Pharmacological characterization of potent and selective NaV1.7 inhibitors engineered from Chilobrachys jingzhao tarantula venom peptide JzTx-V

Selective Closed-State Nav1.7 Blocker JZTX-34 Exhibits Analgesic Effects against Pain

(2018) Xiongzhi Zeng et al.   Toxins

Pharmacologic Characterization of AMG8379, a Potent and Selective Small Molecule Sulfonamide Antagonist of the Voltage-Gated Sodium Channel Na V 1.7

(2017) Thomas J. Kornecook et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

The pharmacology of voltage-gated sodium channel activators

(2017) Jennifer R. Deuis et al.   NEUROPHARMACOLOGY

Na V 1.7 as a pain target – From gene to pharmacology

(2017) Irina Vetter et al.   PHARMACOLOGY & THERAPEUTICS

Insensitivity to pain induced by a potent selective closed-state Nav1.7 inhibitor

(2017) M. Flinspach et al.   Scientific Reports

Pharmacological characterisation of the highly NaV1.7 selective spider venom peptide Pn3a

(2017) Jennifer R. Deuis et al.   Scientific Reports

The tarantula toxin β/δ-TRTX-Pre1a highlights the importance of the S1-S2 voltage-sensor region for sodium channel subtype selectivity

(2017) Joshua S. Wingerd et al.   Scientific Reports

Nav1.7 and other voltage-gated sodium channels as drug targets for pain relief

(2016) Edward C Emery et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Engineering Highly Potent and Selective Microproteins against Nav1.7 Sodium Channel for Treatment of Pain

(2016) Anatoly Shcherbatko et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Single Residue Substitutions That Confer Voltage-Gated Sodium Ion Channel Subtype Selectivity in the NaV1.7 Inhibitory Peptide GpTx-1

(2016) Justin K. Murray et al.   JOURNAL OF MEDICINAL CHEMISTRY

Subtype-Selective Small Molecule Inhibitors Reveal a Fundamental Role for Nav1.7 in Nociceptor Electrogenesis, Axonal Conduction and Presynaptic Release

(2016) Aristos J. Alexandrou et al.   PLoS One

Sustained inhibition of the Na V 1.7 sodium channel by engineered dimers of the domain II binding peptide GpTx-1

(2015) Justin K. Murray et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Seven novel modulators of the analgesic target NaV1.7 uncovered using a high-throughput venom-based discovery approach

(2015) Julie K Klint et al.   BRITISH JOURNAL OF PHARMACOLOGY

Combined automated NOE assignment and structure calculation with CYANA

(2015) Peter Güntert et al.   JOURNAL OF BIOMOLECULAR NMR

Voltage-Gated Sodium Channels: Structure, Function, Pharmacology, and Clinical Indications

(2015) Manuel de Lera Ruiz et al.   JOURNAL OF MEDICINAL CHEMISTRY

Pharmaceutical Optimization of Peptide Toxins for Ion Channel Targets: Potent, Selective, and Long-Lived Antagonists of Kv1.3

(2015) Justin K. Murray et al.   JOURNAL OF MEDICINAL CHEMISTRY

Engineering Potent and Selective Analogues of GpTx-1, a Tarantula Venom Peptide Antagonist of the NaV1.7 Sodium Channel

(2015) Justin K. Murray et al.   JOURNAL OF MEDICINAL CHEMISTRY

From Foe to Friend: Using Animal Toxins to Investigate Ion Channel Function

(2015) Jeet Kalia et al.   JOURNAL OF MOLECULAR BIOLOGY

Global Nav1.7 Knockout Mice Recapitulate the Phenotype of Human Congenital Indifference to Pain

(2014) Jacinthe Gingras et al.   PLoS One

Molecular Surface of JZTX-V (β-Theraphotoxin-Cj2a) Interacting with Voltage-Gated Sodium Channel Subtype NaV1.4

(2014) Ji Luo et al.   Toxins

Structure and Function of Hainantoxin-III, a Selective Antagonist of Neuronal Tetrodotoxin-sensitive Voltage-gated Sodium Channels Isolated from the Chinese Bird SpiderOrnithoctonus hainana

(2013) Zhonghua Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Analysis of the Structural and Molecular Basis of Voltage-sensitive Sodium Channel Inhibition by the Spider Toxin Huwentoxin-IV (μ-TRTX-Hh2a)

(2013) Natali A. Minassian et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The NaV1.7 sodium channel: from molecule to man

(2012) Sulayman D. Dib-Hajj et al.   NATURE REVIEWS NEUROSCIENCE

Spider-venom peptides that target voltage-gated sodium channels: Pharmacological tools and potential therapeutic leads

(2012) Julie K. Klint et al.   TOXICON

Distinct Nav1.7-dependent pain sensations require different sets of sensory and sympathetic neurons

(2012) Michael S. Minett et al.   Nature Communications

Gain of function NaV1.7 mutations in idiopathic small fiber neuropathy

(2011) Catharina G. Faber et al.   ANNALS OF NEUROLOGY

Comparative study of voltage-gated sodium channel α-subunits in non-overlapping four neuronal populations in the rat dorsal root ganglion

(2011) Tetsuo Fukuoka et al.   NEUROSCIENCE RESEARCH

Single-cell analysis of sodium channel expression in dorsal root ganglion neurons

(2010) Cojen Ho et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

The Tarantula Toxins ProTx-II and Huwentoxin-IV Differentially Interact with Human Nav1.7 Voltage Sensors to Inhibit Channel Activation and Inactivation

(2010) Y. Xiao et al.   MOLECULAR PHARMACOLOGY

Spider-Venom Peptides as Therapeutics

(2010) Natalie J. Saez et al.   Toxins

Hepcidin Revisited, Disulfide Connectivity, Dynamics, and Structure

(2009) John B. Jordan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tarantula Huwentoxin-IV Inhibits Neuronal Sodium Channels by Binding to Receptor Site 4 and Trapping the Domain II Voltage Sensor in the Closed Configuration

(2008) Yucheng Xiao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Comparative study of the distribution of the α-subunits of voltage-gated sodium channels in normal and axotomized rat dorsal root ganglion neurons

(2008) Tetsuo Fukuoka et al.   JOURNAL OF COMPARATIVE NEUROLOGY

ProTx-II, a Selective Inhibitor of NaV1.7 Sodium Channels, Blocks Action Potential Propagation in Nociceptors

(2008) W. A. Schmalhofer et al.   MOLECULAR PHARMACOLOGY

Role of TTX-Sensitive and TTX-Resistant Sodium Channels in Aδ- and C-Fiber Conduction and Synaptic Transmission

(2007) Vitor Pinto et al.   JOURNAL OF NEUROPHYSIOLOGY