Amyloid-β-independent regulators of tau pathology in Alzheimer disease

Longitudinal tau accumulation and atrophy in aging and alzheimer disease

(2019) Theresa M. Harrison et al.   ANNALS OF NEUROLOGY

Genome-wide meta-analysis identifies new loci and functional pathways influencing Alzheimer’s disease risk

(2019) Iris E. Jansen et al.   NATURE GENETICS

A critical appraisal of amyloid-β-targeting therapies for Alzheimer disease

(2019) Francesco Panza et al.   Nature Reviews Neurology

Associations between tau, Aβ, and cortical thickness with cognition in Alzheimer disease

(2019) Rik Ossenkoppele et al.   NEUROLOGY

REST and Neural Gene Network Dysregulation in iPSC Models of Alzheimer’s Disease

(2019) Katharina Meyer et al.   Cell Reports

Adeno-associated virus vector as a platform for gene therapy delivery

(2019) Dan Wang et al.   NATURE REVIEWS DRUG DISCOVERY

Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing

(2019) Brian W. Kunkle et al.   NATURE GENETICS

Reduction of the expression of the late-onset Alzheimer's disease (AD) risk-factor BIN1 does not affect amyloid pathology in an AD mouse model

(2019) Robert J. Andrew et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tau PET in autosomal dominant Alzheimer’s disease: relationship with cognition, dementia and other biomarkers

(2019) Brian A Gordon et al.   BRAIN

A nonsynonymous mutation in PLCG2 reduces the risk of Alzheimer’s disease, dementia with Lewy bodies and frontotemporal dementia, and increases the likelihood of longevity

(2019) Sven J. van der Lee et al.   ACTA NEUROPATHOLOGICA

A multicentre longitudinal study of flortaucipir (18F) in normal ageing, mild cognitive impairment and Alzheimer’s disease dementia

(2019) Michael J Pontecorvo et al.   BRAIN

Progressive tau accumulation in Alzheimer’s disease: two-year follow-up study

(2019) Hanna Cho et al.   JOURNAL OF NUCLEAR MEDICINE

Preliminary Results of a Trial of Atabecestat in Preclinical Alzheimer’s Disease

(2019) David Henley et al.   NEW ENGLAND JOURNAL OF MEDICINE

Randomized Trial of Verubecestat for Prodromal Alzheimer’s Disease

(2019) Michael F. Egan et al.   NEW ENGLAND JOURNAL OF MEDICINE

The BIN1 rs744373 SNP is associated with increased tau-PET levels and impaired memory

(2019) Nicolai Franzmeier et al.   Nature Communications

A Single-Cell Model for Synaptic Transmission and Plasticity in Human iPSC-Derived Neurons

(2019) Marieke Meijer et al.   Cell Reports

Persistent neuropathological effects 14 years following amyloid-β immunization in Alzheimer’s disease

(2019) James A R Nicoll et al.   BRAIN

The bivariate distribution of amyloid-β and tau: relationship with established neurocognitive clinical syndromes

(2019) Clifford R Jack et al.   BRAIN

A Large Panel of Isogenic APP and PSEN1 Mutant Human iPSC Neurons Reveals Shared Endosomal Abnormalities Mediated by APP β-CTFs, Not Aβ

(2019) Dylan Kwart et al.   NEURON

Prevalence of the apolipoprotein E ε4 allele in amyloid β positive subjects across the spectrum of Alzheimer's disease

(2018) Niklas Mattsson et al.   Alzheimers & Dementia

ApoE isoforms and carboxyl-terminal-truncated apoE4 forms affect neuronal BACE1 levels and Aβ production independently of their cholesterol efflux capacity

(2018) Ioannis Dafnis et al.   BIOCHEMICAL JOURNAL

Longitudinal tau PET in ageing and Alzheimer’s disease

(2018) Clifford R Jack et al.   BRAIN

Tau reduction in the presence of amyloid-β prevents tau pathology and neuronal death in vivo

(2018) Sarah L DeVos et al.   BRAIN

Diffuse Amyloid-β Plaques, Neurofibrillary Tangles, and the Impact of APOE in Elderly Persons’ Brains Lacking Neuritic Amyloid Plaques

(2018) Erin L. Abner et al.   JOURNAL OF ALZHEIMERS DISEASE

Full-length amyloid precursor protein regulates lipoprotein metabolism and amyloid-β clearance in human astrocytes

(2018) Lauren K. Fong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Gain of toxic apolipoprotein E4 effects in human iPSC-derived neurons is ameliorated by a small-molecule structure corrector

(2018) Chengzhong Wang et al.   NATURE MEDICINE

Structural tract alterations predict downstream tau accumulation in amyloid-positive older individuals

(2018) Heidi I. L. Jacobs et al.   NATURE NEUROSCIENCE

Tau-targeting therapies for Alzheimer disease

(2018) Erin E. Congdon et al.   Nature Reviews Neurology

Trial of Solanezumab for Mild Dementia Due to Alzheimer’s Disease

(2018) Lawrence S. Honig et al.   NEW ENGLAND JOURNAL OF MEDICINE

Amyloid clearance defect in ApoE4 astrocytes is reversed by epigenetic correction of endosomal pH

(2018) Hari Prasad et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Alzheimer’s Transgenic Model Is Characterized by Very Early Brain Network Alterations and β-CTF Fragment Accumulation: Reversal by β-Secretase Inhibition

(2018) Siddhartha Mondragón-Rodríguez et al.   Frontiers in Cellular Neuroscience

A transcriptomic atlas of aged human microglia

(2018) Marta Olah et al.   Nature Communications

Association Between Amyloid and Tau Accumulation in Young Adults With Autosomal Dominant Alzheimer Disease

(2018) Yakeel T. Quiroz et al.   JAMA Neurology

Stabilizing the Retromer Complex in a Human Stem Cell Model of Alzheimer’s Disease Reduces TAU Phosphorylation Independently of Amyloid Precursor Protein

(2018) Jessica E. Young et al.   Stem Cell Reports

An exploratory clinical study of p38α kinase inhibition in Alzheimer's disease

(2018) Philip Scheltens et al.   Annals of Clinical and Translational Neurology

Alzheimer's genetic risk is reduced in primary age-related tauopathy: a potential model of resistance?

(2018) Corey T. McMillan et al.   Annals of Clinical and Translational Neurology

The Trem2 R47H Alzheimer’s risk variant impairs splicing and reduces Trem2 mRNA and protein in mice but not in humans

(2018) Xianyuan Xiang et al.   Molecular Neurodegeneration

Influence of tau PET, amyloid PET, and hippocampal volume on cognition in Alzheimer disease

(2018) Andrew J. Aschenbrenner et al.   NEUROLOGY

Human Induced Pluripotent Stem Cell-Derived Microglia-Like Cells Harboring TREM2 Missense Mutations Show Specific Deficits in Phagocytosis

(2018) Pablo Garcia-Reitboeck et al.   Cell Reports

Neuropathologic, genetic, and longitudinal cognitive profiles in primary age-related tauopathy (PART) and Alzheimer's disease

(2018) W. Robert Bell et al.   Alzheimers & Dementia

Tau impairs neural circuits, dominating amyloid-β effects, in Alzheimer models in vivo

(2018) Marc Aurel Busche et al.   NATURE NEUROSCIENCE

Presenilin-mediated cleavage of APP regulates synaptotagmin-7 and presynaptic plasticity

(2018) Gaël Barthet et al.   Nature Communications

Reversal of ApoE4-induced recycling block as a novel prevention approach for Alzheimer’s disease

(2018) Xunde Xian et al.   eLife

Correlation of In Vivo [18F]Flortaucipir With Postmortem Alzheimer Disease Tau Pathology

(2018) Ruben Smith et al.   JAMA Neurology

Structural Basis of Tau Interaction With BIN1 and Regulation by Tau Phosphorylation

(2018) Alessia Lasorsa et al.   Frontiers in Molecular Neuroscience

Characterization of pathogenic SORL1 genetic variants for association with Alzheimer’s disease: a clinical interpretation strategy

(2017) Henne Holstege et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

The TREM2-APOE Pathway Drives the Transcriptional Phenotype of Dysfunctional Microglia in Neurodegenerative Diseases

(2017) Susanne Krasemann et al.   IMMUNITY

In vitrocytochrome P450 46A1 (CYP46A1) activation by neuroactive compounds

(2017) Natalia Mast et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Microglia in Alzheimer’s disease

(2017) David V. Hansen et al.   JOURNAL OF CELL BIOLOGY

Flortaucipir F 18 Quantitation Using Parametric Estimation of Reference Signal Intensity

(2017) Sudeepti Southekal et al.   JOURNAL OF NUCLEAR MEDICINE

Test–Retest Reproducibility for the Tau PET Imaging Agent Flortaucipir F 18

(2017) Michael D. Devous et al.   JOURNAL OF NUCLEAR MEDICINE

Age-specific and sex-specific prevalence of cerebral β-amyloidosis, tauopathy, and neurodegeneration in cognitively unimpaired individuals aged 50–95 years: a cross-sectional study

(2017) Clifford R Jack et al.   LANCET NEUROLOGY

Glial contributions to neurodegeneration in tauopathies

(2017) Cheryl E. G. Leyns et al.   Molecular Neurodegeneration

TREM2 deficiency exacerbates tau pathology through dysregulated kinase signaling in a mouse model of tauopathy

(2017) Shane M. Bemiller et al.   Molecular Neurodegeneration

Late onset Alzheimer’s disease genetics implicates microglial pathways in disease risk

(2017) Anastasia G. Efthymiou et al.   Molecular Neurodegeneration

ApoE4 markedly exacerbates tau-mediated neurodegeneration in a mouse model of tauopathy

(2017) Yang Shi et al.   NATURE

Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease

(2017) Rebecca Sims et al.   NATURE GENETICS

Generation of pure GABAergic neurons by transcription factor programming

(2017) Nan Yang et al.   NATURE METHODS

The association between tau PET and retrospective cortical thinning in clinically normal elderly

(2017) Molly R. LaPoint et al.   NEUROIMAGE

Effect of simvastatin on CSF Alzheimer disease biomarkers in cognitively normal adults

(2017) Ge Li et al.   NEUROLOGY

In vivo staging of regional amyloid deposition

(2017) Michel J. Grothe et al.   NEUROLOGY

Hallmarks of Alzheimer’s Disease in Stem-Cell-Derived Human Neurons Transplanted into Mouse Brain

(2017) Ira Espuny-Camacho et al.   NEURON

Cholesterol-metabolizing enzyme cytochrome P450 46A1 as a pharmacologic target for Alzheimer's disease

(2017) Natalia Mast et al.   NEUROPHARMACOLOGY

TREM2 deficiency attenuates neuroinflammation and protects against neurodegeneration in a mouse model of tauopathy

(2017) Cheryl E. G. Leyns et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tau reduction prevents neuronal loss and reverses pathological tau deposition and seeding in mice with tauopathy

(2017) Sarah L. DeVos et al.   Science Translational Medicine

A phase III randomized trial of gantenerumab in prodromal Alzheimer’s disease

(2017) Susanne Ostrowitzki et al.   Alzheimers Research & Therapy

iPSC-Based Compound Screening and In Vitro Trials Identify a Synergistic Anti-amyloid β Combination for Alzheimer’s Disease

(2017) Takayuki Kondo et al.   Cell Reports

Sex and Race Differences in the Association Between Statin Use and the Incidence of Alzheimer Disease

(2017) Julie M. Zissimopoulos et al.   JAMA Neurology

The Endosomal–Lysosomal Pathway Is Dysregulated by APOE4 Expression in Vivo

(2017) Tal Nuriel et al.   Frontiers in Neuroscience

Phenotypic Screening Identifies Modulators of Amyloid Precursor Protein Processing in Human Stem Cell Models of Alzheimer’s Disease

(2017) Philip W. Brownjohn et al.   Stem Cell Reports

Intraneuronal aggregation of the β-CTF fragment of APP (C99) induces Aβ-independent lysosomal-autophagic pathology

(2016) Inger Lauritzen et al.   ACTA NEUROPATHOLOGICA

Regional profiles of the candidate tau PET ligand18F-AV-1451 recapitulate key features of Braak histopathological stages

(2016) Adam J. Schwarz et al.   BRAIN

Tau PET patterns mirror clinical and neuroanatomical variability in Alzheimer’s disease

(2016) Rik Ossenkoppele et al.   BRAIN

The Cellular Phase of Alzheimer’s Disease

(2016) Bart De Strooper et al.   CELL

Apolipoprotein E as a Therapeutic Target in Alzheimer’s Disease: A Review of Basic Research and Clinical Evidence

(2016) Yu Yamazaki et al.   CNS DRUGS

The amyloid hypothesis of Alzheimer's disease at 25 years

(2016) Dennis J Selkoe et al.   EMBO Molecular Medicine

Bin1 and CD2AP polarise the endocytic generation of beta‐amyloid

(2016) Florent Ubelmann et al.   EMBO REPORTS

Mapping of the Allosteric Site in Cholesterol Hydroxylase CYP46A1 for Efavirenz, a Drug That Stimulates Enzyme Activity

(2016) Kyle W. Anderson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The amyloid cascade hypothesis: are we poised for success or failure?

(2016) Eric Karran et al.   JOURNAL OF NEUROCHEMISTRY

Neuropathology of Autosomal Dominant Alzheimer Disease in the National Alzheimer Coordinating Center Database

(2016) John M. Ringman et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

TREM2 modifies microglial phenotype and provides neuroprotection in P301S tau transgenic mice

(2016) Teng Jiang et al.   NEUROPHARMACOLOGY

Double-blind, placebo-controlled, proof-of-concept trial of bexarotene in moderate Alzheimer’s disease

(2016) Jeffrey L. Cummings et al.   Alzheimers Research & Therapy

Defective Transcytosis of APP and Lipoproteins in Human iPSC-Derived Neurons with Familial Alzheimer’s Disease Mutations

(2016) Grace Woodruff et al.   Cell Reports

PART is part of Alzheimer disease

(2015) Charles Duyckaerts et al.   ACTA NEUROPATHOLOGICA

Tau positron emission tomographic imaging in aging and early Alzheimer disease

(2015) Keith A. Johnson et al.   ANNALS OF NEUROLOGY

Regional brain hypometabolism is unrelated to regional amyloid plaque burden

(2015) Andre Altmann et al.   BRAIN

Reactive microglia drive tau pathology and contribute to the spreading of pathological tau in the brain

(2015) Nicole Maphis et al.   BRAIN

Glial Lipid Droplets and ROS Induced by Mitochondrial Defects Promote Neurodegeneration

(2015) Lucy Liu et al.   CELL

Elucidating Molecular Phenotypes Caused by the SORL1 Alzheimer’s Disease Genetic Risk Factor Using Human Induced Pluripotent Stem Cells

(2015) Jessica E. Young et al.   Cell Stem Cell

Cellular Functions of the Amyloid Precursor Protein from Development to Dementia

(2015) Rik van der Kant et al.   DEVELOPMENTAL CELL

Prevalence of Cerebral Amyloid Pathology in Persons Without Dementia

(2015) Willemijn J. Jansen et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Evidence that the rab5 effector APPL1 mediates APP-βCTF-induced dysfunction of endosomes in Down syndrome and Alzheimer’s disease

(2015) S Kim et al.   MOLECULAR PSYCHIATRY

Three dimensions of the amyloid hypothesis: time, space and 'wingmen'

(2015) Erik S Musiek et al.   NATURE NEUROSCIENCE

Depletion of microglia and inhibition of exosome synthesis halt tau propagation

(2015) Hirohide Asai et al.   NATURE NEUROSCIENCE

Tau in physiology and pathology

(2015) Yipeng Wang et al.   NATURE REVIEWS NEUROSCIENCE

Silencing of TREM2 exacerbates tau pathology, neurodegenerative changes, and spatial learning deficits in P301S tau transgenic mice

(2015) Teng Jiang et al.   NEUROBIOLOGY OF AGING

Network Diffusion Model of Progression Predicts Longitudinal Patterns of Atrophy and Metabolism in Alzheimer’s Disease

(2015) Ashish Raj et al.   Cell Reports

Primary age-related tauopathy (PART): a common pathology associated with human aging

(2014) John F. Crary et al.   ACTA NEUROPATHOLOGICA

The familial Alzheimer's disease APPV717I mutation alters APP processing and Tau expression in iPSC-derived neurons

(2014) Christina R. Muratore et al.   HUMAN MOLECULAR GENETICS

Reversal of apoE4-Driven Brain Pathology and Behavioral Deficits by Bexarotene

(2014) A. Boehm-Cagan et al.   JOURNAL OF NEUROSCIENCE

A three-dimensional human neural cell culture model of Alzheimer’s disease

(2014) Se Hoon Choi et al.   NATURE

Pharmacological chaperones stabilize retromer to limit APP processing

(2014) Vincent J Mecozzi et al.   Nature Chemical Biology

Two Phase 3 Trials of Bapineuzumab in Mild-to-Moderate Alzheimer's Disease

(2014) Stephen Salloway et al.   NEW ENGLAND JOURNAL OF MEDICINE

The A4 Study: Stopping AD Before Symptoms Begin?

(2014) R. A. Sperling et al.   Science Translational Medicine

Exercise, APOE genotype, and the evolution of the human lifespan

(2014) David A. Raichlen et al.   TRENDS IN NEUROSCIENCES

Stuck in traffic: an emerging theme in diseases of the nervous system

(2014) Jacques Neefjes et al.   TRENDS IN NEUROSCIENCES

Decreased CALM expression reduces Aβ42 to total Aβ ratio through clathrin-mediated endocytosis of γ-secretase

(2014) Kunihiko Kanatsu et al.   Nature Communications

PICALM modulates autophagy activity and tau accumulation

(2014) Kevin Moreau et al.   Nature Communications

SnapShot: Genetics of Alzheimer’s Disease

(2013) Rita Guerreiro et al.   CELL

Modeling Alzheimer’s Disease with iPSCs Reveals Stress Phenotypes Associated with Intracellular Aβ and Differential Drug Responsiveness

(2013) Takayuki Kondo et al.   Cell Stem Cell

Pharmacologic Stimulation of Cytochrome P450 46A1 and Cerebral Cholesterol Turnover in Mice

(2013) Natalia Mast et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Normal cognition in transgenic BRI2-Aβ mice

(2013) Jungsu Kim et al.   Molecular Neurodegeneration

Increased expression of BIN1 mediates Alzheimer genetic risk by modulating tau pathology

(2013) J Chapuis et al.   MOLECULAR PSYCHIATRY

Apolipoprotein E and Alzheimer disease: risk, mechanisms and therapy

(2013) Chia-Chen Liu et al.   Nature Reviews Neurology

Rapid Single-Step Induction of Functional Neurons from Human Pluripotent Stem Cells

(2013) Yingsha Zhang et al.   NEURON

Biomarker Modeling of Alzheimer’s Disease

(2013) Clifford R. Jack et al.   NEURON

Comment on "ApoE-Directed Therapeutics Rapidly Clear  -Amyloid and Reverse Deficits in AD Mouse Models"

(2013) I. Tesseur et al.   SCIENCE

Comment on "ApoE-Directed Therapeutics Rapidly Clear  -Amyloid and Reverse Deficits in AD Mouse Models"

(2013) K. Veeraraghavalu et al.   SCIENCE

Comment on "ApoE-Directed Therapeutics Rapidly Clear  -Amyloid and Reverse Deficits in AD Mouse Models"

(2013) A. R. Price et al.   SCIENCE

Neuropathological Alterations in Alzheimer Disease

(2013) A. Serrano-Pozo et al.   Cold Spring Harbor Perspectives in Medicine

Role of Phosphatidylinositol Clathrin Assembly Lymphoid-Myeloid Leukemia (PICALM) in Intracellular Amyloid Precursor Protein (APP) Processing and Amyloid Plaque Pathogenesis

(2012) Qingli Xiao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Probing sporadic and familial Alzheimer’s disease using induced pluripotent stem cells

(2012) Mason A. Israel et al.   NATURE

The Amyloid Precursor Protein Has a Flexible Transmembrane Domain and Binds Cholesterol

(2012) P. J. Barrett et al.   SCIENCE

ApoE-Directed Therapeutics Rapidly Clear  -Amyloid and Reverse Deficits in AD Mouse Models

(2012) P. E. Cramer et al.   SCIENCE

Cholesterol Level and Statin Use in Alzheimer Disease

(2011) Nina E. Shepardson   ARCHIVES OF NEUROLOGY

Cholesterol Level and Statin Use in Alzheimer Disease

(2011) Nina E. Shepardson   ARCHIVES OF NEUROLOGY

Comparative Lipidomic Analysis of Mouse and Human Brain with Alzheimer Disease

(2011) Robin B. Chan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structure-dependent Impairment of Intracellular Apolipoprotein E4 Trafficking and Its Detrimental Effects Are Rescued by Small-molecule Structure Correctors

(2011) Jens Brodbeck et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Microglial p38α MAPK is a key regulator of proinflammatory cytokine up-regulation induced by toll-like receptor (TLR) ligands or beta-amyloid (Aβ)

(2011) Adam D Bachstetter et al.   Journal of Neuroinflammation

Stages of the Pathologic Process in Alzheimer Disease: Age Categories From 1 to 100 Years

(2011) Heiko Braak et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

The amyloid cascade hypothesis for Alzheimer's disease: an appraisal for the development of therapeutics

(2011) Eric Karran et al.   NATURE REVIEWS DRUG DISCOVERY

Linking lipids to Alzheimer's disease: cholesterol and beyond

(2011) Gilbert Di Paolo et al.   NATURE REVIEWS NEUROSCIENCE

Plasma apolipoprotein E and Alzheimer disease risk: The AIBL study of aging

(2011) V. B. Gupta et al.   NEUROLOGY

ADP ribosylation factor 6 (ARF6) controls amyloid precursor protein (APP) processing by mediating the endosomal sorting of BACE1

(2011) R. Sannerud et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CX3CR1 Deficiency Alters Microglial Activation and Reduces Beta-Amyloid Deposition in Two Alzheimer's Disease Mouse Models

(2010) Sungho Lee et al.   AMERICAN JOURNAL OF PATHOLOGY

Atorvastatin and pitavastatin improve cognitive function and reduce senile plaque and phosphorylated tau in aged APP mice

(2010) Tomoko Kurata et al.   BRAIN RESEARCH

Reduction of Brain β-Amyloid (Aβ) by Fluvastatin, a Hydroxymethylglutaryl-CoA Reductase Inhibitor, through Increase in Degradation of Amyloid Precursor Protein C-terminal Fragments (APP-CTFs) and Aβ Clearance

(2010) Mitsuru Shinohara et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

CX3CR1 in Microglia Regulates Brain Amyloid Deposition through Selective Protofibrillar Amyloid-  Phagocytosis

(2010) Z. Liu et al.   JOURNAL OF NEUROSCIENCE

Regulation of Tau Pathology by the Microglial Fractalkine Receptor

(2010) Kiran Bhaskar et al.   NEURON

Inhibition of acyl-coenzyme A: cholesterol acyl transferase modulates amyloid precursor protein trafficking in the early secretory pathway

(2009) Henri J. Huttunen et al.   FASEB JOURNAL

Statins Reduce the Neurofibrillary Tangle Burden in a Mouse Model of Tauopathy

(2009) Moran Boimel et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Apolipoprotein E: structure determines function, from atherosclerosis to Alzheimer's disease to AIDS

(2008) Robert W. Mahley et al.   JOURNAL OF LIPID RESEARCH

ACAT as a Drug Target for Alzheimer’s Disease

(2008) Henri J. Huttunen et al.   Neurodegenerative Diseases

Linking Aβ and Tau in Late-Onset Alzheimer's Disease: A Dual Pathway Hypothesis

(2008) Scott A. Small et al.   NEURON

Retromer deficiency observed in Alzheimer's disease causes hippocampal dysfunction, neurodegeneration, and A  accumulation

(2008) A. Muhammad et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

APOE genotype-specific differences in the innate immune response

(2007) Michael P. Vitek et al.   NEUROBIOLOGY OF AGING