Seven novel modulators of the analgesic target NaV1.7 uncovered using a high-throughput venom-based discovery approach

No Gain, No Pain: NaV1.7 as an Analgesic Target

(2014) Glenn F. King et al.   ACS Chemical Neuroscience

A Tarantula-Venom Peptide Antagonizes the TRPA1 Nociceptor Ion Channel by Binding to the S1–S4 Gating Domain

(2014) Junhong Gui et al.   CURRENT BIOLOGY

The Concise Guide to PHARMACOLOGY 2013/14: Ion Channels

(2013) Stephen P.H. Alexander et al.   BRITISH JOURNAL OF PHARMACOLOGY

Analysis of the Structural and Molecular Basis of Voltage-sensitive Sodium Channel Inhibition by the Spider Toxin Huwentoxin-IV (μ-TRTX-Hh2a)

(2013) Natali A. Minassian et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The IUPHAR/BPS Guide to PHARMACOLOGY: an expert-driven knowledgebase of drug targets and their ligands

(2013) Adam J. Pawson et al.   NUCLEIC ACIDS RESEARCH

Potency optimization of Huwentoxin-IV on hNav1.7: A neurotoxin TTX-S sodium-channel antagonist from the venom of the Chinese bird-eating spider Selenocosmia huwena

(2013) Jefferson D. Revell et al.   PEPTIDES

Expression and Pharmacology of Endogenous Cav Channels in SH-SY5Y Human Neuroblastoma Cells

(2013) Silmara R. Sousa et al.   PLoS One

Production of Recombinant Disulfide-Rich Venom Peptides for Structural and Functional Analysis via Expression in the Periplasm of E. coli

(2013) Julie K. Klint et al.   PLoS One

A Tobacco Etch Virus Protease with Increased Substrate Tolerance at the P1' position

(2013) Christian Renicke et al.   PLoS One

A Single-nucleotide Polymorphism in SCN9A May Decrease Postoperative Pain Sensitivity in the General Population

(2012) Guangyou Duan et al.   ANESTHESIOLOGY

Characterisation of Nav types endogenously expressed in human SH-SY5Y neuroblastoma cells

(2012) Irina Vetter et al.   BIOCHEMICAL PHARMACOLOGY

The Economic Costs of Pain in the United States

(2012) Darrell J. Gaskin et al.   JOURNAL OF PAIN

A positively charged surface patch is important for hainantoxin-IV binding to voltage-gated sodium channels

(2012) Yu Liu et al.   JOURNAL OF PEPTIDE SCIENCE

Chemical Punch Packed in Venoms Makes Centipedes Excellent Predators

(2012) Shilong Yang et al.   MOLECULAR & CELLULAR PROTEOMICS

Spider-venom peptides that target voltage-gated sodium channels: Pharmacological tools and potential therapeutic leads

(2012) Julie K. Klint et al.   TOXICON

Polymorphism in the SCN9A Voltage-Gated Sodium Channel Gene Associated With Interstitial Cystitis/Bladder Pain Syndrome

(2012) Jay E. Reeder et al.   UROLOGY

Deletion mutation of sodium channel NaV1.7 in inherited erythromelalgia: enhanced slow inactivation modulates dorsal root ganglion neuron hyperexcitability

(2011) X. Cheng et al.   BRAIN

Macromolecular NMR spectroscopy for the non-spectroscopist

(2011) Ann H. Kwan et al.   FEBS Journal

Common Molecular Determinants of Tarantula Huwentoxin-IV Inhibition of Na+Channel Voltage Sensors in Domains II and IV

(2011) Yucheng Xiao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Functional properties and toxin pharmacology of a dorsal root ganglion sodium channel viewed through its voltage sensors

(2011) Frank Bosmans et al.   JOURNAL OF GENERAL PHYSIOLOGY

Venomics: a new paradigm for natural products-based drug discovery

(2010) Irina Vetter et al.   AMINO ACIDS

Peptide toxins that selectively target insect NaVand CaVchannels

(2010) Glenn F. King et al.   Channels

A non-uniformly sampled 4D HCC(CO)NH-TOCSY experiment processed using maximum entropy for rapid protein sidechain assignment

(2010) Mehdi Mobli et al.   JOURNAL OF MAGNETIC RESONANCE

Nav1.7 mutations associated with paroxysmal extreme pain disorder, but not erythromelalgia, enhance Navβ4 peptide-mediated resurgent sodium currents

(2010) Jonathan W. Theile et al.   JOURNAL OF PHYSIOLOGY-LONDON

ArachnoServer 2.0, an updated online resource for spider toxin sequences and structures

(2010) V. Herzig et al.   NUCLEIC ACIDS RESEARCH

Pain perception is altered by a nucleotide polymorphism in SCN9A

(2010) F. Reimann et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Targeting voltage sensors in sodium channels with spider toxins

(2010) Frank Bosmans et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

MolProbity: all-atom structure validation for macromolecular crystallography

(2009) Vincent B. Chen et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

TALOS+: a hybrid method for predicting protein backbone torsion angles from NMR chemical shifts

(2009) Yang Shen et al.   JOURNAL OF BIOMOLECULAR NMR

Tarantula Huwentoxin-IV Inhibits Neuronal Sodium Channels by Binding to Receptor Site 4 and Trapping the Domain II Voltage Sensor in the Closed Configuration

(2008) Yucheng Xiao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

NaV1.7 Gain-of-Function Mutations as a Continuum: A1632E Displays Physiological Changes Associated with Erythromelalgia and Paroxysmal Extreme Pain Disorder Mutations and Produces Symptoms of Both Disorders

(2008) M. Estacion et al.   JOURNAL OF NEUROSCIENCE

Deconstructing voltage sensor function and pharmacology in sodium channels

(2008) Frank Bosmans et al.   NATURE

A rational nomenclature for naming peptide toxins from spiders and other venomous animals

(2008) Glenn F. King et al.   TOXICON