The NaV1.7 Channel Subtype as an Antinociceptive Target for Spider Toxins in Adult Dorsal Root Ganglia Neurons

Gating modifier toxins isolated from spider venom: Modulation of voltage-gated sodium channels and the role of lipid membranes

(2018) Akello J. Agwa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Drug Distribution into Peripheral Nerve

(2018) Houfu Liu et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Variable epilepsy phenotypes associated with heterozygous mutation in the SCN9A gene: report of two cases

(2018) Cuiwei Yang et al.   NEUROLOGICAL SCIENCES

Direct evidence for high affinity blockade of Na V 1.6 channel subtype by huwentoxin-IV spider peptide, using multiscale functional approaches

(2018) Tânia C. Gonçalves et al.   NEUROPHARMACOLOGY

A complicated complex: Ion channels, voltage sensing, cell membranes and peptide inhibitors

(2018) Alan H. Zhang et al.   NEUROSCIENCE LETTERS

Pharmacological characterization of potent and selective NaV1.7 inhibitors engineered from Chilobrachys jingzhao tarantula venom peptide JzTx-V

(2018) Bryan D. Moyer et al.   PLoS One

Na V 1.7 as a Pharmacogenomic Target for Pain: Moving Toward Precision Medicine

(2018) Yang Yang et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Addressing the Opioid Crisis: The Importance of Choosing Translational Endpoints in Analgesic Drug Discovery

(2018) S. Stevens Negus   TRENDS IN PHARMACOLOGICAL SCIENCES

Selective Closed-State Nav1.7 Blocker JZTX-34 Exhibits Analgesic Effects against Pain

(2018) Xiongzhi Zeng et al.   Toxins

Targeting dorsal root ganglia and primary sensory neurons for the treatment of chronic pain

(2017) Temugin Berta et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Sodium channel NaV1.9 mutations associated with insensitivity to pain dampen neuronal excitability

(2017) Jianying Huang et al.   JOURNAL OF CLINICAL INVESTIGATION

Gain-of-function mutation p.Arg225Cys in SCN11A causes familial episodic pain and contributes to essential tremor

(2017) Xue-Rong Leng et al.   JOURNAL OF HUMAN GENETICS

The NAv1.7 blocker protoxin II reduces burn injury-induced spinal nociceptive processing

(2017) Jose Vicente Torres-Pérez et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Molecular Characterization of Voltage-Gated Sodium Channels and Their Relations with Paralytic Shellfish Toxin Bioaccumulation in the Pacific Oyster Crassostrea gigas

(2017) Floriane Boullot et al.   Marine Drugs

Breaking barriers to novel analgesic drug development

(2017) Ajay S. Yekkirala et al.   NATURE REVIEWS DRUG DISCOVERY

SCN3A deficiency associated with increased seizure susceptibility

(2017) Tyra Lamar et al.   NEUROBIOLOGY OF DISEASE

Pain insensitivity: distal S6-segment mutations in NaV1.9 emerge as critical hotspot

(2017) Margaret K. King et al.   NEUROGENETICS

The pharmacology of voltage-gated sodium channel activators

(2017) Jennifer R. Deuis et al.   NEUROPHARMACOLOGY

Gap junctions, pannexins and pain

(2017) David C. Spray et al.   NEUROSCIENCE LETTERS

Reward, motivation, and emotion of pain and its relief

(2017) Frank Porreca et al.   PAIN

Rare Nav1.7 variants associated with painful diabetic peripheral neuropathy

(2017) Iulia Blesneac et al.   PAIN

Na V 1.7 as a pain target – From gene to pharmacology

(2017) Irina Vetter et al.   PHARMACOLOGY & THERAPEUTICS

Pharmacology of the Na v 1.1 domain IV voltage sensor reveals coupling between inactivation gating processes

(2017) Jeremiah D. Osteen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Blocking voltage-gated sodium channels as a strategy to suppress pathological cough

(2017) Hui Sun et al.   PULMONARY PHARMACOLOGY & THERAPEUTICS

Tetrodotoxin for Moderate to Severe Cancer-Related Pain: A Multicentre, Randomized, Double-Blind, Placebo-Controlled, Parallel-Design Trial

(2017) Neil A. Hagen et al.   Pain Research & Management

Somatosensory Neuron Typing with High-Coverage Single-Cell RNA Sequencing and Functional Analysis

(2017) Changlin Li et al.   Neuroscience Bulletin

Expression and Role of Voltage-Gated Sodium Channels in Human Dorsal Root Ganglion Neurons with Special Focus on Nav1.7, Species Differences, and Regulation by Paclitaxel

(2017) Wonseok Chang et al.   Neuroscience Bulletin

Insensitivity to pain induced by a potent selective closed-state Nav1.7 inhibitor

(2017) M. Flinspach et al.   Scientific Reports

Pharmacological characterisation of the highly NaV1.7 selective spider venom peptide Pn3a

(2017) Jennifer R. Deuis et al.   Scientific Reports

Pain-Causing Venom Peptides: Insights into Sensory Neuron Pharmacology

(2017) Sina Jami et al.   Toxins

Voltage-gated Na+ currents in human dorsal root ganglion neurons

(2017) Xiulin Zhang et al.   eLife

The structure, dynamics and selectivity profile of a NaV1.7 potency-optimised huwentoxin-IV variant

(2017) Sassan Rahnama et al.   PLoS One

Discovery and mode of action of a novel analgesic β-toxin from the African spider Ceratogyrus darlingi

(2017) Silmara R. Sousa et al.   PLoS One

Multiple sodium channel isoforms mediate the pathological effects of Pacific ciguatoxin-1

(2017) Marco C. Inserra et al.   Scientific Reports

Unexpected Efficacy of a Novel Sodium Channel Modulator in Dravet Syndrome

(2017) Lyndsey L. Anderson et al.   Scientific Reports

Membrane-binding properties of gating modifier and pore-blocking toxins: Membrane interaction is not a prerequisite for modification of channel gating

(2016) Evelyne Deplazes et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Pathogenic copy number variants and SCN1A mutations in patients with intellectual disability and childhood-onset epilepsy

(2016) Andrew E. Fry et al.   BMC Medical Genetics

Congenital insensitivity to pain: Fracturing without apparent skeletal pathobiology caused by an autosomal dominant, second mutation in SCN11A encoding voltage-gated sodium channel 1.9

(2016) Voraluck Phatarakijnirund et al.   BONE

The peptide Phα1β, from spider venom, acts as a TRPA1 channel antagonist with antinociceptive effects in mice

(2016) Raquel Tonello et al.   BRITISH JOURNAL OF PHARMACOLOGY

Interaction of Tarantula Venom Peptide ProTx-II with Lipid Membranes Is a Prerequisite for Its Inhibition of Human Voltage-gated Sodium Channel NaV1.7

(2016) Sónia Troeira Henriques et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Single Residue Substitutions That Confer Voltage-Gated Sodium Ion Channel Subtype Selectivity in the NaV1.7 Inhibitory Peptide GpTx-1

(2016) Justin K. Murray et al.   JOURNAL OF MEDICINAL CHEMISTRY

Familial gain-of-function Na v 1.9 mutation in a painful channelopathy

(2016) Chongyang Han et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

New Insight in Cold Pain: Role of Ion Channels, Modulation, and Clinical Perspectives

(2016) Stéphane Lolignier et al.   JOURNAL OF NEUROSCIENCE

Decreased Na v 1.9 channel expression in Hirschsprung's disease

(2016) Anne-Marie O'Donnell et al.   JOURNAL OF PEDIATRIC SURGERY

Dravet syndrome with autism inherited from a paternal mosaic heterozygous mutation on SCN1A

(2016) Zeyu Xiong et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Methylglyoxal mediates streptozotocin-induced diabetic neuropathic pain via activation of the peripheral TRPA1 and Nav1.8 channels

(2016) Qian Huang et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

A Novel Pathophysiological Mechanism Contributing to Trigeminal Neuralgia

(2016) Giovanni Grasso et al.   MOLECULAR MEDICINE

A Gain-of-Function Mutation in Nav1.6 in a Case of Trigeminal Neuralgia

(2016) Brian S Tanaka et al.   MOLECULAR MEDICINE

Association of rare missense variants in the second intracellular loop of NaV1.7 sodium channels with familial autism

(2016) M Rubinstein et al.   MOLECULAR PSYCHIATRY

The pain drain

(2016) David Holmes   NATURE

Selective spider toxins reveal a role for the Nav1.1 channel in mechanical pain

(2016) Jeremiah D. Osteen et al.   NATURE

Sodium channel Nav1.8

(2016) Chongyang Han et al.   NEUROLOGY

Upregulation of the sodium channel NaVβ4 subunit and its contributions to mechanical hypersensitivity and neuronal hyperexcitability in a rat model of radicular pain induced by local dorsal root ganglion inflammation

(2016) Wenrui Xie et al.   PAIN

Infantile Pain Episodes Associated with Novel Nav1.9 Mutations in Familial Episodic Pain Syndrome in Japanese Families

(2016) Hiroko Okuda et al.   PLoS One

The Dorsal Root Ganglion as a Therapeutic Target for Chronic Pain

(2016) Liong Liem et al.   REGIONAL ANESTHESIA AND PAIN MEDICINE

Exploring pain pathophysiology in patients

(2016) C. Sommer   SCIENCE

Pharmacological reversal of a pain phenotype in iPSC-derived sensory neurons and patients with inherited erythromelalgia

(2016) Lishuang Cao et al.   Science Translational Medicine

Analgesic Effects of GpTx-1, PF-04856264 and CNV1014802 in a Mouse Model of NaV1.7-Mediated Pain

(2016) Jennifer Deuis et al.   Toxins

Pathological nociceptors in two patients with erythromelalgia-like symptoms and rare genetic Nav 1.9 variants

(2016) Inge P. Kleggetveit et al.   Brain and Behavior

SCN10A Mutation in a Patient with Erythromelalgia Enhances C-Fiber Activity Dependent Slowing

(2016) Andreas M. Kist et al.   PLoS One

Seven novel modulators of the analgesic target NaV1.7 uncovered using a high-throughput venom-based discovery approach

(2015) Julie K Klint et al.   BRITISH JOURNAL OF PHARMACOLOGY

Role of common and rare variants in SCN10A: results from the Brugada syndrome QRS locus gene discovery collaborative study

(2015) Elijah R. Behr et al.   CARDIOVASCULAR RESEARCH

Association Between Genetic Variation in the SCN10A Gene and Cardiac Conduction Abnormalities in Patients With Hypertrophic Cardiomyopathy

(2015) Chiharuko Iio et al.   International Heart Journal

Voltage-Gated Sodium Channels: Structure, Function, Pharmacology, and Clinical Indications

(2015) Manuel de Lera Ruiz et al.   JOURNAL OF MEDICINAL CHEMISTRY

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(2015) Andrew Tan et al.   MOLECULAR MEDICINE

Navβ4 Regulates Fast Resurgent Sodium Currents and Excitability in Sensory Neurons

(2015) Cindy Barbosa et al.   Molecular Pain

NaV1.9: a sodium channel linked to human pain

(2015) Sulayman D. Dib-Hajj et al.   NATURE REVIEWS NEUROSCIENCE

The voltage-gated sodium channel NaV1.9 in visceral pain

(2015) J. R. F. Hockley et al.   NEUROGASTROENTEROLOGY AND MOTILITY

The Domain II S4-S5 Linker in Nav1.9: A Missense Mutation Enhances Activation, Impairs Fast Inactivation, and Produces Human Painful Neuropathy

(2015) Chongyang Han et al.   NEUROMOLECULAR MEDICINE

Mapping the interaction site for the tarantula toxin hainantoxin-IV (β-TRTX-Hn2a) in the voltage sensor module of domain II of voltage-gated sodium channels

(2015) Tianfu Cai et al.   PEPTIDES

Role of cerebrospinal fluid-contacting nucleus in sodium sensing and sodium appetite

(2015) Dan Xing et al.   PHYSIOLOGY & BEHAVIOR

Regulation of Nav1.7: A Conserved SCN9A Natural Antisense Transcript Expressed in Dorsal Root Ganglia

(2015) Jennifer Koenig et al.   PLoS One

Cold-aggravated pain in humans caused by a hyperactive NaV1.9 channel mutant

(2015) Enrico Leipold et al.   Nature Communications

A new look at sodium channel   subunits

(2015) S. Namadurai et al.   Open Biology

Post-translational modifications of voltage-gated sodium channels in chronic pain syndromes

(2015) Cedric J. Laedermann et al.   Frontiers in Pharmacology

Acid-sensing ion channels and their modulators

(2015) D. I. Osmakov et al.   BIOCHEMISTRY-MOSCOW

Gain-of-function mutations in sodium channel NaV1.9 in painful neuropathy

(2014) Jianying Huang et al.   BRAIN

A Monoclonal Antibody that Targets a NaV1.7 Channel Voltage Sensor for Pain and Itch Relief

(2014) Jun-Ho Lee et al.   CELL

Exon 11 skipping ofSCN10Acoding for voltage-gated sodium channels in dorsal root ganglia

(2014) Jana Schirmeyer et al.   Channels

A Tarantula-Venom Peptide Antagonizes the TRPA1 Nociceptor Ion Channel by Binding to the S1–S4 Gating Domain

(2014) Junhong Gui et al.   CURRENT BIOLOGY

The phenotype of congenital insensitivity to pain due to the NaV1.9 variant p.L811P

(2014) Christopher Geoffrey Woods et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Functional up-regulation of Nav1.8 sodium channel in Aβ afferent fibers subjected to chronic peripheral inflammation

(2014) Mounir Belkouch et al.   Journal of Neuroinflammation

Resurgent current of voltage-gated Na+channels

(2014) Amanda H. Lewis et al.   JOURNAL OF PHYSIOLOGY-LONDON

Regulation of membrane excitability: a convergence on voltage-gated sodium conductance

(2014) Wei-Hsiang Lin et al.   MOLECULAR NEUROBIOLOGY

Characteristics of Dorsal Root Ganglia Neurons Sensitive to Substance P

(2014) Eder Ricardo Moraes et al.   Molecular Pain

Role of the hippocampus in Nav1.6 (Scn8a) mediated seizure resistance

(2014) Christopher D. Makinson et al.   NEUROBIOLOGY OF DISEASE

Infantile Epileptic Encephalopathy, Transient Choreoathetotic Movements, and Hypersomnia due to a De Novo Missense Mutation in the SCN2A Gene

(2014) Alessandra Baumer et al.   NEUROPEDIATRICS

Mechanical allodynia

(2014) Stéphane Lolignier et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Functional Upregulation of Nav1.8 Sodium Channels on the Membrane of Dorsal Root Ganglia Neurons Contributes to the Development of Cancer-Induced Bone Pain

(2014) Xiao-Dan Liu et al.   PLoS One

Analgesic Effects of Huwentoxin-IV on Animal Models of Inflammatory and Neuropathic Pain

(2014) Yu Liu et al.   PROTEIN AND PEPTIDE LETTERS

Synthesis and Analgesic Effects of μ-TRTX-Hhn1b on Models of Inflammatory and Neuropathic Pain

(2014) Yu Liu et al.   Toxins

Gain-of-Function Mutations in SCN11A Cause Familial Episodic Pain

(2013) Xiang Yang Zhang et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Effective contractile response to voltage-gated Na+ channels revealed by a channel activator

(2013) W.-S. Vanessa Ho et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Role of the sodium channelSCN9Ain genetic epilepsy with febrile seizures plus and Dravet syndrome

(2013) John C. Mulley et al.   EPILEPSIA

Structure and Function of Hainantoxin-III, a Selective Antagonist of Neuronal Tetrodotoxin-sensitive Voltage-gated Sodium Channels Isolated from the Chinese Bird SpiderOrnithoctonus hainana

(2013) Zhonghua Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Analysis of the Structural and Molecular Basis of Voltage-sensitive Sodium Channel Inhibition by the Spider Toxin Huwentoxin-IV (μ-TRTX-Hh2a)

(2013) Natali A. Minassian et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Targeting Voltage Gated Sodium Channels NaV1.7, NaV1.8, and NaV1.9 for Treatment of Pathological Cough

(2013) Yukiko Muroi et al.   LUNG

A de novo gain-of-function mutation in SCN11A causes loss of pain perception

(2013) Enrico Leipold et al.   NATURE GENETICS

Noncanonical Roles of Voltage-Gated Sodium Channels

(2013) Joel A. Black et al.   NEURON

An animal model of oxaliplatin-induced cold allodynia reveals a crucial role for Nav1.6 in peripheral pain pathways

(2013) Jennifer R. Deuis et al.   PAIN

Knockdown of sodium channel NaV1.6 blocks mechanical pain and abnormal bursting activity of afferent neurons in inflamed sensory ganglia

(2013) Wenrui Xie et al.   PAIN

Sodium channel SCN8A (Nav1.6): properties and de novo mutations in epileptic encephalopathy and intellectual disability

(2013) Janelle E. O'Brien et al.   Frontiers in Genetics

An Evaluation of the Antinociceptive Effects of Phα1β, a Neurotoxin from the Spider Phoneutria nigriventer, and ω-Conotoxin MVIIA, a Cone Snail Conus magus Toxin, in Rat Model of Inflammatory and Neuropathic Pain

(2012) Alessandra Hubner de Souza et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

The NaV1.7 sodium channel: from molecule to man

(2012) Sulayman D. Dib-Hajj et al.   NATURE REVIEWS NEUROSCIENCE

Enhanced SCN7A/Nax expression contributes to bone cancer pain by increasing excitability of neurons in dorsal root ganglion

(2012) C.B. Ke et al.   NEUROSCIENCE

Increased expression of tetrodotoxin-resistant sodium channels Nav1.8 and Nav1.9 within dorsal root ganglia in a rat model of bone cancer pain

(2012) Fang Qiu et al.   NEUROSCIENCE LETTERS

Transient opening of the perineurial barrier for analgesic drug delivery

(2012) D. Hackel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Gain-of-function Nav1.8 mutations in painful neuropathy

(2012) C. G. Faber et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Spider-venom peptides that target voltage-gated sodium channels: Pharmacological tools and potential therapeutic leads

(2012) Julie K. Klint et al.   TOXICON

The Expression Pattern of the Na+ Sensor, NaX in the Hydromineral Homeostatic Network: A Comparative Study between the Rat and Mouse

(2012) Benjamin Nehmé et al.   Frontiers in Neuroanatomy

Pain as a global public health priority

(2011) Daniel S Goldberg et al.   BMC PUBLIC HEALTH

Sodium channel Nav1.6 is up-regulated in the dorsal root ganglia in a mouse model of type 2 diabetes

(2011) Yan-Shun Ren et al.   BRAIN RESEARCH BULLETIN

SCN1A splice variants exhibit divergent sensitivity to commonly used antiepileptic drugs

(2011) Christopher H. Thompson et al.   EPILEPSIA

The crystal structure of a voltage-gated sodium channel

(2011) Jian Payandeh et al.   NATURE

The generation of rat dorsal root ganglion cell lines to identify the target of KW-7158, a novel treatment for overactive bladder

(2011) Yoichi Nishiya et al.   NEUROSCIENCE RESEARCH

Nav1.9 Channel Contributes to Mechanical and Heat Pain Hypersensitivity Induced by Subacute and Chronic Inflammation

(2011) Stéphane Lolignier et al.   PLoS One

Palmitoylation influences the function and pharmacology of sodium channels

(2011) F. Bosmans et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Characterization of voltage-dependent calcium channel blocking peptides from the venom of the tarantula Grammostola rosea

(2011) Seigo Ono et al.   TOXICON

Alternative splicing of NaV1.7 exon 5 increases the impact of the painful PEPD mutant channel I1461T

(2010) Brian W. Jarecki et al.   Channels

Induction of sodium channel Nax (SCN7A) expression in rat and human hippocampus in temporal lobe epilepsy

(2010) Jan A. Gorter et al.   EPILEPSIA

NaV1.1 channels and epilepsy

(2010) William A. Catterall et al.   JOURNAL OF PHYSIOLOGY-LONDON

Single-cell analysis of sodium channel expression in dorsal root ganglion neurons

(2010) Cojen Ho et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

SCN2A mutation associated with neonatal epilepsy, late-onset episodic ataxia, myoclonus, and pain

(2010) Y. Liao et al.   NEUROLOGY

Autoimmunity to the Sodium-Level Sensor in the Brain Causes Essential Hypernatremia

(2010) Takeshi Y. Hiyama et al.   NEURON

Spider-Venom Peptides as Therapeutics

(2010) Natalie J. Saez et al.   Toxins

Role of neurotrophin signalling in the differentiation of neurons from dorsal root ganglia and sympathetic ganglia

(2009) Uwe Ernsberger   CELL AND TISSUE RESEARCH

Identification and functional characterization of the promoter of the mouse sodium-activated sodium channel Naxgene (Scn7a)

(2009) Refugio García-Villegas et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Increased Peripheral Nerve Excitability and Local Nav1.8 RNA Up-Regulation in Painful Neuropathy

(2009) Devang Kashyap Thakor et al.   Molecular Pain

Animal models of pain: progress and challenges

(2009) Jeffrey S. Mogil   NATURE REVIEWS NEUROSCIENCE

The voltage-gated sodium channel Nav1.9 is required for inflammation-based urinary bladder dysfunction

(2009) Amy M. Ritter et al.   NEUROSCIENCE LETTERS

Comparative study of the distribution of the α-subunits of voltage-gated sodium channels in normal and axotomized rat dorsal root ganglion neurons

(2008) Tetsuo Fukuoka et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Biophysical Properties of Human Nav1.7 Splice Variants and Their Regulation by Protein Kinase A

(2008) Aurélien Chatelier et al.   JOURNAL OF NEUROPHYSIOLOGY

Vascularization of the Dorsal Root Ganglia and Peripheral Nerve of the Mouse: Implications for Chemical-Induced Peripheral Sensory Neuropathies

(2008) Juan M Jimenez-Andrade et al.   Molecular Pain

ProTx-II, a Selective Inhibitor of NaV1.7 Sodium Channels, Blocks Action Potential Propagation in Nociceptors

(2008) W. A. Schmalhofer et al.   MOLECULAR PHARMACOLOGY

Transcriptional and functional profiles of voltage-gated Na+ channels in injured and non-injured DRG neurons in the SNI model of neuropathic pain

(2007) Temugin Berta et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Modulation of pain transmission by G-protein-coupled receptors

(2007) Hui-Lin Pan et al.   PHARMACOLOGY & THERAPEUTICS

Synthesis and characterization of huwentoxin-IV, a neurotoxin inhibiting central neuronal sodium channels

(2007) Yucheng Xiao et al.   TOXICON