Fatty acid synthase as a potential therapeutic target in cancer

Overexpression of fatty acid synthase gene activates HER1/HER2 tyrosine kinase receptors in human breast epithelial cells

(2010) A. Vazquez-Martin et al.   CELL PROLIFERATION

Interaction between fatty acid synthase- and ErbB-systems in ovarian cancer cells

(2009) Thomas W. Grunt et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Novel fatty acid synthase (FAS) inhibitors: Design, synthesis, biological evaluation, and molecular docking studies

(2009) Xiaokui Wang et al.   BIOORGANIC & MEDICINAL CHEMISTRY

De novo fatty-acid synthesis and related pathways as molecular targets for cancer therapy

(2009) T Mashima et al.   BRITISH JOURNAL OF CANCER

Novel Inhibitors of Fatty Acid Synthase with Anticancer Activity

(2009) T. Puig et al.   CLINICAL CANCER RESEARCH

Increased expression of fatty acid synthase in human aberrant crypt foci: Possible target for colorectal cancer prevention

(2009) Kathleen E. Kearney et al.   INTERNATIONAL JOURNAL OF CANCER

Fatty Acid Synthase: A Metabolic Enzyme and Candidate Oncogene in Prostate Cancer

(2009) Toshiro Migita et al.   JNCI-Journal of the National Cancer Institute

Inhibition of Fatty Acid Synthase by Orlistat Accelerates Gastric Tumor Cell Apoptosis in Culture and Increases Survival Rates in Gastric Tumor Bearing Mice In Vivo

(2009) Shawn Dowling et al.   LIPIDS

Malonyl-CoA decarboxylase inhibition is selectively cytotoxic to human breast cancer cells

(2009) W Zhou et al.   ONCOGENE

Dietary soy protein inhibits DNA damage and cell survival of colon epithelial cells through attenuated expression of fatty acid synthase

(2008) Rijin Xiao et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

AMPK-sensed cellular energy state regulates the release of extracellular Fatty Acid Synthase

(2008) Cristina Oliveras-Ferraros et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Selectivity of inhibitors of endocannabinoid biosynthesis evaluated by activity-based protein profiling

(2008) Heather S. Hoover et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

β-Lactam congeners of orlistat as inhibitors of fatty acid synthase

(2008) Wei Zhang et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Fatty Acid Synthase Gene Is Up-regulated by Hypoxia via Activation of Akt and Sterol Regulatory Element Binding Protein-1

(2008) E. Furuta et al.   CANCER RESEARCH

Inhibiting Fatty Acid Synthase for Chemoprevention of Chemically Induced Lung Tumors

(2008) H. Orita et al.   CLINICAL CANCER RESEARCH

Discovery of GSK837149A, an inhibitor of human fatty acid synthase targeting the β-ketoacyl reductase reaction

(2008) María Jesús Vázquez et al.   FEBS Journal

Fatty acid synthase inhibition with Orlistat promotes apoptosis and reduces cell growth and lymph node metastasis in a mouse melanoma model

(2008) Marco A. Carvalho et al.   INTERNATIONAL JOURNAL OF CANCER

Proto-oncogene FBI-1 (Pokemon) and SREBP-1 Synergistically Activate Transcription of Fatty-acid Synthase Gene (FASN)

(2008) Won-Il Choi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inhibition of Fatty-acid Synthase Induces Caspase-8-mediated Tumor Cell Apoptosis by Up-regulating DDIT4

(2008) Lynn M. Knowles et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Fatty Acid Synthase and AKT Pathway Signaling in a Subset of Papillary Thyroid Cancers

(2008) Shahab Uddin et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Cohort Study of Fatty Acid Synthase Expression and Patient Survival in Colon Cancer

(2008) Shuji Ogino et al.   JOURNAL OF CLINICAL ONCOLOGY

Synthesis of Novel β-Lactone Inhibitors of Fatty Acid Synthase

(2008) Robyn D. Richardson et al.   JOURNAL OF MEDICINAL CHEMISTRY

Increased fatty acid synthase as a potential therapeutic target in multiple myeloma

(2008) Wei-qin Wang et al.   Journal of Zhejiang University-SCIENCE B

Overexpression of fatty acid synthase is associated with palmitoylation of Wnt1 and cytoplasmic stabilization of β-catenin in prostate cancer

(2008) Michelangelo Fiorentino et al.   LABORATORY INVESTIGATION

Disruption of crosstalk between the fatty acid synthesis and proteasome pathways enhances unfolded protein response signaling and cell death

(2008) J. L. Little et al.   MOLECULAR CANCER THERAPEUTICS

A new mechanism of drug resistance in breast cancer cells: fatty acid synthase overexpression-mediated palmitate overproduction

(2008) H. Liu et al.   MOLECULAR CANCER THERAPEUTICS

The Crystal Structure of a Mammalian Fatty Acid Synthase

(2008) T. Maier et al.   SCIENCE