Article
Oncology
Yingping Zhu, Yu Qiu, Xueqin Zhang
Summary: The study revealed that TKTL1 participated in the malignant progression of cervical cancer cells by regulating AKT signal-mediated HK2 and PFKFB3, influencing cell proliferation, invasion, migration, apoptosis, as well as glycolysis.
CANCER CELL INTERNATIONAL
(2021)
Article
Biochemistry & Molecular Biology
Kexin Wang, Qiuzi Li, Yufeng Fan, Pingping Fang, Haibing Zhou, Jian Huang
Summary: Abnormal glycometabolism has become a fundamental research topic in tumor biology due to the poor metabolic conditions promoting the emergence of the Warburg effect (WE) phenotype. This study investigated the potential of Oxabicycloheptene sulfonate (OBHS), a selective estrogen receptor modulator, in targeting breast cancer glycometabolism. The results revealed that OBHS inhibits the expression of glucose transporter 1 (GLUT1) via the PI3K/Akt signaling pathway, leading to the suppression of breast cancer progression and proliferation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Benjamin R. E. Harris, Ye Zhang, Jianxin Tao, Renhui Shen, Xiaoqian Zhao, Margot P. Cleary, Tong Wang, Da-Qing Yang
Summary: Enhanced glucose uptake in cancer cells is closely correlated with poor prognosis, and the protein kinase ATM plays a key role in insulin-mediated glucose uptake. Inhibition of ATM by KU-55933 inhibits glucose uptake and glycolysis, induces apoptosis, and inhibits motility of cancer cells with overactivated Akt, showing potential as a therapeutic agent against cancer.
Article
Engineering, Environmental
Qi Qin, Bingwei Yang, Jing Liu, Erqun Song, Yang Song
Summary: The exposure of PCB29-pQ was found to promote aerobic glycolysis in breast cancer through the activation of GLUT1 signaling pathway. Inhibition of GLUT1 reversed the effects on migration and invasion of MDA-MB-231 cells induced by PCB29-pQ, and repression of GLUT1 also suppressed breast cancer metastasis in nude mice inoculated with 4T1-luc cells.
JOURNAL OF HAZARDOUS MATERIALS
(2022)
Article
Oncology
Ping Zhu, Guoping Liu, Xue Wang, Jingjing Lu, Yue Zhou, Shuyi Chen, Yabiao Gao, Chaofu Wang, Jerry Yu, Yangbai Sun, Ping Zhou
Summary: The study revealed that GLUT1 mRNA expression is significantly increased in breast cancer tissues, which is associated with metastasis and poor prognosis. The transcription factor c-Jun may regulate GLUT1 gene expression by binding to its promoter, thereby affecting glycolysis and breast cancer metastasis.
Article
Oncology
Xiaodan Zhang, Xiaocong Pang, Zhuo Zhang, Qianxin Liu, Hanxu Zhang, Qian Xiang, Yimin Cui
Summary: The study systematically analyzed the co-expression of GLUT1-4 and their influence on breast cancer prognosis. It was found that SLC2A1 mRNA expression was significantly higher in breast cancer, and there was a significant correlation between SLC2A1 and RB1 mRNA expression. Further analysis is needed to explore their roles in regulation pathways.
Review
Oncology
Alakananda Basu, Christoffer Briggs Lambring
Summary: This article discusses the importance of breast cancer in women in the United States and the role of Akt isoforms in the development of breast cancer. While Akt isoforms share similar structures, they exhibit redundant, distinct, and opposite functions in breast cancer. Understanding the isoform-specific function of Akt is critical for effectively targeting the Akt signaling pathway in cancer therapy.
Article
Biochemistry & Molecular Biology
Monika Mlinaric, Ivan Lucic, Lidija Milkovic, Ines V. da Silva, Ivana Tartaro Bujak, Vesna Musani, Graca Soveral, Ana Cipak Gasparovic
Summary: Aquaporin 3 (AQP3) is a membrane protein that transports hydrogen peroxide, water, and glycerol. It is implicated in tumor progression and malignancy in breast cancer and may be a target for therapy. This study examined the relationship between AQP3 expression, disruption of lipid raft harboring EGFR, and the EGFR/PI3K/Akt signaling pathway in breast cancer cell lines. The results indicate that AQP3 may not directly affect the PI3K/Akt pathway but rather its role is cell-line specific.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Cell Biology
Kunrui Zhu, Yanqi Wu, Ping He, Yu Fan, Xiaorong Zhong, Hong Zheng, Ting Luo
Summary: Phosphatidylinositol 3-kinase (PI3K), protein kinase B (PKB/AKT) and mechanistic target of rapamycin (mTOR) (PAM) pathways play important roles in breast tumorigenesis and offer potential targets for cancer therapy.
Article
Biochemistry & Molecular Biology
Jiabei He, Chien-Feng Li, Hong-Jen Lee, Dong-Hui Shin, Yi-Jye Chern, Bruno Pereira De Carvalho, Chia-Hsin Chan
Summary: MIG-6 is upregulated in TNBC and associated with poor clinical outcomes, playing a role in reprogramming glucose metabolism and driving tumor growth. This study identifies MIG-6 as a novel prognostic biomarker, metabolism regulator, and molecular driver in triple-negative breast cancer.
Article
Multidisciplinary Sciences
Xun Liu, Kiyoshi Yamaguchi, Kiyoko Takane, Chi Zhu, Makoto Hirata, Yoko Hikiba, Shin Maeda, Yoichi Furukawa, Tsuneo Ikenoue
Summary: The study revealed that IDH1/2 mutations can induce intracellular 2-HG accumulation and inhibit cell proliferation, leading to dysregulation of glucose metabolism. Glut1 may be a potential target regulated by cancer-associated IDH1/2 mutations.
Article
Cell Biology
Avital Granit Mizrahi, Ahinoam Gugenheim, Haneen Hamad, Roa'a Hamed, Nino Tetro, Ofra Maimon, Salome Khutsurauli, Hovav Nechushtan, Benjamin Nisman, Deborah Duran, Widad Samman, Liron Birimberg-Schwartz, Myriam Grunewald, Sara Eyal, Tamar Peretz
Summary: This study found that histone deacetylase inhibitor valproic acid (VPA) can alter glucose metabolism in triple-negative breast cancer (TNBC) cells and is correlated with cisplatin sensitivity. Overexpression of ALDH may be one mechanism of cellular resistance to VPA, and its inhibition can enhance the therapeutic efficacy of VPA-chemotherapeutic drug combinations.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Anatomy & Morphology
Nazanin Joudaki, Mohammad Rashno, Ali Asadirad, Ali Khodadadi
Summary: Tumor cells modulate immune responses by secreting exosomes, which affect the metabolism of immune cells via the PD1-GLUT1-HK2 metabolic axis. Exosomes from breast cancer patients increase the expression of key genes in the glycolysis pathway in PBMCs.
Article
Pharmacology & Pharmacy
Mengqi Sun, Shu Zhao, Yuchen Duan, Yumeng Ma, Yicheng Wang, Hongfei Ji, Qingyuan Zhang
Summary: The study revealed that in tamoxifen-resistant breast cancer cells, GLUT1 expression and autophagy flux were increased, and knockdown of GLUT1 could promote sensitivity to tamoxifen. Additionally, inhibiting autophagy could resensitize tamoxifen-resistant cells to tamoxifen.
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
(2021)
Review
Pharmacology & Pharmacy
Federica Martorana, Gianmarco Motta, Giuliana Pavone, Lucia Motta, Stefania Stella, Silvia Rita Vitale, Livia Manzella, Paolo Vigneri
Summary: The AKT protein kinase is crucial in breast cancer treatment, especially in resistant subtypes. Several AKT inhibitors are in clinical trials, with new combination strategies being explored to enhance therapeutic efficacy.
FRONTIERS IN PHARMACOLOGY
(2021)
