标题
TGF-β signaling in the tumor metabolic microenvironment and targeted therapies
作者
关键词
-
出版物
Journal of Hematology & Oncology
Volume 15, Issue 1, Pages -
出版商
Springer Science and Business Media LLC
发表日期
2022-09-17
DOI
10.1186/s13045-022-01349-6
参考文献
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注意：仅列出部分参考文献，下载原文获取全部文献信息。- TGF-βRII regulates glucose metabolism in oral cancer-associated fibroblasts via promoting PKM2 nuclear translocation
- (2022) Fanglong Wu et al. Cell Death Discovery
- Microenvironment in Oral Potentially Malignant Disorders: Multi-Dimensional Characteristics and Mechanisms of Carcinogenesis
- (2022) Shuzhi Deng et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Integrin αvβ6–TGFβ–SOX4 Pathway Drives Immune Evasion in Triple-Negative Breast Cancer
- (2021) Archis Bagati et al. CANCER CELL
- TGF-β in Cancer: Metabolic Driver of the Tolerogenic Crosstalk in the Tumor Microenvironment
- (2021) Roberta Angioni et al. Cancers
- Metabolism of Dendritic Cells in Tumor Microenvironment: For Immunotherapy
- (2021) Xin Peng et al. Frontiers in Immunology
- TGFβ drives NK cell metabolic dysfunction in human metastatic breast cancer
- (2021) Karen Slattery et al. Journal for ImmunoTherapy of Cancer
- NSDHL promotes triple-negative breast cancer metastasis through the TGFβ signaling pathway and cholesterol biosynthesis
- (2021) Mengting Chen et al. BREAST CANCER RESEARCH AND TREATMENT
- GLUT1 Expression in Tumor-Associated Neutrophils Promotes Lung Cancer Growth and Resistance to Radiotherapy
- (2021) Pierre-Benoit Ancey et al. CANCER RESEARCH
- Glycolysis reprogramming in cancer-associated fibroblasts promotes the growth of oral cancer through the lncRNA H19/miR-675-5p/PFKFB3 signaling pathway
- (2021) Jin Yang et al. International Journal of Oral Science
- Caveolin‐1 increases glycolysis in pancreatic cancer cells and triggers cachectic states
- (2021) Lijuan Hu et al. FASEB JOURNAL
- Epithelial–Mesenchymal Transition (EMT) Induced by TGF-β in Hepatocellular Carcinoma Cells Reprograms Lipid Metabolism
- (2021) Jitka Soukupova et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Cancer-Associated Fibroblasts Facilitate Squamous Cell Carcinoma Lung Metastasis in Mice by Providing TGFβ-Mediated Cancer Stem Cell Niche
- (2021) Xueke Shi et al. Frontiers in Cell and Developmental Biology
- TGF-β-dependent reprogramming of amino acid metabolism induces epithelial–mesenchymal transition in non-small cell lung cancers
- (2021) Fumie Nakasuka et al. Communications Biology
- Integrative analyses of gene expression and chemosensitivity of patient-derived ovarian cancer spheroids link G6PD-driven redox metabolism to cisplatin chemoresistance
- (2021) Kaoru Yamawaki et al. CANCER LETTERS
- Glycogen accumulation and phase separation drives liver tumor initiation
- (2021) Qingxu Liu et al. CELL
- Efficient hemogenic endothelial cell specification by RUNX1 is dependent on baseline chromatin accessibility of RUNX1-regulated TGFβ target genes
- (2021) Elizabeth D. Howell et al. GENES & DEVELOPMENT
- A case of malignant hyperlactaemic acidosis appearing upon treatment with the mono-carboxylase transporter 1 inhibitor AZD3965
- (2020) Rosie McNeillis et al. BRITISH JOURNAL OF CANCER
- Enhanced lipid accumulation and metabolism are required for the differentiation and activation of tumor-associated macrophages
- (2020) Pan Su et al. CANCER RESEARCH
- Tumor cell‐derived angiopoietin‐like protein 2 establishes a preference for glycolytic metabolism in lung cancer cells
- (2020) Hironobu Osumi et al. CANCER SCIENCE
- Adipocyte extracellular vesicles carry enzymes and fatty acids that stimulate mitochondrial metabolism and remodeling in tumor cells
- (2020) Emily Clement et al. EMBO JOURNAL
- Structure-Based Design and Identification of FT-2102 (Olutasidenib), a Potent Mutant-Selective IDH1 Inhibitor
- (2020) Justin A. Caravella et al. JOURNAL OF MEDICINAL CHEMISTRY
- Assessment of acyl-CoA cholesterol acyltransferase (ACAT-1) role in ovarian cancer progression—An in vitro study
- (2020) Vijayalakshmi N. Ayyagari et al. PLoS One
- Vorasidenib (AG-881): A First-in-Class, Brain-Penetrant Dual Inhibitor of Mutant IDH1 and 2 for Treatment of Glioma
- (2020) Zenon Konteatis et al. ACS Medicinal Chemistry Letters
- TGFβ2-induced formation of lipid droplets supports acidosis-driven EMT and the metastatic spreading of cancer cells
- (2020) Cyril Corbet et al. Nature Communications
- Pyruvate Kinase M2 and Cancer: The Role of PKM2 in Promoting Tumorigenesis
- (2020) Kulsoom Zahra et al. Frontiers in Oncology
- Ivosidenib in IDH1-mutant, chemotherapy-refractory cholangiocarcinoma (ClarIDHy): a multicentre, randomised, double-blind, placebo-controlled, phase 3 study
- (2020) Ghassan K Abou-Alfa et al. LANCET ONCOLOGY
- LEFTY2/endometrial bleeding-associated factor up-regulates Na+ Coupled Glucose Transporter SGLT1 expression and Glycogen Accumulation in Endometrial Cancer Cells
- (2020) Ni Zeng et al. PLoS One
- Metabolic reprogramming and cancer progression
- (2020) Brandon Faubert et al. SCIENCE
- Reprogramming of lipid metabolism in cancer-associated fibroblasts potentiates migration of colorectal cancer cells
- (2020) Jin Gong et al. Cell Death & Disease
- Protection from β-cell apoptosis by inhibition of TGF-β/Smad3 signaling
- (2020) Ji-Hyeon Lee et al. Cell Death & Disease
- Red blood cells exposed to cancer cells in culture have altered cytokine profiles and immune function
- (2020) Elisabeth Karsten et al. Scientific Reports
- Targeting G6PD reverses paclitaxel resistance in ovarian cancer by suppressing GSTP1
- (2020) Qi Feng et al. BIOCHEMICAL PHARMACOLOGY
- 3-Bromopyruvate regulates the status of glycolysis and BCNU sensitivity in human hepatocellular carcinoma cells
- (2020) Xiaodong Sun et al. BIOCHEMICAL PHARMACOLOGY
- Metabolic alterations in the tumor microenvironment and their role in oncogenesis
- (2020) Lihie Eisenberg et al. CANCER LETTERS
- Ivosidenib in Isocitrate Dehydrogenase 1–Mutated Advanced Glioma
- (2020) Ingo K. Mellinghoff et al. JOURNAL OF CLINICAL ONCOLOGY
- TGFβ biology in cancer progression and immunotherapy
- (2020) Rik Derynck et al. Nature Reviews Clinical Oncology
- TGF‑β1‑induced epithelial‑mesenchymal transition increases fatty acid oxidation and OXPHOS activity via the p‑AMPK pathway in breast cancer cells
- (2020) Qian‑Qian Liu et al. ONCOLOGY REPORTS
- Discovery of Hordenine as a Potential Inhibitor of Pyruvate Dehydrogenase Kinase 3: Implication in Lung Cancer Therapy
- (2020) Saleha Anwar et al. Biomedicines
- Inhibitors of Fatty Acid Synthesis and Oxidation as Potential Anticancer Agents in Colorectal Cancer Treatment
- (2020) PAULINA MOZOLEWSKA et al. ANTICANCER RESEARCH
- Cholesterol Pathway Inhibition Induces TGF-β Signaling to Promote Basal Differentiation in Pancreatic Cancer
- (2020) Linara Gabitova-Cornell et al. CANCER CELL
- Metabolism
- (2020) Ayesha Judge et al. Essays in Biochemistry
- Exploring the NK cell platform for cancer immunotherapy
- (2020) Jacob A. Myers et al. Nature Reviews Clinical Oncology
- Breast cancer–associated macrophages promote tumorigenesis by suppressing succinate dehydrogenase in tumor cells
- (2020) Valentí Gómez et al. Science Signaling
- Modulating NK cell metabolism for cancer immunotherapy
- (2020) Iñigo Terrén et al. SEMINARS IN HEMATOLOGY
- The Emerging Role of Neutrophil Extracellular Traps (NETs) in Tumor Progression and Metastasis
- (2020) Maria Teresa Masucci et al. Frontiers in Immunology
- Targeting SREBP-2-Regulated Mevalonate Metabolism for Cancer Therapy
- (2020) Linyuan Xue et al. Frontiers in Oncology
- Glutamine-Directed Migration of Cancer-Activated Fibroblasts Facilitates Epithelial Tumor Invasion
- (2020) Aida Mestre-Farrera et al. CANCER RESEARCH
- Discovery and optimization of withangulatin A derivatives as novel glutaminase 1 inhibitors for the treatment of triple-negative breast cancer
- (2020) Wu-Xi Zhou et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- The glutaminase inhibitor CB-839 (Telaglenastat) enhances the anti-melanoma activity of T cell mediated immunotherapies.
- (2020) Sruthy Varghese et al. MOLECULAR CANCER THERAPEUTICS
- Different Regulation of Glut1 Expression and Glucose Uptake during the Induction and Chronic Stages of TGFβ1-Induced EMT in Breast Cancer Cells
- (2020) Azadeh Nilchian et al. Biomolecules
- Transforming Growth Factor-β Signaling in Fibrotic Diseases and Cancer-Associated Fibroblasts
- (2020) Xueke Shi et al. Biomolecules
- Metastasis-on-a-chip reveals adipocyte-derived lipids trigger cancer cell migration via HIF-1α activation in cancer cells
- (2020) Jieun Seo et al. BIOMATERIALS
- TGF-β2, catalase activity, H2O2 output and metastatic potential of diverse types of tumour
- (2019) Malak Haidar et al. FREE RADICAL BIOLOGY AND MEDICINE
- Opposing roles and potential antagonistic mechanism between TGF-β and BMP pathways: Implications for cancer progression
- (2019) Junya Ning et al. EBioMedicine
- Cachexia induced by cancer and chemotherapy yield distinct perturbations to energy metabolism
- (2019) Fabrizio Pin et al. Journal of Cachexia Sarcopenia and Muscle
- Neutrophil Degranulation, Plasticity, and Cancer Metastasis
- (2019) Faustino Mollinedo TRENDS IN IMMUNOLOGY
- Hypoxia-induced tumor exosomes promote M2-like macrophage polarization of infiltrating myeloid cells and microRNA-mediated metabolic shift
- (2019) Jung Eun Park et al. ONCOGENE
- Navigating metabolic pathways to enhance antitumour immunity and immunotherapy
- (2019) Xiaoyun Li et al. Nature Reviews Clinical Oncology
- Long non-coding RNA PVT1 promotes tumor progression by regulating the miR-143/HK2 axis in gallbladder cancer
- (2019) Jianan Chen et al. Molecular Cancer
- PMEPA1 induces EMT via a non‐canonical TGF‐β signalling in colorectal cancer
- (2019) Lei Zhang et al. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
- Cholesterol Induces CD8+ T Cell Exhaustion in the Tumor Microenvironment
- (2019) Xingzhe Ma et al. Cell Metabolism
- Transforming Growth Factor-β Signaling in Immunity and Cancer
- (2019) Eduard Batlle et al. IMMUNITY
- Glucose-6-phosphate dehydrogenase blockade potentiates tyrosine kinase inhibitor effect on breast cancer cells through autophagy perturbation
- (2019) Luigi Mele et al. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
- Autophagy Exacerbates Muscle Wasting in Cancer Cachexia and Impairs Mitochondrial Function
- (2019) Fabio Penna et al. JOURNAL OF MOLECULAR BIOLOGY
- Inhibition of FASN suppresses the malignant biological behavior of non-small cell lung cancer cells via deregulating glucose metabolism and AKT/ERK pathway
- (2019) Ligong Chang et al. Lipids in Health and Disease
- Metabolic regulation of cell growth and proliferation
- (2019) Jiajun Zhu et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- A New Switch for TGFβ in Cancer
- (2019) Hsi-Wen Yeh et al. CANCER RESEARCH
- The Tumor Metabolic Microenvironment: Lessons from Lactate
- (2019) Juan C. García-Cañaveras et al. CANCER RESEARCH
- Macrophages Promote Growth of Squamous Cancer Independent of T cells
- (2019) F.L. Wu et al. JOURNAL OF DENTAL RESEARCH
- Lipid accumulation impairs natural killer cell cytotoxicity and tumor control in the postoperative period
- (2019) Seyedeh Raheleh Niavarani et al. BMC CANCER
- Fluvastatin inhibits HMG-CoA reductase and prevents non-small cell lung carcinogenesis
- (2019) Tianshun Zhang et al. Cancer Prevention Research
- Tumor-derived TGF-β inhibits mitochondrial respiration to suppress IFN-γ production by human CD4+ T cells
- (2019) Sarah Dimeloe et al. Science Signaling
- Discovery of a Potent GLUT Inhibitor from a Library of Rapafucins by Using 3D Microarrays
- (2019) Zufeng Guo et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Small molecules targeting HIF-1α pathway for cancer therapy in recent years
- (2019) Wendi Tang et al. BIOORGANIC & MEDICINAL CHEMISTRY
- Metabolic landscape of the tumor microenvironment at single cell resolution
- (2019) Zhengtao Xiao et al. Nature Communications
- Restricting Glycolysis Preserves T Cell Effector Functions and Augments Checkpoint Therapy
- (2019) Kathrin Renner et al. Cell Reports
- The Metabolic Profile of Tumor and Virally Infected Cells Shapes Their Microenvironment Counteracting T Cell Immunity
- (2019) Isabelle Magalhaes et al. Frontiers in Immunology
- Lactate in the Regulation of Tumor Microenvironment and Therapeutic Approaches
- (2019) Karen G. de la Cruz-López et al. Frontiers in Oncology
- Transcriptomic analysis of human primary breast cancer identifies fatty acid oxidation as a target for metformin
- (2019) Simon R. Lord et al. BRITISH JOURNAL OF CANCER
- Reprogramming of fatty acid metabolism in cancer
- (2019) Nikos Koundouros et al. BRITISH JOURNAL OF CANCER
- A Novel Allosteric Inhibitor of Phosphoglycerate Mutase 1 Suppresses Growth and Metastasis of Non-Small-Cell Lung Cancer
- (2019) Ke Huang et al. Cell Metabolism
- TGFβ-induced metabolic reprogramming during epithelial-to-mesenchymal transition in cancer
- (2019) Wan Hua et al. CELLULAR AND MOLECULAR LIFE SCIENCES
- Rescue of TCA Cycle Dysfunction for Cancer Therapy
- (2019) Jubert Marquez et al. Journal of Clinical Medicine
- TGF-β signaling promotes tumor vasculature by enhancing the pericyte-endothelium association
- (2018) Justin Zonneville et al. BMC CANCER
- Increased Tumor Glycolysis Characterizes Immune Resistance to Adoptive T Cell Therapy
- (2018) Tina Cascone et al. Cell Metabolism
- Dysfunction of Natural Killer Cells by FBP1-Induced Inhibition of Glycolysis during Lung Cancer Progression
- (2018) Jingjing Cong et al. Cell Metabolism
- Fatty acid synthase mediates EGFR palmitoylation in EGFR mutated non‐small cell lung cancer
- (2018) Azhar Ali et al. EMBO Molecular Medicine
- Fasting Blood Glucose Levels Provide Estimate of Duration and Progression of Pancreatic Cancer Before Diagnosis
- (2018) Ayush Sharma et al. GASTROENTEROLOGY
- Upregulation of lactate-inducible snail protein suppresses oncogene-mediated senescence through p16INK4a inactivation
- (2018) Xiangrui Li et al. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
- Canonical TGF-β Signaling Pathway Represses Human NK Cell Metabolism
- (2018) Vanessa Zaiatz-Bittencourt et al. JOURNAL OF IMMUNOLOGY
- Metabolism within the tumor microenvironment and its implication on cancer progression: An ongoing therapeutic target
- (2018) Ma Carmen Ocaña et al. MEDICINAL RESEARCH REVIEWS
- Exosomes Induce Fibroblast Differentiation into Cancer-Associated Fibroblasts through TGFβ Signaling
- (2018) Cassandra Ringuette Goulet et al. MOLECULAR CANCER RESEARCH
- TGF-β-mediated LEFTY/Akt/GSK-3β/Snail axis modulates epithelial-mesenchymal transition and cancer stem cell properties in ovarian clear cell carcinomas
- (2018) Toshihide Matsumoto et al. MOLECULAR CARCINOGENESIS
- A Metabolic Basis for Endothelial-to-Mesenchymal Transition
- (2018) Jianhua Xiong et al. MOLECULAR CELL
- Myeloid-derived suppressor cells coming of age
- (2018) Filippo Veglia et al. NATURE IMMUNOLOGY
- Lapachol inhibits glycolysis in cancer cells by targeting pyruvate kinase M2
- (2018) Mani Shankar Babu et al. PLoS One
- Absorption, distribution, metabolism and excretion of an isocitrate dehydrogenase-2 inhibitor enasidenib in rats and humans
- (2018) Zeen Tong et al. XENOBIOTICA
- Lysophosphatidylcholine acyltransferase 2-mediated lipid droplet production supports colorectal cancer chemoresistance
- (2018) Alexia Karen Cotte et al. Nature Communications
- Amino acid-dependent cMyc expression is essential for NK cell metabolic and functional responses in mice
- (2018) Róisín M. Loftus et al. Nature Communications
- Metabolic Reprogramming of Cancer Associated Fibroblasts: The Slavery of Stromal Fibroblasts
- (2018) Angelica Avagliano et al. Biomed Research International
- Inhibition of Glucose-6-Phosphate Dehydrogenase Reverses Cisplatin Resistance in Lung Cancer Cells via the Redox System
- (2018) Weipeng Hong et al. Frontiers in Pharmacology
- Dysregulation of the MiR-449b target TGFBI alters the TGFβ pathway to induce cisplatin resistance in nasopharyngeal carcinoma
- (2018) Pierre-Antoine Bissey et al. Oncogenesis
- Teaming Up for Trouble: Cancer Cells, Transforming Growth Factor-β1 Signaling and the Epigenetic Corruption of Stromal Naïve Fibroblasts
- (2018) Sergio Lamprecht et al. Cancers
- Methyl-β-cyclodextrin potentiates the BITC-induced anti-cancer effect through modulation of the Akt phosphorylation in human colorectal cancer cells
- (2018) Qifu Yang et al. BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY
- Fatty acid oxidation is associated with proliferation and prognosis in breast and other cancers
- (2018) Aziz Aiderus et al. BMC CANCER
- Cutting Edge: TGF-β and Phosphatidylinositol 3-Kinase Signals Modulate Distinct Metabolism of Regulatory T Cell Subsets
- (2018) Bhavana Priyadharshini et al. JOURNAL OF IMMUNOLOGY
- Radiation-Induced Myofibroblasts Promote Tumor Growth via Mitochondrial ROS–Activated TGFβ Signaling
- (2018) Tsutomu Shimura et al. MOLECULAR CANCER RESEARCH
- Tissue-resident NK cells differ in their expression profile of the nutrient transporters Glut1, CD98 and CD71
- (2018) Wilhelm Salzberger et al. PLoS One
- Transketolase like 1 (TKTL1) expression alterations in prostate cancer tumorigenesis
- (2018) Inês Anselmo da Costa et al. UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS
- Large-Scale Human Dendritic Cell Differentiation Revealing Notch-Dependent Lineage Bifurcation and Heterogeneity
- (2018) Sreekumar Balan et al. Cell Reports
- Immunosuppression mediated by myeloid-derived suppressor cells (MDSCs) during tumour progression
- (2018) Christopher Groth et al. BRITISH JOURNAL OF CANCER
- HMGB1/autophagy pathway mediates the atrophic effect of TGF-β1 in denervated skeletal muscle
- (2018) Xiaofan Yang et al. Cell Communication and Signaling
- Tissue Factor Facilitates Wound Healing in Human Airway Epithelial Cells
- (2018) Michael D. Davis et al. CHEST
- Cancer-associated fibroblasts modify lung cancer metabolism involving ROS and TGF-β signaling
- (2018) Alberto Cruz-Bermúdez et al. FREE RADICAL BIOLOGY AND MEDICINE
- Effects of tumor metabolic microenvironment on regulatory T cells
- (2018) Yi-an Wang et al. Molecular Cancer
- Dynamics and functions of lipid droplets
- (2018) James A. Olzmann et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- CtBP promotes metastasis of breast cancer through repressing cholesterol and activating TGF-β signaling
- (2018) Zhiqiang Zhao et al. ONCOGENE
- EMT Transition States during Tumor Progression and Metastasis
- (2018) Ievgenia Pastushenko et al. TRENDS IN CELL BIOLOGY
- Tumour-elicited neutrophils engage mitochondrial metabolism to circumvent nutrient limitations and maintain immune suppression
- (2018) Christopher M. Rice et al. Nature Communications
- Fatty acid synthase (FASN) as a therapeutic target in breast cancer
- (2017) Javier A. Menendez et al. EXPERT OPINION ON THERAPEUTIC TARGETS
- TGF-β1 targets Smad, p38 MAPK, and PI3K/Akt signaling pathways to induce PFKFB3 gene expression and glycolysis in glioblastoma cells
- (2017) Ana Rodríguez-García et al. FEBS Journal
- TGF-β1/Smad3 Pathway Targets PP2A-AMPK-FoxO1 Signaling to Regulate Hepatic Gluconeogenesis
- (2017) Hariom Yadav et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Macrophages as Key Drivers of Cancer Progression and Metastasis
- (2017) Sebastian R. Nielsen et al. MEDIATORS OF INFLAMMATION
- Association of long-chain acyl-coenzyme A synthetase 5 expression in human breast cancer by estrogen receptor status and its clinical significance
- (2017) Meng-Chi Yen et al. ONCOLOGY REPORTS
- Oncogene KRAS activates fatty acid synthase, resulting in specific ERK and lipid signatures associated with lung adenocarcinoma
- (2017) Arvin M. Gouw et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- TGF-β Signaling in Control of Cardiovascular Function
- (2017) Marie-José Goumans et al. Cold Spring Harbor Perspectives in Biology
- TGF-β Family Signaling in Tumor Suppression and Cancer Progression
- (2017) Joan Seoane et al. Cold Spring Harbor Perspectives in Biology
- The cholesterol metabolite 27 hydroxycholesterol facilitates breast cancer metastasis through its actions on immune cells
- (2017) Amy E. Baek et al. Nature Communications
- HIF drives lipid deposition and cancer in ccRCC via repression of fatty acid metabolism
- (2017) Weinan Du et al. Nature Communications
- TGF-β in pancreatic cancer initiation and progression: two sides of the same coin
- (2017) Wei Shen et al. Cell and Bioscience
- Mammalian Target of Rapamycin (mTOR) Regulates Transforming Growth Factor-β1 (TGF-β1)-Induced Epithelial-Mesenchymal Transition via Decreased Pyruvate Kinase M2 (PKM2) Expression in Cervical Cancer Cells
- (2017) Ke-yan Cheng et al. MEDICAL SCIENCE MONITOR
- An Overview of Lipid Droplets in Cancer and Cancer Stem Cells
- (2017) L. Tirinato et al. Stem Cells International
- CD39/CD73 upregulation on myeloid-derived suppressor cells via TGF-β-mTOR-HIF-1 signaling in patients with non-small cell lung cancer
- (2017) Jieyao Li et al. OncoImmunology
- Exogenous lipid uptake induces metabolic and functional reprogramming of tumor-associated myeloid-derived suppressor cells
- (2017) Amir A. Al-Khami et al. OncoImmunology
- Metabolic Cooperation and Competition in the Tumor Microenvironment: Implications for Therapy
- (2017) Seema Gupta et al. Frontiers in Oncology
- The Central Role of Amino Acids in Cancer Redox Homeostasis: Vulnerability Points of the Cancer Redox Code
- (2017) Milica Vučetić et al. Frontiers in Oncology
- Role of the Transforming Growth Factor-β in regulating hepatocellular carcinoma oxidative metabolism
- (2017) Jitka Soukupova et al. Scientific Reports
- When the endothelium scores an own goal: endothelial cells actively augment metastatic extravasation through endothelial-mesenchymal transition
- (2016) Ákos Gasparics et al. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
- Clinical and prognostic significance of serum transforming growth factor-beta1 levels in patients with pancreatic ductal adenocarcinoma
- (2016) J. Zhao et al. BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH
- Hexokinase 2 is a determinant of neuroblastoma metastasis
- (2016) Liat Edry Botzer et al. BRITISH JOURNAL OF CANCER
- Inhibition of the Glycolytic Activator PFKFB3 in Endothelium Induces Tumor Vessel Normalization, Impairs Metastasis, and Improves Chemotherapy
- (2016) Anna Rita Cantelmo et al. CANCER CELL
- Candidate Antimetastasis Drugs Suppress the Metastatic Capacity of Breast Cancer Cells by Reducing Membrane Fluidity
- (2016) Weina Zhao et al. CANCER RESEARCH
- Phenotypic changes of acid-adapted cancer cells push them toward aggressiveness in their evolution in the tumor microenvironment
- (2016) Mehdi Damaghi et al. CELL CYCLE
- Targeting Stromal Glutamine Synthetase in Tumors Disrupts Tumor Microenvironment-Regulated Cancer Cell Growth
- (2016) Lifeng Yang et al. Cell Metabolism
- Macrophage Metabolism Controls Tumor Blood Vessel Morphogenesis and Metastasis
- (2016) Mathias Wenes et al. Cell Metabolism
- Aspirin-triggered resolvin D1 inhibits TGF-β1-induced EMT through the inhibition of the mTOR pathway by reducing the expression of PKM2 and is closely linked to oxidative stress
- (2016) Yu Liu et al. INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
- Metabolic Reprogramming Supports IFN-γ Production by CD56brightNK Cells
- (2016) Sinéad E. Keating et al. JOURNAL OF IMMUNOLOGY
- Comprehensive Proteomics Analysis Reveals Metabolic Reprogramming of Tumor-Associated Macrophages Stimulated by the Tumor Microenvironment
- (2016) Di Liu et al. JOURNAL OF PROTEOME RESEARCH
- The Evolving Landscape in the Development of Isocitrate Dehydrogenase Mutant Inhibitors
- (2016) Jiao Chen et al. MINI-REVIEWS IN MEDICINAL CHEMISTRY
- Glutaminolysis Was Induced by TGF-β1 through PP2Ac Regulated Raf-MEK-ERK Signaling in Endothelial Cells
- (2016) YanYan Guo et al. PLoS One
- Adipose tissue at the nexus of systemic and cellular immunometabolism
- (2016) Ayano C. Kohlgruber et al. SEMINARS IN IMMUNOLOGY
- SDHB deficiency promotes TGFβ-mediated invasion and metastasis of colorectal cancer through transcriptional repression complex SNAIL1-SMAD3/4
- (2016) Haiyu Wang et al. Translational Oncology
- CAF cellular glycolysis: linking cancer cells with the microenvironment
- (2016) Amrita Roy et al. TUMOR BIOLOGY
- Structural Biology and Evolution of the TGF-β Family
- (2016) Andrew P. Hinck et al. Cold Spring Harbor Perspectives in Biology
- A FASN-TGF-β1-FASN regulatory loop contributes to high EMT/metastatic potential of cisplatin-resistant non-small cell lung cancer
- (2016) Li Yang et al. Oncotarget
- Intrinsic and Tumor Microenvironment-Induced Metabolism Adaptations of T Cells and Impact on Their Differentiation and Function
- (2016) Soumaya Kouidhi et al. Frontiers in Immunology
- Transcriptional and metabolic reprogramming induce an inflammatory phenotype in non-medullary thyroid carcinoma-induced macrophages
- (2016) Rob J. W. Arts et al. OncoImmunology
- Metabolic reprogramming of myeloid-derived suppressor cells (MDSC) in cancer
- (2016) Amir A. Al-Khami et al. OncoImmunology
- Progress in the development of fatty acid synthase inhibitors as anticancer targets
- (2015) Genevieve E. Mullen et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Cutaneous keratoacanthomas/squamous cell carcinomas associated with neutralization of transforming growth factor β by the monoclonal antibody fresolimumab (GC1008)
- (2015) Mario E. Lacouture et al. CANCER IMMUNOLOGY IMMUNOTHERAPY
- Phosphoenolpyruvate Is a Metabolic Checkpoint of Anti-tumor T Cell Responses
- (2015) Ping-Chih Ho et al. CELL
- Reprogramming of glucose, fatty acid and amino acid metabolism for cancer progression
- (2015) Zhaoyong Li et al. CELLULAR AND MOLECULAR LIFE SCIENCES
- Molecular pathogenesis of ovarian clear cell carcinoma
- (2015) Ioannis Gounaris et al. Future Oncology
- Network Integration of Parallel Metabolic and Transcriptional Data Reveals Metabolic Modules that Regulate Macrophage Polarization
- (2015) Abhishek K. Jha et al. IMMUNITY
- A phase I open-labeled, single-arm, dose-escalation, study of dichloroacetate (DCA) in patients with advanced solid tumors
- (2015) Quincy Siu-Chung Chu et al. INVESTIGATIONAL NEW DRUGS
- Immunometabolism governs dendritic cell and macrophage function
- (2015) Luke A.J. O’Neill et al. JOURNAL OF EXPERIMENTAL MEDICINE
- MicroRNA-10a silencing reverses cisplatin resistance in the A549/cisplatin human lung cancer cell line via the transforming growth factor-β/Smad2/STAT3/STAT5 pathway
- (2015) WEI SUN et al. Molecular Medicine Reports
- Metabolic pathways promoting cancer cell survival and growth
- (2015) Lindsey K. Boroughs et al. NATURE CELL BIOLOGY
- Mitochondrial SOD2 regulates epithelial–mesenchymal transition and cell populations defined by differential CD44 expression
- (2015) H Kinugasa et al. ONCOGENE
- Metabolic Reprogramming of Cancer-Associated Fibroblasts by IDH3α Downregulation
- (2015) Daoxiang Zhang et al. Cell Reports
- Inhibition of Fatty Acid Oxidation Modulates Immunosuppressive Functions of Myeloid-Derived Suppressor Cells and Enhances Cancer Therapies
- (2015) F. Hossain et al. Cancer Immunology Research
- Mesothelioma Tumor Cells Modulate Dendritic Cell Lipid Content, Phenotype and Function
- (2015) Joanne K. Gardner et al. PLoS One
- Lithium Modulates Autophagy in Esophageal and Colorectal Cancer Cells and Enhances the Efficacy of Therapeutic Agents In Vitro and In Vivo
- (2015) Tracey R. O’Donovan et al. PLoS One
- TGF-β Blockade Reduces Mortality and Metabolic Changes in a Validated Murine Model of Pancreatic Cancer Cachexia
- (2015) Stephanie H. Greco et al. PLoS One
- Frequent amplification of ORAOV1 gene in esophageal squamous cell cancer promotes an aggressive phenotype via proline metabolism and ROS production
- (2015) Yosuke Togashi et al. Oncotarget
- Clear Cell Melanoma: A Cutaneous Clear Cell Malignancy
- (2014) Maria A. Pletneva et al. ARCHIVES OF PATHOLOGY & LABORATORY MEDICINE
- Molecular mechanisms of neutrophil dysfunction in glycogen storage disease type Ib
- (2014) H. S. Jun et al. BLOOD
- A Systems Biology Approach Identifies Effective Tumor–Stroma Common Targets for Oral Squamous Cell Carcinoma
- (2014) Wenxia Meng et al. CANCER RESEARCH
- Hexokinase 2 regulates G1/S checkpoint through CDK2 in cancer-associated fibroblasts
- (2014) Jun-wei Hu et al. CELLULAR SIGNALLING
- Dehydroepiandrosterone (DHEA): Hypes and Hopes
- (2014) Krzysztof Rutkowski et al. DRUGS
- Metabolic Reprogramming Is Required for Antibody Production That Is Suppressed in Anergic but Exaggerated in Chronically BAFF-Exposed B Cells
- (2014) A. Caro-Maldonado et al. JOURNAL OF IMMUNOLOGY
- Dichloroacetate Enhances Adriamycin-Induced Hepatoma Cell Toxicity In Vitro and In Vivo by Increasing Reactive Oxygen Species Levels
- (2014) Yunhai Dai et al. PLoS One
- Role of pyruvate kinase M2 in transcriptional regulation leading to epithelial-mesenchymal transition
- (2014) A. Hamabe et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The pentose phosphate pathway and cancer
- (2014) Krushna C. Patra et al. TRENDS IN BIOCHEMICAL SCIENCES
- Fatty Acid Uptake and Lipid Storage Induced by HIF-1α Contribute to Cell Growth and Survival after Hypoxia-Reoxygenation
- (2014) Karim Bensaad et al. Cell Reports
- Regulation of the pentose phosphate pathway in cancer
- (2014) Peng Jiang et al. Protein & Cell
- Evolutionary Roots of Arginase Expression and Regulation
- (2014) Jolanta Maria Dzik Frontiers in Immunology
- Autophagic Degradation Contributes to Muscle Wasting in Cancer Cachexia
- (2013) Fabio Penna et al. AMERICAN JOURNAL OF PATHOLOGY
- SDH Mutations Establish a Hypermethylator Phenotype in Paraganglioma
- (2013) Eric Letouzé et al. CANCER CELL
- Role of PFKFB3-Driven Glycolysis in Vessel Sprouting
- (2013) Katrien De Bock et al. CELL
- Inhibiting glycolytic metabolism enhances CD8+ T cell memory and antitumor function
- (2013) Madhusudhanan Sukumar et al. JOURNAL OF CLINICAL INVESTIGATION
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- (2013) Gustavo Ayala et al. JOURNAL OF PATHOLOGY
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- (2013) Y. Pang et al. Cancer Discovery
- BAY 87-2243, a highly potent and selective inhibitor of hypoxia-induced gene activation has antitumor activities by inhibition of mitochondrial complex I
- (2013) Peter Ellinghaus et al. Cancer Medicine
- Phosphoglycerate Mutase 1 Coordinates Glycolysis and Biosynthesis to Promote Tumor Growth
- (2012) Taro Hitosugi et al. CANCER CELL
- Metabolic reprogramming of cancer-associated fibroblasts by TGF-β drives tumor growth: Connecting TGF-β signaling with “Warburg-like” cancer metabolism and L-lactate production
- (2012) Carmela Guido et al. CELL CYCLE
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- (2012) Elena Favaro et al. Cell Metabolism
- Hypoxia-Inducible Factor Prolyl Hydroxylase Inhibition: Robust New Target or Another Big Bust for Stroke Therapeutics?
- (2012) Saravanan S Karuppagounder et al. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
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- (2012) Angela Maria Cozzolino et al. JOURNAL OF HEPATOLOGY
- Interaction with colon cancer cells hyperactivates TGF-β signaling in cancer-associated fibroblasts
- (2012) L J A C Hawinkels et al. ONCOGENE
- Akt/PKB-Mediated Phosphorylation of Twist1 Promotes Tumor Metastasis via Mediating Cross-Talk between PI3K/Akt and TGF-β Signaling Axes
- (2012) Gongda Xue et al. Cancer Discovery
- Glycogen Synthesis is Induced in Hypoxia by the Hypoxia-Inducible Factor and Promotes Cancer Cell Survival
- (2012) Joffrey Pelletier et al. Frontiers in Oncology
- Aerobic Glycolysis: Meeting the Metabolic Requirements of Cell Proliferation
- (2011) Sophia Y. Lunt et al. Annual Review of Cell and Developmental Biology
- A novel approach to cancer therapy using PX-478 as a HIF-1α inhibitor
- (2011) Kyeong Lee et al. ARCHIVES OF PHARMACAL RESEARCH
- Downregulation of TGF-beta receptor types II and III in oral squamous cell carcinoma and oral carcinoma-associated fibroblasts
- (2011) Wenxia Meng et al. BMC CANCER
- Identification of transaldolase as a novel serum biomarker for hepatocellular carcinoma metastasis using xenografted mouse model and clinic samples
- (2011) Cun Wang et al. CANCER LETTERS
- The reverse Warburg effect: Aerobic glycolysis in cancer associated fibroblasts and the tumor stroma
- (2011) Stephanos Pavlides et al. CELL CYCLE
- Cancer cells metabolically "fertilize" the tumor microenvironment with hydrogen peroxide, driving the Warburg effect
- (2011) Ubaldo E. Martinez-Outschoorn et al. CELL CYCLE
- Pericytes: Developmental, Physiological, and Pathological Perspectives, Problems, and Promises
- (2011) Annika Armulik et al. DEVELOPMENTAL CELL
- Stromal–epithelial metabolic coupling in cancer: Integrating autophagy and metabolism in the tumor microenvironment
- (2011) Ubaldo E. Martinez-Outschoorn et al. INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
- Chemokine nitration prevents intratumoral infiltration of antigen-specific T cells
- (2011) Barbara Molon et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Novel TGF- Antagonist Inhibits Tumor Growth and Angiogenesis by Inducing IL-2 Receptor-Driven STAT1 Activation
- (2011) C. Penafuerte et al. JOURNAL OF IMMUNOLOGY
- Cutting Edge: Distinct Glycolytic and Lipid Oxidative Metabolic Programs Are Essential for Effector and Regulatory CD4+ T Cell Subsets
- (2011) R. D. Michalek et al. JOURNAL OF IMMUNOLOGY
- Definition and classification of cancer cachexia: an international consensus
- (2011) Kenneth Fearon et al. LANCET ONCOLOGY
- Adipocytes promote ovarian cancer metastasis and provide energy for rapid tumor growth
- (2011) Kristin M Nieman et al. NATURE MEDICINE
- Shikonin and its analogs inhibit cancer cell glycolysis by targeting tumor pyruvate kinase-M2
- (2011) J Chen et al. ONCOGENE
- Carcinoma-associated fibroblasts promotes the proliferation of a lingual carcinoma cell line by secreting keratinocyte growth factor
- (2011) Jingwen Lin et al. TUMOR BIOLOGY
- Ketones and lactate “fuel” tumor growth and metastasis
- (2010) Gloria Bonuccelli et al. CELL CYCLE
- Oxidative stress in cancer associated fibroblasts drives tumor-stroma co-evolution
- (2010) Ubaldo E. Martinez-Outschoorn et al. CELL CYCLE
- Tumors as Organs: Complex Tissues that Interface with the Entire Organism
- (2010) Mikala Egeblad et al. DEVELOPMENTAL CELL
- Hypoxia-inducible factor 1-mediated regulation of PPP1R3C promotes glycogen accumulation in human MCF-7 cells under hypoxia
- (2010) Guo-Min Shen et al. FEBS LETTERS
- Fatty acid synthase as a potential therapeutic target in cancer
- (2010) Richard Flavin et al. Future Oncology
- IKK controls canonical TGF -SMAD signaling to regulate genes expressing SNAIL and SLUG during EMT in Panc1 cells
- (2010) M. Brandl et al. JOURNAL OF CELL SCIENCE
- Increased 18F-FDG uptake and expression of Glut1 in the EMT transformed breast cancer cells induced by TGF-β
- (2010) W. Li et al. NEOPLASMA
- Hypoxia Promotes Glycogen Accumulation through Hypoxia Inducible Factor (HIF)-Mediated Induction of Glycogen Synthase 1
- (2010) Nuria Pescador et al. PLoS One
- A study of high-dose oral silybin-phytosome followed by prostatectomy in patients with localized prostate cancer
- (2010) Thomas W. Flaig et al. PROSTATE
- Targeting tumor metabolism with 2-deoxyglucose in patients with castrate-resistant prostate cancer and advanced malignancies
- (2010) Mark Stein et al. PROSTATE
- Macrophages: Master Regulators of Inflammation and Fibrosis
- (2010) Thomas Wynn et al. SEMINARS IN LIVER DISEASE
- Identification of small molecule inhibitors of pyruvate kinase M2
- (2009) Matthew G. Vander Heiden et al. BIOCHEMICAL PHARMACOLOGY
- IL-8 induces exocytosis of arginase 1 by neutrophil polymorphonuclears in nonsmall cell lung cancer
- (2009) Rita Rotondo et al. INTERNATIONAL JOURNAL OF CANCER
- Glycolytic phenotype in breast cancer: activation of Akt, up-regulation of GLUT1, TKTL1 and down-regulation of M2PK
- (2009) Melanie Schmidt et al. JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
- Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation
- (2009) M. G. Vander Heiden et al. SCIENCE
- Endocytic regulation of TGF-β signaling
- (2008) Ye-Guang Chen CELL RESEARCH
- TKTL1 is overexpressed in a large portion of non-small cell lung cancer specimens
- (2008) Holger Schultz et al. Diagnostic Pathology
- Glucose deprivation inhibits multiple key gene expression events and effector functions in CD8+ T cells
- (2008) Candace M. Cham et al. EUROPEAN JOURNAL OF IMMUNOLOGY
- Axin and GSK3- control Smad3 protein stability and modulate TGF- signaling
- (2008) X. Guo et al. GENES & DEVELOPMENT
- Molecular mechanisms for the activity of PX-478, an antitumor inhibitor of the hypoxia-inducible factor-1
- (2008) M. Y. Koh et al. MOLECULAR CANCER THERAPEUTICS
- Transcriptional Paradigms in Mammalian Mitochondrial Biogenesis and Function
- (2008) Richard C. Scarpulla PHYSIOLOGICAL REVIEWS
- Cholesterol modulates cellular TGF-β responsiveness by altering TGF-β binding to TGF-β receptors
- (2007) Chun-Lin Chen et al. JOURNAL OF CELLULAR PHYSIOLOGY
- Apigenin inhibits HGF-promoted invasive growth and metastasis involving blocking PI3K/Akt pathway and β4 integrin function in MDA-MB-231 breast cancer cells
- (2007) Wei-Jiunn Lee et al. TOXICOLOGY AND APPLIED PHARMACOLOGY
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