Interaction of Tarantula Venom Peptide ProTx-II with Lipid Membranes Is a Prerequisite for Its Inhibition of Human Voltage-gated Sodium Channel NaV1.7

Membrane-binding properties of gating modifier and pore-blocking toxins: Membrane interaction is not a prerequisite for modification of channel gating

(2016) Evelyne Deplazes et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Structural insights into the mechanism of activation of the TRPV1 channel by a membrane-bound tarantula toxin

(2016) Chanhyung Bae et al.   eLife

Cell-penetrating compounds preferentially bind glycosaminoglycans over plasma membrane lipids in a charge density- and stereochemistry-dependent manner

(2015) Lisa E. Prevette et al.   BIOPHYSICAL CHEMISTRY

The Prototypic Cyclotide Kalata B1 Has a Unique Mechanism of Entering Cells

(2015) Sónia Troeira Henriques et al.   CHEMISTRY & BIOLOGY

The Cystine Knot Is Responsible for the Exceptional Stability of the Insecticidal Spider Toxin ω-Hexatoxin-Hv1a

(2015) Volker Herzig et al.   Toxins

Tarantula toxins use common surfaces for interacting with Kv and ASIC ion channels

(2015) Kanchan Gupta et al.   eLife

No Gain, No Pain: NaV1.7 as an Analgesic Target

(2014) Glenn F. King et al.   ACS Chemical Neuroscience

One-pot hydrazide-based native chemical ligation for efficient chemical synthesis and structure determination of toxin Mambalgin-1

(2014) Man Pan et al.   CHEMICAL COMMUNICATIONS

Testing and validation of the Automated Topology Builder (ATB) version 2.0: prediction of hydration free enthalpies

(2014) Katarzyna B. Koziara et al.   JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN

Studies Examining the Relationship between the Chemical Structure of Protoxin II and Its Activity on Voltage Gated Sodium Channels

(2014) Jae H. Park et al.   JOURNAL OF MEDICINAL CHEMISTRY

Structural interactions of a voltage sensor toxin with lipid membranes

(2014) Mihaela Mihailescu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Characterisation of Nav types endogenously expressed in human SH-SY5Y neuroblastoma cells

(2012) Irina Vetter et al.   BIOCHEMICAL PHARMACOLOGY

Structural Characterization of the Cyclic Cystine Ladder Motif of θ-Defensins

(2012) Anne C. Conibear et al.   BIOCHEMISTRY

Cell surface binding and uptake of arginine- and lysine-rich penetratin peptides in absence and presence of proteoglycans

(2012) Helene L. Åmand et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Design and characterization of novel antimicrobial peptides, R-BP100 and RW-BP100, with activity against Gram-negative and Gram-positive bacteria

(2012) Inês M. Torcato et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Lipid Bilayers: The Effect of Force Field on Ordering and Dynamics

(2012) David Poger et al.   Journal of Chemical Theory and Computation

Ion Channels as Therapeutic Targets: A Drug Discovery Perspective

(2012) Sharan K. Bagal et al.   JOURNAL OF MEDICINAL CHEMISTRY

Sphingomyelinase D Activity in Model Membranes: Structural Effects of in situ Generation of Ceramide-1-Phosphate

(2012) Roberto P. Stock et al.   PLoS One

Spider-venom peptides that target voltage-gated sodium channels: Pharmacological tools and potential therapeutic leads

(2012) Julie K. Klint et al.   TOXICON

Conotoxins Targeting Neuronal Voltage-Gated Sodium Channel Subtypes: Potential Analgesics?

(2012) Oliver Knapp et al.   Toxins

Ion-Channel Modulators: More Diversity Than Previously Thought

(2011) Sébastien Dilly et al.   CHEMBIOCHEM

Definition and testing of the GROMOS force-field versions 54A7 and 54B7

(2011) Nathan Schmid et al.   EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS

Decoding the Membrane Activity of the Cyclotide Kalata B1

(2011) Sónia Troeira Henriques et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

An Automated Force Field Topology Builder (ATB) and Repository: Version 1.0

(2011) Alpeshkumar K. Malde et al.   Journal of Chemical Theory and Computation

MDAnalysis: A toolkit for the analysis of molecular dynamics simulations

(2011) Naveen Michaud-Agrawal et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

Translocation of HIV TAT peptide and analogues induced by multiplexed membrane and cytoskeletal interactions

(2011) A. Mishra et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Development of a sea anemone toxin as an immunomodulator for therapy of autoimmune diseases

(2011) Victor Chi et al.   TOXICON

Structure and Orientation of a Voltage-Sensor Toxin in Lipid Membranes

(2010) Hyun Ho Jung et al.   BIOPHYSICAL JOURNAL

Possible Roles of Exceptionally Conserved Residues around the Selectivity Filters of Sodium and Calcium Channels

(2010) Denis B. Tikhonov et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SYMPOSIUM REVIEW: Lipid microdomains and the regulation of ion channel function

(2010) Caroline Dart   JOURNAL OF PHYSIOLOGY-LONDON

The Tarantula Toxins ProTx-II and Huwentoxin-IV Differentially Interact with Human Nav1.7 Voltage Sensors to Inhibit Channel Activation and Inactivation

(2010) Y. Xiao et al.   MOLECULAR PHARMACOLOGY

Ion Channel Voltage Sensors: Structure, Function, and Pathophysiology

(2010) William A. Catterall   NEURON

Targeting voltage sensors in sodium channels with spider toxins

(2010) Frank Bosmans et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

The Toxicity of Prion Protein Fragment PrP(106−126) is Not Mediated by Membrane Permeabilization as Shown by a M112W Substitution

(2009) Sónia Troeira Henriques et al.   BIOCHEMISTRY

The Biological Activity of the Prototypic Cyclotide Kalata B1 Is Modulated by the Formation of Multimeric Pores

(2009) Yen-Hua Huang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A new force field for simulating phosphatidylcholine bilayers

(2009) David Poger et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

Voltage-gated potassium channels as therapeutic targets

(2009) Heike Wulff et al.   NATURE REVIEWS DRUG DISCOVERY

Interactions between lipids and voltage sensor paddles detected with tarantula toxins

(2009) Mirela Milescu et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Sea anemone toxins affecting voltage-gated sodium channels – molecular and evolutionary features

(2009) Yehu Moran et al.   TOXICON

PrP(106-126) Does Not Interact with Membranes under Physiological Conditions

(2008) Sónia Troeira Henriques et al.   BIOPHYSICAL JOURNAL

Regulation of phospholipid asymmetry in the erythrocyte membrane

(2008) David L Daleke   CURRENT OPINION IN HEMATOLOGY

ProTx-II, a Selective Inhibitor of NaV1.7 Sodium Channels, Blocks Action Potential Propagation in Nociceptors

(2008) W. A. Schmalhofer et al.   MOLECULAR PHARMACOLOGY

Membrane lipids: where they are and how they behave

(2008) Gerrit van Meer et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Synthesis and characterization of huwentoxin-IV, a neurotoxin inhibiting central neuronal sodium channels

(2007) Yucheng Xiao et al.   TOXICON