期刊
FUTURE ONCOLOGY
卷 11, 期 9, 页码 1389-1405出版社
FUTURE MEDICINE LTD
DOI: 10.2217/fon.15.45
关键词
ARID1A; endometriosis; genetically engineered mouse models; glycogen; HNF1B; ovarian clear; PIK3CA cell cancer
类别
资金
- MRC [G1001957]
- MRC [G1001957] Funding Source: UKRI
- Cancer Research UK [15601] Funding Source: researchfish
- Medical Research Council [G1001957] Funding Source: researchfish
Ovarian clear cell carcinoma is a distinct subtype of epithelial ovarian cancer, characterized by an association with endometriosis, glycogen accumulation and resistance to chemotherapy. Key driver events, including ARID1A mutations and HNF1B overexpression, have been recently identified and their functional characterization is ongoing. Additionally, the role of glycogen in promoting the malignant phenotype is coming under scrutiny. Appreciation of the notion that ovarian clear cell carcinoma is essentially an ectopic uterine cancer will hopefully lead to improved animal models of the disease, in turn paving the way for effective treatments.
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