Selective spider toxins reveal a role for the Nav1.1 channel in mechanical pain

De novo expression of Nav1.7 in injured putative proprioceptive afferents: Multiple tetrodotoxin-sensitive sodium channels are retained in the rat dorsal root after spinal nerve ligation

(2015) T. Fukuoka et al.   NEUROSCIENCE

Painful peripheral neuropathy and sodium channel mutations

(2015) Janneke G.J. Hoeijmakers et al.   NEUROSCIENCE LETTERS

Three Peptide Modulators of the Human Voltage-Gated Sodium Channel 1.7, an Important Analgesic Target, from the Venom of an Australian Tarantula

(2015) Chun Chow et al.   Toxins

Nav1.1 Modulation by a Novel Triazole Compound Attenuates Epileptic Seizures in Rodents

(2014) John Gilchrist et al.   ACS Chemical Biology

Unbiased classification of sensory neuron types by large-scale single-cell RNA sequencing

(2014) Dmitry Usoskin et al.   NATURE NEUROSCIENCE

Delta Opioid Receptors Presynaptically Regulate Cutaneous Mechanosensory Neuron Input to the Spinal Cord Dorsal Horn

(2014) Rita Bardoni et al.   NEURON

Therapeutic potential of NaV1.1 activators

(2014) Henrik S. Jensen et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

A distinct sodium channel voltage-sensor locus determines insect selectivity of the spider toxin Dc1a

(2014) Niraj S. Bende et al.   Nature Communications

Selenoether oxytocin analogues have analgesic properties in a mouse model of chronic abdominal pain

(2014) Aline Dantas de Araujo et al.   Nature Communications

Gain-of-Function Mutations in SCN11A Cause Familial Episodic Pain

(2013) Xiang Yang Zhang et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Linaclotide Inhibits Colonic Nociceptors and Relieves Abdominal Pain via Guanylate Cyclase-C and Extracellular Cyclic Guanosine 3′,5′-Monophosphate

(2013) Joel Castro et al.   GASTROENTEROLOGY

Increased κ-opioid receptor expression and function during chronic visceral hypersensitivity

(2013) Patrick A Hughes et al.   GUT

A ‘toothache tree’ alkylamide inhibits Aδ mechanonociceptors to alleviate mechanical pain

(2013) Makoto Tsunozaki et al.   JOURNAL OF PHYSIOLOGY-LONDON

Voltage sensor interaction site for selective small molecule inhibitors of voltage-gated sodium channels

(2013) K. McCormack et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nonfunctional NaV1.1 familial hemiplegic migraine mutant transformed into gain of function by partial rescue of folding defects

(2013) S. Cestele et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Rufinamide Attenuates Mechanical Allodynia in a Model of Neuropathic Pain in the Mouse and Stabilizes Voltage-gated Sodium Channel Inactivated State

(2012) Marc R. Suter et al.   ANESTHESIOLOGY

Isolation, characterization and total regioselective synthesis of the novel μO-conotoxin MfVIA from Conus magnificus that targets voltage-gated sodium channels

(2012) Irina Vetter et al.   BIOCHEMICAL PHARMACOLOGY

Inhibitory Interneuron Deficit Links Altered Network Activity and Cognitive Dysfunction in Alzheimer Model

(2012) Laure Verret et al.   CELL

Autistic-like behaviour in Scn1a +/− mice and rescue by enhanced GABA-mediated neurotransmission

(2012) Sung Han et al.   NATURE

The NaV1.7 sodium channel: from molecule to man

(2012) Sulayman D. Dib-Hajj et al.   NATURE REVIEWS NEUROSCIENCE

Acid-Labile Cys-Protecting Groups for the Fmoc/tBu Strategy: Filling the Gap

(2012) Miriam Góngora-Benítez et al.   ORGANIC LETTERS

Gain-of-function Nav1.8 mutations in painful neuropathy

(2012) C. G. Faber et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Specific deletion of NaV1.1 sodium channels in inhibitory interneurons causes seizures and premature death in a mouse model of Dravet syndrome

(2012) C. S. Cheah et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Receptor-targeting mechanisms of pain-causing toxins: How ow?

(2012) Christopher J. Bohlen et al.   TOXICON

Functional properties and toxin pharmacology of a dorsal root ganglion sodium channel viewed through its voltage sensors

(2011) Frank Bosmans et al.   JOURNAL OF GENERAL PHYSIOLOGY

Assessing the Role of the Cadherin/Catenin Complex at the Schwann Cell-Axon Interface and in the Initiation of Myelination

(2011) K. A. Lewallen et al.   JOURNAL OF NEUROSCIENCE

Are Voltage-Gated Sodium Channels on the Dorsal Root Ganglion Involved in the Development of Neuropathic Pain?

(2011) Wei Wang et al.   Molecular Pain

Mapping the receptor site for  -scorpion toxins on a Na+ channel voltage sensor

(2011) J. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sodium Channels in Normal and Pathological Pain

(2010) Sulayman D. Dib-Hajj et al.   Annual Review of Neuroscience

A Bivalent Tarantula Toxin Activates the Capsaicin Receptor, TRPV1, by Targeting the Outer Pore Domain

(2010) Christopher J. Bohlen et al.   CELL

TRPV1-lineage neurons are required for thermal sensation

(2010) Santosh K Mishra et al.   EMBO JOURNAL

NaV1.1 channels and epilepsy

(2010) William A. Catterall et al.   JOURNAL OF PHYSIOLOGY-LONDON

ArachnoServer 2.0, an updated online resource for spider toxin sequences and structures

(2010) V. Herzig et al.   NUCLEIC ACIDS RESEARCH

VGLUT2 expression in primary afferent neurons is essential for normal acute pain and injury-induced heat hypersensitivity

(2010) G. Scherrer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cellular and Molecular Mechanisms of Pain

(2009) Allan I. Basbaum et al.   CELL

Post-inflammatory colonic afferent sensitisation: different subtypes, different pathways and different time courses

(2009) P A Hughes et al.   GUT

Ablation of TrpV1 neurons reveals their selective role in thermal pain sensation

(2009) Santosh K. Mishra et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Distinct subsets of unmyelinated primary sensory fibers mediate behavioral responses to noxious thermal and mechanical stimuli

(2009) D. J. Cavanaugh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Comparative study of the distribution of the α-subunits of voltage-gated sodium channels in normal and axotomized rat dorsal root ganglion neurons

(2008) Tetsuo Fukuoka et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Deconstructing voltage sensor function and pharmacology in sodium channels

(2008) Frank Bosmans et al.   NATURE