Mechanisms of Amyloid-β Peptide Clearance: Potential Therapeutic Targets for Alzheimer's Disease

False Recognition Correlates with Amyloid-β1–42 but not with Total Tau in Cerebrospinal Fluid of Patients with Dementia and Mild Cognitive Impairment

(2017) Helmut Hildebrandt et al.   JOURNAL OF ALZHEIMERS DISEASE

Effects of 4-Hydroxy-Nonenal and Amyloid-β on Expression and Activity of Endothelin Converting Enzyme and Insulin Degrading Enzyme in SH-SY5Y Cells

(2017) Rui Wang et al.   JOURNAL OF ALZHEIMERS DISEASE

Testing the Neurovascular Hypothesis of Alzheimer's Disease: LRP-1 Antisense Reduces Blood-brain Barrier Clearance, Increases Brain Levels of Amyloid-β Protein, and Impairs Cognition

(2017) Laura B. Jaeger et al.   JOURNAL OF ALZHEIMERS DISEASE

Peroxisome Proliferator-Activated Receptor Gamma Enhances the Activity of an Insulin Degrading Enzyme-Like Metalloprotease for Amyloid-β

(2017) Ira Espuny-Camacho et al.   JOURNAL OF ALZHEIMERS DISEASE

The Role of Microglial Cell Subsets in Alzheimers Disease

(2012) G. Naert et al.   Current Alzheimer Research

Cellular Prion Protein Participates in Amyloid-β Transcytosis across the Blood—Brain Barrier

(2012) Thorsten Pflanzner et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Withania somnifera reverses Alzheimer's disease pathology by enhancing low-density lipoprotein receptor-related protein in liver

(2012) N. Sehgal et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neprilysin-2 Is an Important β-Amyloid Degrading Enzyme

(2011) Daniel Hafez et al.   AMERICAN JOURNAL OF PATHOLOGY

Cerebral amyloid angiopathy in the elderly

(2011) Anand Viswanathan et al.   ANNALS OF NEUROLOGY

Notch signaling proteins HES-1 and Hey-1 bind to insulin degrading enzyme (IDE) proximal promoter and repress its transcription and activity: Implications for cellular Aβ metabolism

(2011) María C. Leal et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Soluble intracellular adhesion molecule-1 secreted by human umbilical cord blood-derived mesenchymal stem cell reduces amyloid-β plaques

(2011) J-Y Kim et al.   CELL DEATH AND DIFFERENTIATION

Perindopril, a centrally active angiotensin-converting enzyme inhibitor, prevents cognitive impairment in mouse models of Alzheimer's disease

(2011) Yi-Fei Dong et al.   FASEB JOURNAL

Are amyloid-degrading enzymes viable therapeutic targets in Alzheimer’s disease?

(2011) Natalia N. Nalivaeva et al.   JOURNAL OF NEUROCHEMISTRY

Compounding artefacts with uncertainty, and an amyloid cascade hypothesis that is ‘too big to fail’

(2011) Rudy J Castellani et al.   JOURNAL OF PATHOLOGY

Mechanisms of Enzymatic Degradation of Amyloid β Microfibrils Generating Nanofilaments and Nanospheres Related to Cytotoxicity

(2010) Keiji Numata et al.   BIOCHEMISTRY

Changes with Age in the Activities of β-Secretase and the Aβ-Degrading Enzymes Neprilysin, Insulin-Degrading Enzyme and Angiotensin-Converting Enzyme

(2010) J. Scott Miners et al.   BRAIN PATHOLOGY

Glutamate carboxypeptidase II: an amyloid peptide-degrading enzyme with physiological function in the brain

(2010) Min-Ju Kim et al.   FASEB JOURNAL

Circulating neprilysin clears brain amyloid

(2010) Yinxing Liu et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Structural conversion of neurotoxic amyloid-β1–42 oligomers to fibrils

(2010) Mahiuddin Ahmed et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Endothelin-Converting Enzyme-2 Is Increased in Alzheimer’s Disease and Up-Regulated by Aβ

(2009) Jennifer C. Palmer et al.   AMERICAN JOURNAL OF PATHOLOGY

In vivo metabolism study of ginsenoside Re in rat using high-performance liquid chromatography coupled with tandem mass spectrometry

(2009) Liu Yang et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Survival, neuron-like differentiation and functionality of mesenchymal stem cells in neurotoxic environment: the critical role of erythropoietin

(2009) L Danielyan et al.   CELL DEATH AND DIFFERENTIATION

Clearance of Amyloid-β Peptide Across the Blood-Brain Barrier: Implication for Therapies in Alzheimers Disease

(2009) R. Deane et al.   CNS & Neurological Disorders-Drug Targets

A PPARdelta Agonist Reduces Amyloid Burden and Brain Inflammation in a Transgenic Mouse Model of Alzheimers Disease

(2009) Sergey Kalinin et al.   Current Alzheimer Research

Estrogen Stimulates Degradation of β-Amyloid Peptide by Up-regulating Neprilysin

(2009) Kaiwei Liang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Estrogen Regulation of the Neprilysin Gene Through A Hormone-Responsive Element

(2009) Zhi-Min Xiao et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

The N-terminal tripeptide of insulin-like growth factor-I protects against β-amyloid-induced somatostatin depletion by calcium and glycogen synthase kinase 3β modulation

(2009) Emma Burgos-Ramos et al.   JOURNAL OF NEUROCHEMISTRY

Plasminogen activator activity is inhibited while neuroserpin is up-regulated in the Alzheimer disease brain

(2009) Shay Fabbro et al.   JOURNAL OF NEUROCHEMISTRY

Neprilysin and Insulin-Degrading Enzyme Levels Are Increased in Alzheimer Disease in Relation to Disease Severity

(2009) James Scott Miners et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Increased Matrix Metalloproteinase 9 Activity in Mild Cognitive Impairment

(2009) Martin A. Bruno et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Neprilysin Overexpression Inhibits Plaque Formation But Fails to Reduce Pathogenic A  Oligomers and Associated Cognitive Deficits in Human Amyloid Precursor Protein Transgenic Mice

(2009) W. J. Meilandt et al.   JOURNAL OF NEUROSCIENCE

Cellular prion protein mediates impairment of synaptic plasticity by amyloid-β oligomers

(2009) Juha Laurén et al.   NATURE

Neprilysin: An Enzyme Candidate to Slow the Progression of Alzheimer's Disease

(2008) Salim S. El-Amouri et al.   AMERICAN JOURNAL OF PATHOLOGY

Long-term neprilysin gene transfer is associated with reduced levels of intracellular Abeta and behavioral improvement in APP transgenic mice

(2008) Brian Spencer et al.   BMC NEUROSCIENCE

Association of BACE1 Gene Polymorphism with Alzheimer’s Disease in Asian Populations: Meta-Analysis Including Korean Samples

(2008) Sangmee A. Jo et al.   DEMENTIA AND GERIATRIC COGNITIVE DISORDERS

Neprilysin gene expression requires binding of the amyloid precursor protein intracellular domain to its promoter: implications for Alzheimer disease

(2008) Nikolai D Belyaev et al.   EMBO REPORTS

Binding and uptake of Aβ1-42 by primary human astrocytesin vitro

(2008) Henrietta M. Nielsen et al.   GLIA

Yin Yang 1 Is a Critical Repressor of Matrix Metalloproteinase-9 Expression in Brain Neurons

(2008) Marcin Rylski et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Effects of HNE-modification induced by Aβ on neprilysin expression and activity in SH-SY5Y cells

(2008) Rui Wang et al.   JOURNAL OF NEUROCHEMISTRY

Minocycline prevents Aβ(25–35)-induced reduction of somatostatin and neprilysin content in rat temporal cortex

(2008) E. Burgos-Ramos et al.   LIFE SCIENCES

JunB is a repressor of MMP-9 transcription in depolarized rat brain neurons

(2008) Marcin Rylski et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Solutes, but not cells, drain from the brain parenchyma along basement membranes of capillaries and arteries: significance for cerebral amyloid angiopathy and neuroimmunology

(2008) R. O. Carare et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Enhanced clearance of A  in brain by sustaining the plasmin proteolysis cascade

(2008) J. S. Jacobsen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Immunocapture-based fluorometric assay for the measurement of neprilysin-specific enzyme activity in brain tissue homogenates and cerebrospinal fluid

(2007) James Scott Miners et al.   JOURNAL OF NEUROSCIENCE METHODS

Immunocapture-based fluorometric assay for the measurement of insulin-degrading enzyme activity in brain tissue homogenates

(2007) James Scott Miners et al.   JOURNAL OF NEUROSCIENCE METHODS

MMP-2, -3 and -9 levels and activity are not related to Aβ load in the frontal cortex in Alzheimer's disease

(2007) S. Baig et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Angiotensin-converting enzyme (ACE) levels and activity in Alzheimer's disease, and relationship of perivascular ACE-1 to cerebral amyloid angiopathy

(2007) J. S. Miners et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Age-dependent decline of neprilysin in Alzheimer's disease and normal brain: Inverse correlation with Aβ levels

(2006) E. Hellström-Lindahl et al.   NEUROBIOLOGY OF AGING