Structure and Dynamics Determined by Hydrogen Exchange and Mass Spectrometry

(2012) Palaniappan Sevugan Chetty et al.   BIOCHEMISTRY

Mechanisms of Amyloid-β Peptide Clearance: Potential Therapeutic Targets for Alzheimer's Disease

(2012) Sang-Sun Yoon et al.   Biomolecules & Therapeutics

Metal ions as modulators of protein conformation and misfolding in neurodegeneration

(2012) Sónia S. Leal et al.   COORDINATION CHEMISTRY REVIEWS

TTR Fibril Formation Inhibitors: Is there a SAR?

(2012)   CURRENT MEDICINAL CHEMISTRY

Meta-Analysis of the Cystatin C(CST3) Gene G73A Polymorphism and Susceptibility to Alzheimer's Disease

(2012) Ye Hua et al.   INTERNATIONAL JOURNAL OF NEUROSCIENCE

Cathepsin B Degrades Amyloid-β in Mice Expressing Wild-type Human Amyloid Precursor Protein

(2012) Chao Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cross-seeding effects of amyloid β-protein and α-synuclein

(2012) Kenjiro Ono et al.   JOURNAL OF NEUROCHEMISTRY

Stability of the Transthyretin Molecule as a Key Factor in the Interaction with A-Beta Peptide - Relevance in Alzheimer's Disease

(2012) Carlos A. Ribeiro et al.   PLoS One

Identification of beta-amyloid-binding sites on transthyretin

(2012) J. Du et al.   PROTEIN ENGINEERING DESIGN & SELECTION

Structural insights into a zinc-dependent pathway leading to Leu55Pro transthyretin amyloid fibrils

(2011) Artur F. Castro-Rodrigues et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Recombinant HDLMilano exerts greater anti-inflammatory and plaque stabilizing properties than HDLwild-type

(2011) Borja Ibanez et al.   ATHEROSCLEROSIS

Synergistic Interactions between Repeats in Tau Protein and Aβ Amyloids May Be Responsible for Accelerated Aggregation via Polymorphic States

(2011) Yifat Miller et al.   BIOCHEMISTRY

The Crystal Structure of the C-Terminal Truncated Apolipoprotein A-I Sheds New Light on Amyloid Formation by the N-Terminal Fragment

(2011) Olga Gursky et al.   BIOCHEMISTRY

Crystal Structure of C-terminal Truncated Apolipoprotein A-I Reveals the Assembly of High Density Lipoprotein (HDL) by Dimerization

(2011) Xiaohu Mei et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Distinct Effects of Zn2+, Cu2+, Fe3+, and Al3+on Amyloid-β Stability, Oligomerization, and Aggregation

(2011) Wei-Ting Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Transthyretin and the brain re-visited: Is neuronal synthesis of transthyretin protective in Alzheimer's disease?

(2011) Xinyi Li et al.   Molecular Neurodegeneration

Resolving controversies on the path to Alzheimer's therapeutics

(2011) Dennis J Selkoe   NATURE MEDICINE

Human apoE Isoforms Differentially Regulate Brain Amyloid-  Peptide Clearance

(2011) J. M. Castellano et al.   Science Translational Medicine

Astrocytes are important mediators of Aβ-induced neurotoxicity and tau phosphorylation in primary culture

(2011) C J Garwood et al.   Cell Death & Disease

Co-localization of β/A4 and cystatin C in cortical blood vessels in Dutch, but not in Icelandic hereditary cerebral hemorrhage with amyloidosis

(2010) J. Haan et al.   ACTA NEUROLOGICA SCANDINAVICA

Characterization of the Interaction of β-Amyloid with Transthyretin Monomers and Tetramers

(2010) Jiali Du et al.   BIOCHEMISTRY

Crystal structure of human cystatin C stabilized against amyloid formation

(2010) Robert Kolodziejczyk et al.   FEBS Journal

Apolipoprotein A-I Deficiency Increases Cerebral Amyloid Angiopathy and Cognitive Deficits in APP/PS1ΔE9 Mice

(2010) Iliya Lefterov et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Overexpression of Human Apolipoprotein A-I Preserves Cognitive Function and Attenuates Neuroinflammation and Cerebral Amyloid Angiopathy in a Mouse Model of Alzheimer Disease

(2010) Terry L. Lewis et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Progesterone Enhances Transthyretin Expression in the Rat Choroid Plexus In Vitro and In Vivo via Progesterone Receptor

(2010) Telma Quintela et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

A  Oligomers Cause Localized Ca2+ Elevation, Missorting of Endogenous Tau into Dendrites, Tau Phosphorylation, and Destruction of Microtubules and Spines

(2010) H. Zempel et al.   JOURNAL OF NEUROSCIENCE

Synergistic Interactions between A , Tau, and  -Synuclein: Acceleration of Neuropathology and Cognitive Decline

(2010) L. K. Clinton et al.   JOURNAL OF NEUROSCIENCE

Hinge-loop mutation can be used to control 3D domain swapping and amyloidogenesis of human cystatin C

(2010) Marta Orlikowska et al.   JOURNAL OF STRUCTURAL BIOLOGY

RVX-208

(2010) Dana Bailey et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Amyloid-β and tau — a toxic pas de deux in Alzheimer's disease

(2010) Lars M. Ittner et al.   NATURE REVIEWS NEUROSCIENCE

17β-Estradiol Induces Transthyretin Expression in Murine Choroid Plexus via an Oestrogen Receptor Dependent Pathway

(2009) T. Quintela et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Electrochemical and Conformational Consequences of Copper (CuIand CuII) Binding to β-Amyloid(1-40)

(2009) Maria Brzyska  et al.   CHEMBIOCHEM

GSK3: A possible link between beta amyloid peptide and tau protein

(2009) Félix Hernández et al.   EXPERIMENTAL NEUROLOGY

Binding Epitopes and Interaction Structure of the Neuroprotective Protease Inhibitor Cystatin C with β-Amyloid Revealed by Proteolytic Excision Mass Spectrometry and Molecular Docking Simulation

(2009) Paulina Juszczyk et al.   JOURNAL OF MEDICINAL CHEMISTRY

Hereditary Apolipoprotein AI-Associated Amyloidosis in Surgical Pathology Specimens

(2009) Magdalena Eriksson et al.   JOURNAL OF MOLECULAR DIAGNOSTICS

Amyloid β Protein: Aβ40 Inhibits Aβ42 Oligomerization

(2009) Megan M. Murray et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The Role of Apolipoprotein E in Alzheimer's Disease

(2009) Jungsu Kim et al.   NEURON

Novel Transthyretin Amyloid Fibril Formation Inhibitors: Synthesis, Biological Evaluation, and X-Ray Structural Analysis

(2009) Satheesh K. Palaninathan et al.   PLoS One

 -Helix targeting reduces amyloid-  peptide toxicity

(2009) C. Nerelius et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Amyloid Activates GSK-3β to Aggravate Neuronal Tauopathy in Bigenic Mice

(2008) Dick Terwel et al.   AMERICAN JOURNAL OF PATHOLOGY

Domain Conformation of Tau Protein Studied by Solution Small-Angle X-ray Scattering†

(2008) Efstratios Mylonas et al.   BIOCHEMISTRY

5α-dihydrotestosterone up-regulates transthyretin levels in mice and rat choroid plexus via an androgen receptor independent pathway

(2008) T. Quintela et al.   BRAIN RESEARCH

Lack of an Association between Alzheimer’s Disease and the Cystatin C (CST3) Gene G73A Polymorphism in Mainland Chinese

(2008) Binbin Wang et al.   DEMENTIA AND GERIATRIC COGNITIVE DISORDERS

Proteomic identification of novel proteins associated with Lewy bodies

(2008) Qiangwei Xia   Frontiers in Bioscience-Landmark

Human apolipoprotein A–I binds amyloid-β and prevents Aβ-induced neurotoxicity

(2008) Andréa C. Paula-Lima et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

apoE isoform–specific disruption of amyloid β peptide clearance from mouse brain

(2008) Rashid Deane et al.   JOURNAL OF CLINICAL INVESTIGATION

Safety, pharmacokinetics, and pharmacodynamics of oral apoA-I mimetic peptide D-4F in high-risk cardiovascular patients

(2008) LeAnne T. Bloedon et al.   JOURNAL OF LIPID RESEARCH

Cystatin C-Cathepsin B Axis Regulates Amyloid Beta Levels and Associated Neuronal Deficits in an Animal Model of Alzheimer's Disease

(2008) Binggui Sun et al.   NEURON

Transthyretin protects Alzheimer's mice from the behavioral and biochemical effects of A  toxicity

(2008) J. N. Buxbaum et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Alzheimer's disease-type neuronal tau hyperphosphorylation induced by Aβ oligomers

(2007) Fernanda G. De Felice et al.   NEUROBIOLOGY OF AGING