NaV1.9: a sodium channel linked to human pain

The Domain II S4-S5 Linker in Nav1.9: A Missense Mutation Enhances Activation, Impairs Fast Inactivation, and Produces Human Painful Neuropathy

(2015) Chongyang Han et al.   NEUROMOLECULAR MEDICINE

Gain-of-function mutations in sodium channel NaV1.9 in painful neuropathy

(2014) Jianying Huang et al.   BRAIN

A Monoclonal Antibody that Targets a NaV1.7 Channel Voltage Sensor for Pain and Itch Relief

(2014) Jun-Ho Lee et al.   CELL

Nav1.9 expression in magnocellular neurosecretory cells of supraoptic nucleus

(2014) J.A. Black et al.   EXPERIMENTAL NEUROLOGY

Dynamic-clamp analysis of wild-type human Nav1.7 and erythromelalgia mutant channel L858H

(2014) Dmytro V. Vasylyev et al.   JOURNAL OF NEUROPHYSIOLOGY

Specialized Functions of Nav1.5 and Nav1.9 Channels in Electrogenesis of Myenteric Neurons in Intact Mouse Ganglia

(2014) N. Osorio et al.   JOURNAL OF NEUROSCIENCE

Sodium channel genes in pain-related disorders: phenotype–genotype associations and recommendations for clinical use

(2014) Stephen G Waxman et al.   LANCET NEUROLOGY

Characterizing Human Stem Cell–derived Sensory Neurons at the Single-cell Level Reveals Their Ion Channel Expression and Utility in Pain Research

(2014) Gareth T Young et al.   MOLECULAR THERAPY

Gene editing at CRISPR speed

(2014)   NATURE BIOTECHNOLOGY

Selective conversion of fibroblasts into peripheral sensory neurons

(2014) Joel W Blanchard et al.   NATURE NEUROSCIENCE

Modeling pain in vitro using nociceptor neurons reprogrammed from fibroblasts

(2014) Brian J Wainger et al.   NATURE NEUROSCIENCE

Multiple roles for NaV1.9 in the activation of visceral afferents by noxious inflammatory, mechanical, and human disease–derived stimuli

(2014) James R.F. Hockley et al.   PAIN

Translational pain research: Lessons from genetics and genomics

(2014) S. D. Dib-Hajj et al.   Science Translational Medicine

Gain-of-Function Mutations in SCN11A Cause Familial Episodic Pain

(2013) Xiang Yang Zhang et al.   AMERICAN JOURNAL OF HUMAN GENETICS

The G1662S NaV1.8 mutation in small fibre neuropathy: impaired inactivation underlying DRG neuron hyperexcitability

(2013) C. Han et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Small-Fiber Neuropathy Nav1.8 Mutation Shifts Activation to Hyperpolarized Potentials and Increases Excitability of Dorsal Root Ganglion Neurons

(2013) J. Huang et al.   JOURNAL OF NEUROSCIENCE

A de novo gain-of-function mutation in SCN11A causes loss of pain perception

(2013) Enrico Leipold et al.   NATURE GENETICS

Voltage sensor interaction site for selective small molecule inhibitors of voltage-gated sodium channels

(2013) K. McCormack et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neuropathy-associated NaV1.7 variant I228M impairs integrity of dorsal root ganglion neuron axons

(2012) Anna-Karin Persson et al.   ANNALS OF NEUROLOGY

Functional profiles of SCN9A variants in dorsal root ganglion neurons and superior cervical ganglion neurons correlate with autonomic symptoms in small fibre neuropathy

(2012) Chongyang Han et al.   BRAIN

Combined small-molecule inhibition accelerates developmental timing and converts human pluripotent stem cells into nociceptors

(2012) Stuart M Chambers et al.   NATURE BIOTECHNOLOGY

The NaV1.7 sodium channel: from molecule to man

(2012) Sulayman D. Dib-Hajj et al.   NATURE REVIEWS NEUROSCIENCE

The distribution of low-threshold TTX-resistant Na+ currents in rat trigeminal ganglion cells

(2012) R.S. Scroggs   NEUROSCIENCE

Increased expression of tetrodotoxin-resistant sodium channels Nav1.8 and Nav1.9 within dorsal root ganglia in a rat model of bone cancer pain

(2012) Fang Qiu et al.   NEUROSCIENCE LETTERS

The Corneal Pain System. Part I: The Missing Piece of the Dry Eye Puzzle

(2012) Perry Rosenthal et al.   Ocular Surface

Nav1.8 expression is not restricted to nociceptors in mouse peripheral nervous system

(2012) Shannon D. Shields et al.   PAIN

Sensory and Signaling Mechanisms of Bradykinin, Eicosanoids, Platelet-Activating Factor, and Nitric Oxide in Peripheral Nociceptors

(2012) Gábor Pethő et al.   PHYSIOLOGICAL REVIEWS

Gain-of-function Nav1.8 mutations in painful neuropathy

(2012) C. G. Faber et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Gain of function NaV1.7 mutations in idiopathic small fiber neuropathy

(2011) Catharina G. Faber et al.   ANNALS OF NEUROLOGY

Sodium Channels in Normal and Pathological Pain

(2010) Sulayman D. Dib-Hajj et al.   Annual Review of Neuroscience

Cellular and Molecular Mechanisms of Pain

(2009) Allan I. Basbaum et al.   CELL

Activation of neurokinin 3 receptor increases Nav1.9 current in enteric neurons

(2009) Carine Copel et al.   JOURNAL OF PHYSIOLOGY-LONDON

Transfection of rat or mouse neurons by biolistics or electroporation

(2009) Sulayman D Dib-Hajj et al.   Nature Protocols

Animal models of pain: progress and challenges

(2009) Jeffrey S. Mogil   NATURE REVIEWS NEUROSCIENCE

Spontaneous action potential generation due to persistent sodium channel currents in simulated carotid body afferent fibers

(2008) David F. Donnelly   JOURNAL OF APPLIED PHYSIOLOGY

Inflammatory Mediators Increase Nav1.9 Current and Excitability in Nociceptors through a Coincident Detection Mechanism

(2008) François Maingret et al.   JOURNAL OF GENERAL PHYSIOLOGY

Nociceptors Are Interleukin-1  Sensors

(2008) A. M. Binshtok et al.   JOURNAL OF NEUROSCIENCE

GTP up-regulated persistent Na+current and enhanced nociceptor excitability require NaV1.9

(2007) Johan A. R. Östman et al.   JOURNAL OF PHYSIOLOGY-LONDON