Current and future treatment of amyloid diseases

Rethinking Alzheimer's Disease Therapy: Are Mitochondria the Key?

(2017) Maria Ankarcrona et al.   JOURNAL OF ALZHEIMERS DISEASE

Changes in CSF cholinergic biomarkers in response to cell therapy with NGF in patients with Alzheimer's disease

(2015) Azadeh Karami et al.   Alzheimers & Dementia

In Vivo Seeding and Cross-Seeding of Localized Amyloidosis

(2015) Marie E. Oskarsson et al.   AMERICAN JOURNAL OF PATHOLOGY

AA Amyloidosis: Pathogenesis and Targeted Therapy

(2015) Gunilla T. Westermark et al.   Annual Review of Pathology-Mechanisms of Disease

Tafamidis in Transthyretin Amyloid Cardiomyopathy: Effects on Transthyretin Stabilization and Clinical Outcomes

(2015) M. S. Maurer et al.   Circulation-Heart Failure

Proteostatic Hotspots in Amyloid Fibrils Protect Us from Neurodegeneration

(2015) Jay Kumar Singh et al.   DEVELOPMENTAL CELL

Cardiac amyloidosis: the great pretender

(2015) Claudio Rapezzi et al.   HEART FAILURE REVIEWS

Treatment of hepatic amyloid light-chain amyloidosis with bortezomib and dexamethasone in a liver transplant patient

(2015) Ryosuke Nakano et al.   HEPATOLOGY RESEARCH

Folding and Intramembraneous BRICHOS Binding of the Prosurfactant Protein C Transmembrane Segment

(2015) Alejandra Sáenz et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Heparan Sulfate Proteoglycans Are Important for Islet Amyloid Formation and Islet Amyloid Polypeptide-induced Apoptosis

(2015) Marie E. Oskarsson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Diversity of Mechanisms Influenced by Transthyretin in Neurobiology: Development, Disease and Endocrine Disruption

(2015) B. Alshehri et al.   JOURNAL OF NEUROENDOCRINOLOGY

Transthyretin (ATTR) amyloidosis: clinical spectrum, molecular pathogenesis and disease-modifying treatments

(2015) Yoshiki Sekijima   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Brain Microbleeds 12 Years after Orthotopic Liver Transplantation in Val30Met Amyloidosis

(2015) Fabrizio Salvi et al.   Journal of Stroke & Cerebrovascular Diseases

Amyloid polyneuropathy caused by wild-type transthyretin

(2015) Lynda Lam et al.   MUSCLE & NERVE

A molecular chaperone breaks the catalytic cycle that generates toxic Aβ oligomers

(2015) Samuel I A Cohen et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Combined heart-liver transplantation: a single-center experience

(2015) Lucio Careddu et al.   TRANSPLANT INTERNATIONAL

Liver Transplantation for Hereditary Transthyretin Amyloidosis

(2015) Bo-Göran Ericzon et al.   TRANSPLANTATION

Cardiac Findings and Events Observed in an Open-Label Clinical Trial of Tafamidis in Patients with non-Val30Met and non-Val122Ile Hereditary Transthyretin Amyloidosis

(2015) Thibaud Damy et al.   Journal of Cardiovascular Translational Research

A molecular chaperone breaks the catalytic cycle that generates toxic Aβ oligomers

(2015) Samuel I A Cohen et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Brain Microbleeds 12 Years after Orthotopic Liver Transplantation in Val30Met Amyloidosis

(2015) Fabrizio Salvi et al.   Journal of Stroke & Cerebrovascular Diseases

Repurposing Diflunisal for Familial Amyloid Polyneuropathy

(2015) John L. Berk et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Domino liver transplantation as a cause of acquired familial amyloid polyneuropathy

(2014) Mohamed M. Abdelfatah et al.   AMYLOID-JOURNAL OF PROTEIN FOLDING DISORDERS

Islet amyloid with macrophage migration correlates with augmented β-cell deficits in type 2 diabetic patients

(2014) Kosuke Kamata et al.   AMYLOID-JOURNAL OF PROTEIN FOLDING DISORDERS

Amyloid Imaging in Aging and Dementia: Testing the Amyloid HypothesisIn Vivo

(2014) G. D. Rabinovici et al.   BEHAVIOURAL NEUROLOGY

Quantification of Transthyretin Kinetic Stability in Human Plasma Using Subunit Exchange

(2014) Irit Rappley et al.   BIOCHEMISTRY

In vivo detection of nerve injury in familial amyloid polyneuropathy by magnetic resonance neurography

(2014) Jennifer Kollmer et al.   BRAIN

The chaperone domain BRICHOS prevents CNS toxicity of amyloid-  peptide in Drosophila melanogaster

(2014) E. Hermansson et al.   Disease Models & Mechanisms

Oculoleptomeningeal Amyloidosis associated with transthyretin Leu12Pro in an African patient

(2014) P. McColgan et al.   JOURNAL OF NEUROLOGY

CNS involvement in V30M transthyretin amyloidosis: clinical, neuropathological and biochemical findings

(2014) L. F. Maia et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Amyloid- -Induced Action Potential Desynchronization and Degradation of Hippocampal Gamma Oscillations Is Prevented by Interference with Peptide Conformation Change and Aggregation

(2014) F. R. Kurudenkandy et al.   JOURNAL OF NEUROSCIENCE

Retrospective study of a TTR FAP cohort to modify NIS+7 for therapeutic trials

(2014) N. Suanprasert et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

The BRICHOS Domain, Amyloid Fibril Formation, and Their Relationship

(2013) Stefan D. Knight et al.   BIOCHEMISTRY

Resident Macrophages Mediate Islet Amyloid Polypeptide–Induced Islet IL-1β Production and β-Cell Dysfunction

(2013) Clara Y. Westwell-Roper et al.   DIABETES

Long-term effects of tafamidis for the treatment of transthyretin familial amyloid polyneuropathy

(2013) Teresa Coelho et al.   JOURNAL OF NEUROLOGY

Ion Mobility Spectrometry–Mass Spectrometry Defines the Oligomeric Intermediates in Amylin Amyloid Formation and the Mode of Action of Inhibitors

(2013) Lydia M. Young et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Normal cognition in transgenic BRI2-Aβ mice

(2013) Jungsu Kim et al.   Molecular Neurodegeneration

Amiloidosis leptomeníngea debida a la mutación A25T TTR. A propósito de un caso

(2013) L. Llull et al.   NEUROLOGIA

Opportunities and Challenges for Molecular Chaperone Modulation to Treat Protein-Conformational Brain Diseases

(2013) Herman van der Putten et al.   Neurotherapeutics

Safety and Efficacy of RNAi Therapy for Transthyretin Amyloidosis

(2013) Teresa Coelho et al.   NEW ENGLAND JOURNAL OF MEDICINE

Guideline of transthyretin-related hereditary amyloidosis for clinicians

(2013) Yukio Ando et al.   Orphanet Journal of Rare Diseases

Proliferation of amyloid- 42 aggregates occurs through a secondary nucleation mechanism

(2013) S. I. A. Cohen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Stress-Independent Activation of XBP1s and/or ATF6 Reveals Three Functionally Diverse ER Proteostasis Environments

(2013) Matthew D. Shoulders et al.   Cell Reports

Senile Systemic Amyloidosis: Clinical Features at Presentation and Outcome

(2013) Jennifer H. Pinney et al.   Journal of the American Heart Association

Renal Transplantation in Systemic Amyloidosis-Importance of Amyloid Fibril Type and Precursor Protein Abundance

(2012) J. H. Pinney et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Arterial thromboembolism in senile systemic amyloidosis: report of two cases

(2012) Michitaka Nakagawa et al.   AMYLOID-JOURNAL OF PROTEIN FOLDING DISORDERS

AA-Amyloid is cleared by endogenous immunological mechanisms

(2012) Sofia N. Nyström et al.   AMYLOID-JOURNAL OF PROTEIN FOLDING DISORDERS

Genotype – phenotype correlation in FAP

(2012) Steven R. Zeldenrust   AMYLOID-JOURNAL OF PROTEIN FOLDING DISORDERS

Curcumin modulates the self-assembly of the islet amyloid polypeptide by disassembling α-helix

(2012) Samuel Sparks et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Transthyretin is a metallopeptidase with an inducible active site

(2012) Márcia A. Liz et al.   BIOCHEMICAL JOURNAL

Transthyretin (TTR) Cardiac Amyloidosis

(2012) Frederick L. Ruberg et al.   CIRCULATION

Transthyretin Amyloidosis and the Kidney

(2012) L. Lobato et al.   Clinical Journal of the American Society of Nephrology

Long-term outcome in patients treated with combined heart and liver transplantation for familial amyloidotic cardiomyopathy

(2012) Laerke M. Nelson et al.   CLINICAL TRANSPLANTATION

THAOS – The Transthyretin Amyloidosis Outcomes Survey: initial report on clinical manifestations in patients with hereditary and wild-type transthyretin amyloidosis

(2012) Teresa Coelho et al.   CURRENT MEDICAL RESEARCH AND OPINION

Deletion of Fas protects islet beta cells from cytotoxic effects of human islet amyloid polypeptide

(2012) Y. J. Park et al.   DIABETOLOGIA

Novel function of transthyretin in pancreatic alpha cells

(2012) Yu Su et al.   FEBS LETTERS

BRICHOS Domains Efficiently Delay Fibrillation of Amyloid β-Peptide

(2012) Hanna Willander et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tafamidis for transthyretin familial amyloid polyneuropathy: A randomized, controlled trial

(2012) T. Coelho et al.   NEUROLOGY

High-resolution structure of a BRICHOS domain and its implications for anti-amyloid chaperone activity on lung surfactant protein C

(2012) H. Willander et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tafamidis, a potent and selective transthyretin kinetic stabilizer that inhibits the amyloid cascade

(2012) C. E. Bulawa et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Preventing Alzheimer's Disease

(2012) D. J. Selkoe   SCIENCE

Protein misfolding and aggregation in cataract disease and prospects for prevention

(2012) Kate L. Moreau et al.   TRENDS IN MOLECULAR MEDICINE

Operative Risks of Domino Liver Transplantation for the Familial Amyloid Polyneuropathy Liver Donor and Recipient: A Double Analysis

(2011) G. Tincani et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Symptomatic and provende novoamyloid polyneuropathy in familial amyloid polyneuropathy domino liver recipients

(2011) D. Adams et al.   AMYLOID-JOURNAL OF PROTEIN FOLDING DISORDERS

A new transthyretin mutation associated with leptomeningeal amyloidosis

(2011) J. J. Liepnieks et al.   AMYLOID-JOURNAL OF PROTEIN FOLDING DISORDERS

Development of cardiomyopathy after liver transplantation in Swedish hereditary transthyretin amyloidosis (ATTR) patients

(2011) Sadahisa Okamoto et al.   AMYLOID-JOURNAL OF PROTEIN FOLDING DISORDERS

Strategic Role for Mitochondria in Alzheimer's Disease and Cancer

(2011) Louise Hedskog et al.   ANTIOXIDANTS & REDOX SIGNALING

BRICHOS domain associated with lung fibrosis, dementia and cancer - a chaperone that prevents amyloid fibril formation?

(2011) Hanna Willander et al.   FEBS Journal

Heart transplantation and cardiac amyloidosis: Approach to screening and novel management strategies

(2011) Brandon C. Varr et al.   JOURNAL OF HEART AND LUNG TRANSPLANTATION

Variable presentations of TTR-related familial amyloid polyneuropathy in seventeen patients

(2011) Manuel Cappellari et al.   JOURNAL OF THE PERIPHERAL NERVOUS SYSTEM

Amyloid neuropathy in a younger domino liver transplanted recipient

(2011) Konen Obayashi et al.   MUSCLE & NERVE

Amyloid polyneuropathy following domino liver transplantation

(2011) Luca Pradotto et al.   MUSCLE & NERVE

Potent Kinetic Stabilizers That Prevent Transthyretin-Mediated Cardiomyocyte Proteotoxicity

(2011) M. M. Alhamadsheh et al.   Science Translational Medicine

Molecular pathology of human prion disease

(2010) Jonathan D. F. Wadsworth et al.   ACTA NEUROPATHOLOGICA

Solid Organ Transplantation in AL Amyloidosis

(2010) P. T. Sattianayagam et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Usefulness of labial salivary gland biopsy in familial amyloid polyneuropathy Portuguese type

(2010) Barbas Do Amaral et al.   AMYLOID-JOURNAL OF PROTEIN FOLDING DISORDERS

Suppression of choroid plexus transthyretin levels by antisense oligonucleotide treatment

(2010) Merrill D. Benson et al.   AMYLOID-JOURNAL OF PROTEIN FOLDING DISORDERS

The effect of curcumin on human islet amyloid polypeptide misfolding and toxicity

(2010) Marie Daval et al.   AMYLOID-JOURNAL OF PROTEIN FOLDING DISORDERS

Identification of Hot Regions of the Aβ-IAPP Interaction Interface as High-Affinity Binding Sites in both Cross- and Self-Association

(2010) Erika Andreetto et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A competition assay to identify amyloidogenesis inhibitors by monitoring the fluorescence emitted by the covalent attachment of a stilbene derivative to transthyretin

(2010) Sungwook Choi et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Biochemical effect of liver transplantation in two Swedish patients with familial amyloidotic polyneuropathy (FAP-met30)

(2010) Gösta Holmgren et al.   CLINICAL GENETICS

Structure-based design of kinetic stabilizers that ameliorate the transthyretin amyloidoses

(2010) Stephen Connelly et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Toxic oligomers and islet beta cell death: guilty by association or convicted by circumstantial evidence?

(2010) S. Zraika et al.   DIABETOLOGIA

Systemic but asymptomatic transthyretin amyloidosis 8 years after domino liver transplantation

(2010) H. Koike et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

A Substructure Combination Strategy To Create Potent and Selective Transthyretin Kinetic Stabilizers That Prevent Amyloidogenesis and Cytotoxicity

(2010) Sungwook Choi et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A Stilbene That Binds Selectively to Transthyretin in Cells and Remains Dark until It Undergoes a Chemoselective Reaction To Create a Bright Blue Fluorescent Conjugate

(2010) Sungwook Choi et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Risk of transmission of systemic transthyretin amyloidosis after domino liver transplantation

(2010) Laura Lladó et al.   LIVER TRANSPLANTATION

Acquired amyloid neuropathy in a Portuguese patient after domino liver transplantation

(2010) Isabel Conceição et al.   MUSCLE & NERVE

Chemoselective small molecules that covalently modify one lysine in a non-enzyme protein in plasma

(2010) Sungwook Choi et al.   Nature Chemical Biology

Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1β in type 2 diabetes

(2010) Seth L Masters et al.   NATURE IMMUNOLOGY

Progression of transthyretin amyloid neuropathy after liver transplantation

(2010) J. J. Liepnieks et al.   NEUROLOGY

Amyloid β-Protein Aggregation Produces Highly Reproducible Kinetic Data and Occurs by a Two-Phase Process

(2009) Erik Hellstrand et al.   ACS Chemical Neuroscience

Biological and Chemical Approaches to Diseases of Proteostasis Deficiency

(2009) Evan T. Powers et al.   Annual Review of Biochemistry

The extracellular domain of Bri2 (ITM2B) binds the ABri peptide (1–23) and amyloid β-peptide (Aβ1–40): Implications for Bri2 effects on processing of amyloid precursor protein and Aβ aggregation

(2009) Siwei Peng et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Anti-Amyloid Activity of the C-Terminal Domain of proSP-C against Amyloid β-Peptide and Medin†

(2009) Charlotte Nerelius et al.   BIOCHEMISTRY

Reduced IGF-1 Signaling Delays Age-Associated Proteotoxicity in Mice

(2009) Ehud Cohen et al.   CELL

Toward Optimization of the Second Aryl Substructure Common to Transthyretin Amyloidogenesis Inhibitors Using Biochemical and Structural Studies†

(2009) Steven M. Johnson et al.   JOURNAL OF MEDICINAL CHEMISTRY

Preventing Amyloid Formation by Catching Unfolded Transmembrane Segments

(2009) H. Johansson et al.   JOURNAL OF MOLECULAR BIOLOGY

HIGHLY SELECTIVE LEPTOMENINGEAL AMYLOIDOSIS WITH TRANSTHYRETIN VARIANT ALA25THR

(2009) K. Hagiwara et al.   NEUROLOGY

Heterogeneity of penetrance in familial amyloid polyneuropathy, ATTR Val30Met, in the Swedish population

(2008) Urban Hellman et al.   AMYLOID-JOURNAL OF PROTEIN FOLDING DISORDERS

Engineering a Camelid Antibody Fragment That Binds to the Active Site of Human Lysozyme and Inhibits Its Conversion into Amyloid Fibrils†

(2008) Pak-Ho Chan et al.   BIOCHEMISTRY

Small Interfering RNA-Mediated Suppression of Proislet Amyloid Polypeptide Expression Inhibits Islet Amyloid Formation and Enhances Survival of Human Islets in Culture

(2008) L. Marzban et al.   DIABETES

Toward Optimization of the Linker Substructure Common to Transthyretin Amyloidogenesis Inhibitors Using Biochemical and Structural Studies†

(2008) Steven M. Johnson et al.   JOURNAL OF MEDICINAL CHEMISTRY

A new Thr49Pro transthyretin gene mutation associated with leptomeningeal amyloidosis

(2008) Kazuma Nakagawa et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Effect of liver transplantation on transthyretin Tyr114Cys-related cerebral amyloid angiopathy

(2008) T. Yamashita et al.   NEUROLOGY

Adapting Proteostasis for Disease Intervention

(2008) William E. Balch et al.   SCIENCE

Biochemical and Structural Evaluation of Highly Selective 2-Arylbenzoxazole-Based Transthyretin Amyloidogenesis Inhibitors

(2007) Steven M. Johnson et al.   JOURNAL OF MEDICINAL CHEMISTRY