Radiochemical examination of transthyretin (TTR) brain penetration assisted by iododiflunisal, a TTR tetramer stabilizer and a new candidate drug for AD

Transthyretin Mimetics as Anti-β-Amyloid Agents: A Comparison of Peptide and Protein Approaches

(2018) Kayla M. Pate et al.   ChemMedChem

Clinical Trials for Disease-Modifying Therapies in Alzheimer’s Disease: A Primer, Lessons Learned, and a Blueprint for the Future

(2018) Jeffrey Cummings et al.   JOURNAL OF ALZHEIMERS DISEASE

The Rationale Behind the New Alzheimer’s Disease Conceptualization: Lessons Learned During the Last Decades

(2018) José Luis Molinuevo et al.   JOURNAL OF ALZHEIMERS DISEASE

Prospects for dementia research

(2018) Geoff Watts   LANCET

Transthyretin Stabilization by Iododiflunisal Promotes Amyloid-β Peptide Clearance, Decreases its Deposition, and Ameliorates Cognitive Deficits in an Alzheimer's Disease Mouse Model

(2018) Carlos A. Ribeiro et al.   JOURNAL OF ALZHEIMERS DISEASE

Stabilizing Transthyretin to Treat ATTR Cardiomyopathy

(2018) C. Cristina Quarta et al.   NEW ENGLAND JOURNAL OF MEDICINE

Why do trials for Alzheimer’s disease drugs keep failing? A discontinued drug perspective for 2010-2015

(2017) Dev Mehta et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Cerebrospinal Fluid Proteins as Regulators of Beta-amyloid Aggregation and Toxicity

(2017) Kayla M. Pate et al.   ISRAEL JOURNAL OF CHEMISTRY

Efficacy and Safety of Plasma Exchange with 5% Albumin to Modify Cerebrospinal Fluid and Plasma Amyloid-β Concentrations and Cognition Outcomes in Alzheimer’s Disease Patients: A Multicenter, Randomized, Controlled Clinical Trial

(2017) Mercè Boada et al.   JOURNAL OF ALZHEIMERS DISEASE

Atomic-resolution map of the interactions between an amyloid inhibitor protein and amyloid β (Aβ) peptides in the monomer and protofibril states

(2017) Moustafa Algamal et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Transthyretin familial amyloid polyneuropathy: an update

(2017) Violaine Plante-Bordeneuve   JOURNAL OF NEUROLOGY

Targeting Apolipoprotein E/Amyloid β Binding by Peptoid CPO_Aβ17-21 P Ameliorates Alzheimer’s Disease Related Pathology and Cognitive Decline

(2017) Shan Liu et al.   Scientific Reports

CSF, blood-brain barrier, and brain drug delivery

(2016) William M. Pardridge   Expert Opinion on Drug Delivery

TTR kinetic stabilizers and TTR gene silencing: a new era in therapy for familial amyloidotic polyneuropathies

(2016) David Adams et al.   EXPERT OPINION ON PHARMACOTHERAPY

Clusterin Binds to Aβ1–42Oligomers with High Affinity and Interferes with Peptide Aggregation by Inhibiting Primary and Secondary Nucleation

(2016) Marten Beeg et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Repositioning tolcapone as a potent inhibitor of transthyretin amyloidogenesis and associated cellular toxicity

(2016) Ricardo Sant'Anna et al.   Nature Communications

Transthyretin participates in beta-amyloid transport from the brain to the liver- involvement of the low-density lipoprotein receptor-related protein 1?

(2016) Mobina Alemi et al.   Scientific Reports

Positron Emission Tomography: Current Challenges and Opportunities for Technological Advances in Clinical and Preclinical Imaging Systems

(2015) Juan José Vaquero et al.   Annual Review of Biomedical Engineering

Transthyretin suppresses the toxicity of oligomers formed by misfolded proteins in vitro

(2013) Roberta Cascella et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Tafamidis (Vyndaqel): A Light for FAP Patients

(2013) Susanna Nencetti et al.   ChemMedChem

Effect of albumin on transthyretin and amyloidogenic transthyretin Val30Met disposition and tissue deposition in familial amyloidotic polyneuropathy

(2013) Kazuaki Taguchi et al.   LIFE SCIENCES

Transthyretin Decrease in Plasma of MCI and AD Patients: Investigation of Mechanisms for Disease Modulation

(2012) Carlos A. Ribeiro et al.   Current Alzheimer Research

TTR Fibril Formation Inhibitors: Is there a SAR?

(2012)   CURRENT MEDICINAL CHEMISTRY

Stability of the Transthyretin Molecule as a Key Factor in the Interaction with A-Beta Peptide - Relevance in Alzheimer's Disease

(2012) Carlos A. Ribeiro et al.   PLoS One

Tafamidis, a potent and selective transthyretin kinetic stabilizer that inhibits the amyloid cascade

(2012) C. E. Bulawa et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

124I-L19-SIP for immuno-PET imaging of tumour vasculature and guidance of 131I-L19-SIP radioimmunotherapy

(2009) Bernard M. Tijink et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Structure and function of the blood–brain barrier

(2009) N. Joan Abbott et al.   NEUROBIOLOGY OF DISEASE

Iodine Atoms: A New Molecular Feature for the Design of Potent Transthyretin Fibrillogenesis Inhibitors

(2009) Teresa Mairal et al.   PLoS One

Transthyretin binding to A-Beta peptide - Impact on A-Beta fibrillogenesis and toxicity

(2008) R. Costa et al.   FEBS LETTERS

Transthyretin protects Alzheimer's mice from the behavioral and biochemical effects of A  toxicity

(2008) J. N. Buxbaum et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA