Ex Vivo Tumor-on-a-Chip Platforms to Study Intercellular Interactions within the Tumor Microenvironment

Organs-on-a-Chip: A Fast Track for Engineered Human Tissues in Drug Development

(2018) Kacey Ronaldson-Bouchard et al.   Cell Stem Cell

Approved CAR T cell therapies: ice bucket challenges on glaring safety risks and long-term impacts

(2018) Ping-Pin Zheng et al.   DRUG DISCOVERY TODAY

Microfluidic co-culture of pancreatic tumor spheroids with stellate cells as a novel 3D model for investigation of stroma-mediated cell motility and drug resistance

(2018) Ji-Hyun Lee et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

A compartmentalized microfluidic chip with crisscross microgrooves and electrophysiological electrodes for modeling the blood–retinal barrier

(2018) Jose Yeste et al.   LAB ON A CHIP

A microengineered human corneal epithelium-on-a-chip for eye drops mass transport evaluation

(2018) Devasier Bennet et al.   LAB ON A CHIP

A multiplexed microfluidic system for evaluation of dynamics of immune–tumor interactions

(2018) N. Moore et al.   LAB ON A CHIP

Understanding the tumor immune microenvironment (TIME) for effective therapy

(2018) Mikhail Binnewies et al.   NATURE MEDICINE

Inflamed neutrophils sequestered at entrapped tumor cells via chemotactic confinement promote tumor cell extravasation

(2018) Michelle B. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A microfluidics platform for combinatorial drug screening on cancer biopsies

(2018) Federica Eduati et al.   Nature Communications

Molecular signatures associated with tumor-specific immune response in melanoma patients treated with dendritic cell-based immunotherapy

(2018) Tamara García-Salum et al.   Oncotarget

Microfluidic Tumor-Vascular Model to Study Breast Cancer Cell Invasion and Intravasation

(2018) Supriya Nagaraju et al.   Advanced Healthcare Materials

How Biophysical Forces Regulate Human B Cell Lymphomas

(2018) F. Apoorva et al.   Cell Reports

A 3D Human Renal Cell Carcinoma-on-a-Chip for the Study of Tumor Angiogenesis

(2018) Chris P. Miller et al.   NEOPLASIA

TIME (Tumor Immunity in the MicroEnvironment) classification based on tumor CD274 (PD-L1) expression status and tumor-infiltrating lymphocytes in colorectal carcinomas

(2018) Tsuyoshi Hamada et al.   OncoImmunology

3D microfluidic ex vivo culture of organotypic tumor spheroids to model immune checkpoint blockade

(2018) Amir R. Aref et al.   LAB ON A CHIP

A linked organ-on-chip model of the human neurovascular unit reveals the metabolic coupling of endothelial and neuronal cells

(2018) Ben M Maoz et al.   NATURE BIOTECHNOLOGY

Interconnected Microphysiological Systems for Quantitative Biology and Pharmacology Studies

(2018) Collin D. Edington et al.   Scientific Reports

Organs-on-chips: Progress, challenges, and future directions

(2017) Lucie A Low et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Tumour-on-a-chip: microfluidic models of tumour morphology, growth and microenvironment

(2017) Hsieh-Fu Tsai et al.   Journal of the Royal Society Interface

Skeletal muscle-on-a-chip: an in vitro model to evaluate tissue formation and injury

(2017) Gaurav Agrawal et al.   LAB ON A CHIP

Multisensor-integrated organs-on-chips platform for automated and continual in situ monitoring of organoid behaviors

(2017) Yu Shrike Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tumor Evolution as a Therapeutic Target

(2017) Nabil Amirouchene-Angelozzi et al.   Cancer Discovery

Ex Vivo Profiling of PD-1 Blockade Using Organotypic Tumor Spheroids

(2017) Russell W. Jenkins et al.   Cancer Discovery

Organs on chip approach: a tool to evaluate cancer -immune cells interactions

(2017) Elena Biselli et al.   Scientific Reports

A novel microfluidic 3D platform for culturing pancreatic ductal adenocarcinoma cells: comparison with in vitro cultures and in vivo xenografts

(2017) Meike Beer et al.   Scientific Reports

Organ-On-A-Chip Platforms: A Convergence of Advanced Materials, Cells, and Microscale Technologies

(2017) Samad Ahadian et al.   Advanced Healthcare Materials

Biomimetic Model of Tumor Microenvironment on Microfluidic Platform

(2017) Minhwan Chung et al.   Advanced Healthcare Materials

3D Microfluidic model for evaluating immunotherapy efficacy by tracking dendritic cell behaviour toward tumor cells

(2017) Stefania Parlato et al.   Scientific Reports

A Microdevice Platform Recapitulating Hypoxic Tumor Microenvironments

(2017) Yuta Ando et al.   Scientific Reports

Functional coupling of human pancreatic islets and liver spheroids on-a-chip: Towards a novel human ex vivo type 2 diabetes model

(2017) Sophie Bauer et al.   Scientific Reports

CTLA-4 and PD-1 Pathways

(2016) Elizabeth I. Buchbinder et al.   AMERICAN JOURNAL OF CLINICAL ONCOLOGY-CANCER CLINICAL TRIALS

In situ , dual-mode monitoring of organ-on-a-chip with smartphone-based fluorescence microscope

(2016) Soohee Cho et al.   BIOSENSORS & BIOELECTRONICS

Microfluidic blood-brain barrier model provides in vivo-like barrier properties for drug permeability screening

(2016) Ying I. Wang et al.   BIOTECHNOLOGY AND BIOENGINEERING

Beating heart on a chip: a novel microfluidic platform to generate functional 3D cardiac microtissues

(2016) Anna Marsano et al.   LAB ON A CHIP

3D cardiac μtissues within a microfluidic device with real-time contractile stress readout

(2016) Aereas Aung et al.   LAB ON A CHIP

Micro-dissected tumor tissues on chip: an ex vivo method for drug testing and personalized therapy

(2016) M. Astolfi et al.   LAB ON A CHIP

In vitro micro-physiological immune-competent model of the human skin

(2016) Qasem Ramadan et al.   LAB ON A CHIP

Modular, pumpless body-on-a-chip platform for the co-culture of GI tract epithelium and 3D primary liver tissue

(2016) Mandy B. Esch et al.   LAB ON A CHIP

Chemotaxis-driven assembly of endothelial barrier in a tumor-on-a-chip platform

(2016) Aereas Aung et al.   LAB ON A CHIP

Mutations Associated with Acquired Resistance to PD-1 Blockade in Melanoma

(2016) Jesse M. Zaretsky et al.   NEW ENGLAND JOURNAL OF MEDICINE

Microfluidic cell chips for high-throughput drug screening

(2016) Chun-Wei Chi et al.   Bioanalysis

Personalized Oncology Meets Immunology: The Path toward Precision Immunotherapy

(2016) R. Mandal et al.   Cancer Discovery

Engineering a Brain Cancer Chip for High-throughput Drug Screening

(2016) Yantao Fan et al.   Scientific Reports

Breast Cancer Cell Invasion into a Three Dimensional Tumor-Stroma Microenvironment

(2016) Danh Truong et al.   Scientific Reports

Angiogenesis in Liquid Tumors: An In Vitro Assay for Leukemic-Cell-Induced Bone Marrow Angiogenesis

(2016) Yi Zheng et al.   Advanced Healthcare Materials

Skin Diseases Modeling using Combined Tissue Engineering and Microfluidic Technologies

(2016) Mohammad Hossein Mohammadi et al.   Advanced Healthcare Materials

An Engineered Breast Cancer Model on a Chip to Replicate ECM-Activation In Vitro during Tumor Progression

(2016) Filomena Gioiella et al.   Advanced Healthcare Materials

Multi-analyte biosensor interface for real-time monitoring of 3D microtissue spheroids in hanging-drop networks

(2016) Patrick M. Misun et al.   Microsystems & Nanoengineering

Distinct Contributions of Astrocytes and Pericytes to Neuroinflammation Identified in a 3D Human Blood-Brain Barrier on a Chip

(2016) Anna Herland et al.   PLoS One

Immune Checkpoint Blockade to Improve Tumor Infiltrating Lymphocytes for Adoptive Cell Therapy

(2016) Krithika N. Kodumudi et al.   PLoS One

Co-Culture of Tumor Spheroids and Fibroblasts in a Collagen Matrix-Incorporated Microfluidic Chip Mimics Reciprocal Activation in Solid Tumor Microenvironment

(2016) Su-Yeong Jeong et al.   PLoS One

Human Vascular Microphysiological System for in vitro Drug Screening

(2016) C. E. Fernandez et al.   Scientific Reports

Microfluidic co-culture system for cancer migratory analysis and anti-metastatic drugs screening

(2016) Shengli Mi et al.   Scientific Reports

Skin-on-a-chip model simulating inflammation, edema and drug-based treatment

(2016) Maierdanjiang Wufuer et al.   Scientific Reports

Retina-on-a-chip: a microfluidic platform for point access signaling studies

(2015) Kirsten H. Dodson et al.   BIOMEDICAL MICRODEVICES

Recreating blood-brain barrier physiology and structure on chip: A novel neurovascular microfluidic bioreactor

(2015) Jacquelyn A. Brown et al.   Biomicrofluidics

Chip-based human liver–intestine and liver–skin co-cultures – A first step toward systemic repeated dose substance testing in vitro

(2015) Ilka Maschmeyer et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Human-on-a-chip design strategies and principles for physiologically based pharmacokinetics/pharmacodynamics modeling

(2015) Hasan Erbil Abaci et al.   Integrative Biology

Microfluidic devices for construction of contractile skeletal muscle microtissues

(2015) Kazunori Shimizu et al.   JOURNAL OF BIOSCIENCE AND BIOENGINEERING

Towards personalized medicine: chemosensitivity assays of patient lung cancer cell spheroids in a perfused microfluidic platform

(2015) Janine Ruppen et al.   LAB ON A CHIP

A four-organ-chip for interconnected long-term co-culture of human intestine, liver, skin and kidney equivalents

(2015) Ilka Maschmeyer et al.   LAB ON A CHIP

Pumpless microfluidic platform for drug testing on human skin equivalents

(2015) Hasan Erbil Abaci et al.   LAB ON A CHIP

Artery-on-a-chip platform for automated, multimodal assessment of cerebral blood vessel structure and function

(2015) Sanjesh Yasotharan et al.   LAB ON A CHIP

Seeking the right context for evaluating nanomedicine: from tissue models in petri dishes to microfluidic organs-on-a-chip

(2015) Yu Shrike Zhang et al.   Nanomedicine

Chemotherapy-induced antitumor immunity requires formyl peptide receptor 1

(2015) E. Vacchelli et al.   SCIENCE

Embedded 3D Photopatterning of Hydrogels with Diverse and Complex Architectures for Tissue Engineering and Disease Models

(2015) Shruti Krishna Davey et al.   TISSUE ENGINEERING PART C-METHODS

Paclitaxel induces apoptosis and reduces proliferation by targeting epidermal growth factor receptor signaling pathway in oral cavity squamous cell carcinoma

(2015) JING HU et al.   Oncology Letters

Three-dimensional matrix fiber alignment modulates cell migration and MT1-MMP utility by spatially and temporally directing protrusions

(2015) Stephanie I. Fraley et al.   Scientific Reports

A Novel Dynamic Neonatal Blood-Brain Barrier on a Chip

(2015) Sudhir P. Deosarkar et al.   PLoS One

IRF-8 Controls Melanoma Progression by Regulating the Cross Talk between Cancer and Immune Cells within the Tumor Microenvironment

(2015) Fabrizio Mattei et al.   NEOPLASIA

How multi-organ microdevices can help foster drug development

(2014) Mandy B. Esch et al.   ADVANCED DRUG DELIVERY REVIEWS

A microfluidic co-culture system to monitor tumor-stromal interactions on a chip

(2014) Nishanth V. Menon et al.   Biomicrofluidics

3D Traction Stresses Activate Protease-Dependent Invasion of Cancer Cells

(2014) Aereas Aung et al.   BIOPHYSICAL JOURNAL

The extracellular matrix modulates the hallmarks of cancer

(2014) M. W. Pickup et al.   EMBO REPORTS

A three-dimensional in vitro model of tumor cell intravasation

(2014) Seema M. Ehsan et al.   Integrative Biology

A multidisciplinary study usingin vivotumor models and microfluidic cell-on-chip approach to explore the cross-talk between cancer and immune cells

(2014) Fabrizio Mattei et al.   Journal of Immunotoxicology

Body-on-a-chip simulation with gastrointestinal tract and liver tissues suggests that ingested nanoparticles have the potential to cause liver injury

(2014) Mandy B. Esch et al.   LAB ON A CHIP

Microfluidic organs-on-chips

(2014) Sangeeta N Bhatia et al.   NATURE BIOTECHNOLOGY

A Bioartificial Renal Tubule Device Embedding Human Renal Stem/Progenitor Cells

(2014) Anna Giovanna Sciancalepore et al.   PLoS One

Human 3D vascularized organotypic microfluidic assays to study breast cancer cell extravasation

(2014) Jessie S. Jeon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cancer-driven dynamics of immune cells in a microfluidic environment

(2014) Elena Agliari et al.   Scientific Reports

Engineering Challenges for Instrumenting and Controlling Integrated Organ-on-Chip Systems

(2013) J. P. Wikswo et al.   IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING

Human kidney proximal tubule-on-a-chip for drug transport and nephrotoxicity assessment

(2013) Kyung-Jin Jang et al.   Integrative Biology

Mechanisms of tumor cell extravasation in an in vitro microvascular network platform

(2013) Michelle B. Chen et al.   Integrative Biology

Scalable alignment of three-dimensional cellular constructs in a microfluidic chip

(2013) Chukwuemeka George Anene-Nzelu et al.   LAB ON A CHIP

Clear castable polyurethane elastomer for fabrication of microfluidic devices

(2013) Karel Domansky et al.   LAB ON A CHIP

Accelerating drug discovery via organs-on-chips

(2013) Chung Yu Chan et al.   LAB ON A CHIP

Skin and hair on-a-chip: in vitro skin models versus ex vivo tissue maintenance with dynamic perfusion

(2013) Beren Ataç et al.   LAB ON A CHIP

Chip-based liver equivalents for toxicity testing – organotypicalness versus cost-efficient high throughput

(2013) Eva-Maria Materne et al.   LAB ON A CHIP

Engineering of functional, perfusable 3D microvascular networks on a chip

(2013) Sudong Kim et al.   LAB ON A CHIP

Comparison of Biocompatibility and Adsorption Properties of Different Plastics for Advanced Microfluidic Cell and Tissue Culture Models

(2012) Paul M. van Midwoud et al.   ANALYTICAL CHEMISTRY

Quantitative Analysis of Molecular Absorption into PDMS Microfluidic Channels

(2012) Jack D. Wang et al.   ANNALS OF BIOMEDICAL ENGINEERING

BBB ON CHIP: microfluidic platform to mechanically and biochemically modulate blood-brain barrier function

(2012) L. M. Griep et al.   BIOMEDICAL MICRODEVICES

Tumor Microenvironment Complexity: Emerging Roles in Cancer Therapy

(2012) M. A. Swartz et al.   CANCER RESEARCH

Human gut-on-a-chip inhabited by microbial flora that experiences intestinal peristalsis-like motions and flow

(2012) Hyun Jung Kim et al.   LAB ON A CHIP

Cross talk between cancer and immune cells: exploring complex dynamics in a microfluidic environment

(2012) Luca Businaro et al.   LAB ON A CHIP

SyM-BBB: a microfluidic blood brain barrier model

(2012) Balabhaskar Prabhakarpandian et al.   LAB ON A CHIP

A modular approach to create a neurovascular unit-on-a-chip

(2012) Anil Kumar H. Achyuta et al.   LAB ON A CHIP

Three-dimensional microfluidic model for tumor cell intravasation and endothelial barrier function

(2012) I. K. Zervantonakis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pancreatic stellate cells: a starring role in normal and diseased pancreas

(2012) Minoti V. Apte et al.   Frontiers in Physiology

Basic Structure and Cell Culture Condition of a Bioartificial Renal Tubule on Chip towards a Cell-based Separation Microdevice

(2011) Xiaofang GAO et al.   ANALYTICAL SCIENCES

Albumin handling by renal tubular epithelial cells in a microfluidic bioreactor

(2011) Nicholas Ferrell et al.   BIOTECHNOLOGY AND BIOENGINEERING

Analysis of transcriptomic and proteomic profiles demonstrates improved Madin-Darby canine kidney cell function in a renal microfluidic biochip

(2011) Leila Choucha Snouber et al.   BIOTECHNOLOGY PROGRESS

Cancer Invasion and the Microenvironment: Plasticity and Reciprocity

(2011) Peter Friedl et al.   CELL

Remodeling and homeostasis of the extracellular matrix: implications for fibrotic diseases and cancer

(2011) T. R. Cox et al.   Disease Models & Mechanisms

The migration speed of cancer cells influenced by macrophages and myofibroblasts co-cultured in a microfluidic chip

(2011) Tsi-Hsuan Hsu et al.   Integrative Biology

Ensembles of engineered cardiac tissues for physiological and pharmacological study: Heart on a chip

(2011) Anna Grosberg et al.   LAB ON A CHIP

Biocompatibility and Reduced Drug Absorption of Sol−Gel-Treated Poly(dimethyl siloxane) for Microfluidic Cell Culture Applications

(2010) Rafael Gomez-Sjoberg et al.   ANALYTICAL CHEMISTRY

Osteoarthritic chondrocyte-secreted morphogens induce chondrogenic differentiation of human mesenchymal stem cells

(2010) Aereas Aung et al.   ARTHRITIS AND RHEUMATISM

Reconstituting Organ-Level Lung Functions on a Chip

(2010) D. Huh et al.   SCIENCE

Engineering Musculoskeletal Tissues with Human Embryonic Germ Cell Derivatives

(2010) Shyni Varghese et al.   STEM CELLS

Engineering an artificial alveolar-capillary membrane: a novel continuously perfused model within microchannels

(2009) Divya D. Nalayanda et al.   JOURNAL OF PEDIATRIC SURGERY

Towards a human-on-chip: Culturing multiple cell types on a chip with compartmentalized microenvironments

(2009) Chi Zhang et al.   LAB ON A CHIP

A microfluidic 3D hepatocyte chip for drug toxicity testing

(2009) Yi-Chin Toh et al.   LAB ON A CHIP

Integration and application of vitrified collagen in multilayered microfluidic devices for corneal microtissue culture

(2009) Christopher M. Puleo et al.   LAB ON A CHIP