The voltage-gated sodium channel NaV1.9 in visceral pain

Discovery and Optimization of Selective Nav1.8 Modulator Series That Demonstrate Efficacy in Preclinical Models of Pain

(2015) Sharan K. Bagal et al.   ACS Medicinal Chemistry Letters

Voltage-gated sodium channel mutations and painful neuropathy: Nav1.9 joins the family

(2014) David L. H. Bennett   BRAIN

Gain-of-function mutations in sodium channel NaV1.9 in painful neuropathy

(2014) Jianying Huang et al.   BRAIN

A Monoclonal Antibody that Targets a NaV1.7 Channel Voltage Sensor for Pain and Itch Relief

(2014) Jun-Ho Lee et al.   CELL

Loss-of-Function of the Voltage-Gated Sodium Channel NaV1.5 (Channelopathies) in Patients With Irritable Bowel Syndrome

(2014) Arthur Beyder et al.   GASTROENTEROLOGY

Specialized Functions of Nav1.5 and Nav1.9 Channels in Electrogenesis of Myenteric Neurons in Intact Mouse Ganglia

(2014) N. Osorio et al.   JOURNAL OF NEUROSCIENCE

Multiple roles for NaV1.9 in the activation of visceral afferents by noxious inflammatory, mechanical, and human disease–derived stimuli

(2014) James R.F. Hockley et al.   PAIN

Gain-of-Function Mutations in SCN11A Cause Familial Episodic Pain

(2013) Xiang Yang Zhang et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Mechanism of sodium channel NaV1.9 potentiation by G-protein signaling

(2013) Carlos G. Vanoye et al.   JOURNAL OF GENERAL PHYSIOLOGY

A de novo gain-of-function mutation in SCN11A causes loss of pain perception

(2013) Enrico Leipold et al.   NATURE GENETICS

Extrinsic primary afferent signalling in the gut

(2013) Simon J. H. Brookes et al.   Nature Reviews Gastroenterology & Hepatology

The Nav1.9 channel regulates colonic motility in mice

(2013) Carine Copel et al.   Frontiers in Neuroscience

Altered colorectal afferent function associated with TNBS-induced visceral hypersensitivity in mice

(2012) Bin Feng et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Long-term sensitization of mechanosensitive and -insensitive afferents in mice with persistent colorectal hypersensitivity

(2012) Bin Feng et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Translational neuropharmacology: the use of human isolated gastrointestinal tissues

(2012) GJ Sanger et al.   BRITISH JOURNAL OF PHARMACOLOGY

Role of Nav1.9 in activity-dependent axon growth in motoneurons

(2012) Narayan Subramanian et al.   HUMAN MOLECULAR GENETICS

Gain-of-function Nav1.8 mutations in painful neuropathy

(2012) C. G. Faber et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Achieving translation in models of visceral pain

(2011) David Colin Bulmer et al.   CURRENT OPINION IN PHARMACOLOGY

Guidelines for the management of inflammatory bowel disease in adults

(2011) C. Mowat et al.   GUT

Nav1.9 Channel Contributes to Mechanical and Heat Pain Hypersensitivity Induced by Subacute and Chronic Inflammation

(2011) Stéphane Lolignier et al.   PLoS One

Characterization of silent afferents in the pelvic and splanchnic innervations of the mouse colorectum

(2010) Bin Feng et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Sodium Channels in Normal and Pathological Pain

(2010) Sulayman D. Dib-Hajj et al.   Annual Review of Neuroscience

Familial pain syndromes from mutations of the Nav1.7 sodium channel

(2009) Tanya Z. Fischer et al.   Annals of the New York Academy of Sciences

Exploring the role of nociceptor-specific sodium channels in pain transmission using Nav1.8 and Nav1.9 knockout mice

(2009) Sandra Leo et al.   BEHAVIOURAL BRAIN RESEARCH

Post-inflammatory colonic afferent sensitisation: different subtypes, different pathways and different time courses

(2009) P A Hughes et al.   GUT

Pain and inflammatory bowel disease

(2009) Klaus Bielefeldt et al.   INFLAMMATORY BOWEL DISEASES

Trinitrobenzenesulphonic acid colitis alters Nav1.8 channel expression in mouse dorsal root ganglia neurons

(2009) d. e. king et al.   NEUROGASTROENTEROLOGY AND MOTILITY

The voltage-gated sodium channel Nav1.9 is required for inflammation-based urinary bladder dysfunction

(2009) Amy M. Ritter et al.   NEUROSCIENCE LETTERS

Basic and clinical aspects of gastrointestinal pain

(2009) Charles H. Knowles et al.   PAIN

The Functional–Organic Dichotomy: Postinfectious Irritable Bowel Syndrome and Inflammatory Bowel Disease–Irritable Bowel Syndrome

(2008) Madhusudan Grover et al.   Clinical Gastroenterology and Hepatology

Lack of colonic inflammation-induced acute visceral hypersensitivity to colorectal distension in Nav1.9 knockout mice

(2008) V. Martinez et al.   EUROPEAN JOURNAL OF PAIN

Comparative study of the distribution of the α-subunits of voltage-gated sodium channels in normal and axotomized rat dorsal root ganglion neurons

(2008) Tetsuo Fukuoka et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Inflammatory Mediators Increase Nav1.9 Current and Excitability in Nociceptors through a Coincident Detection Mechanism

(2008) François Maingret et al.   JOURNAL OF GENERAL PHYSIOLOGY

GTP up-regulated persistent Na+current and enhanced nociceptor excitability require NaV1.9

(2007) Johan A. R. Östman et al.   JOURNAL OF PHYSIOLOGY-LONDON