Targeting Different Transthyretin Binding Sites with Unusual Natural Compounds

The polyphenol Oleuropein aglycone hinders the growth of toxic transthyretin amyloid assemblies

(2016) Manuela Leri et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Transthyretin Binding Heterogeneity and Anti-amyloidogenic Activity of Natural Polyphenols and Their Metabolites

(2015) Paola Florio et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Transthyretin complexes with curcumin and bromo-estradiol: evaluation of solubilizing multicomponent mixtures

(2015) Lidia Ciccone et al.   New Biotechnology

Discovery of γ-Mangostin as an Amyloidogenesis Inhibitor

(2015) Takeshi Yokoyama et al.   Scientific Reports

Inhibitory Activities of Propolis and Its Promising Component, Caffeic Acid Phenethyl Ester, against Amyloidogenesis of Human Transthyretin

(2014) Takeshi Yokoyama et al.   JOURNAL OF MEDICINAL CHEMISTRY

A Chemical–Biological Study Reveals C9-type Iridoids as Novel Heat Shock Protein 90 (Hsp90) Inhibitors

(2013) Fabrizio Dal Piaz et al.   JOURNAL OF MEDICINAL CHEMISTRY

Modulators of amyloid protein aggregation and toxicity: EGCG and CLR01

(2013) Aida Attar et al.   Translational Neuroscience

Modulating Self-Assembly of Amyloidogenic Proteins as a Therapeutic Approach for Neurodegenerative Diseases: Strategies and Mechanisms

(2012) Tingyu Liu et al.   ChemMedChem

Computational Studies on Transthyretin

(2012) G. Ortore et al.   CURRENT MEDICINAL CHEMISTRY

TTR Fibril Formation Inhibitors: Is there a SAR?

(2012)   CURRENT MEDICINAL CHEMISTRY

Transthyretin Deposition in Familial Amyloidotic Polyneuropathy

(2012) M. J. Saraiva et al.   CURRENT MEDICINAL CHEMISTRY

Clearance of extracellular misfolded proteins in systemic amyloidosis: Experience with transthyretin

(2012) Maria Rosário Almeida et al.   FEBS LETTERS

Plant and mammalian lignans: A review of source, intake, metabolism, intestinal bacteria and health

(2012) J.M. Landete   FOOD RESEARCH INTERNATIONAL

Flavonoid interactions with human transthyretin: Combined structural and thermodynamic analysis

(2012) Daniela B.B. Trivella et al.   JOURNAL OF STRUCTURAL BIOLOGY

Phenolic Derivatives from Ruprechtia polystachya and Their Inhibitory Activities on the Glucose-6-phosphatase System

(2011) Maryan Bruzual De Abreu et al.   CHEMISTRY & BIODIVERSITY

Natural polyphenols inhibit different steps of the process of transthyretin (TTR) amyloid fibril formation

(2011) Nelson Ferreira et al.   FEBS LETTERS

Diterpenes, ionol-derived, and flavone glycosides from Podocarpus elongatus

(2011) Laura Faiella et al.   PHYTOCHEMISTRY

The Crystal Structure of the Green Tea Polyphenol (−)-Epigallocatechin Gallate−Transthyretin Complex Reveals a Novel Binding Site Distinct from the Thyroxine Binding Site,

(2010) Masanori Miyata et al.   BIOCHEMISTRY

Structure-based design of kinetic stabilizers that ameliorate the transthyretin amyloidoses

(2010) Stephen Connelly et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Antitumor and immunoregulatory effects of astragalus on nasopharyngeal carcinoma In Vivo and In Vitro

(2010) Yan Song et al.   PHYTOTHERAPY RESEARCH

Binding of epigallocatechin-3-gallate to transthyretin modulates its amyloidogenicity

(2009) Nelson Ferreira et al.   FEBS LETTERS

Development of a receptor-based 3D-QSAR study for the analysis of MMP2, MMP3, and MMP9 inhibitors

(2008) Tiziano Tuccinardi et al.   BIOORGANIC & MEDICINAL CHEMISTRY