Analgesic Effects of GpTx-1, PF-04856264 and CNV1014802 in a Mouse Model of NaV1.7-Mediated Pain

Activation of κ Opioid Receptors in Cutaneous Nerve Endings by Conorphin-1, a Novel Subtype-Selective Conopeptide, Does Not Mediate Peripheral Analgesia

(2015) Jennifer R. Deuis et al.   ACS Chemical Neuroscience

Sustained inhibition of the Na V 1.7 sodium channel by engineered dimers of the domain II binding peptide GpTx-1

(2015) Justin K. Murray et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Modulation of human Nav1.7 channel gating by synthetic α-scorpion toxin OD1 and its analogs

(2015) Leonid Motin et al.   Channels

Erythromelalgia Mutation Q875E Stabilizes the Activated State of Sodium Channel Nav1.7

(2015) Theresa Stadler et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Engineering Potent and Selective Analogues of GpTx-1, a Tarantula Venom Peptide Antagonist of the NaV1.7 Sodium Channel

(2015) Justin K. Murray et al.   JOURNAL OF MEDICINAL CHEMISTRY

Painful peripheral neuropathy and sodium channel mutations

(2015) Janneke G.J. Hoeijmakers et al.   NEUROSCIENCE LETTERS

Recent progress in sodium channel modulators for pain

(2014) Sharan K. Bagal et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Sodium channel genes in pain-related disorders: phenotype–genotype associations and recommendations for clinical use

(2014) Stephen G Waxman et al.   LANCET NEUROLOGY

Chemical Engineering and Structural and Pharmacological Characterization of the α-Scorpion Toxin OD1

(2013) Thomas Durek et al.   ACS Chemical Biology

An animal model of oxaliplatin-induced cold allodynia reveals a crucial role for Nav1.6 in peripheral pain pathways

(2013) Jennifer R. Deuis et al.   PAIN

Potency optimization of Huwentoxin-IV on hNav1.7: A neurotoxin TTX-S sodium-channel antagonist from the venom of the Chinese bird-eating spider Selenocosmia huwena

(2013) Jefferson D. Revell et al.   PEPTIDES

Voltage sensor interaction site for selective small molecule inhibitors of voltage-gated sodium channels

(2013) K. McCormack et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Two tarantula venom peptides as potent and differential NaV channels blockers

(2013) Ronit S. Cherki et al.   TOXICON

Expression of Nav1.7 in DRG Neurons Extends from Peripheral Terminals in the Skin to Central Preterminal Branches and Terminals in the Dorsal Horn

(2012) Joel A Black et al.   Molecular Pain

Distinct Nav1.7-dependent pain sensations require different sets of sensory and sympathetic neurons

(2012) Michael S. Minett et al.   Nature Communications

The Efficacy of Sodium Channel Blockers to Prevent Phencyclidine-Induced Cognitive Dysfunction in the Rat: Potential for Novel Treatments for Schizophrenia

(2011) C. H. Large et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

 -Conotoxins that differentially block sodium channels NaV1.1 through 1.8 identify those responsible for action potentials in sciatic nerve

(2011) M. J. Wilson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neurotoxins and Their Binding Areas on Voltage-Gated Sodium Channels

(2011) Marijke Stevens et al.   Frontiers in Pharmacology

A sodium channel geneSCN9Apolymorphism that increases nociceptor excitability

(2009) Mark Estacion et al.   ANNALS OF NEUROLOGY

Erythromelalgia mutation L823R shifts activation and inactivation of threshold sodium channel Nav1.7 to hyperpolarized potentials

(2009) Angelika Lampert et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Actions of veratridine on tetrodotoxin-sensitive voltage-gated Na+currents, NaV1.6, in murine vas deferens myocytes

(2009) Hai-Lei Zhu et al.   BRITISH JOURNAL OF PHARMACOLOGY

The relationship between sodium channel inhibition and anticonvulsant activity in a model of generalised seizure in the rat

(2009) Charles H. Large et al.   EPILEPSY RESEARCH

Phenotyping sensory nerve endings in vitro in the mouse

(2009) Katharina Zimmermann et al.   Nature Protocols

Paroxysmal extreme pain disorder mutations within the D3/S4-S5 linker of Nav1.7 cause moderate destabilization of fast inactivation

(2008) Brian W. Jarecki et al.   JOURNAL OF PHYSIOLOGY-LONDON

Paroxysmal Extreme Pain Disorder M1627K Mutation in Human Nav1.7 Renders DRG Neurons Hyperexcitable

(2008) Sulayman D Dib-Hajj et al.   Molecular Pain

Mutation I136V Alters Electrophysiological Properties of the NaV1.7 Channel in a Family with Onset of Erythromelalgia in the Second Decade

(2008) Xiaoyang Cheng et al.   Molecular Pain

ProTx-II, a Selective Inhibitor of NaV1.7 Sodium Channels, Blocks Action Potential Propagation in Nociceptors

(2008) W. A. Schmalhofer et al.   MOLECULAR PHARMACOLOGY