3D Microfluidic model for evaluating immunotherapy efficacy by tracking dendritic cell behaviour toward tumor cells

Immunotherapy and tumor microenvironment

(2016) Haidong Tang et al.   CANCER LETTERS

Dendritic Cells in the Context of Human Tumors: Biology and Experimental Tools

(2016) Ilan Volovitz et al.   INTERNATIONAL REVIEWS OF IMMUNOLOGY

Study of dendritic cell migration using micro-fabrication

(2016) Pablo Vargas et al.   JOURNAL OF IMMUNOLOGICAL METHODS

Identification and characterization of human dendritic cell subsets in the steady state: a review of our current knowledge

(2016) Vineet Indrajit Patel et al.   JOURNAL OF INVESTIGATIVE MEDICINE

Therapy-induced microenvironmental changes in cancer

(2016) Yuting Ma et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Cell stretching devices as research tools: engineering and biological considerations

(2016) Harshad Kamble et al.   LAB ON A CHIP

Take two: Combining immunotherapy with epigenetic drugs to tackle cancer

(2016) Karen Weintraub   NATURE MEDICINE

Antitumor dendritic cell–based vaccines: lessons from 20 years of clinical trials and future perspectives

(2016) João Constantino et al.   Translational Research

IFN-α potentiates the direct and immune-mediated antitumor effects of epigenetic drugs on both metastatic and stem cells of colorectal cancer

(2016) Maria Buoncervello et al.   Oncotarget

Human CD1c+ DCs are critical cellular mediators of immune responses induced by immunogenic cell death

(2016) Stefania Di Blasio et al.   OncoImmunology

Quantitative Study of Cell Invasion Process under Extracellular Stimulation of Cytokine in a Microfluidic Device

(2016) Kin Fong Lei et al.   Scientific Reports

Engineered In Vitro Disease Models

(2015) Kambez H. Benam et al.   Annual Review of Pathology-Mechanisms of Disease

Role of type I interferon in inducing a protective immune response: Perspectives for clinical applications

(2015) Paola Rizza et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Intratumoral injection of IFN-alpha dendritic cells after dacarbazine activates anti-tumor immunity: results from a phase I trial in advanced melanoma

(2015) Carmela Rozera et al.   Journal of Translational Medicine

A microengineered pathophysiological model of early-stage breast cancer

(2015) Yoonseok Choi et al.   LAB ON A CHIP

‘Organs-on-chips’ go mainstream

(2015) Sara Reardon   NATURE

Innate control of actin nucleation determines two distinct migration behaviours in dendritic cells

(2015) Pablo Vargas et al.   NATURE CELL BIOLOGY

Organs-on-chips at the frontiers of drug discovery

(2015) Eric W. Esch et al.   NATURE REVIEWS DRUG DISCOVERY

Chemotherapy-induced antitumor immunity requires formyl peptide receptor 1

(2015) E. Vacchelli et al.   SCIENCE

Ubiquitin-dependent endocytosis of NKG2D-DAP10 receptor complexes activates signaling and functions in human NK cells

(2015) Linda Quatrini et al.   Science Signaling

Local 3D matrix microenvironment regulates cell migration through spatiotemporal dynamics of contractility-dependent adhesions

(2015) Andrew D. Doyle et al.   Nature Communications

Ubiquitin-dependent endocytosis of NKG2D-DAP10 receptor complexes activates signaling and functions in human NK cells

(2015) Linda Quatrini et al.   Science Signaling

Augmenting Antitumor Immune Responses with Epigenetic Modifying Agents

(2015) Erika Héninger et al.   Frontiers in Immunology

Loss of Gadkin Affects Dendritic Cell Migration In Vitro

(2015) Hannah Schachtner et al.   PLoS One

IRF-8 Controls Melanoma Progression by Regulating the Cross Talk between Cancer and Immune Cells within the Tumor Microenvironment

(2015) Fabrizio Mattei et al.   NEOPLASIA

Serum amyloid A chemoattracts immature dendritic cells and indirectly provokes monocyte chemotaxis by induction of cooperating CC and CXC chemokines

(2014) Mieke Gouwy et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Migration of dendritic cells: physical principles, molecular mechanisms, and functional implications

(2014) Mélina L. Heuzé et al.   IMMUNOLOGICAL REVIEWS

Microfluidic single-cell analysis for systems immunology

(2014) Michael Junkin et al.   LAB ON A CHIP

The present and future role of microfluidics in biomedical research

(2014) Eric K. Sackmann et al.   NATURE

Taking the lymphatic route: dendritic cell migration to draining lymph nodes

(2014) Alvaro Teijeira et al.   Seminars in Immunopathology

Microfluidic platform for the quantitative analysis of leukocyte migration signatures

(2014) Leo Boneschansker et al.   Nature Communications

Cancer-driven dynamics of immune cells in a microfluidic environment

(2014) Elena Agliari et al.   Scientific Reports

Antitumor immune responses mediated by dendritic cells: How signals derived from dying cancer cells drive antigen cross-presentation

(2014) Lotte Spel et al.   OncoImmunology

Human-on-chip for therapy development and fundamental science

(2013) Camilla Luni et al.   CURRENT OPINION IN BIOTECHNOLOGY

Exploiting dendritic cells in the development of cancer vaccines

(2013) Laura Bracci et al.   Expert Review of Vaccines

Mechanisms of tumor cell extravasation in an in vitro microvascular network platform

(2013) Michelle B. Chen et al.   Integrative Biology

Dendritic Cell Interactions with Lymphatic Endothelium

(2013) Erica Russo et al.   Lymphatic Research and Biology

IFN-α Regulates Blimp-1 Expression via miR-23a and miR-125b in Both Monocytes-Derived DC and pDC

(2013) Stefania Parlato et al.   PLoS One

Dendritic Cells: Master Regulators of the Immune Response

(2013) I. Mellman   Cancer Immunology Research

ATP-dependent recruitment, survival and differentiation of dendritic cell precursors in the tumor bed after anticancer chemotherapy

(2013) Yuting Ma et al.   OncoImmunology

Cross talk between cancer and immune cells: exploring complex dynamics in a microfluidic environment

(2012) Luca Businaro et al.   LAB ON A CHIP

Microfluidic assay for simultaneous culture of multiple cell types on surfaces or within hydrogels

(2012) Yoojin Shin et al.   Nature Protocols

IFN-  enhances cross-presentation in human dendritic cells by modulating antigen survival, endocytic routing, and processing

(2011) F. Spadaro et al.   BLOOD

Chemokines, costimulatory molecules and fusion proteins for the immunotherapy of solid tumors

(2011) Melissa G Lechner et al.   Immunotherapy

From 3D cell culture to organs-on-chips

(2011) Dongeun Huh et al.   TRENDS IN CELL BIOLOGY

Human CD141+(BDCA-3)+dendritic cells (DCs) represent a unique myeloid DC subset that cross-presents necrotic cell antigens

(2010) Sarah L. Jongbloed et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Spontaneous Regression of Highly Immunogenic Molluscum contagiosum Virus (MCV)-Induced Skin Lesions Is Associated with Plasmacytoid Dendritic Cells and IFN-DC Infiltration

(2010) William Vermi et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Confinement-optimized three-dimensional T cell amoeboid motility is modulated via myosin IIA–regulated adhesions

(2010) Jordan Jacobelli et al.   NATURE IMMUNOLOGY

Soft lithography for micro- and nanoscale patterning

(2010) Dong Qin et al.   Nature Protocols

Reconstituting Organ-Level Lung Functions on a Chip

(2010) D. Huh et al.   SCIENCE

LOX-1 as a natural IFN- -mediated signal for apoptotic cell uptake and antigen presentation in dendritic cells

(2009) S. Parlato et al.   BLOOD

Mechanical modes of ‘amoeboid’ cell migration

(2009) Tim Lämmermann et al.   CURRENT OPINION IN CELL BIOLOGY

Collagen-based cell migration models in vitro and in vivo

(2009) Katarina Wolf et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY