Functional coupling of human pancreatic islets and liver spheroids on-a-chip: Towards a novel human ex vivo type 2 diabetes model

Opportunities and challenges in the wider adoption of liver and interconnected microphysiological systems

(2017) David J Hughes et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

3D-templated, fully automated microfluidic input/output multiplexer for endocrine tissue culture and secretion sampling

(2017) Xiangpeng Li et al.   LAB ON A CHIP

Three-dimensional perfused human in vitro model of non-alcoholic fatty liver disease

(2017) Tomasz Kostrzewski et al.   WORLD JOURNAL OF GASTROENTEROLOGY

A microfluidic culture model of the human reproductive tract and 28-day menstrual cycle

(2017) Shuo Xiao et al.   Nature Communications

Design and demonstration of a pumpless 14 compartment microphysiological system

(2016) Paula G. Miller et al.   BIOTECHNOLOGY AND BIOENGINEERING

Identification of proliferative and mature β-cells in the islets of Langerhans

(2016) Erik Bader et al.   NATURE

Advantageous use of HepaRG cells for the screening and mechanistic study of drug-induced steatosis

(2016) Laia Tolosa et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Biology-inspired microphysiological system approaches to solve the prediction dilemma of substance testing

(2016) Uwe Marx   ALTEX-Alternatives to Animal Experimentation

Of rodents and men: Species-specific glucose regulation and type 2 diabetes research

(2016) P. Charukeshi Chandrasekera   ALTEX-Alternatives to Animal Experimentation

Multi-Organ toxicity demonstration in a functional human in vitro system composed of four organs

(2016) Carlota Oleaga et al.   Scientific Reports

Characterization of primary human hepatocyte spheroids as a model system for drug-induced liver injury, liver function and disease

(2016) Catherine C. Bell et al.   Scientific Reports

Three-dimensional (3D) spheroid cultures improve the metabolic gene expression profiles of HepaRG cells

(2015) Yu Takahashi et al.   BIOSCIENCE REPORTS

Endothelial Cell Metabolism in Normal and Diseased Vasculature

(2015) Guy Eelen et al.   CIRCULATION RESEARCH

Chip-based human liver–intestine and liver–skin co-cultures – A first step toward systemic repeated dose substance testing in vitro

(2015) Ilka Maschmeyer et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

A multi-organ chip co-culture of neurospheres and liver equivalents for long-term substance testing

(2015) Eva-Maria Materne et al.   JOURNAL OF BIOTECHNOLOGY

A four-organ-chip for interconnected long-term co-culture of human intestine, liver, skin and kidney equivalents

(2015) Ilka Maschmeyer et al.   LAB ON A CHIP

Small airway-on-a-chip enables analysis of human lung inflammation and drug responses in vitro

(2015) Kambez H Benam et al.   NATURE METHODS

Organs-on-chips at the frontiers of drug discovery

(2015) Eric W. Esch et al.   NATURE REVIEWS DRUG DISCOVERY

Hormone and Drug-Mediated Modulation of Glucose Metabolism in a Microscale Model of the Human Liver

(2015) Matthew D. Davidson et al.   TISSUE ENGINEERING PART C-METHODS

Improved physiological properties of gravity-enforced reassembled rat and human pancreatic pseudo-islets

(2014) R. A. Zuellig et al.   Journal of Tissue Engineering and Regenerative Medicine

Metabolism of stromal and immune cells in health and disease

(2014) Bart Ghesquière et al.   NATURE

The role of hepatic lipids in hepatic insulin resistance and type 2 diabetes

(2014) Rachel J. Perry et al.   NATURE

Diagnosis and Classification of Diabetes Mellitus

(2013)   DIABETES CARE

Integrating biological vasculature into a multi-organ-chip microsystem

(2013) Katharina Schimek et al.   LAB ON A CHIP

A dynamic multi-organ-chip for long-term cultivation and substance testing proven by 3D human liver and skin tissue co-culture

(2013) Ilka Wagner et al.   LAB ON A CHIP

Chip-based liver equivalents for toxicity testing – organotypicalness versus cost-efficient high throughput

(2013) Eva-Maria Materne et al.   LAB ON A CHIP

Metabolomic signatures in lipid-loaded HepaRGs reveal pathways involved in steatotic progression

(2013) Meredith V. Brown et al.   Obesity

3D Organotypic Cultures of Human HepaRG Cells: A Tool for In Vitro Toxicity Studies

(2013) Patrina Gunness et al.   TOXICOLOGICAL SCIENCES

The HepaRG cell line: a uniquein vitrotool for understanding drug metabolism and toxicology in human

(2012) Tommy B Andersson et al.   Expert Opinion on Drug Metabolism & Toxicology

The human hepatocyte cell lines IHH and HepaRG: models to study glucose, lipid and lipoprotein metabolism

(2012) Carolina Huaman Samanez et al.   ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY

Culturing Pancreatic Islets in Microfluidic Flow Enhances Morphology of the Associated Endothelial Cells

(2011) Krishana S. Sankar et al.   PLoS One

Reconstituting Organ-Level Lung Functions on a Chip

(2010) D. Huh et al.   SCIENCE

Role of the kidney in normal glucose homeostasis and in the hyperglycaemia of diabetes mellitus: therapeutic implications

(2009) J. E. Gerich   DIABETIC MEDICINE

Microfluidic device for multimodal characterization of pancreatic islets

(2008) Javeed Shaikh Mohammed et al.   LAB ON A CHIP