Transthyretin Mimetics as Anti-β-Amyloid Agents: A Comparison of Peptide and Protein Approaches

An isogenic blood-brain barrier model comprising brain endothelial cells, astrocytes, and neurons derived from human induced pluripotent stem cells

(2017) Scott G. Canfield et al.   JOURNAL OF NEUROCHEMISTRY

Rationally Designed Peptides and Peptidomimetics as Inhibitors of Amyloid-β (Aβ) Aggregation: Potential Therapeutics of Alzheimer’s Disease

(2017) Deepti Goyal et al.   ACS Combinatorial Science

TANGO-Inspired Design of Anti-Amyloid Cyclic Peptides

(2016) Xiaomeng Lu et al.   ACS Chemical Neuroscience

Natural Tripeptide-Based Inhibitor of Multifaceted Amyloid β Toxicity

(2016) K. Rajasekhar et al.   ACS Chemical Neuroscience

Amyloid cascade in Alzheimer's disease: Recent advances in medicinal chemistry

(2016) Tarek Mohamed et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Peptides Composed of Alternating L- and D-Amino Acids Inhibit Amyloidogenesis in Three Distinct Amyloid Systems Independent of Sequence

(2016) Jackson Kellock et al.   JOURNAL OF MOLECULAR BIOLOGY

The antibody aducanumab reduces Aβ plaques in Alzheimer’s disease

(2016) Jeff Sevigny et al.   NATURE

Bapineuzumab for mild to moderate Alzheimer’s disease in two global, randomized, phase 3 trials

(2016) Rik Vandenberghe et al.   Alzheimers Research & Therapy

A Cyclic Peptide Mimic of the β-Amyloid Binding Domain on Transthyretin

(2015) Patricia Y. Cho et al.   ACS Chemical Neuroscience

β-Sheet interfering molecules acting against β-amyloid aggregation and fibrillogenesis

(2015) Antonio Francioso et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Function and toxicity of amyloid beta and recent therapeutic interventions targeting amyloid beta in Alzheimer's disease

(2015) K. Rajasekhar et al.   CHEMICAL COMMUNICATIONS

Perspectives on Inhibiting β-Amyloid Aggregation through Structure-Based Drug Design

(2015) Pankaj Mishra et al.   ChemMedChem

Transthyretin-Derived Peptides as β-Amyloid Inhibitors

(2014) Patricia Y. Cho et al.   ACS Chemical Neuroscience

Therapeutic approaches against common structural features of toxic oligomers shared by multiple amyloidogenic proteins

(2014) Marcos J. Guerrero-Muñoz et al.   BIOCHEMICAL PHARMACOLOGY

Amyloid-directed monoclonal antibodies for the treatment of Alzheimer’s disease: the point of no return?

(2014) Francesco Panza et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

Phase 3 Trials of Solanezumab for Mild-to-Moderate Alzheimer's Disease

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Human Cerebrospinal Fluid Fatty Acid Levels Differ between Supernatant Fluid and Brain-Derived Nanoparticle Fractions, and Are Altered in Alzheimer's Disease

(2014) Alfred N. Fonteh et al.   PLoS One

Immunotherapy for Alzheimer’s disease: past, present and future

(2014) Brian Spencer et al.   Frontiers in Aging Neuroscience

Transthyretin as both a Sensor and a Scavenger of β-Amyloid Oligomers

(2013) Dennis T. Yang et al.   BIOCHEMISTRY

Mechanisms of Transthyretin Inhibition of  -Amyloid Aggregation In Vitro

(2013) X. Li et al.   JOURNAL OF NEUROSCIENCE

Modulators of amyloid protein aggregation and toxicity: EGCG and CLR01

(2013) Aida Attar et al.   Translational Neuroscience

The Future of Peptide-based Drugs

(2012) David J. Craik et al.   Chemical Biology & Drug Design

Conformational Differences between Two Amyloid β Oligomers of Similar Size and Dissimilar Toxicity

(2012) Ali Reza A. Ladiwala et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Neurotoxicity and Memory Deficits Induced by Soluble Low-Molecular-Weight Amyloid- 1-42 Oligomers Are Revealed In Vivo by Using a Novel Animal Model

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Identification of beta-amyloid-binding sites on transthyretin

(2012) J. Du et al.   PROTEIN ENGINEERING DESIGN & SELECTION

Small molecule inhibitors of amyloid β peptide aggregation as a potential therapeutic strategy for Alzheimer's disease

(2011) Qin Nie et al.   ACTA PHARMACOLOGICA SINICA

New pharmacological strategies for treatment of Alzheimer's disease: focus on disease modifying drugs

(2011) Salvatore Salomone et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Neuronal Production of Transthyretin in Human and Murine Alzheimer's Disease: Is It Protective?

(2011) X. Li et al.   JOURNAL OF NEUROSCIENCE

Islet Amyloid Polypeptide, Islet Amyloid, and Diabetes Mellitus

(2011) Per Westermark et al.   PHYSIOLOGICAL REVIEWS

Identification of Hot Regions of the Aβ-IAPP Interaction Interface as High-Affinity Binding Sites in both Cross- and Self-Association

(2010) Erika Andreetto et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Characterization of the Interaction of β-Amyloid with Transthyretin Monomers and Tetramers

(2010) Jiali Du et al.   BIOCHEMISTRY

Molecular mechanism of Thioflavin-T binding to amyloid fibrils

(2010) Matthew Biancalana et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

On the Mechanism of Nonspecific Inhibitors of Protein Aggregation: Dissecting the Interactions of α-Synuclein with Congo Red and Lacmoid

(2009) Christofer Lendel et al.   BIOCHEMISTRY

Peptide and Protein Mimetics Inhibiting Amyloid β-Peptide Aggregation

(2008) Tsuyoshi Takahashi et al.   ACCOUNTS OF CHEMICAL RESEARCH

Characterization of α-Synuclein Interactions with Selected Aggregation-Inhibiting Small Molecules†

(2008) Jampani Nageswara Rao et al.   BIOCHEMISTRY

Transthyretin binding to A-Beta peptide - Impact on A-Beta fibrillogenesis and toxicity

(2008) R. Costa et al.   FEBS LETTERS

EGCG redirects amyloidogenic polypeptides into unstructured, off-pathway oligomers

(2008) Dagmar E Ehrnhoefer et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Transthyretin protects Alzheimer's mice from the behavioral and biochemical effects of A  toxicity

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