标题
Lactate in the Regulation of Tumor Microenvironment and Therapeutic Approaches
作者
关键词
-
出版物
Frontiers in Oncology
Volume 9, Issue -, Pages -
出版商
Frontiers Media SA
发表日期
2019-11-01
DOI
10.3389/fonc.2019.01143
参考文献
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- Cellular Uptake of MCT1 Inhibitors AR-C155858 and AZD3965 and Their Effects on MCT-Mediated Transport of L-Lactate in Murine 4T1 Breast Tumor Cancer Cells
- (2019) Xiaowen Guan et al. AAPS Journal
- Blockade of Lactate Dehydrogenase-A (LDH-A) Improves Efficacy of Anti-Programmed Cell Death-1 (PD-1) Therapy in Melanoma
- (2019) Saeed Daneshmandi et al. Cancers
- The Role of Lactate Metabolism in Prostate Cancer Progression and Metastases Revealed by Dual-Agent Hyperpolarized 13C MRSI
- (2019) Robert Bok et al. Cancers
- Oxidized ATM-mediated glycolysis enhancement in breast cancer-associated fibroblasts contributes to tumor invasion through lactate as metabolic coupling
- (2019) Kexin Sun et al. EBioMedicine
- Pretreatment lactate dehydrogenase may predict outcome of advanced non small-cell lung cancer patients treated with immune checkpoint inhibitors: A meta-analysis
- (2019) Zhibo Zhang et al. Cancer Medicine
- Enhanced oxidative phosphorylation in NKT cells is essential for their survival and function
- (2019) Ajay Kumar et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Roles of NKT cells in cancer immunotherapy
- (2019) Eun-Ah Bae et al. ARCHIVES OF PHARMACAL RESEARCH
- Tumor microenvironment-driven non-cell-autonomous resistance to antineoplastic treatment
- (2019) Yidi Qu et al. Molecular Cancer
- Lactate dehydrogenase A regulates autophagy and tamoxifen resistance in breast cancer
- (2019) Chandan Kanta Das et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
- The Tumor Metabolic Microenvironment: Lessons from Lactate
- (2019) Juan C. García-Cañaveras et al. CANCER RESEARCH
- The future of peptides in cancer treatment
- (2019) Kaido Kurrikoff et al. CURRENT OPINION IN PHARMACOLOGY
- Development of novel human lactate dehydrogenase A inhibitors: High-throughput screening, synthesis, and biological evaluations
- (2019) Yuan Zhou et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Aberrant FGFR tyrosine kinase signaling enhances the Warburg effect by reprogramming LDH isoform expression and activity in prostate cancer
- (2018) Junchen Liu et al. CANCER RESEARCH
- Tumor-derived lactate induces M2 macrophage polarization via the activation of the ERK/STAT3 signaling pathway in breast cancer
- (2018) Xianmin Mu et al. CELL CYCLE
- The Science and Translation of Lactate Shuttle Theory
- (2018) George A. Brooks Cell Metabolism
- Meta-analysis of serum lactate dehydrogenase and prognosis for osteosarcoma
- (2018) Yucheng Fu et al. MEDICINE
- The proteoglycan-like domain of carbonic anhydrase IX mediates non-catalytic facilitation of lactate transport in cancer cells
- (2018) Samantha Ames et al. Oncotarget
- MCT1 regulates aggressive and metabolic phenotypes in bladder cancer
- (2018) Guiming Zhang et al. Journal of Cancer
- Targeting MCT4 to reduce lactic acid secretion and glycolysis for treatment of neuroendocrine prostate cancer
- (2018) Stephen Yiu Chuen Choi et al. Cancer Medicine
- Fundamental role of dendritic cells in inducing Th2 responses
- (2018) Byoungjae Kim et al. KOREAN JOURNAL OF INTERNAL MEDICINE
- Carbonic anhydrase IX is a pH-stat that sets an acidic tumour extracellular pH in vivo
- (2018) Shen-Han Lee et al. BRITISH JOURNAL OF CANCER
- Increased Lactate Secretion by Cancer Cells Sustains Non-cell-autonomous Adaptive Resistance to MET and EGFR Targeted Therapies
- (2018) Maria Apicella et al. Cell Metabolism
- Peptides as Therapeutic Agents for Inflammatory-Related Diseases
- (2018) Sara La Manna et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Intratumor lactate levels reflect HER2 addiction status in HER2-positive breast cancer
- (2018) Lorenzo Castagnoli et al. JOURNAL OF CELLULAR PHYSIOLOGY
- Preclinical Efficacy of the Novel Monocarboxylate Transporter 1 Inhibitor BAY-8002 and Associated Markers of Resistance
- (2018) Maria Quanz et al. MOLECULAR CANCER THERAPEUTICS
- Monocarboxylate Transporter 4 (MCT4) Knockout Mice Have Attenuated 4NQO Induced Carcinogenesis; A Role for MCT4 in Driving Oral Squamous Cell Cancer
- (2018) Sara Bisetto et al. Frontiers in Oncology
- LDH-A promotes malignant behavior via activation of epithelial-to-mesenchymal transition in lung adenocarcinoma
- (2018) Xiao-ming Hou et al. BIOSCIENCE REPORTS
- Roles of the immune system in cancer: from tumor initiation to metastatic progression
- (2018) Hugo Gonzalez et al. GENES & DEVELOPMENT
- Membrane-anchored carbonic anhydrase IV interacts with monocarboxylate transporters via their chaperones CD147 and GP70
- (2018) Linda S. Forero-Quintero et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Prognostic value of pretreatment serum lactate dehydrogenase level in pancreatic cancer patients
- (2018) Jianxin Gan et al. MEDICINE
- Aberrant expression of membranous carbonic anhydrase IX (CAIX) is associated with unfavorable disease course in papillary and clear cell renal cell carcinoma
- (2018) Franziska Büscheck et al. UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS
- Nuclear lactate dehydrogenase A senses ROS to produce α-hydroxybutyrate for HPV-induced cervical tumor growth
- (2018) Yuan Liu et al. Nature Communications
- Glutamine: Metabolism and Immune Function, Supplementation and Clinical Translation
- (2018) Vinicius Cruzat et al. Nutrients
- Transmembrane Protease TMPRSS11B Promotes Lung Cancer Growth by Enhancing Lactate Export and Glycolytic Metabolism
- (2018) Barrett L. Updegraff et al. Cell Reports
- Dual Inhibition of the Lactate Transporters MCT1 and MCT4 Is Synthetic Lethal with Metformin due to NAD+ Depletion in Cancer Cells
- (2018) Don Benjamin et al. Cell Reports
- Lactate-mediated acidification of tumor microenvironment induces apoptosis of liver-resident NK cells in colorectal liver metastasis
- (2018) Cathal Harmon et al. Cancer Immunology Research
- Lactate dehydrogenase A: A key player in carcinogenesis and potential target in cancer therapy
- (2018) Yangbo Feng et al. Cancer Medicine
- Lactate: A Metabolic Driver in the Tumour Landscape
- (2018) Luigi Ippolito et al. TRENDS IN BIOCHEMICAL SCIENCES
- LDH inhibition impacts on heat shock response and induces senescence of hepatocellular carcinoma cells
- (2017) Marcella Manerba et al. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
- Cell Biology of the Mitochondrion
- (2017) Alexander M. van der Bliek et al. GENETICS
- Targeting hexokinase 2 inhibition promotes radiosensitization in HPV16 E7-induced cervical cancer and suppresses tumor growth
- (2017) Yuan Liu et al. INTERNATIONAL JOURNAL OF ONCOLOGY
- The Current State of Peptide Drug Discovery: Back to the Future?
- (2017) Antoine Henninot et al. JOURNAL OF MEDICINAL CHEMISTRY
- Glucose feeds the TCA cycle via circulating lactate
- (2017) Sheng Hui et al. NATURE
- L-2-Hydroxyglutarate production arises from noncanonical enzyme function at acidic pH
- (2017) Andrew M Intlekofer et al. Nature Chemical Biology
- Phosphorylation-mediated activation of LDHA promotes cancer cell invasion and tumour metastasis
- (2017) L Jin et al. ONCOGENE
- Cancer-associated fibroblasts enhance pancreatic cancer cell invasion by remodeling the metabolic conversion mechanism
- (2017) Tao Shan et al. ONCOLOGY REPORTS
- Metabolic Interactions in the Tumor Microenvironment
- (2017) Costas A. Lyssiotis et al. TRENDS IN CELL BIOLOGY
- Discovery of human lactate dehydrogenase A (LDHA) inhibitors as anticancer agents to inhibit the proliferation of MG-63 osteosarcoma cells
- (2017) Aiping Fang et al. MedChemComm
- Lactate stimulates CA IX expression in normoxic cancer cells
- (2017) Elena Panisova et al. Oncotarget
- Lactate-activated macrophages induced aerobic glycolysis and epithelial-mesenchymal transition in breast cancer by regulation of CCL5-CCR5 axis: a positive metabolic feedback loop
- (2017) Sensen Lin et al. Oncotarget
- The reverse Warburg effect is likely to be an Achilles’ heel of cancer that can be exploited for cancer therapy
- (2017) Yaojie Fu et al. Oncotarget
- Pre-clinical pharmacology of AZD3965, a selective inhibitor of MCT1: DLBCL, NHL and Burkitt’s lymphoma anti-tumor activity
- (2017) Nicola J. Curtis et al. Oncotarget
- The emerging role and targetability of the TCA cycle in cancer metabolism
- (2017) Nicole M. Anderson et al. Protein & Cell
- Cell Biology of the Mitochondrion
- (2017) Alexander M. van der Bliek et al. GENETICS
- The Molecular Mechanism of Natural Killer Cells Function and Its Importance in Cancer Immunotherapy
- (2017) Sourav Paul et al. Frontiers in Immunology
- Reexamining cancer metabolism: lactate production for carcinogenesis could be the purpose and explanation of the Warburg Effect
- (2016) Iñigo San-Millán et al. CARCINOGENESIS
- Mitochondria and Cancer
- (2016) Sejal Vyas et al. CELL
- Metabolic Heterogeneity in Human Lung Tumors
- (2016) Christopher T. Hensley et al. CELL
- The metabolic microenvironment of melanomas: Prognostic value of MCT1 and MCT4
- (2016) Céline Pinheiro et al. CELL CYCLE
- Oxidative stress induced autophagy in cancer associated fibroblast enhances proliferation and metabolism of colorectal cancer cells
- (2016) Wenjing Zhou et al. CELL CYCLE
- The Emerging Hallmarks of Cancer Metabolism
- (2016) Natalya N. Pavlova et al. Cell Metabolism
- LDHA-Associated Lactic Acid Production Blunts Tumor Immunosurveillance by T and NK Cells
- (2016) Almut Brand et al. Cell Metabolism
- Monocarboxylate Transporters: Therapeutic Targets and Prognostic Factors in Disease
- (2016) RS Jones et al. CLINICAL PHARMACOLOGY & THERAPEUTICS
- Exercise Inducible Lactate Dehydrogenase B Regulates Mitochondrial Function in Skeletal Muscle
- (2016) Xijun Liang et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Lactate metabolism is associated with mammalian mitochondria
- (2016) Ying-Jr Chen et al. Nature Chemical Biology
- Lactic acid in tumor microenvironments causes dysfunction of NKT cells by interfering with mTOR signaling
- (2016) Di Xie et al. Science China-Life Sciences
- The Warburg Effect: How Does it Benefit Cancer Cells?
- (2016) Maria V. Liberti et al. TRENDS IN BIOCHEMICAL SCIENCES
- ERRα-Regulated Lactate Metabolism Contributes to Resistance to Targeted Therapies in Breast Cancer
- (2016) Sunghee Park et al. Cell Reports
- Fundamentals of cancer metabolism
- (2016) R. J. DeBerardinis et al. Science Advances
- Elevated lactic acid is a negative prognostic factor in metastatic lung cancer
- (2015) Panagiotis J. Vlachostergios et al. Cancer Biomarkers
- Monocarboxylate transport inhibition potentiates the cytotoxic effect of 5-fluorouracil in colorectal cancer cells
- (2015) Ricardo Amorim et al. CANCER LETTERS
- PKM2 contributes to cancer metabolism
- (2015) Nicholas Wong et al. CANCER LETTERS
- Neutralization of Tumor Acidity Improves Antitumor Responses to Immunotherapy
- (2015) Shari Pilon-Thomas et al. CANCER RESEARCH
- Lactate promotes glutamine uptake and metabolism in oxidative cancer cells
- (2015) Jhudit Pérez-Escuredo et al. CELL CYCLE
- Hypoxia Induces Production of L-2-Hydroxyglutarate
- (2015) Andrew M. Intlekofer et al. Cell Metabolism
- Expression of lactate/H+ symporters MCT1 and MCT4 and their chaperone CD147 predicts tumor progression in clear cell renal cell carcinoma: immunohistochemical and The Cancer Genome Atlas data analyses
- (2015) Younghye Kim et al. HUMAN PATHOLOGY
- Immunosuppressive cells in tumor immune escape and metastasis
- (2015) Yang Liu et al. JOURNAL OF MOLECULAR MEDICINE-JMM
- Equating salivary lactate dehydrogenase (LDH) with LDH-5 expression in patients with oral squamous cell carcinoma: An insight into metabolic reprogramming of cancer cell as a predictor of aggressive phenotype
- (2015) Tajindra Singh Saluja et al. TUMOR BIOLOGY
- Hypoxia-induced carbonic anhydrase IX facilitates lactate flux in human breast cancer cells by non-catalytic function
- (2015) Somayeh Jamali et al. Scientific Reports
- Serum IL-10 Predicts Worse Outcome in Cancer Patients: A Meta-Analysis
- (2015) Shuai Zhao et al. PLoS One
- Lactate transporters and vascular factors in HPV-induced squamous cell carcinoma of the uterine cervix
- (2014) Céline Pinheiro et al. BMC CANCER
- GLUT-1 expression is largely unrelated to both hypoxia and the Warburg phenotype in squamous cell carcinomas of the vulva
- (2014) Arnulf Mayer et al. BMC CANCER
- Tumor-Secreted Lactic Acid Promotes IL-23/IL-17 Proinflammatory Pathway
- (2014) H. Shime et al. JOURNAL OF IMMUNOLOGY
- Comprehensive review on lactate metabolism in human health
- (2014) M. Adeva-Andany et al. MITOCHONDRION
- Functional polarization of tumour-associated macrophages by tumour-derived lactic acid
- (2014) Oscar R. Colegio et al. NATURE
- PCK2 activation mediates an adaptive response to glucose depletion in lung cancer
- (2014) K Leithner et al. ONCOGENE
- Hexokinase 2-Mediated Warburg Effect Is Required for PTEN- and p53-Deficiency-Driven Prostate Cancer Growth
- (2014) Lei Wang et al. Cell Reports
- MCT4 Defines a Glycolytic Subtype of Pancreatic Cancer with Poor Prognosis and Unique Metabolic Dependencies
- (2014) GuemHee Baek et al. Cell Reports
- New modalities of cancer treatment for NSCLC: focus on immunotherapy
- (2014) Marianne Davies Cancer Management and Research
- Acidity Generated by the Tumor Microenvironment Drives Local Invasion
- (2013) V. Estrella et al. CANCER RESEARCH
- Cancer metabolism, stemness and tumor recurrence
- (2013) Joseph M. Curry et al. CELL CYCLE
- Role of dendritic cells in innate and adaptive immune response in human aging
- (2013) Sudhir Gupta EXPERIMENTAL GERONTOLOGY
- Dendritic Cell Reprogramming by Endogenously Produced Lactic Acid
- (2013) A. Nasi et al. JOURNAL OF IMMUNOLOGY
- Tumor-Derived Lactate Modifies Antitumor Immune Response: Effect on Myeloid-Derived Suppressor Cells and NK Cells
- (2013) Z. Husain et al. JOURNAL OF IMMUNOLOGY
- MHC Class I Antigen Processing and Presenting Machinery: Organization, Function, and Defects in Tumor Cells
- (2013) P. Leone et al. JNCI-Journal of the National Cancer Institute
- Metabolite damage and its repair or pre-emption
- (2013) Carole L Linster et al. Nature Chemical Biology
- Correlation between Biological Marker Expression and18F-Fluorodeoxyglucose Uptake in Cervical Cancer Measured by Positron Emission Tomography
- (2013) Sang I. Park et al. ONKOLOGIE
- Catabolism of Exogenous Lactate Reveals It as a Legitimate Metabolic Substrate in Breast Cancer
- (2013) Kelly M. Kennedy et al. PLoS One
- Modulation of Microenvironment Acidity Reverses Anergy in Human and Murine Tumor-Infiltrating T Lymphocytes
- (2012) A. Calcinotto et al. CANCER RESEARCH
- Reciprocal Metabolic Reprogramming through Lactate Shuttle Coordinately Influences Tumor-Stroma Interplay
- (2012) T. Fiaschi et al. CANCER RESEARCH
- Glucose-Independent Glutamine Metabolism via TCA Cycling for Proliferation and Survival in B Cells
- (2012) Anne Le et al. Cell Metabolism
- Multiple Biological Activities of Lactic Acid in Cancer: Influences on Tumor Growth,Angiogenesis and Metastasis
- (2012) Suveera Dhup et al. CURRENT PHARMACEUTICAL DESIGN
- Links between metabolism and cancer
- (2012) C. V. Dang GENES & DEVELOPMENT
- Genome-wide RNA interference analysis of renal carcinoma survival regulators identifies MCT4 as a Warburg effect metabolic target
- (2012) Marco Gerlinger et al. JOURNAL OF PATHOLOGY
- Nuclear factor-κB, p53, and mitochondria: regulation of cellular metabolism and the Warburg effect
- (2012) Renée F. Johnson et al. TRENDS IN BIOCHEMICAL SCIENCES
- Hallmarks of Cancer: The Next Generation
- (2011) Douglas Hanahan et al. CELL
- Cancer cells metabolically "fertilize" the tumor microenvironment with hydrogen peroxide, driving the Warburg effect
- (2011) Ubaldo E. Martinez-Outschoorn et al. CELL CYCLE
- Hyperactivation of oxidative mitochondrial metabolism in epithelial cancer cells in situ
- (2011) Diana Whitaker-Menezes et al. CELL CYCLE
- CCND1 amplification and protein overexpression in oral squamous cell carcinoma of young patients
- (2011) Estela Kaminagakura et al. HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
- Transport Activity of the High-affinity Monocarboxylate Transporter MCT2 Is Enhanced by Extracellular Carbonic Anhydrase IV but Not by Intracellular Carbonic Anhydrase II
- (2011) Michael Klier et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Tyrosine Phosphorylation of Lactate Dehydrogenase A Is Important for NADH/NAD+ Redox Homeostasis in Cancer Cells
- (2011) J. Fan et al. MOLECULAR AND CELLULAR BIOLOGY
- Ketones and lactate “fuel” tumor growth and metastasis
- (2010) Gloria Bonuccelli et al. CELL CYCLE
- Basics and principles of radiopharmaceuticals for PET/CT
- (2010) W. Wadsak et al. EUROPEAN JOURNAL OF RADIOLOGY
- Activating and inhibitory receptors of natural killer cells
- (2010) Hollie J Pegram et al. IMMUNOLOGY AND CELL BIOLOGY
- Inhibition of lactate dehydrogenase A induces oxidative stress and inhibits tumor progression
- (2010) A. Le et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The Control of the Metabolic Switch in Cancers by Oncogenes and Tumor Suppressor Genes
- (2010) A. J. Levine et al. SCIENCE
- The human brain utilizes lactate via the tricarboxylic acid cycle: a 13C-labelled microdialysis and high-resolution nuclear magnetic resonance study
- (2009) Clare N. Gallagher et al. BRAIN
- Quantitative Metabolome Profiling of Colon and Stomach Cancer Microenvironment by Capillary Electrophoresis Time-of-Flight Mass Spectrometry
- (2009) A. Hirayama et al. CANCER RESEARCH
- Cell-cell and intracellular lactate shuttles
- (2009) George A. Brooks JOURNAL OF PHYSIOLOGY-LONDON
- Upregulation of lactate dehydrogenase A by ErbB2 through heat shock factor 1 promotes breast cancer cell glycolysis and growth
- (2009) Y H Zhao et al. ONCOGENE
- Analytical investigation: Assay of d-lactate in diabetic plasma and urine
- (2008) J. Petteri Talasniemi et al. CLINICAL BIOCHEMISTRY
- Interleukin 10 suppresses Th17 cytokines secreted by macrophages and T cells
- (2008) Yongpeng Gu et al. EUROPEAN JOURNAL OF IMMUNOLOGY
- Targeting lactate-fueled respiration selectively kills hypoxic tumor cells in mice
- (2008) Pierre Sonveaux et al. JOURNAL OF CLINICAL INVESTIGATION
- Evidence for the Mitochondrial Lactate Oxidation Complex in Rat Neurons: Demonstration of an Essential Component of Brain Lactate Shuttles
- (2008) Takeshi Hashimoto et al. PLoS One
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