Metabolism within the tumor microenvironment and its implication on cancer progression: An ongoing therapeutic target

Breast cancer metabolic cross-talk: Fibroblasts are hubs and breast cancer cells are gatherers of lipids

(2018) Filipa Lopes-Coelho et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Metabolic enzyme PFKFB4 activates transcriptional coactivator SRC-3 to drive breast cancer

(2018) Subhamoy Dasgupta et al.   NATURE

Cellular metabolism of tumor-associated macrophages - functional impact and consequences

(2017) Katrin Rabold et al.   FEBS LETTERS

Pyruvate dehydrogenase has a major role in mast cell function, and its activity is regulated by mitochondrial microphthalmia transcription factor

(2017) Israa Sharkia et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Resisting fatal attraction: a glioma oncometabolite prevents CD8+ T cell recruitment

(2017) Liliana E. Lucca et al.   JOURNAL OF CLINICAL INVESTIGATION

Drought stress obliterates the preference for ammonium as an N source in the C 4 plant Spartina alterniflora

(2017) Kamel Hessini et al.   JOURNAL OF PLANT PHYSIOLOGY

Glucose feeds the TCA cycle via circulating lactate

(2017) Sheng Hui et al.   NATURE

mTORC1-dependent AMD1 regulation sustains polyamine metabolism in prostate cancer

(2017) Amaia Zabala-Letona et al.   NATURE

First metabolic oncology inhibitor gets FDA green light, with record price tag

(2017) Ken Garber   NATURE BIOTECHNOLOGY

Assessment of the Role of Everolimus Therapy in Patients with Renal Cell Carcinoma Based on Daily Routine and Recent Research Results

(2017) Anikó Maráz et al.   PATHOLOGY & ONCOLOGY RESEARCH

Nerves switch on angiogenic metabolism

(2017) Yoku Hayakawa et al.   SCIENCE

Anti-inflammatory effect of IL-10 mediated by metabolic reprogramming of macrophages

(2017) W. K. Eddie Ip et al.   SCIENCE

Metabolic recycling of ammonia via glutamate dehydrogenase supports breast cancer biomass

(2017) Jessica B. Spinelli et al.   SCIENCE

Inflammation by way of macrophage metabolism

(2017) Agnieszka M. Kabat et al.   SCIENCE

Adrenergic nerves activate an angio-metabolic switch in prostate cancer

(2017) Ali H. Zahalka et al.   SCIENCE

Targeting endothelial metabolism for anti-angiogenesis therapy: A pharmacological perspective

(2017) Rindert Missiaen et al.   VASCULAR PHARMACOLOGY

The role of autophagy in asparaginase-induced immune suppression of macrophages

(2017) Ping Song et al.   Cell Death & Disease

Adipocytes activate mitochondrial fatty acid oxidation and autophagy to promote tumor growth in colon cancer

(2017) Yang-An Wen et al.   Cell Death & Disease

AG-221, a First-in-Class Therapy Targeting Acute Myeloid Leukemia Harboring Oncogenic IDH2 Mutations

(2017) Katharine Yen et al.   Cancer Discovery

Does the 1H-NMR plasma metabolome reflect the host-tumor interactions in human breast cancer?

(2017) Vincent Richard et al.   Oncotarget

Oncometabolite succinate promotes angiogenesis by upregulating VEGF expression through GPR91-mediated STAT3 and ERK activation

(2017) Xianmin Mu et al.   Oncotarget

Lipid catabolism inhibition sensitizes prostate cancer cells to antiandrogen blockade

(2017) Thomas W. Flaig et al.   Oncotarget

Inhibition of Lysyl Oxidases Impairs Migration and Angiogenic Properties of Tumor-Associated Pericytes

(2017) Aline Lopes Ribeiro et al.   Stem Cells International

Impact of Metabolism in on T-Cell Differentiation and Function and Cross Talk with Tumor Microenvironment

(2017) Soumaya Kouidhi et al.   Frontiers in Immunology

Are Mast Cells MASTers in Cancer?

(2017) Gilda Varricchi et al.   Frontiers in Immunology

Increased Pyruvate Dehydrogenase Kinase 4 Expression in Lung Pericytes Is Associated with Reduced Endothelial-Pericyte Interactions and Small Vessel Loss in Pulmonary Arterial Hypertension

(2016) Ke Yuan et al.   AMERICAN JOURNAL OF PATHOLOGY

Intracellular sources of ornithine for polyamine synthesis in endothelial cells

(2016) Hui Li et al.   AMINO ACIDS

The anti-tumour agent lonidamine is a potent inhibitor of the mitochondrial pyruvate carrier and plasma membrane monocarboxylate transporters

(2016) B. Nancolas et al.   BIOCHEMICAL JOURNAL

Targeting polyamine metabolism for cancer therapy and prevention

(2016) T. R. Murray-Stewart et al.   BIOCHEMICAL JOURNAL

Monocarboxylate transporters in the brain and in cancer

(2016) Jhudit Pérez-Escuredo et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Curcumin directly inhibits the transport activity of GLUT1

(2016) Leesha K. Gunnink et al.   BIOCHIMIE

Tumor microenvironment-mediated chemoresistance in breast cancer

(2016) Kobra velaei et al.   BREAST

Inhibition of the Glycolytic Activator PFKFB3 in Endothelium Induces Tumor Vessel Normalization, Impairs Metastasis, and Improves Chemotherapy

(2016) Anna Rita Cantelmo et al.   CANCER CELL

Molecular or Metabolic Reprograming: What Triggers Tumor Subtypes?

(2016) Katherine Eason et al.   CANCER RESEARCH

Lung Adenocarcinoma Distally Rewires Hepatic Circadian Homeostasis

(2016) Selma Masri et al.   CELL

L-Arginine Modulates T Cell Metabolism and Enhances Survival and Anti-tumor Activity

(2016) Roger Geiger et al.   CELL

Targeting Stromal Glutamine Synthetase in Tumors Disrupts Tumor Microenvironment-Regulated Cancer Cell Growth

(2016) Lifeng Yang et al.   Cell Metabolism

The Emerging Hallmarks of Cancer Metabolism

(2016) Natalya N. Pavlova et al.   Cell Metabolism

Itaconate Links Inhibition of Succinate Dehydrogenase with Macrophage Metabolic Remodeling and Regulation of Inflammation

(2016) Vicky Lampropoulou et al.   Cell Metabolism

Tumor-Induced IL-6 Reprograms Host Metabolism to Suppress Anti-tumor Immunity

(2016) Thomas R. Flint et al.   Cell Metabolism

Evidence for Clinical Differentiation and Differentiation Syndrome in Patients With Acute Myeloid Leukemia and IDH1 Mutations Treated With the Targeted Mutant IDH1 Inhibitor, AG-120

(2016) K.C. Birendra et al.   Clinical Lymphoma Myeloma & Leukemia

Targeting fatty acid metabolism in cancer and endothelial cells

(2016) Ulrike Harjes et al.   CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY

PIKfyve Regulates Vacuole Maturation and Nutrient Recovery following Engulfment

(2016) Shefali Krishna et al.   DEVELOPMENTAL CELL

Effect of diclofenac on SLC16A3/MCT4 by the Caco-2 cell line

(2016) Shotaro Sasaki et al.   Drug Metabolism and Pharmacokinetics

The hallmarks of CAFs in cancer invasion

(2016) Youmna Attieh et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

Dimethyl- and monomethylfumarate regulate indoleamine 2,3-dioxygenase (IDO) activity in human immune cells

(2016) Sevgi Eminel et al.   EXPERIMENTAL DERMATOLOGY

Hypothesis: solid tumours behave as systemic metabolic dictators

(2016) Yang-Ming Lee et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

S-nitrosylation of fatty acid synthase regulates its activity through dimerization

(2016) Min Sik Choi et al.   JOURNAL OF LIPID RESEARCH

Role of lipids in the metabolism and activation of immune cells

(2016) Merla J. Hubler et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Comprehensive Proteomics Analysis Reveals Metabolic Reprogramming of Tumor-Associated Macrophages Stimulated by the Tumor Microenvironment

(2016) Di Liu et al.   JOURNAL OF PROTEOME RESEARCH

Mitochondrial Targeting of Metformin Enhances Its Activity against Pancreatic Cancer

(2016) Stepana Boukalova et al.   MOLECULAR CANCER THERAPEUTICS

Friendly neighbours feed tumour cells

(2016) Jurre J. Kamphorst et al.   NATURE

Fibroblasts for all seasons

(2016) Erwin F. Wagner   NATURE

Pancreatic stellate cells support tumour metabolism through autophagic alanine secretion

(2016) Cristovão M. Sousa et al.   NATURE

Targeting metastasis-initiating cells through the fatty acid receptor CD36

(2016) Gloria Pascual et al.   NATURE

Metabolic plasticity underpins innate and acquired resistance to LDHA inhibition

(2016) Aaron Boudreau et al.   Nature Chemical Biology

Emerging concepts of T cell metabolism as a target of immunotherapy

(2016) Chih-Hao Chang et al.   NATURE IMMUNOLOGY

Nitric oxide, the new architect of epigenetic landscapes

(2016) Divya Vasudevan et al.   NITRIC OXIDE-BIOLOGY AND CHEMISTRY

Interaction between Treg cells and tumor-associated macrophages in the tumor microenvironment of epithelial ovarian cancer

(2016) Qinyi Zhu et al.   ONCOLOGY REPORTS

Role of the tumor microenvironment in tumor progression and the clinical applications (Review)

(2016) YAO YUAN et al.   ONCOLOGY REPORTS

Circadian physiology of metabolism

(2016) Satchidananda Panda   SCIENCE

Blockage of glutaminolysis enhances the sensitivity of ovarian cancer cells to PI3K/mTOR inhibition involvement of STAT3 signaling

(2016) Lili Guo et al.   TUMOR BIOLOGY

CAF cellular glycolysis: linking cancer cells with the microenvironment

(2016) Amrita Roy et al.   TUMOR BIOLOGY

The IDO1 selective inhibitor epacadostat enhances dendritic cell immunogenicity and lytic ability of tumor antigen-specific T cells

(2016) Caroline Jochems et al.   Oncotarget

Pharmacological targeting of glucose-6-phosphate dehydrogenase in human erythrocytes by Bay 11–7082, parthenolide and dimethyl fumarate

(2016) Mehrdad Ghashghaeinia et al.   Scientific Reports

Resistance to Antiangiogenic Therapies by Metabolic Symbiosis in Renal Cell Carcinoma PDX Models and Patients

(2016) Gabriela Jiménez-Valerio et al.   Cell Reports

Metabolic Symbiosis Enables Adaptive Resistance to Anti-angiogenic Therapy that Is Dependent on mTOR Signaling

(2016) Elizabeth Allen et al.   Cell Reports

Targeting Metabolic Symbiosis to Overcome Resistance to Anti-angiogenic Therapy

(2016) Laura Pisarsky et al.   Cell Reports

TPL-2 Regulates Macrophage Lipid Metabolism and M2 Differentiation to Control TH2-Mediated Immunopathology

(2016) Yashaswini Kannan et al.   PLoS Pathogens

Akt-mTORC1 signaling regulates Acly to integrate metabolic input to control of macrophage activation

(2016) Anthony J Covarrubias et al.   eLife

Lipid metabolic reprogramming in cancer cells

(2016) S Beloribi-Djefaflia et al.   Oncogenesis

Lactate Contribution to the Tumor Microenvironment: Mechanisms, Effects on Immune Cells and Therapeutic Relevance

(2016) Susana Romero-Garcia et al.   Frontiers in Immunology

Pyruvate Kinase M2: A Potential Target for Regulating Inflammation

(2016) Jose C. Alves-Filho et al.   Frontiers in Immunology

Transcriptional and metabolic reprogramming induce an inflammatory phenotype in non-medullary thyroid carcinoma-induced macrophages

(2016) Rob J. W. Arts et al.   OncoImmunology

Trial Watch—Small molecules targeting the immunological tumor microenvironment for cancer therapy

(2016) Aitziber Buqué et al.   OncoImmunology

Warburg metabolism in tumor-conditioned macrophages promotes metastasis in human pancreatic ductal adenocarcinoma

(2016) Hweixian Leong Penny et al.   OncoImmunology

Metabolic communication in tumors: a new layer of immunoregulation for immune evasion

(2016) Ping-Chih Ho et al.   Journal for ImmunoTherapy of Cancer

Metabolic shifts induced by human H460 cells in tumor-bearing mice

(2015) Linsheng Liu et al.   BIOMEDICAL CHROMATOGRAPHY

Glioblastoma cells induce differential glutamatergic gene expressions in human tumor-associated microglia/macrophages and monocyte-derived macrophages

(2015) Judy Choi et al.   CANCER BIOLOGY & THERAPY

Human Pancreatic Cancer Tumors Are Nutrient Poor and Tumor Cells Actively Scavenge Extracellular Protein

(2015) J. J. Kamphorst et al.   CANCER RESEARCH

Nutrient Competition: A New Axis of Tumor Immunosuppression

(2015) Madhusudhanan Sukumar et al.   CELL

Phosphoenolpyruvate Is a Metabolic Checkpoint of Anti-tumor T Cell Responses

(2015) Ping-Chih Ho et al.   CELL

The Utilization of Extracellular Proteins as Nutrients Is Suppressed by mTORC1

(2015) Wilhelm Palm et al.   CELL

Metabolic Competition in the Tumor Microenvironment Is a Driver of Cancer Progression

(2015) Chih-Hao Chang et al.   CELL

Metabolic reprogramming in macrophages and dendritic cells in innate immunity

(2015) Beth Kelly et al.   CELL RESEARCH

Molecular Pathways: Fatty Acid Synthase

(2015) S. F. Jones et al.   CLINICAL CANCER RESEARCH

Molecular Pathways: Trafficking of Metabolic Resources in the Tumor Microenvironment

(2015) I. L. Romero et al.   CLINICAL CANCER RESEARCH

Arginine deprivation in cancer therapy

(2015) Lynn G. Feun et al.   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

Sugar, fat, and protein: new insights into what T cells crave

(2015) Greg M Delgoffe et al.   CURRENT OPINION IN IMMUNOLOGY

Role of AMP-activated protein kinase in metabolic depression in animals

(2015) Mark H. Rider   JOURNAL OF COMPARATIVE PHYSIOLOGY B-BIOCHEMICAL SYSTEMIC AND ENVIRONMENTAL PHYSIOLOGY

IKKβ acts as a tumor suppressor in cancer-associated fibroblasts during intestinal tumorigenesis

(2015) Charles K. Pallangyo et al.   JOURNAL OF EXPERIMENTAL MEDICINE

IKKβ in intestinal mesenchymal cells promotes initiation of colitis-associated cancer

(2015) Vasiliki Koliaraki et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Asparagine deprivation mediated by Salmonella asparaginase causes suppression of activation-induced T cell metabolic reprogramming

(2015) AnnMarie Torres et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Fatty acid carbon is essential for dNTP synthesis in endothelial cells

(2015) Sandra Schoors et al.   NATURE

Impacts of CD44 knockdown in cancer cells on tumor and host metabolic systems revealed by quantitative imaging mass spectrometry

(2015) Mitsuyo Ohmura et al.   NITRIC OXIDE-BIOLOGY AND CHEMISTRY

The complex liaison between cachexia and tumor burden (Review)

(2015) ANDREA DE LERMA BARBARO   ONCOLOGY REPORTS

A Phase I Trial of DFMO Targeting Polyamine Addiction in Patients with Relapsed/Refractory Neuroblastoma

(2015) Giselle L. Saulnier Sholler et al.   PLoS One

Control of macrophage metabolism and activation by mTOR and Akt signaling

(2015) Anthony J. Covarrubias et al.   SEMINARS IN IMMUNOLOGY

Current treatment strategies for inhibiting mTOR in cancer

(2015) Francesca Chiarini et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Inhibition of pentose phosphate pathway suppresses acute myelogenous leukemia

(2015) Yan Chen et al.   TUMOR BIOLOGY

The effect of statins on cancer cells—review

(2015) Lucyna Matusewicz et al.   TUMOR BIOLOGY

PD-1 alters T-cell metabolic reprogramming by inhibiting glycolysis and promoting lipolysis and fatty acid oxidation

(2015) Nikolaos Patsoukis et al.   Nature Communications

Inhibition of the Warburg effect with a natural compound reveals a novel measurement for determining the metastatic potential of breast cancers

(2015) Ritu Arora et al.   Oncotarget

CCL18 from tumor-associated macrophages promotes angiogenesis in breast cancer

(2015) Ling Lin et al.   Oncotarget

Metabolic Reprogramming of Cancer-Associated Fibroblasts by IDH3α Downregulation

(2015) Daoxiang Zhang et al.   Cell Reports

Insights into molecular and metabolic events associated with fruit response to post-harvest fungal pathogens

(2015) Noam Alkan et al.   Frontiers in Plant Science

Glutamine, Glucose and other Fuels for Cancer

(2015) Maria Ruiz-Perez et al.   CURRENT PHARMACEUTICAL DESIGN

Metformin limits the adipocyte tumor-promoting effect on ovarian cancer

(2015) Calvin Tebbe et al.   Oncotarget

Role of mesenchymal stem cells in osteosarcoma and metabolic reprogramming of tumor cells

(2015) Gloria Bonuccelli et al.   Oncotarget

A tryptophan metabolite, kynurenine, promotes mast cell activation through aryl hydrocarbon receptor

(2014) H. Kawasaki et al.   ALLERGY

Metabolic Regulation of Immune Responses

(2014) Kirthana Ganeshan et al.   Annual Review of Immunology

Dual regulation of mast cell degranulation through IgE receptor-mediated modulation of M2-type pyruvate kinase

(2014) Mei Zheng et al.   ARCHIVES OF PHARMACAL RESEARCH

Nitric Oxide Mediates Metabolic Coupling of Omentum-Derived Adipose Stroma to Ovarian and Endometrial Cancer Cells

(2014) B. Salimian Rizi et al.   CANCER RESEARCH

Cancer-Associated Fibroblasts Expressing CXCL14 Rely upon NOS1-Derived Nitric Oxide Signaling for Their Tumor-Supporting Properties

(2014) M. Augsten et al.   CANCER RESEARCH

Genetic Disruption of Lactate/H+ Symporters (MCTs) and Their Subunit CD147/BASIGIN Sensitizes Glycolytic Tumor Cells to Phenformin

(2014) I. Marchiq et al.   CANCER RESEARCH

The Reprogramming of Tumor Stroma by HSF1 Is a Potent Enabler of Malignancy

(2014) Ruth Scherz-Shouval et al.   CELL

The origin and function of tumor-associated macrophages

(2014) Yang Liu et al.   Cellular & Molecular Immunology

Chloroquine synergizes sunitinib cytotoxicity via modulating autophagic, apoptotic and angiogenic machineries

(2014) Amal Kamal Abdel-Aziz et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Statins in oncological research: From experimental studies to clinical practice

(2014) Peter Kubatka et al.   CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY

Principles of targeting endothelial cell metabolism to treat angiogenesis and endothelial cell dysfunction in disease

(2014) J. Goveia et al.   EMBO Molecular Medicine

Gemcitabine: Metabolism and molecular mechanisms of action, sensitivity and chemoresistance in pancreatic cancer

(2014) Lucas de Sousa Cavalcante et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Tumor aerobic glycolysis: new insights into therapeutic strategies with targeted delivery

(2014) Meghna Talekar et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

Tumor-Associated Macrophages: From Mechanisms to Therapy

(2014) Roy Noy et al.   IMMUNITY

Molecular Profiling Reveals a Tumor-Promoting Phenotype of Monocytes and Macrophages in Human Cancer Progression

(2014) Manesh Chittezhath et al.   IMMUNITY

PD-L1 is a novel direct target of HIF-1α, and its blockade under hypoxia enhanced MDSC-mediated T cell activation

(2014) Muhammad Zaeem Noman et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Tumor-Secreted Lactic Acid Promotes IL-23/IL-17 Proinflammatory Pathway

(2014) H. Shime et al.   JOURNAL OF IMMUNOLOGY

Antitumor Activity of the Glutaminase Inhibitor CB-839 in Triple-Negative Breast Cancer

(2014) M. I. Gross et al.   MOLECULAR CANCER THERAPEUTICS

Asparagine Plays a Critical Role in Regulating Cellular Adaptation to Glutamine Depletion

(2014) Ji Zhang et al.   MOLECULAR CELL

Functional polarization of tumour-associated macrophages by tumour-derived lactic acid

(2014) Oscar R. Colegio et al.   NATURE

Standing the test of time: targeting thymidylate biosynthesis in cancer therapy

(2014) Peter M. Wilson et al.   Nature Reviews Clinical Oncology

Glioblastoma: A Pathogenic Crosstalk between Tumor Cells and Pericytes

(2014) Elisabetta M. Caspani et al.   PLoS One

Metabolic shift may train immune cells

(2014) E. Pennisi   SCIENCE

The cellular and molecular origin of tumor-associated macrophages

(2014) R. A. Franklin et al.   SCIENCE

Tumor Macroenvironment and Metabolism

(2014) Wael Al-Zhoughbi et al.   SEMINARS IN ONCOLOGY

Serine and glycine metabolism in cancer

(2014) Ivano Amelio et al.   TRENDS IN BIOCHEMICAL SCIENCES

Targeting T Cell Immunometabolism for Cancer Immunotherapy; Understanding the Impact of the Tumor Microenvironment

(2014) Mary B. Mockler et al.   Frontiers in Oncology

Asparagine synthetase: regulation by cell stress and involvement in tumor biology

(2013) Mukundh N. Balasubramanian et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Impeding Macrophage Entry into Hypoxic Tumor Areas by Sema3A/Nrp1 Signaling Blockade Inhibits Angiogenesis and Restores Antitumor Immunity

(2013) Andrea Casazza et al.   CANCER CELL

Posttranscriptional Control of T Cell Effector Function by Aerobic Glycolysis

(2013) Chih-Hao Chang et al.   CELL

Role of PFKFB3-Driven Glycolysis in Vessel Sprouting

(2013) Katrien De Bock et al.   CELL

Role of Endothelial Cell Metabolism in Vessel Sprouting

(2013) Katrien De Bock et al.   Cell Metabolism

Activity of the Monocarboxylate Transporter 1 Inhibitor AZD3965 in Small Cell Lung Cancer

(2013) R. Polanski et al.   CLINICAL CANCER RESEARCH

Targeting CD73 Enhances the Antitumor Activity of Anti-PD-1 and Anti-CTLA-4 mAbs

(2013) B. Allard et al.   CLINICAL CANCER RESEARCH

Glutaminase regulation in cancer cells: a druggable chain of events

(2013) William P. Katt et al.   DRUG DISCOVERY TODAY

Platelet-derived growth factor-D and Rho GTPases regulate recruitment of cancer-associated fibroblasts in cholangiocarcinoma

(2013) Massimiliano Cadamuro et al.   HEPATOLOGY

AMXT-1501, a novel polyamine transport inhibitor, synergizes with DFMO in inhibiting neuroblastoma cell proliferation by targeting both ornithine decarboxylase and polyamine transport

(2013) Katherine Samal et al.   INTERNATIONAL JOURNAL OF CANCER

Lactate Engages Receptor Tyrosine Kinases Axl, Tie2, and Vascular Endothelial Growth Factor Receptor 2 to Activate Phosphoinositide 3-Kinase/Akt and Promote Angiogenesis

(2013) Guo-Xiang Ruan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Targeting lactate metabolism for cancer therapeutics

(2013) Joanne R. Doherty et al.   JOURNAL OF CLINICAL INVESTIGATION

Endothelial cell metabolism and tumour angiogenesis: glucose and glutamine as essential fuels and lactate as the driving force

(2013) F. Polet et al.   JOURNAL OF INTERNAL MEDICINE

Preferential transfer of mitochondria from endothelial to cancer cells through tunneling nanotubes modulates chemoresistance

(2013) Jennifer Pasquier et al.   Journal of Translational Medicine

Targeting 6-Phosphofructo-2-Kinase (PFKFB3) as a Therapeutic Strategy against Cancer

(2013) B. F. Clem et al.   MOLECULAR CANCER THERAPEUTICS

Macropinocytosis of protein is an amino acid supply route in Ras-transformed cells

(2013) Cosimo Commisso et al.   NATURE

Succinate is an inflammatory signal that induces IL-1β through HIF-1α

(2013) G. M. Tannahill et al.   NATURE

Assessing the differential action on cancer cells of LDH-A inhibitors based on the N-hydroxyindole-2-carboxylate (NHI) and malonic (Mal) scaffolds

(2013) Carlotta Granchi et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Combined 5-FU and ChoKα Inhibitors as a New Alternative Therapy of Colorectal Cancer: Evidence in Human Tumor-Derived Cell Lines and Mouse Xenografts

(2013) Ana de la Cueva et al.   PLoS One

Hypoxic and Ras-transformed cells support growth by scavenging unsaturated fatty acids from lysophospholipids

(2013) J. J. Kamphorst et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An Inhibitor of Mutant IDH1 Delays Growth and Promotes Differentiation of Glioma Cells

(2013) D. Rohle et al.   SCIENCE

Targeted Inhibition of Mutant IDH2 in Leukemia Cells Induces Cellular Differentiation

(2013) F. Wang et al.   SCIENCE

Control of vessel sprouting by genetic and metabolic determinants

(2013) Guy Eelen et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

ATP citrate lyase knockdown impacts cancer stem cells in vitro

(2013) J-i Hanai et al.   Cell Death & Disease

Choline kinase inhibition induces exacerbated endoplasmic reticulum stress and triggers apoptosis via CHOP in cancer cells

(2013) E Sanchez-Lopez et al.   Cell Death & Disease

Long-Term Nitric Oxide Exposure Enhances Lung Cancer Cell Migration

(2013) Arpasinee Sanuphan et al.   Biomed Research International

3-Hydroxy-3-methylglutaryl coenzyme A reductase inhibitor (fluvastatin) decreases inflammatory angiogenesis in mice

(2012) Fernanda A. Araújo et al.   APMIS

Endothelial cell metabolism and implications for cancer therapy

(2012) U Harjes et al.   BRITISH JOURNAL OF CANCER

Metabolic Signatures Uncover Distinct Targets in Molecular Subsets of Diffuse Large B Cell Lymphoma

(2012) Pilar Caro et al.   CANCER CELL

Phosphoglycerate Mutase 1 Coordinates Glycolysis and Biosynthesis to Promote Tumor Growth

(2012) Taro Hitosugi et al.   CANCER CELL

Accessories to the Crime: Functions of Cells Recruited to the Tumor Microenvironment

(2012) Douglas Hanahan et al.   CANCER CELL

Energy transfer in "parasitic" cancer metabolism

(2012) Ubaldo E. Martinez-Outschoorn et al.   CELL CYCLE

Metabolic remodeling of the tumor microenvironment: Migration stimulating factor (MSF) reprograms myofibroblasts toward lactate production, fueling anabolic tumor growth

(2012) Valentina Carito et al.   CELL CYCLE

Antifolates in cancer therapy: Structure, activity and mechanisms of drug resistance

(2012) Nitzan Gonen et al.   DRUG RESISTANCE UPDATES

Combined arginine and glutamine decrease release of de novo synthesized leukotrienes and expression of proinflammatory cytokines in activated human intestinal mast cells

(2012) Sandra Lechowski et al.   EUROPEAN JOURNAL OF NUTRITION

Galloflavin, a new lactate dehydrogenase inhibitor, induces the death of human breast cancer cells with different glycolytic attitude by affecting distinct signaling pathways

(2012) F. Farabegoli et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Lipid metabolism in cancer

(2012) Claudio R. Santos et al.   FEBS Journal

Fludarabine and cytarabine in patients with relapsed acute myeloid leukemia refractory to initial salvage therapy

(2012) Brian McLaughlin et al.   INTERNATIONAL JOURNAL OF HEMATOLOGY

A phase 1 dose-escalating study of pegylated recombinant human arginase 1 (Peg-rhArg1) in patients with advanced hepatocellular carcinoma

(2012) Thomas Yau et al.   INVESTIGATIONAL NEW DRUGS

D-Amino acid oxidase-induced oxidative stress, 3-bromopyruvate and citrate inhibit angiogenesis, exhibiting potent anticancer effects

(2012) S. M. El Sayed et al.   JOURNAL OF BIOENERGETICS AND BIOMEMBRANES

Energy metabolism in cancer cells: How to explain the Warburg and Crabtree effects?

(2012) Paolo Dell’ Antone   MEDICAL HYPOTHESES

How cancer metabolism is tuned for proliferation and vulnerable to disruption

(2012) Almut Schulze et al.   NATURE

Stromal control of cystine metabolism promotes cancer cell survival in chronic lymphocytic leukaemia

(2012) Wan Zhang et al.   NATURE CELL BIOLOGY

Pancreatic Tumor Sensitivity to Plasma L-Asparagine Starvation

(2012) Emmanuelle Dufour et al.   PANCREAS

Glutamine-fueled mitochondrial metabolism is decoupled from glycolysis in melanoma

(2012) Fabian V. Filipp et al.   Pigment Cell & Melanoma Research

Targeting the Lactate Transporter MCT1 in Endothelial Cells Inhibits Lactate-Induced HIF-1 Activation and Tumor Angiogenesis

(2012) Pierre Sonveaux et al.   PLoS One

Reprogramming of proline and glutamine metabolism contributes to the proliferative and metabolic responses regulated by oncogenic transcription factor c-MYC

(2012) W. Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hallmarks of cancer: of all cancer cells, all the time?

(2012) Sébastien L. Floor et al.   TRENDS IN MOLECULAR MEDICINE

Interactions between epigenetics and metabolism in cancers

(2012) Jihye Yun et al.   Frontiers in Oncology

The emerging role of fumarate as an oncometabolite

(2012) Ming Yang et al.   Frontiers in Oncology

Aerobic Glycolysis: Meeting the Metabolic Requirements of Cell Proliferation

(2011) Sophia Y. Lunt et al.   Annual Review of Cell and Developmental Biology

Therapeutic potential of cladribine in combination with STAT3 inhibitor against multiple myeloma

(2011) Jian Ma et al.   BMC CANCER

Mast cell: insight into remodeling a tumor microenvironment

(2011) Jing Liu et al.   CANCER AND METASTASIS REVIEWS

Ectonucleotidases CD39 and CD73 on OvCA cells are potent adenosine-generating enzymes responsible for adenosine receptor 2A-dependent suppression of T cell function and NK cell cytotoxicity

(2011) Sebastian F. M. Häusler et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Ovarian cancer-associated fibroblasts contribute to epithelial ovarian carcinoma metastasis by promoting angiogenesis, lymphangiogenesis and tumor cell invasion

(2011) Yuan Zhang et al.   CANCER LETTERS

Cancer-Associated Adipocytes Exhibit an Activated Phenotype and Contribute to Breast Cancer Invasion

(2011) B. Dirat et al.   CANCER RESEARCH

Lactate Influx through the Endothelial Cell Monocarboxylate Transporter MCT1 Supports an NF- B/IL-8 Pathway that Drives Tumor Angiogenesis

(2011) F. Vegran et al.   CANCER RESEARCH

Pyruvate Kinase M2 Is a PHD3-Stimulated Coactivator for Hypoxia-Inducible Factor 1

(2011) Weibo Luo et al.   CELL

Control of TH17/Treg Balance by Hypoxia-Inducible Factor 1

(2011) Eric V. Dang et al.   CELL

Basic and Therapeutic Aspects of Angiogenesis

(2011) Michael Potente et al.   CELL

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

The reverse Warburg effect: Aerobic glycolysis in cancer associated fibroblasts and the tumor stroma

(2011) Stephanos Pavlides et al.   CELL CYCLE

Evidence for a stromal-epithelial “lactate shuttle” in human tumors

(2011) Diana Whitaker-Menezes et al.   CELL CYCLE

Enolase 1 and calreticulin regulate the differentiation and function of mouse mast cells

(2011) Su Youn Ryu et al.   CELLULAR SIGNALLING

Lactate shuttles at a glance: from physiological paradigms to anti-cancer treatments

(2011) N. Draoui et al.   Disease Models & Mechanisms

Lactate is a mediator of metabolic cooperation between stromal carcinoma associated fibroblasts and glycolytic tumor cells in the tumor microenvironment

(2011) Yanique I. Rattigan et al.   EXPERIMENTAL CELL RESEARCH

Hydroxyurea: a key player in cancer chemotherapy

(2011) Kapish Madaan et al.   Expert Review of Anticancer Therapy

The Transcription Factor Myc Controls Metabolic Reprogramming upon T Lymphocyte Activation

(2011) Ruoning Wang et al.   IMMUNITY

The role of melanoma tumor-derived nitric oxide in the tumor inflammatory microenvironment: Its impact on the chemokine expression profile, including suppression of CXCL10

(2011) Keiji Tanese et al.   INTERNATIONAL JOURNAL OF CANCER

The Antifungal Drug Itraconazole Inhibits Vascular Endothelial Growth Factor Receptor 2 (VEGFR2) Glycosylation, Trafficking, and Signaling in Endothelial Cells

(2011) Benjamin A. Nacev et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Gemcitabine Plusnab-Paclitaxel Is an Active Regimen in Patients With Advanced Pancreatic Cancer: A Phase I/II Trial

(2011) Daniel D. Von Hoff et al.   JOURNAL OF CLINICAL ONCOLOGY

Activated CD69+ T Cells Foster Immune Privilege by Regulating IDO Expression in Tumor-Associated Macrophages

(2011) Q. Zhao et al.   JOURNAL OF IMMUNOLOGY

Dimethylfumarate Inhibits Angiogenesis In Vitro and In Vivo: A Possible Role for Its Antipsoriatic Effect?

(2011) Melissa García-Caballero et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Functional genomics reveal that the serine synthesis pathway is essential in breast cancer

(2011) Richard Possemato et al.   NATURE

An endogenous tumour-promoting ligand of the human aryl hydrocarbon receptor

(2011) Christiane A. Opitz et al.   NATURE

Adipocytes promote ovarian cancer metastasis and provide energy for rapid tumor growth

(2011) Kristin M Nieman et al.   NATURE MEDICINE

Targeting cancer metabolism: a therapeutic window opens

(2011) Matthew G. Vander Heiden   NATURE REVIEWS DRUG DISCOVERY

Shikonin and its analogs inhibit cancer cell glycolysis by targeting tumor pyruvate kinase-M2

(2011) J Chen et al.   ONCOGENE

A novel small molecule antagonist of choline kinase-α that simultaneously suppresses MAPK and PI3K/AKT signaling

(2011) B F Clem et al.   ONCOGENE

Adipose Triglyceride Lipase Contributes to Cancer-Associated Cachexia

(2011) S. K. Das et al.   SCIENCE

Regulation of blood vessel sprouting

(2011) John C. Chappell et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Critical role for lactate dehydrogenase A in aerobic glycolysis that sustains pulmonary microvascular endothelial cell proliferation

(2010) Glenda Parra-Bonilla et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Mast cells, angiogenesis, and tumour growth

(2010) Domenico Ribatti et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Selective inhibition of IDO1 effectively regulates mediators of antitumor immunity

(2010) X. Liu et al.   BLOOD

Cancer Metabolism: Is Glutamine Sweeter than Glucose?

(2010) Weiqin Lu et al.   CANCER CELL

Notch Signaling Determines the M1 versus M2 Polarization of Macrophages in Antitumor Immune Responses

(2010) Yao-Chun Wang et al.   CANCER RESEARCH

Inhibition of Glutaminase Preferentially Slows Growth of Glioma Cells with Mutant IDH1

(2010) M. J. Seltzer et al.   CANCER RESEARCH

Immunity, Inflammation, and Cancer

(2010) Sergei I. Grivennikov et al.   CELL

Oxidative stress in cancer associated fibroblasts drives tumor-stroma co-evolution

(2010) Ubaldo E. Martinez-Outschoorn et al.   CELL CYCLE

Ornithine decarboxylase and extracellular polyamines regulate microvascular sprouting and actin cytoskeleton dynamics in endothelial cells

(2010) Paulina Kucharzewska et al.   EXPERIMENTAL CELL RESEARCH

Anticancer drugs that target metabolism: Is dichloroacetate the new paradigm?

(2010) Ioanna Papandreou et al.   INTERNATIONAL JOURNAL OF CANCER

Silybin and dehydrosilybin decrease glucose uptake by inhibiting GLUT proteins

(2010) Tianzuo Zhan et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Protein Tyrosine Nitration of Aldolase in Mast Cells: A Plausible Pathway in Nitric Oxide-Mediated Regulation of Mast Cell Function

(2010) Y. Sekar et al.   JOURNAL OF IMMUNOLOGY

Substrate Fate in Activated Macrophages: A Comparison between Innate, Classic, and Alternative Activation

(2010) J.-C. Rodriguez-Prados et al.   JOURNAL OF IMMUNOLOGY

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(2010) Miguel Lopez-Lazaro   MOLECULAR MEDICINE

Antiangiogenic Activity of 2-Deoxy-D-Glucose

(2010) Jaime R. Merchan et al.   PLoS One

Polyamines Are Present in Mast Cell Secretory Granules and Are Important for Granule Homeostasis

(2010) Gianni García-Faroldi et al.   PLoS One

Inhibition of lactate dehydrogenase A induces oxidative stress and inhibits tumor progression

(2010) A. Le et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tumor antigen-specific CD8 T cells infiltrating the tumor express high levels of PD-1 and are functionally impaired

(2009) M. Ahmadzadeh et al.   BLOOD

Changes in Human Endothelial Cell Energy Metabolic Capacities during in vitro Cultivation. The Role of “Aerobic Glycolysis” and Proliferation

(2009) Kirsten Peters et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Visualizing cancer and immune cell function with metabolic positron emission tomography

(2009) Rachel E Laing et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

The mTOR Kinase Differentially Regulates Effector and Regulatory T Cell Lineage Commitment

(2009) Greg M. Delgoffe et al.   IMMUNITY

Pharmacologic inhibition of fatty acid oxidation sensitizes human leukemia cells to apoptosis induction

(2009) Ismael Samudio et al.   JOURNAL OF CLINICAL INVESTIGATION

Cell-cell and intracellular lactate shuttles

(2009) George A. Brooks   JOURNAL OF PHYSIOLOGY-LONDON

Q's next: the diverse functions of glutamine in metabolism, cell biology and cancer

(2009) R J DeBerardinis et al.   ONCOGENE

Methyl jasmonate: A plant stress hormone as an anti-cancer drug

(2009) Sharon Cohen et al.   PHYTOCHEMISTRY

Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

(2009) M. G. Vander Heiden et al.   SCIENCE

Catechin gallates are NADP+-competitive inhibitors of glucose-6-phosphate dehydrogenase and other enzymes that employ NADP+ as a coenzyme

(2008) Eui Seok Shin et al.   BIOORGANIC & MEDICINAL CHEMISTRY

The polyamine and histamine metabolic interplay in cancer and chronic inflammation

(2008) Gianni García-Faroldi et al.   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

Tumor microenvironment and angiogenesis

(2008) Pia Nyberg   Frontiers in Bioscience-Landmark

Stromal Fibroblasts Activated by Tumor Cells Promote Angiogenesis in Mouse Gastric Cancer

(2008) Xiaoying Guo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Fatty acid metabolism: target for metabolic syndrome

(2008) Salih J. Wakil et al.   JOURNAL OF LIPID RESEARCH

A novel inhibitor of glucose uptake sensitizes cells to FAS-induced cell death

(2008) T. E. Wood et al.   MOLECULAR CANCER THERAPEUTICS