Article
Medicine, Research & Experimental
Sabrina Qader Kudsi, Bruna Candia Piccoli, Daniel Ardisson-Araujo, Gabriela Trevisan
Summary: This article aims to analyze the baseline distribution of TRPA1, TRPV1, TRPV4, and TRPM8 channels in human systems at the transcriptional level. Using the RNA-seq dataset, the transcriptional levels of these channels were investigated and compared in 95 human subjects representing 33 different tissues, providing essential suggestions for further studies on these proteins.
Article
Biochemistry & Molecular Biology
Xiaolu Lei, Junwei Zeng, Yan Yan, Xiaohong Liu
Summary: This study aimed to investigate the modulation of HCN channel activity on the expression and function of P2X2 and P2X3 receptors. The results showed that intrathecal administration of HCN channel blocker ZD7288 significantly reduced mechanical hyperalgesia and the increased expression of P2X2 and P2X3 receptors in rats with chronic constriction injury of sciatic nerve. Furthermore, it was found that the opening of HCN channels could enhance the expression and function of P2X2 and P2X3 receptors via the cAMP-PKA signaling pathway. These findings provide important insights into the mechanism of nerve injury-induced pain hypersensitivity.
NEUROCHEMICAL RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Cristina Fraquelli, Jasmine Hauzinger, Christian Humpel, Maria Nolano, Vincenzo Provitera, Vinay Kumar Sharma, Peng Loh, Zenon Pidsudko, Georgios Blatsios, Josef Troger
Summary: This study investigated the presence and source of serpinins in the skin, and found that serpinin was present in the dorsal root ganglia and sensory nerves of rats, with colocalization with substance P. Although predominantly found in its free form in the skin, the serpinins may have functional significance in the sensory innervation of the skin.
Article
Engineering, Biomedical
Mara Evany de Oliveira, Joyce Teixeira Da Silva, Marcos Leal Brioschi, Marucia Chacur
Summary: Nerve injury triggers the release of peptides and the upregulation of receptors contributing to chronic pain, while PBMT has shown to reduce nociceptive mediators and temperature in a rodent model of neuropathic pain, suggesting its potential therapeutic role in modulating thermoregulation and inflammation associated with peripheral nerve injuries.
LASERS IN MEDICAL SCIENCE
(2021)
Article
Pharmacology & Pharmacy
Jing Meng, Siyan Qiu, Ling Zhang, Min You, Haizhu Xing, Jing Zhu
Summary: The study found that berberine can improve chemotherapy-induced peripheral neuropathy through anti-inflammatory mechanisms, possibly involving TRPV1.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Neurosciences
Xiao-Xing Song, Lin-Yu Jin, Qiang Li, Xin-Feng Li, Yan Luo
Summary: This study investigated the antinociceptive effects of selective ER beta agonists on discogenic low back pain (DLBP) related behavior by regulating substance P in the spinal cord and dorsal root ganglia. The results showed that activation of ER beta could improve both axial and radiating behavioral disorders of DLBP and decrease substance P content. This study provides a therapeutic target for managing DLBP in the clinic.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2023)
Review
Neurosciences
Parth Shirolkar, Santosh K. Mishra
Summary: The TRP channel superfamily responds to various stimuli, including itch. Six TRP channels are involved in itch perception, primarily in the skin and dorsal root ganglia. Mutations and activations of these channels can cause discomfort and disease.
NEUROSCIENCE LETTERS
(2022)
Article
Neurosciences
Jichao Ma, Anas Mistareehi, Jazune Madas, Andrew M. M. Kwiat, Kohlton Bendowski, Duyen Nguyen, Jin Chen, De-Pei Li, John B. Furness, Terry L. Powley, Zixi (Jack) Cheng
Summary: The study reveals the distribution and morphology of SP-IR axons and terminals in the whole stomach, providing an anatomical foundation for functional mapping of SP-IR axon innervation in the stomach and its pathological remodeling in gastrointestinal diseases.
JOURNAL OF COMPARATIVE NEUROLOGY
(2023)
Article
Neurosciences
Rachel Feldman-Goriachnik, Menachem Hanani
Summary: Neuronal excitation leads to NO release, inducing SGCs activation, with ATP potentially playing a role in NO's action.
Article
Biochemistry & Molecular Biology
Benjamin M. Zemel, Lianteng Zhi, Eric V. Brown, Stephen R. Tymanskyj, Qiansheng Liang, Manuel Covarrubias
Summary: The study suggests that a physical interaction between Kv3.4 channel and functional PKC epsilon primarily determines its stability and localization in DRG neurons, without significantly affecting its gating.
Article
Pharmacology & Pharmacy
Mircea Iftinca, Manon Defaye, Christophe Altier
Summary: TRPV1 is a significant channel in pain perception and its agonists are being studied for chronic pain management. While TRPV1 antagonists have limited clinical use due to side effects, capsaicin offers a potential avenue for long-lasting pain relief by defunctionalising nociceptors. The development of TRPV1-targeted drugs could provide a new generation of analgesics for various pain conditions.
Article
Multidisciplinary Sciences
Tianci Li, Gaoge Wang, Vivian Chin Chin Hui, Daniel Saad, Joao de Sousa Valente, Paolo La Montanara, Istvan Nagy
Summary: Increased activity and excitability of molecules like TRPV1 in pain-sensing neurons are crucial for pathological pain. Two major mechanisms, post-translational changes in TRPV1 induced by inflammatory mediators and TRPV1 activation-induced feed-forward signalling, contribute to TRPV1 sensitisation in injured tissues. Upregulation in COX2 expression and increased synthesis of COX2 products play a role in TRPV1 activation-induced sensitisation in nociceptive neurons.
SCIENTIFIC REPORTS
(2021)
Article
Neurosciences
Anhui Wang, Xiangchao Shi, Ruoyang Yu, Bao Qiao, Runan Yang, Changshui Xu
Summary: This study found that in DNP, the P2X(7) receptor is involved in modulating DNP hypersensitivity by decreasing the expression of TRPV1 and the phosphorylation levels of p38 and ERK1/2.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2021)
Article
Multidisciplinary Sciences
Sara Caxaria, Sabah Bharde, Alice M. Fuller, Romy Evans, Bethan Thomas, Petek Celik, Francesco Dell'Accio, Simon Yona, Derek Gilroy, Mathieu-Benoit Voisin, John N. Wood, Shafaq Sikandar
Summary: We demonstrated the role of neutrophils in fibromyalgia by using a back-translational approach in mice. Adoptive transfer of neutrophils from mice with chronic widespread pain or patients with fibromyalgia can induce mechanical pain in recipient mice, sensitize spinal cord neurons, and cause changes in the expression of neutrophil proteins that lead to neutrophil infiltration into dorsal root ganglia. These findings suggest an immunological basis for chronic widespread pain in fibromyalgia mediated by neutrophils.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Cell Biology
Xiuqi Xu, Ziqi Yuan, Shijia Zhang, Guang Li, Guangqin Zhang
Summary: This study observed the changes in the TRPV1 channel in MSU-induced gouty arthritis and found that TRPV1 plays an important role in mediating mechanical hyperalgesia in gouty arthritis. This suggests that TRPV1 could be a potential new target for the clinical treatment of gouty arthritis.
INFLAMMATION RESEARCH
(2022)