Modular, pumpless body-on-a-chip platform for the co-culture of GI tract epithelium and 3D primary liver tissue

A four-organ-chip for interconnected long-term co-culture of human intestine, liver, skin and kidney equivalents

(2015) Ilka Maschmeyer et al.   LAB ON A CHIP

Multi-cellular 3D human primary liver cell culture elevates metabolic activity under fluidic flow

(2015) Mandy B. Esch et al.   LAB ON A CHIP

Bioreactor technologies to support liver function in vitro

(2014) Mohammad R. Ebrahimkhani et al.   ADVANCED DRUG DELIVERY REVIEWS

How multi-organ microdevices can help foster drug development

(2014) Mandy B. Esch et al.   ADVANCED DRUG DELIVERY REVIEWS

First pass intestinal and liver metabolism of paracetamol in a microfluidic platform coupled with a mathematical modeling as a means of evaluating ADME processes in humans

(2014) Jean Matthieu Prot et al.   BIOTECHNOLOGY AND BIOENGINEERING

Three dimensional human small intestine models for ADME-Tox studies

(2014) Jiajie Yu et al.   DRUG DISCOVERY TODAY

Body-on-a-chip simulation with gastrointestinal tract and liver tissues suggests that ingested nanoparticles have the potential to cause liver injury

(2014) Mandy B. Esch et al.   LAB ON A CHIP

3-D Intestinal Scaffolds for Evaluating the Therapeutic Potential of Probiotics

(2014) Cait M. Costello et al.   MOLECULAR PHARMACEUTICS

Inflammatory findings on species extrapolations: humans are definitely no 70-kg mice

(2013) Marcel Leist et al.   ARCHIVES OF TOXICOLOGY

Phase II and Phase III attrition rates 2011–2012

(2013) John Arrowsmith et al.   NATURE REVIEWS DRUG DISCOVERY

Genomic responses in mouse models poorly mimic human inflammatory diseases

(2013) Junhee Seok et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A long-term three dimensional liver co-culture system for improved prediction of clinically relevant drug-induced hepatotoxicity

(2013) Radina Kostadinova et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

On chip porous polymer membranes for integration of gastrointestinal tract epithelium with microfluidic ‘body-on-a-chip’ devices

(2012) Mandy Brigitte Esch et al.   BIOMEDICAL MICRODEVICES

Investigation of ifosfamide nephrotoxicity induced in a liver-kidney co-culture biochip

(2012) Leila Choucha-Snouber et al.   BIOTECHNOLOGY AND BIOENGINEERING

In vitro 3D human small intestinal villous model for drug permeability determination

(2012) Jiajie Yu et al.   BIOTECHNOLOGY AND BIOENGINEERING

Human gut-on-a-chip inhabited by microbial flora that experiences intestinal peristalsis-like motions and flow

(2012) Hyun Jung Kim et al.   LAB ON A CHIP

Reinventing clinical trials

(2012) Malorye Allison   NATURE BIOTECHNOLOGY

LIFE SCIENCE TECHNOLOGIES: Animal-Free Toxicology: Sometimes, in Vitro is Better

(2012) J. M. Perkel   SCIENCE

First-Pass Metabolism via UDP-Glucuronosyltransferase: a Barrier to Oral Bioavailability of Phenolics

(2011) Baojian Wu et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Phase II failures: 2008–2010

(2011) John Arrowsmith   NATURE REVIEWS DRUG DISCOVERY

Ethical and Scientific Considerations Regarding Animal Testing and Research

(2011) Hope R. Ferdowsian et al.   PLoS One

Predictive toxicology using systemic biology and liver microfluidic “on chip” approaches: Application to acetaminophen injury

(2011) Jean-Matthieu Prot et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

A microfluidic device for a pharmacokinetic–pharmacodynamic (PK–PD) model on a chip

(2010) Jong Hwan Sung et al.   LAB ON A CHIP

Characterization of a gastrointestinal tract microscale cell culture analog used to predict drug toxicity

(2009) Gretchen J. Mahler et al.   BIOTECHNOLOGY AND BIOENGINEERING

Quantification of chemical-polymer surface interactions in microfluidic cell culture devices

(2009) Hui Xu et al.   BIOTECHNOLOGY PROGRESS

Towards a human-on-chip: Culturing multiple cell types on a chip with compartmentalized microenvironments

(2009) Chi Zhang et al.   LAB ON A CHIP

Survey of the Quality of Experimental Design, Statistical Analysis and Reporting of Research Using Animals

(2009) Carol Kilkenny et al.   PLoS One

A novel system for evaluation of drug mixtures for potential efficacy in treating multidrug resistant cancers

(2008) Daniel A. Tatosian et al.   BIOTECHNOLOGY AND BIOENGINEERING

Characterization of Caco-2 and HT29-MTX cocultures in an in vitro digestion/cell culture model used to predict iron bioavailability☆

(2008) Gretchen J. Mahler et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Development of a Microscale Cell Culture Analog To Probe Naphthalene Toxicity

(2004) Kwanchanok Viravaidya et al.   BIOTECHNOLOGY PROGRESS

Incorporation of 3T3-L1 Cells To Mimic Bioaccumulation in a Microscale Cell Culture Analog Device for Toxicity Studies

(2004) Kwanchanok Viravaidya et al.   BIOTECHNOLOGY PROGRESS