Amyloid-β42/40 ratio drives tau pathology in 3D human neural cell culture models of Alzheimer’s disease

Familial Alzheimer’s disease patient-derived neurons reveal distinct mutation-specific effects on amyloid beta

(2019) Charles Arber et al.   MOLECULAR PSYCHIATRY

Advantages and disadvantages of the use of the CSF Amyloid β (Aβ) 42/40 ratio in the diagnosis of Alzheimer’s Disease

(2019) Oskar Hansson et al.   Alzheimers Research & Therapy

A Large Panel of Isogenic APP and PSEN1 Mutant Human iPSC Neurons Reveals Shared Endosomal Abnormalities Mediated by APP β-CTFs, Not Aβ

(2019) Dylan Kwart et al.   NEURON

Physiological Aβ Concentrations Produce a More Biomimetic Representation of the Alzheimer’s Disease Phenotype in iPSC Derived Human Neurons

(2018) Bonnie J. Berry et al.   ACS Chemical Neuroscience

Anti-Amyloid-β Monoclonal Antibodies for Alzheimer’s Disease: Pitfalls and Promise

(2018) Christopher H. van Dyck   BIOLOGICAL PSYCHIATRY

The Amyloid-β Oligomer Hypothesis: Beginning of the Third Decade

(2018) Erika N. Cline et al.   JOURNAL OF ALZHEIMERS DISEASE

A 3D human triculture system modeling neurodegeneration and neuroinflammation in Alzheimer’s disease

(2018) Joseph Park et al.   NATURE NEUROSCIENCE

Randomized Trial of Verubecestat for Mild-to-Moderate Alzheimer’s Disease

(2018) Michael F. Egan et al.   NEW ENGLAND JOURNAL OF MEDICINE

Oxidative stress and altered mitochondrial protein expression in the absence of amyloid-β and tau pathology in iPSC-derived neurons from sporadic Alzheimer's disease patients

(2018) Julian H. Birnbaum et al.   Stem Cell Research

The Impact of APP on Alzheimer-like Pathogenesis and Gene Expression in Down Syndrome iPSC-Derived Neurons

(2018) Dmitry A. Ovchinnikov et al.   Stem Cell Reports

A Brief History of Alzheimer's Disease Gene Discovery

(2018) Rudolph E. Tanzi   JOURNAL OF ALZHEIMERS DISEASE

Clusterin Is Required for β-Amyloid Toxicity in Human iPSC-Derived Neurons

(2018) Jacqueline P. Robbins et al.   Frontiers in Neuroscience

The Cerebrospinal Fluid Aβ1–42/Aβ1–40 Ratio Improves Concordance with Amyloid-PET for Diagnosing Alzheimer’s Disease in a Clinical Setting

(2017) Ellis Niemantsverdriet et al.   JOURNAL OF ALZHEIMERS DISEASE

Pharmacological and Toxicological Properties of the Potent Oral γ -Secretase Modulator BPN-15606

(2017) Steven L. Wagner et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Neurons derived from sporadic Alzheimer’s disease iPSCs reveal elevated TAU hyperphosphorylation, increased amyloid levels, and GSK3B activation

(2017) Anna Ochalek et al.   Alzheimers Research & Therapy

The amyloid hypothesis of Alzheimer's disease at 25 years

(2016) Dennis J Selkoe et al.   EMBO Molecular Medicine

The amyloid-beta forming tripeptide cleavage mechanism of γ-secretase

(2016) David M Bolduc et al.   eLife

The Role of Amyloid-β Oligomers in Toxicity, Propagation, and Immunotherapy

(2016) Urmi Sengupta et al.   EBioMedicine

Three Dimensional Human Neuro-Spheroid Model of Alzheimer’s Disease Based on Differentiated Induced Pluripotent Stem Cells

(2016) Han-Kyu Lee et al.   PLoS One

Self-Organizing 3D Human Neural Tissue Derived from Induced Pluripotent Stem Cells Recapitulate Alzheimer’s Disease Phenotypes

(2016) Waseem K. Raja et al.   PLoS One

Alzheimer's in 3D culture: Challenges and perspectives

(2015) Carla D'Avanzo et al.   BIOESSAYS

Early maturation and distinct tau pathology in induced pluripotent stem cell-derived neurons from patients withMAPTmutations

(2015) Mariangela Iovino et al.   BRAIN

Developmental regulation of tau splicing is disrupted in stem cell-derived neurons from frontotemporal dementia patients with the 10 + 16 splice-site mutation in MAPT

(2015) Teresa Sposito et al.   HUMAN MOLECULAR GENETICS

η-Secretase processing of APP inhibits neuronal activity in the hippocampus

(2015) Michael Willem et al.   NATURE

A 3D human neural cell culture system for modeling Alzheimer's disease

(2015) Young Hye Kim et al.   Nature Protocols

Alzheimer's disease-related amyloid-β induces synaptotoxicity in human iPS cell-derived neurons

(2015) K Nieweg et al.   Cell Death & Disease

APP Metabolism Regulates Tau Proteostasis in Human Cerebral Cortex Neurons

(2015) Steven Moore et al.   Cell Reports

The multifaceted nature of amyloid precursor protein and its proteolytic fragments: friends and foes

(2014) Hoang S. Nhan et al.   ACTA NEUROPATHOLOGICA

HTSeq--a Python framework to work with high-throughput sequencing data

(2014) S. Anders et al.   BIOINFORMATICS

The coexistence of an equal amount of Alzheimer's amyloid-β 40 and 42 forms structurally stable and toxic oligomers through a distinct pathway

(2014) Yu-Jen Chang et al.   FEBS Journal

A critical analysis of the ‘amyloid cascade hypothesis’

(2014) Richard A. Armstrong   FOLIA NEUROPATHOLOGICA

The familial Alzheimer's disease APPV717I mutation alters APP processing and Tau expression in iPSC-derived neurons

(2014) Christina R. Muratore et al.   HUMAN MOLECULAR GENETICS

A three-dimensional human neural cell culture model of Alzheimer’s disease

(2014) Se Hoon Choi et al.   NATURE

Single App knock-in mouse models of Alzheimer's disease

(2014) Takashi Saito et al.   NATURE NEUROSCIENCE

Characterization and Molecular Profiling of PSEN1 Familial Alzheimer's Disease iPSC-Derived Neural Progenitors

(2014) Andrew A. Sproul et al.   PLoS One

Single-Molecule Imaging Reveals Aβ42:Aβ40 Ratio-Dependent Oligomer Growth on Neuronal Processes

(2013) Robin D. Johnson et al.   BIOPHYSICAL JOURNAL

Normal cognition in transgenic BRI2-Aβ mice

(2013) Jungsu Kim et al.   Molecular Neurodegeneration

STAR: ultrafast universal RNA-seq aligner

(2012) Alexander Dobin et al.   BIOINFORMATICS

Reviewing reasons for the decreased CSF Abeta42 concentration in Alzheimer

(2012) Petra et al.   Frontiers in Bioscience-Landmark

Probing sporadic and familial Alzheimer’s disease using induced pluripotent stem cells

(2012) Mason A. Israel et al.   NATURE

Clinical and Biomarker Changes in Dominantly Inherited Alzheimer's Disease

(2012) Randall J. Bateman et al.   NEW ENGLAND JOURNAL OF MEDICINE

Presenilins function in ER calcium leak and Alzheimer's disease pathogenesis

(2011) Charlene Supnet et al.   CELL CALCIUM

Modeling familial Alzheimer's disease with induced pluripotent stem cells

(2011) Takuya Yagi et al.   HUMAN MOLECULAR GENETICS

The Cerebrospinal Fluid Amyloid β42/40 Ratio in the Differentiation of Alzheimers Disease from Non-Alzheimers Dementia

(2010) P.E. Spies et al.   Current Alzheimer Research

Amyloid  -Protein Dimers Rapidly Form Stable Synaptotoxic Protofibrils

(2010) B. O'Nuallain et al.   JOURNAL OF NEUROSCIENCE

β-Amyloid 1-42 Oligomers Impair Function of Human Embryonic Stem Cell-Derived Forebrain Cholinergic Neurons

(2010) Linn Wicklund et al.   PLoS One

edgeR: a Bioconductor package for differential expression analysis of digital gene expression data

(2009) M. D. Robinson et al.   BIOINFORMATICS

Phosphorylation of Tau at S422 is enhanced by Aβ in TauPS2APP triple transgenic mice

(2009) Fiona Grueninger et al.   NEUROBIOLOGY OF DISEASE

Alzheimer's disease-like pathological features in transgenic mice expressing the APP intracellular domain

(2009) K. Ghosal et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Amyloid-β protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory

(2008) Ganesh M Shankar et al.   NATURE MEDICINE

Animal models of Alzheimer's disease and frontotemporal dementia

(2008) Jürgen Götz et al.   NATURE REVIEWS NEUROSCIENCE