Cellular factors modulating the mechanism of tau protein aggregation

Nuclear Magnetic Resonance Analysis of the Acetylation Pattern of the Neuronal Tau Protein

(2014) Amina Kamah et al.   BIOCHEMISTRY

Hsp90-Tau Complex Reveals Molecular Basis for Specificity in Chaperone Action

(2014) G. Elif Karagöz et al.   CELL

Structural Insight into Tau Protein’s Paradox of Intrinsically Disordered Behavior, Self-Acetylation Activity, and Aggregation

(2014) Yin Luo et al.   Journal of Physical Chemistry Letters

Cleavage of tau by asparagine endopeptidase mediates the neurofibrillary pathology in Alzheimer's disease

(2014) Zhentao Zhang et al.   NATURE MEDICINE

In vitro Methylation Assay to Study Protein Arginine Methylation

(2014) Rama Kamesh Bikkavilli et al.   Jove-Journal of Visualized Experiments

Synthesis and Initial Evaluation of YM-08, a Blood-Brain Barrier Permeable Derivative of the Heat Shock Protein 70 (Hsp70) Inhibitor MKT-077, Which Reduces Tau Levels

(2013) Yoshinari Miyata et al.   ACS Chemical Neuroscience

Mechanistic Basis of Phenothiazine-Driven Inhibition of Tau Aggregation

(2013) Elias Akoury et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Mechanistic Studies Unravel the Complexity Inherent in Tau Aggregation Leading to Alzheimer’s Disease and the Tauopathies

(2013) Gayathri Ramachandran et al.   BIOCHEMISTRY

Allosteric Heat Shock Protein 70 Inhibitors Rapidly Rescue Synaptic Plasticity Deficits by Reducing Aberrant Tau

(2013) Jose Abisambra et al.   BIOLOGICAL PSYCHIATRY

Acetylation of the KXGS motifs in tau is a critical determinant in modulation of tau aggregation and clearance

(2013) Casey Cook et al.   HUMAN MOLECULAR GENETICS

Molecular mechanisms of Tau binding to microtubules and its role in microtubule dynamics in live cells

(2013) G. Breuzard et al.   JOURNAL OF CELL SCIENCE

Accelerated neurodegeneration through chaperone-mediated oligomerization of tau

(2013) Laura J. Blair et al.   JOURNAL OF CLINICAL INVESTIGATION

The microtubule-associated tau protein has intrinsic acetyltransferase activity

(2013) Todd J Cohen et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Variation in tau isoform expression in different brain regions and disease states

(2013) Elisa Majounie et al.   NEUROBIOLOGY OF AGING

A Novel MAPT Mutation, G55R, in a Frontotemporal Dementia Patient Leads to Altered Tau Function

(2013) Abhinaya Iyer et al.   PLoS One

HDAC6 mutations rescue human tau-induced microtubule defects in Drosophila

(2013) Y. Xiong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tau protein kinases: Involvement in Alzheimer's disease

(2012) Ludovic Martin et al.   AGEING RESEARCH REVIEWS

Hsp70 Alters Tau Function and Aggregation in an Isoform Specific Manner

(2012) Kellen Voss et al.   BIOCHEMISTRY

The Conformational Ensembles of α-Synuclein and Tau: Combining Single-Molecule FRET and Simulations

(2012) Abhinav Nath et al.   BIOPHYSICAL JOURNAL

Four-repeat tau-selective deposition in subthalamic nucleus and motor cortex in Alzheimer disease

(2012) Takahiro Takeda et al.   CLINICAL NEUROLOGY AND NEUROSURGERY

Loss of HDAC6, a novel CHIP substrate, alleviates abnormal tau accumulation

(2012) Casey Cook et al.   HUMAN MOLECULAR GENETICS

Cross-seeding and Conformational Selection between Three- and Four-repeat Human Tau Proteins

(2012) Xiang Yu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

β-Sheet Core of Tau Paired Helical Filaments Revealed by Solid-State NMR

(2012) Venita Daebel et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Identification of an Aggregation-Prone Structure of Tau

(2012) Shana Elbaum-Garfinkle et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

“Clicked” Sugar–Curcumin Conjugate: Modulator of Amyloid-β and Tau Peptide Aggregation at Ultralow Concentrations

(2011) Sukanta Dolai et al.   ACS Chemical Neuroscience

Heat Shock Protein 70 Prevents both Tau Aggregation and the Inhibitory Effects of Preexisting Tau Aggregates on Fast Axonal Transport

(2011) Kristina R. Patterson et al.   BIOCHEMISTRY

The Hsp90 Kinase Co-chaperone Cdc37 Regulates Tau Stability and Phosphorylation Dynamics

(2011) Umesh K. Jinwal et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Characterization of Prefibrillar Tau Oligomersin Vitroand in Alzheimer Disease

(2011) Kristina R. Patterson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Neuropathology of Frontotemporal Lobar Degeneration-Tau (FTLD-Tau)

(2011) Dennis W. Dickson et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Interplay between glycogen synthase kinase-3β and tau in the cerebellum of Hsp27 transgenic mouse

(2011) Shan Wang et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Transglutaminase 1 and its regulator tazarotene-induced gene 3 localize to neuronal tau inclusions in tauopathies

(2011) Micha MM Wilhelmus et al.   JOURNAL OF PATHOLOGY

Age-dependent axonal transport and locomotor changes and tau hypophosphorylation in a “P301L” tau knockin mouse

(2011) Jonathan Gilley et al.   NEUROBIOLOGY OF AGING

Dynamic association of tau with neuronal membranes is regulated by phosphorylation

(2011) Amy M. Pooler et al.   NEUROBIOLOGY OF AGING

The acetylation of tau inhibits its function and promotes pathological tau aggregation

(2011) Todd J. Cohen et al.   Nature Communications

Neuropathology of variants of progressive supranuclear palsy

(2010) Dennis W Dickson et al.   CURRENT OPINION IN NEUROLOGY

Hsc70 Rapidly Engages Tau after Microtubule Destabilization

(2010) Umesh K. Jinwal et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nuclear Tau, a Key Player in Neuronal DNA Protection

(2010) Audrey Sultan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Phosphorylation Dynamics Regulate Hsp27-Mediated Rescue of Neuronal Plasticity Deficits in Tau Transgenic Mice

(2010) J. F. Abisambra et al.   JOURNAL OF NEUROSCIENCE

The Hsp90 Cochaperone, FKBP51, Increases Tau Stability and Polymerizes Microtubules

(2010) U. K. Jinwal et al.   JOURNAL OF NEUROSCIENCE

Cleavage of Tau by calpain in Alzheimer's disease: the quest for the toxic 17 kD fragment

(2010) Sarika Garg et al.   NEUROBIOLOGY OF AGING

Acetylation of Tau Inhibits Its Degradation and Contributes to Tauopathy

(2010) Sang-Won Min et al.   NEURON

A role for FKBP52 in Tau protein function

(2010) B. Chambraud et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Three-/four-repeat-dependent aggregation profile of tau microtubule-binding domain clarified by dynamic light scattering analysis

(2009) Etsuko Sugino et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Human Microtubule-Associated-Protein Tau Regulates the Number of Protofilaments in Microtubules: A Synchrotron X-Ray Scattering Study

(2009) M.C. Choi et al.   BIOPHYSICAL JOURNAL

Reduced O-GlcNAcylation links lower brain glucose metabolism and tau pathology in Alzheimer's disease

(2009) F. Liu et al.   BRAIN

Genetic testing in familial AD and FTD: Mutation and phenotype spectrum in a Danish cohort

(2009) SG Lindquist et al.   CLINICAL GENETICS

Familial FTDP-17 Missense Mutations Inhibit Microtubule Assembly-promoting Activity of Tau by Increasing Phosphorylation at Ser202in Vitro

(2009) Dong Han et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

BAG-1M is up-regulated in hippocampus of Alzheimer’s disease patients and associates with tau and APP proteins

(2009) Evan Elliott et al.   JOURNAL OF NEUROCHEMISTRY

Proteasome-caspase-cathepsin sequence leading to tau pathology induced by prostaglandin J2 in neuronal cells

(2009) Lisette T. Arnaud et al.   JOURNAL OF NEUROCHEMISTRY

Accumulation of Aspartic Acid421- and Glutamic Acid391-Cleaved Tau in Neurofibrillary Tangles Correlates With Progression in Alzheimer Disease

(2009) Gustavo Basurto-Islas et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

The Cochaperone BAG2 Sweeps Paired Helical Filament- Insoluble Tau from the Microtubule

(2009) D. C. Carrettiero et al.   JOURNAL OF NEUROSCIENCE

Pin1 affects Tau phosphorylation in response to Aβ oligomers

(2009) Alessandra Bulbarelli et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Search for Higgs Bosons Predicted in Two-Higgs-Doublet Models via Decays to Tau Lepton Pairs in 1.96 TeVpp¯Collisions

(2009) T. Aaltonen et al.   PHYSICAL REVIEW LETTERS

Structural Polymorphism of 441-Residue Tau at Single Residue Resolution

(2009) Marco D Mukrasch et al.   PLOS BIOLOGY

O -GlcNAcylation modulates the self-aggregation ability of the fourth microtubule-binding repeat of tau

(2008) Chun-Hui Yu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The Natively Unfolded Character of Tau and Its Aggregation to Alzheimer-like Paired Helical Filaments†

(2008) Sadasivam Jeganathan et al.   BIOCHEMISTRY

Domain Conformation of Tau Protein Studied by Solution Small-Angle X-ray Scattering†

(2008) Efstratios Mylonas et al.   BIOCHEMISTRY

Mutations in Progranulin Gene: Clinical, Pathological, and Ribonucleic Acid Expression Findings

(2008) Adolfo López de Munain et al.   BIOLOGICAL PSYCHIATRY

Mutational Analysis in Early-Onset Familial Dementia in the Japanese Population

(2008) Takeshi Ikeuchi et al.   DEMENTIA AND GERIATRIC COGNITIVE DISORDERS

Biochemistry of Tau in Alzheimer’s disease and related neurological disorders

(2008) Nicolas Sergeant et al.   Expert Review of Proteomics

Histone deacetylase 6 interacts with the microtubule-associated protein tau

(2008) Huiping Ding et al.   JOURNAL OF NEUROCHEMISTRY

Clinicopathological and genetic correlates of frontotemporal lobar degeneration and corticobasal degeneration

(2008) Albert Lladó et al.   JOURNAL OF NEUROLOGY

Two motifs within the tau microtubule-binding domain mediate its association with the hsc70 molecular chaperone

(2008) Mitul Sarkar et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Co-occurrence of Alzheimer's disease β-amyloid and tau pathologies at synapses

(2008) Reisuke H. Takahashi et al.   NEUROBIOLOGY OF AGING

High-fat diet aggravates amyloid-beta and tau pathologies in the 3xTg-AD mouse model

(2008) Carl Julien et al.   NEUROBIOLOGY OF AGING

A possible link between astrocyte activation and tau nitration in Alzheimer's disease

(2008) Juan F. Reyes et al.   NEUROBIOLOGY OF DISEASE

FTDP-17 missense mutations site-specifically inhibit as well as promote dephosphorylation of microtubule-associated protein tau by protein phosphatases of HEK-293 cell extract

(2008) Dong Han et al.   NEUROCHEMISTRY INTERNATIONAL

SUMO-1 immunoreactivity co-localizes with phospho-Tau in APP transgenic mice but not in mutant Tau transgenic mice

(2008) Kaoru Takahashi et al.   NEUROSCIENCE LETTERS

Differential Regulation of Dynein and Kinesin Motor Proteins by Tau

(2008) R. Dixit et al.   SCIENCE

Small heat shock proteins Hsp27 or αB-crystallin and the protein components of neurofibrillary tangles: Tau and neurofilaments

(2007) Cecilia Björkdahl et al.   JOURNAL OF NEUROSCIENCE RESEARCH