Aβ-induced acceleration of Alzheimer-related τ-pathology spreading and its association with prion protein

Amyloid-β pathology enhances pathological fibrillary tau seeding induced by Alzheimer PHF in vivo

(2019) Cristina Vergara et al.   ACTA NEUROPATHOLOGICA

Anti-PrPC antibody rescues cognition and synapses in transgenic alzheimer mice

(2019) Timothy O. Cox et al.   Annals of Clinical and Translational Neurology

Soluble tau aggregates inhibit synaptic long-term depression and amyloid β-facilitated LTD in vivo

(2019) Tomas Ondrejcak et al.   NEUROBIOLOGY OF DISEASE

Pyk2 is a Novel Tau Tyrosine Kinase that is Regulated by the Tyrosine Kinase Fyn

(2018) Chuanzhou Li et al.   JOURNAL OF ALZHEIMERS DISEASE

The Amyloid-β Oligomer Hypothesis: Beginning of the Third Decade

(2018) Erika N. Cline et al.   JOURNAL OF ALZHEIMERS DISEASE

Disease-modifying benefit of Fyn blockade persists after washout in mouse Alzheimer's model

(2018) Levi M. Smith et al.   NEUROPHARMACOLOGY

Extracellular Forms of Aβ and Tau from iPSC Models of Alzheimer’s Disease Disrupt Synaptic Plasticity

(2018) Neng-Wei Hu et al.   Cell Reports

Alzheimer's Disease Risk Factor Pyk2 Mediates Amyloid-β Induced Synaptic Dysfunction and Loss

(2018) Santiago V. Salazar et al.   JOURNAL OF NEUROSCIENCE

Cellular Prion Protein Mediates the Disruption of Hippocampal Synaptic Plasticity by Soluble Tau In Vivo

(2018) Tomas Ondrejcak et al.   JOURNAL OF NEUROSCIENCE

Neurogenetic contributions to amyloid beta and tau spreading in the human cortex

(2018) Jorge Sepulcre et al.   NATURE MEDICINE

Conditional Deletion of Prnp Rescues Behavioral and Synaptic Deficits after Disease Onset in Transgenic Alzheimer's Disease

(2017) Santiago V. Salazar et al.   JOURNAL OF NEUROSCIENCE

Amyloid-β plaques enhance Alzheimer's brain tau-seeded pathologies by facilitating neuritic plaque tau aggregation

(2017) Zhuohao He et al.   NATURE MEDICINE

α-synuclein interacts with PrPC to induce cognitive impairment through mGluR5 and NMDAR2B

(2017) Diana G Ferreira et al.   NATURE NEUROSCIENCE

Prion Protein is Reduced in Aging and in Sporadic but not in Familial Alzheimer's Disease

(2017) Isobel J. Whitehouse et al.   JOURNAL OF ALZHEIMERS DISEASE

Heterotypic seeding of Tau fibrillization by pre-aggregated Abeta provides potent seeds for prion-like seeding and propagation of Tau-pathology in vivo

(2016) Bruno Vasconcelos et al.   ACTA NEUROPATHOLOGICA

Regional profiles of the candidate tau PET ligand18F-AV-1451 recapitulate key features of Braak histopathological stages

(2016) Adam J. Schwarz et al.   BRAIN

Exosomal cellular prion protein drives fibrillization of amyloid beta and counteracts amyloid beta-mediated neurotoxicity

(2016) Clemens Falker et al.   JOURNAL OF NEUROCHEMISTRY

Critical residues involved in tau binding to fyn: implications for tau phosphorylation in Alzheimer’s disease

(2016) Dawn H. W. Lau et al.   Acta Neuropathologica Communications

Prion Disease Induces Alzheimer Disease—Like Neuropathologic Changes

(2015) Thomas Tousseyn et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Early-onset axonal pathology in a novel P301S-Tau transgenic mouse model of frontotemporal lobar degeneration

(2015) Janet van Eersel et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

The prion protein constitutively controls neuronal store-operated Ca2+ entry through Fyn kinase

(2015) Agnese De Mario et al.   Frontiers in Cellular Neuroscience

Synaptic Contacts Enhance Cell-to-Cell Tau Pathology Propagation

(2015) Sara Calafate et al.   Cell Reports

Tau aggregation and its interplay with amyloid-β

(2014) Rebecca M. Nisbet et al.   ACTA NEUROPATHOLOGICA

Biochemical stages of amyloid-β peptide aggregation and accumulation in the human brain and their association with symptomatic and pathologically preclinical Alzheimer’s disease

(2014) Ajeet Rijal Upadhaya et al.   BRAIN

Role of PrPC Expression in Tau Protein Levels and Phosphorylation in Alzheimer’s Disease Evolution

(2014) C. Vergara et al.   MOLECULAR NEUROBIOLOGY

Fyn kinase inhibition as a novel therapy for Alzheimer’s disease

(2014) Haakon B Nygaard et al.   Alzheimers Research & Therapy

Alzheimer’s Amyloid-β Oligomers Rescue Cellular Prion Protein Induced Tau Reduction via the Fyn Pathway

(2013) Rong-Jie Chen et al.   ACS Chemical Neuroscience

Oligomers, fact or artefact? SDS-PAGE induces dimerization of β-amyloid in human brain samples

(2013) Andrew D. Watt et al.   ACTA NEUROPATHOLOGICA

Cellular prion protein modulates β-amyloid deposition in aged APP/PS1 transgenic mice

(2013) Lara Ordóñez-Gutiérrez et al.   NEUROBIOLOGY OF AGING

Prion Protein Is Decreased in Alzheimer's Brain and Inversely Correlates with BACE1 Activity, Amyloid-β Levels and Braak Stage

(2013) Isobel J. Whitehouse et al.   PLoS One

Plin2 Inhibits Cellular Glucose Uptake through Interactions with SNAP23, a SNARE Complex Protein

(2013) Subramanian Senthivinayagam et al.   PLoS One

National Institute on Aging–Alzheimer's Association guidelines for the neuropathologic assessment of Alzheimer's disease

(2012) Bradley T. Hyman et al.   Alzheimers & Dementia

Interaction of Endogenous Tau Protein with Synaptic Proteins Is Regulated byN-Methyl-d-aspartate Receptor-dependent Tau Phosphorylation

(2012) Siddhartha Mondragón-Rodríguez et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Transgenic Expression of Intraneuronal A 42 But Not A 40 Leads to Cellular A  Lesions, Degeneration, and Functional Impairment without Typical Alzheimer's Disease Pathology

(2012) D. Abramowski et al.   JOURNAL OF NEUROSCIENCE

Alzheimer amyloid-β oligomer bound to postsynaptic prion protein activates Fyn to impair neurons

(2012) Ji Won Um et al.   NATURE NEUROSCIENCE

Dispersible amyloid β-protein oligomers, protofibrils, and fibrils represent diffusible but not soluble aggregates: their role in neurodegeneration in amyloid precursor protein (APP) transgenic mice

(2012) Ajeet Rijal Upadhaya et al.   NEUROBIOLOGY OF AGING

Cellular Prion Protein Expression Is Not Regulated by the Alzheimer's Amyloid Precursor Protein Intracellular Domain

(2012) Victoria Lewis et al.   PLoS One

Regulation of amyloid-β production by the prion protein

(2012) Heledd H. Griffiths et al.   Prion

Alzheimer’s pathogenesis: is there neuron-to-neuron propagation?

(2011) Heiko Braak et al.   ACTA NEUROPATHOLOGICA

Pathogenic protein seeding in alzheimer disease and other neurodegenerative disorders

(2011) Mathias Jucker et al.   ANNALS OF NEUROLOGY

High-molecular weight Aβ oligomers and protofibrils are the predominant Aβ species in the native soluble protein fraction of the AD brain

(2011) Ajeet Rijal Upadhaya et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Stages of the Pathologic Process in Alzheimer Disease: Age Categories From 1 to 100 Years

(2011) Heiko Braak et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Correlations between cortical and subcortical tau pathology

(2011) J. Attems et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

The pathological process underlying Alzheimer’s disease in individuals under thirty

(2010) Heiko Braak et al.   ACTA NEUROPATHOLOGICA

Aβ Accelerates the Spatiotemporal Progression of Tau Pathology and Augments Tau Amyloidosis in an Alzheimer Mouse Model

(2010) David E. Hurtado et al.   AMERICAN JOURNAL OF PATHOLOGY

The presence of sodium dodecyl sulphate-stable Aβ dimers is strongly associated with Alzheimer-type dementia

(2010) Jessica M. Mc Donald et al.   BRAIN

Dendritic Function of Tau Mediates Amyloid-β Toxicity in Alzheimer's Disease Mouse Models

(2010) Lars M. Ittner et al.   CELL

Prion protein and Aβ-related synaptic toxicity impairment

(2010) Anna Maria Calella et al.   EMBO Molecular Medicine

Memory Impairment in Transgenic Alzheimer Mice Requires Cellular Prion Protein

(2010) D. A. Gimbel et al.   JOURNAL OF NEUROSCIENCE

Accumulation of cellular prion protein within dystrophic neurites of amyloid plaques in the Alzheimer's disease brain

(2010) Reisuke H. Takahashi et al.   NEUROPATHOLOGY

The cellular prion protein and its role in Alzheimer disease

(2010) J. L. Velayos et al.   Prion

Synthetic amyloid-  oligomers impair long-term memory independently of cellular prion protein

(2010) C. Balducci et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

p53-Dependent Transcriptional Control of Cellular Prion by Presenilins

(2009) B. Vincent et al.   JOURNAL OF NEUROSCIENCE

Cellular prion protein mediates impairment of synaptic plasticity by amyloid-β oligomers

(2009) Juha Laurén et al.   NATURE

Transmission and spreading of tauopathy in transgenic mouse brain

(2009) Florence Clavaguera et al.   NATURE CELL BIOLOGY

The dorsal raphe nucleus shows phospho-tau neurofibrillary changes before the transentorhinal region in Alzheimer's disease. A precocious onset?

(2009) L. T. Grinberg et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Tau isoform regulation is region- and cell-specific in mouse brain

(2008) Pamela McMillan et al.   JOURNAL OF COMPARATIVE NEUROLOGY