Hypoxia-Inducible Factor Prolyl Hydroxylase Inhibition: Robust New Target or Another Big Bust for Stroke Therapeutics?
出版年份 2012 全文链接
标题
Hypoxia-Inducible Factor Prolyl Hydroxylase Inhibition: Robust New Target or Another Big Bust for Stroke Therapeutics?
作者
关键词
-
出版物
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
Volume 32, Issue 7, Pages 1347-1361
出版商
SAGE Publications
发表日期
2012-03-14
DOI
10.1038/jcbfm.2012.28
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- Inhibition of 2-oxoglutarate dependent oxygenases
- (2011) Nathan R. Rose et al. CHEMICAL SOCIETY REVIEWS
- Development of Neh2-Luciferase Reporter and Its Application for High Throughput Screening and Real-Time Monitoring of Nrf2 Activators
- (2011) Natalya A. Smirnova et al. CHEMISTRY & BIOLOGY
- Cardiomyocyte-specific Prolyl-4-hydroxylase Domain 2 Knock Out Protects from Acute Myocardial Ischemic Injury
- (2011) Marion Hölscher et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Prophylactic neuroprotection against stroke: Low-dose, prolonged treatment with deferoxamine or deferasirox establishes prolonged neuroprotection independent of HIF-1 function
- (2011) Yanxin Zhao et al. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
- Inhibition of prolyl hydroxylases by dimethyloxaloylglycine after stroke reduces ischemic brain injury and requires hypoxia inducible factor-1α
- (2011) Molly E. Ogle et al. NEUROBIOLOGY OF DISEASE
- Uptake, metabolism and toxicity of hemin in cultured neurons
- (2011) Theresa N. Dang et al. NEUROCHEMISTRY INTERNATIONAL
- Enhancing the Delivery of Erythropoietin and Its Variants into the Ischemic Brain
- (2011) Dirk M. Hermann TheScientificWorldJOURNAL
- Utilization of an In Vivo Reporter for High Throughput Identification of Branched Small Molecule Regulators of Hypoxic Adaptation
- (2010) Natalya A. Smirnova et al. CHEMISTRY & BIOLOGY
- Neuroprotection by Dimethyloxalylglycine following Permanent and Transient Focal Cerebral Ischemia in Rats
- (2010) Simon Nagel et al. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
- Hemoglobin and Iron Handling in Brain after Subarachnoid Hemorrhage and the Effect of Deferoxamine on Early Brain Injury
- (2010) Jin-Yul Lee et al. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
- Selective Inhibitors of the JMJD2 Histone Demethylases: Combined Nondenaturing Mass Spectrometric Screening and Crystallographic Approaches
- (2010) Nathan R. Rose et al. JOURNAL OF MEDICINAL CHEMISTRY
- Cerebral tissue repair and atrophy after embolic stroke in rat: A magnetic resonance imaging study of erythropoietin therapy
- (2010) Guangliang Ding et al. JOURNAL OF NEUROSCIENCE RESEARCH
- O2 regulates stem cells through Wnt/β-catenin signalling
- (2010) Jolly Mazumdar et al. NATURE CELL BIOLOGY
- Erythropoietin promotes hippocampal neurogenesis in in vitro models of neonatal stroke
- (2010) Damjan Osredkar et al. NEUROBIOLOGY OF DISEASE
- Do-not-resuscitate orders and predictive models after intracerebral hemorrhage
- (2010) D. B. Zahuranec et al. NEUROLOGY
- Reactivation of Hepatic EPO Synthesis in Mice After PHD Loss
- (2010) Y. A. Minamishima et al. SCIENCE
- Deferoxamine Treatment for Intracerebral Hemorrhage in Aged Rats
- (2010) Masanobu Okauchi et al. STROKE
- Enhanced Oligodendrogenesis and Recovery of Neurological Function by Erythropoietin After Neonatal Hypoxic/Ischemic Brain Injury
- (2010) Masanori Iwai et al. STROKE
- Physiological and biochemical aspects of hydroxylations and demethylations catalyzed by human 2-oxoglutarate oxygenases
- (2010) Christoph Loenarz et al. TRENDS IN BIOCHEMICAL SCIENCES
- Enhanced Delivery of Erythropoietin Across the Blood–Brain Barrier for Neuroprotection Against Ischemic Neuronal Injury
- (2010) Feng Zhang et al. Translational Stroke Research
- Strain Differences in Behavioral and Cellular Responses to Perinatal Hypoxia and Relationships to Neural Stem Cell Survival and Self-Renewal
- (2009) Qi Li et al. AMERICAN JOURNAL OF PATHOLOGY
- Cellular oxygen sensing: Importins and exportins are mediators of intracellular localisation of prolyl-4-hydroxylases PHD1 and PHD2
- (2009) Amrei Steinhoff et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Role of the intracellular localization of HIF-prolyl hydroxylases
- (2009) Ken-ichi Yasumoto et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
- 2-Oxoglutarate analogue inhibitors of prolyl hydroxylase domain 2
- (2009) Jasmin Mecinović et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- The role of hypoxia-inducible transcription factors in the hypoxic neonatal brain
- (2009) Regina Trollmann et al. BRAIN & DEVELOPMENT
- Putting the ‘HAT’ back on survival signalling: the promises and challenges of HDAC inhibition in the treatment of neurological conditions
- (2009) Sama F Sleiman et al. EXPERT OPINION ON INVESTIGATIONAL DRUGS
- Selective Inhibition of Hypoxia-Inducible Factor (HIF) Prolyl-Hydroxylase 1 Mediates Neuroprotection against Normoxic Oxidative Death via HIF- and CREB-Independent Pathways
- (2009) A. Siddiq et al. JOURNAL OF NEUROSCIENCE
- Intranasal Deferoxamine Provides Increased Brain Exposure and Significant Protection in Rat Ischemic Stroke
- (2009) L. R. Hanson et al. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
- Forebrain neurogenesis after focal Ischemic and traumatic brain injury
- (2009) Steven G. Kernie et al. NEUROBIOLOGY OF DISEASE
- Hemin toxicity: a preventable source of brain damage following hemorrhagic stroke
- (2009) Stephen R. Robinson et al. REDOX REPORT
- Oxygen-Regulated 2-Adrenergic Receptor Hydroxylation by EGLN3 and Ubiquitylation by pVHL
- (2009) L. Xie et al. Science Signaling
- Targeting Histone Deacetylases as a Multifaceted Approach to Treat the Diverse Outcomes of Stroke
- (2009) Brett Langley et al. STROKE
- Deferoxamine Reduces Intracerebral Hematoma-Induced Iron Accumulation and Neuronal Death in Piglets
- (2009) Yuxiang Gu et al. STROKE
- Antioxidants, HIF Prolyl Hydroxylase Inhibitors or Short Interfering RNAs to BNIP3 or PUMA, Can Prevent Prodeath Effects of the Transcriptional Activator, HIF-1α, in a Mouse Hippocampal Neuronal Line
- (2008) Leila R. Aminova et al. ANTIOXIDANTS & REDOX SIGNALING
- The Nrf2/ARE Pathway as a Potential Therapeutic Target in Neurodegenerative Disease
- (2008) Marcus J. Calkins et al. ANTIOXIDANTS & REDOX SIGNALING
- Discovery of novel hydroxy-thiazoles as HIF-α prolyl hydroxylase inhibitors: SAR, synthesis, and modeling evaluation
- (2008) Christopher M. Tegley et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- ATF4 is an oxidative stress–inducible, prodeath transcription factor in neurons in vitro and in vivo
- (2008) Philipp S. Lange et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Nitric oxide donor up-regulation of SDF1/CXCR4 and Ang1/Tie2 promotes neuroblast cell migration after stroke
- (2008) Xu Cui et al. JOURNAL OF NEUROSCIENCE RESEARCH
- Abnormal Sympathoadrenal Development and Systemic Hypotension in PHD3-/- Mice
- (2008) T. Bishop et al. MOLECULAR AND CELLULAR BIOLOGY
- The von Hippel-Lindau Tumor Suppressor Protein and Egl-9-Type Proline Hydroxylases Regulate the Large Subunit of RNA Polymerase II in Response to Oxidative Stress
- (2008) O. Mikhaylova et al. MOLECULAR AND CELLULAR BIOLOGY
- Oxygen Sensing by Metazoans: The Central Role of the HIF Hydroxylase Pathway
- (2008) William G. Kaelin et al. MOLECULAR CELL
- Deficiency or inhibition of oxygen sensor Phd1 induces hypoxia tolerance by reprogramming basal metabolism
- (2008) Julián Aragonés et al. NATURE GENETICS
- Ischemic stroke and neurogenesis in the subventricular zone
- (2008) Rui Lan Zhang et al. NEUROPHARMACOLOGY
- Abundance of aspargynyl-hydroxylase FIH is regulated by Siah-1 under normoxic conditions
- (2008) Hiromasa Fukuba et al. NEUROSCIENCE LETTERS
- Novel Multi-Modal Strategies to Promote Brain and Spinal Cord Injury Recovery
- (2008) R. R. Ratan et al. STROKE
- Regulation of adult erythropoiesis by prolyl hydroxylase domain proteins
- (2007) K. Takeda et al. BLOOD
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