Metabolic Cooperation and Competition in the Tumor Microenvironment: Implications for Therapy
出版年份 2017 全文链接
标题
Metabolic Cooperation and Competition in the Tumor Microenvironment: Implications for Therapy
作者
关键词
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出版物
Frontiers in Oncology
Volume 7, Issue -, Pages -
出版商
Frontiers Media SA
发表日期
2017-04-12
DOI
10.3389/fonc.2017.00068
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- The peritumoural adipose tissue microenvironment and cancer. The roles of fatty acid binding protein 4 and fatty acid binding protein 5
- (2018) S. Guaita-Esteruelas et al. MOLECULAR AND CELLULAR ENDOCRINOLOGY
- Local and systemic Th17 immune response associated with advanced stage colon cancer
- (2017) Stephen P. Sharp et al. JOURNAL OF SURGICAL RESEARCH
- Adipocytes activate mitochondrial fatty acid oxidation and autophagy to promote tumor growth in colon cancer
- (2017) Yang-An Wen et al. Cell Death & Disease
- Hexokinase 2 is a determinant of neuroblastoma metastasis
- (2016) Liat Edry Botzer et al. BRITISH JOURNAL OF CANCER
- Inhibition of the Glycolytic Activator PFKFB3 in Endothelium Induces Tumor Vessel Normalization, Impairs Metastasis, and Improves Chemotherapy
- (2016) Anna Rita Cantelmo et al. CANCER CELL
- Inhibition of glycolytic enzyme hexokinase II (HK2) suppresses lung tumor growth
- (2016) Huanan Wang et al. Cancer Cell International
- The Quid Pro Quo of the Tumor/Stromal Interaction
- (2016) Mylène Tajan et al. Cell Metabolism
- Targeting Stromal Glutamine Synthetase in Tumors Disrupts Tumor Microenvironment-Regulated Cancer Cell Growth
- (2016) Lifeng Yang et al. Cell Metabolism
- Macrophage Metabolism Controls Tumor Blood Vessel Morphogenesis and Metastasis
- (2016) Mathias Wenes et al. Cell Metabolism
- Intratumor stromal proportion predicts aggressive phenotype of gastric signet ring cell carcinomas
- (2016) Dakeun Lee et al. Gastric Cancer
- The Tumor Microenvironment Represses T Cell Mitochondrial Biogenesis to Drive Intratumoral T Cell Metabolic Insufficiency and Dysfunction
- (2016) Nicole E. Scharping et al. IMMUNITY
- Polarization of macrophages towards M1 phenotype by a combination of 2-deoxy- d -glucose and radiation: Implications for tumor therapy
- (2016) Abdullah Farooque et al. IMMUNOBIOLOGY
- Metabolic reprogramming and AMPKα1 pathway activation by caulerpin in colorectal cancer cells
- (2016) Hua Yu et al. INTERNATIONAL JOURNAL OF ONCOLOGY
- Curcumin inhibits aerobic glycolysis in hepatic stellate cells associated with activation of adenosine monophosphate-activated protein kinase
- (2016) Naqi Lian et al. IUBMB LIFE
- TP53-inducible Glycolysis and Apoptosis Regulator (TIGAR) Metabolically Reprograms Carcinoma and Stromal Cells in Breast Cancer
- (2016) Ying-Hui Ko et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Clinical relevance of the tumor microenvironment and immune escape of oral squamous cell carcinoma
- (2016) Alexander W. Eckert et al. Journal of Translational Medicine
- Galectin-9 modulates immunity by promoting Th2/M2 differentiation and impacts survival in patients with metastatic melanoma
- (2016) Elizabeth Ann L. Enninga et al. MELANOMA RESEARCH
- The HK2 Dependent “Warburg Effect” and Mitochondrial Oxidative Phosphorylation in Cancer: Targets for Effective Therapy with 3-Bromopyruvate
- (2016) Paweł Lis et al. MOLECULES
- Targeting metastasis-initiating cells through the fatty acid receptor CD36
- (2016) Gloria Pascual et al. NATURE
- The ever-expanding role of HIF in tumour and stromal biology
- (2016) Edward L. LaGory et al. NATURE CELL BIOLOGY
- Immunometabolism of regulatory T cells
- (2016) Ryan Newton et al. NATURE IMMUNOLOGY
- Foxp3 and Toll-like receptor signaling balance Treg cell anabolic metabolism for suppression
- (2016) Valerie A Gerriets et al. NATURE IMMUNOLOGY
- Cytoplasmic GPER translocation in cancer-associated fibroblasts mediates cAMP/PKA/CREB/glycolytic axis to confer tumor cells with multidrug resistance
- (2016) T Yu et al. ONCOGENE
- Bidirectional cross talk between patient-derived melanoma and cancer-associated fibroblasts promotes invasion and proliferation
- (2016) Benjamin Izar et al. Pigment Cell & Melanoma Research
- An indispensable role of CPT-1a to survive cancer cells during energy stress through rewiring cancer metabolism
- (2016) Jingtao Luo et al. TUMOR BIOLOGY
- Phospholipase D1-regulated autophagy supplies free fatty acids to counter nutrient stress in cancer cells
- (2016) Ming Cai et al. Cell Death & Disease
- Molecular regulation of apoptotic machinery and lipid metabolism by mTORC1/mTORC2 dual inhibitors in preclinical models of HER2+/PIK3CAmut breast cancer
- (2016) Jianchang Qian et al. Oncotarget
- Hypoxia-mediated upregulation of MCT1 expression supports the glycolytic phenotype of glioblastomas
- (2016) Vera Miranda-Gonçalves et al. Oncotarget
- Unique metabolic features of pancreatic cancer stroma: relevance to the tumor compartment, prognosis, and invasive potential
- (2016) Erik S. Knudsen et al. Oncotarget
- In vitro and in vivo study of epigallocatechin-3-gallate-induced apoptosis in aerobic glycolytic hepatocellular carcinoma cells involving inhibition of phosphofructokinase activity
- (2016) Sainan Li et al. Scientific Reports
- Targeting Metabolic Symbiosis to Overcome Resistance to Anti-angiogenic Therapy
- (2016) Laura Pisarsky et al. Cell Reports
- Notch stimulates growth by direct regulation of genes involved in the control of glycolysis and the tricarboxylic acid cycle
- (2016) Vera Slaninova et al. Open Biology
- Cancer: An Oxidative Crosstalk between Solid Tumor Cells and Cancer Associated Fibroblasts
- (2016) Alessandro Arcucci et al. Biomed Research International
- Lipid metabolic reprogramming in cancer cells
- (2016) S Beloribi-Djefaflia et al. Oncogenesis
- Energy disruptors: rising stars in anticancer therapy?
- (2016) F Bost et al. Oncogenesis
- Intrinsic and Tumor Microenvironment-Induced Metabolism Adaptations of T Cells and Impact on Their Differentiation and Function
- (2016) Soumaya Kouidhi et al. Frontiers in Immunology
- T Cells and Cancer: How Metabolism Shapes Immunity
- (2016) Barbara Molon et al. Frontiers in Immunology
- PFK15, a Small Molecule Inhibitor of PFKFB3, Induces Cell Cycle Arrest, Apoptosis and Inhibits Invasion in Gastric Cancer
- (2016) Wei Zhu et al. PLoS One
- Autophagy is required for PDAC glutamine metabolism
- (2016) Ju-Won Seo et al. Scientific Reports
- The role of lipid droplets and adipocytes in cancer. Raman imaging of cell cultures: MCF10A, MCF7, and MDA-MB-231 compared to adipocytes in cancerous human breast tissue
- (2015) Halina Abramczyk et al. ANALYST
- Transient elevation of glycolysis confers radio-resistance by facilitating DNA repair in cells
- (2015) Anant Narayan Bhatt et al. BMC CANCER
- Interactions between Myc and MondoA transcription factors in metabolism and tumourigenesis
- (2015) Blake R Wilde et al. BRITISH JOURNAL OF CANCER
- Glioblastoma cells induce differential glutamatergic gene expressions in human tumor-associated microglia/macrophages and monocyte-derived macrophages
- (2015) Judy Choi et al. CANCER BIOLOGY & THERAPY
- Phosphoenolpyruvate Is a Metabolic Checkpoint of Anti-tumor T Cell Responses
- (2015) Ping-Chih Ho et al. CELL
- Metabolic Competition in the Tumor Microenvironment Is a Driver of Cancer Progression
- (2015) Chih-Hao Chang et al. CELL
- Lactate promotes glutamine uptake and metabolism in oxidative cancer cells
- (2015) Jhudit Pérez-Escuredo et al. CELL CYCLE
- Overexpression of monocarboxylate anion transporter 1 and 4 in T24-induced cancer-associated fibroblasts regulates the progression of bladder cancer cells in a 3D microfluidic device
- (2015) Haoqing Shi et al. CELL CYCLE
- mTOR coordinates protein synthesis, mitochondrial activity and proliferation
- (2015) Masahiro Morita et al. CELL CYCLE
- Metabolic reprogramming in macrophages and dendritic cells in innate immunity
- (2015) Beth Kelly et al. CELL RESEARCH
- Molecular Pathways: Trafficking of Metabolic Resources in the Tumor Microenvironment
- (2015) I. L. Romero et al. CLINICAL CANCER RESEARCH
- Expression of lactate/H+ symporters MCT1 and MCT4 and their chaperone CD147 predicts tumor progression in clear cell renal cell carcinoma: immunohistochemical and The Cancer Genome Atlas data analyses
- (2015) Younghye Kim et al. HUMAN PATHOLOGY
- Molecular Connections between Cancer Cell Metabolism and the Tumor Microenvironment
- (2015) Calvin Justus et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- T cell metabolism drives immunity
- (2015) Michael D. Buck et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Targeting ASCT2-mediated glutamine uptake blocks prostate cancer growth and tumour development
- (2015) Qian Wang et al. JOURNAL OF PATHOLOGY
- Cancer-associated fibroblasts provide a suitable microenvironment for tumor development and progression in oral tongue squamous cancer
- (2015) Huan Li et al. Journal of Translational Medicine
- ASCT2/SLC1A5 controls glutamine uptake and tumour growth in triple-negative basal-like breast cancer
- (2015) M van Geldermalsen et al. ONCOGENE
- Associations among pretreatment tumor necrosis and the expression of HIF-1α and PD-L1 in advanced oral squamous cell carcinoma and the prognostic impact thereof
- (2015) Tseng-Cheng Chen et al. ORAL ONCOLOGY
- Confusing signals: Recent progress in CTLA-4 biology
- (2015) Lucy S.K. Walker et al. TRENDS IN IMMUNOLOGY
- Targeting T cell metabolism for therapy
- (2015) David O'Sullivan et al. TRENDS IN IMMUNOLOGY
- T cell metabolic fitness in antitumor immunity
- (2015) Peter J. Siska et al. TRENDS IN IMMUNOLOGY
- PD-1 alters T-cell metabolic reprogramming by inhibiting glycolysis and promoting lipolysis and fatty acid oxidation
- (2015) Nikolaos Patsoukis et al. Nature Communications
- Apoptosis of tumor infiltrating effector TIM-3+CD8+ T cells in colon cancer
- (2015) Chiao-Wen Kang et al. Scientific Reports
- Metabolic Reprogramming of Cancer-Associated Fibroblasts by IDH3α Downregulation
- (2015) Daoxiang Zhang et al. Cell Reports
- Lactic acid polarizes macrophages to a tumor-promoting state
- (2015) Oscar R Colegio OncoImmunology
- The PTEN pathway in Tregs is a critical driver of the suppressive tumor microenvironment
- (2015) M. D. Sharma et al. Science Advances
- A2aR antagonists: Next generation checkpoint blockade for cancer immunotherapy
- (2015) Robert D. Leone et al. Computational and Structural Biotechnology Journal
- Chronic Dietary Administration of the Glycolytic Inhibitor 2-Deoxy-D-Glucose (2-DG) Inhibits the Growth of Implanted Ehrlich’s Ascites Tumor in Mice
- (2015) Saurabh Singh et al. PLoS One
- Mitochondrial Fission Induces Glycolytic Reprogramming in Cancer-Associated Myofibroblasts, Driving Stromal Lactate Production, and Early Tumor Growth
- (2015) Carmela Guido et al. Oncotarget
- Two hits are better than one: targeting both phosphatidylinositol 3-kinase and mammalian target of rapamycin as a therapeutic strategy for acute leukemia treatment
- (2015) Alberto M. Martelli et al. Oncotarget
- Metformin limits the adipocyte tumor-promoting effect on ovarian cancer
- (2015) Calvin Tebbe et al. Oncotarget
- Role of mesenchymal stem cells in osteosarcoma and metabolic reprogramming of tumor cells
- (2015) Gloria Bonuccelli et al. Oncotarget
- Killing multiple myeloma cells with the small molecule 3-bromopyruvate
- (2014) Grażyna Majkowska-Skrobek et al. ANTI-CANCER DRUGS
- A lactate shuttle system between tumour and stromal cells is associated with poor prognosis in prostate cancer
- (2014) Nelma Pértega-Gomes et al. BMC CANCER
- Mechanisms of Hypoxia-Mediated Immune Escape in Cancer
- (2014) I. B. Barsoum et al. CANCER RESEARCH
- Th17 cells and interleukin-17 increase with poor prognosis in patients with acute myeloid leukemia
- (2014) Yixiang Han et al. CANCER SCIENCE
- The Glucose Transporter Glut1 Is Selectively Essential for CD4 T Cell Activation and Effector Function
- (2014) Andrew N. Macintyre et al. Cell Metabolism
- Metabolism of activated T lymphocytes
- (2014) Jason A Maciolek et al. CURRENT OPINION IN IMMUNOLOGY
- PD-1 regulates extrathymic regulatory T-cell differentiation
- (2014) Xiufen Chen et al. EUROPEAN JOURNAL OF IMMUNOLOGY
- Inflammatory T Cell Responses Rely on Amino Acid Transporter ASCT2 Facilitation of Glutamine Uptake and mTORC1 Kinase Activation
- (2014) Mako Nakaya et al. IMMUNITY
- The Transcription Factor FoxO1 Sustains Expression of the Inhibitory Receptor PD-1 and Survival of Antiviral CD8+ T Cells during Chronic Infection
- (2014) Matthew M. Staron et al. IMMUNITY
- Memory CD8+ T Cells Use Cell-Intrinsic Lipolysis to Support the Metabolic Programming Necessary for Development
- (2014) David O’Sullivan et al. IMMUNITY
- Akt-dependent Activation of mTORC1 Complex Involves Phosphorylation of mTOR (Mammalian Target of Rapamycin) by IκB Kinase α (IKKα)
- (2014) Han C. Dan et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Glucose Uptake Is Limiting in T Cell Activation and Requires CD28-Mediated Akt-Dependent and Independent Pathways
- (2014) S. R. Jacobs et al. JOURNAL OF IMMUNOLOGY
- A reverse Warburg metabolism in oral squamous cell carcinoma is not dependent upon myofibroblasts
- (2014) David H. Jensen et al. JOURNAL OF ORAL PATHOLOGY & MEDICINE
- Metformin Attenuates Experimental Autoimmune Arthritis through Reciprocal Regulation of Th17/Treg Balance and Osteoclastogenesis
- (2014) Hye-Jin Son et al. MEDIATORS OF INFLAMMATION
- Functional polarization of tumour-associated macrophages by tumour-derived lactic acid
- (2014) Oscar R. Colegio et al. NATURE
- Enhanced Antitumor Immunity Contributes to the Radio-Sensitization of Ehrlich Ascites Tumor by the Glycolytic Inhibitor 2-Deoxy-D-Glucose in Mice
- (2014) Abdullah Farooque et al. PLoS One
- Catabolic cancer-associated fibroblasts transfer energy and biomass to anabolic cancer cells, fueling tumor growth
- (2014) Ubaldo E. Martinez-Outschoorn et al. SEMINARS IN CANCER BIOLOGY
- Tumor Microenvironment and Metabolic Synergy in Breast Cancers: Critical Importance of Mitochondrial Fuels and Function
- (2014) Ubaldo Martinez-Outschoorn et al. SEMINARS IN ONCOLOGY
- Gene and protein expression of glucose transporter 1 and glucose transporter 3 in human laryngeal cancer—the relationship with regulatory hypoxia-inducible factor-1α expression, tumor invasiveness, and patient prognosis
- (2014) Katarzyna Starska et al. TUMOR BIOLOGY
- Beyond Warburg effect – dual metabolic nature of cancer cells
- (2014) Jiansheng Xie et al. Scientific Reports
- Targeting Arginine-Dependent Cancers with Arginine-Degrading Enzymes: Opportunities and Challenges
- (2014) Melissa M. Phillips et al. Cancer Research and Treatment
- Regulation of the pentose phosphate pathway in cancer
- (2014) Peng Jiang et al. Protein & Cell
- Regulation of the pentose phosphate pathway by an androgen receptor–mTOR-mediated mechanism and its role in prostate cancer cell growth
- (2014) E Tsouko et al. Oncogenesis
- Metabolic Reprograming in Macrophage Polarization
- (2014) Silvia Galván-Peña et al. Frontiers in Immunology
- The Intercellular Metabolic Interplay between Tumor and Immune Cells
- (2014) Tingting Wang et al. Frontiers in Immunology
- Trial watch: IDO inhibitors in cancer therapy
- (2014) Erika Vacchelli et al. OncoImmunology
- Targeting T Cell Immunometabolism for Cancer Immunotherapy; Understanding the Impact of the Tumor Microenvironment
- (2014) Mary B. Mockler et al. Frontiers in Oncology
- Anti-inflammatory M2, but not pro-inflammatory M1 macrophages promote angiogenesis in vivo
- (2013) Nadine Jetten et al. ANGIOGENESIS
- Cancer immunoediting: antigens, mechanisms, and implications to cancer immunotherapy
- (2013) Matthew D. Vesely et al. Annals of the New York Academy of Sciences
- Metabolic Regulation of T Lymphocytes
- (2013) Nancie J. MacIver et al. Annual Review of Immunology
- Immune Modulation in Cancer with Antibodies
- (2013) David B. Page et al. Annual Review of Medicine
- Host programmed death ligand 1 is dominant over programmed death ligand 2 expression in regulating graft-versus-host disease lethality
- (2013) A. Saha et al. BLOOD
- Tumor Hypoxia Does Not Drive Differentiation of Tumor-Associated Macrophages but Rather Fine-Tunes the M2-like Macrophage Population
- (2013) D. Laoui et al. CANCER RESEARCH
- Posttranscriptional Control of T Cell Effector Function by Aerobic Glycolysis
- (2013) Chih-Hao Chang et al. CELL
- T cell anergy, exhaustion, senescence, and stemness in the tumor microenvironment
- (2013) Joel Crespo et al. CURRENT OPINION IN IMMUNOLOGY
- Metabolic Pathways in Immune Cell Activation and Quiescence
- (2013) Erika L. Pearce et al. IMMUNITY
- Dichloroacetate improves immune dysfunction caused by tumor-secreted lactic acid and increases antitumor immunoreactivity
- (2013) Toshimitsu Ohashi et al. INTERNATIONAL JOURNAL OF CANCER
- Erratum to: Case Report: Sodium dichloroacetate (DCA) inhibition of the “Warburg Effect” in a human cancer patient: complete response in non-Hodgkin’s lymphoma after disease progression with rituximab-CHOP
- (2013) Stephen B. Strum et al. JOURNAL OF BIOENERGETICS AND BIOMEMBRANES
- The tumor microenvironment at a glance
- (2013) F. R. Balkwill et al. JOURNAL OF CELL SCIENCE
- Inhibiting glycolytic metabolism enhances CD8+ T cell memory and antitumor function
- (2013) Madhusudhanan Sukumar et al. JOURNAL OF CLINICAL INVESTIGATION
- Glutamine and cancer: cell biology, physiology, and clinical opportunities
- (2013) Christopher T. Hensley et al. JOURNAL OF CLINICAL INVESTIGATION
- Targeting lactate metabolism for cancer therapeutics
- (2013) Joanne R. Doherty et al. JOURNAL OF CLINICAL INVESTIGATION
- Oncometabolites: linking altered metabolism with cancer
- (2013) Ming Yang et al. JOURNAL OF CLINICAL INVESTIGATION
- Cancer-generated lactic acid: a regulatory, immunosuppressive metabolite?
- (2013) Stephen Yiu Chuen Choi et al. JOURNAL OF PATHOLOGY
- PD-1 Increases PTEN Phosphatase Activity While Decreasing PTEN Protein Stability by Inhibiting Casein Kinase 2
- (2013) Nikolaos Patsoukis et al. MOLECULAR AND CELLULAR BIOLOGY
- Succinate is an inflammatory signal that induces IL-1β through HIF-1α
- (2013) G. M. Tannahill et al. NATURE
- mTORC1 couples immune signals and metabolic programming to establish Treg-cell function
- (2013) Hu Zeng et al. NATURE
- Hypoxia-inducible factors enhance the effector responses of CD8+ T cells to persistent antigen
- (2013) Andrew L Doedens et al. NATURE IMMUNOLOGY
- Control of amino-acid transport by antigen receptors coordinates the metabolic reprogramming essential for T cell differentiation
- (2013) Linda V Sinclair et al. NATURE IMMUNOLOGY
- Acidosis Activation of the Proton-Sensing GPR4 Receptor Stimulates Vascular Endothelial Cell Inflammatory Responses Revealed by Transcriptome Analysis
- (2013) Lixue Dong et al. PLoS One
- M2 macrophage polarisation is associated with alveolar formation during postnatal lung development
- (2013) Christina V Jones et al. RESPIRATORY RESEARCH
- Fueling Immunity: Insights into Metabolism and Lymphocyte Function
- (2013) E. L. Pearce et al. SCIENCE
- Nutrient transporters: the Achilles’ heel of anabolism
- (2013) Alison N. McCracken et al. TRENDS IN ENDOCRINOLOGY AND METABOLISM
- Acidic tumor microenvironment and pH-sensing G protein-coupled receptors
- (2013) Calvin R. Justus et al. Frontiers in Physiology
- Metabolic changes in cancer: beyond the Warburg effect
- (2012) W. Wu et al. ACTA BIOCHIMICA ET BIOPHYSICA SINICA
- Accessories to the Crime: Functions of Cells Recruited to the Tumor Microenvironment
- (2012) Douglas Hanahan et al. CANCER CELL
- Modulation of Microenvironment Acidity Reverses Anergy in Human and Murine Tumor-Infiltrating T Lymphocytes
- (2012) A. Calcinotto et al. CANCER RESEARCH
- Reciprocal Metabolic Reprogramming through Lactate Shuttle Coordinately Influences Tumor-Stroma Interplay
- (2012) T. Fiaschi et al. CANCER RESEARCH
- BRCA1 mutations drive oxidative stress and glycolysis in the tumor microenvironment
- (2012) Ubaldo E. Martinez-Outschoorn et al. CELL CYCLE
- Metabolic reprogramming of cancer-associated fibroblasts by TGF-β drives tumor growth: Connecting TGF-β signaling with “Warburg-like” cancer metabolism and L-lactate production
- (2012) Carmela Guido et al. CELL CYCLE
- Proton Pump Inhibitors Reduce the Risk of Neoplastic Progression in Patients With Barrett's Esophagus
- (2012) Florine Kastelein et al. Clinical Gastroenterology and Hepatology
- Adipocyte-released insulin-like growth factor-1 is regulated by glucose and fatty acids and controls breast cancer cell growth in vitro
- (2012) V. D’Esposito et al. DIABETOLOGIA
- Mature breast adipocytes promote breast cancer cell motility
- (2012) Jennifer C. Carter et al. EXPERIMENTAL AND MOLECULAR PATHOLOGY
- Lipid metabolism in cancer
- (2012) Claudio R. Santos et al. FEBS Journal
- Radiosensitization by 2-deoxy-D-glucose and 6-aminonicotinamide involves activation of redox sensitive ASK1-JNK/p38MAPK signaling in head and neck cancer cells
- (2012) Pradeep Kumar Sharma et al. FREE RADICAL BIOLOGY AND MEDICINE
- Network Analysis Reveals Centrally Connected Genes and Pathways Involved in CD8+ T Cell Exhaustion versus Memory
- (2012) Travis A. Doering et al. IMMUNITY
- mTOR, metabolism, and the regulation of T-cell differentiation and function
- (2012) Adam T. Waickman et al. IMMUNOLOGICAL REVIEWS
- Molecular mechanisms of metabolic reprogramming in proliferating cells: implications for T-cell-mediated immunity
- (2012) Federica M. Marelli-Berg et al. IMMUNOLOGY
- From tumor cell metabolism to tumor immune escape
- (2012) Martin Villalba et al. INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
- Mode of Cell Death Induction by Pharmacological Vacuolar H+-ATPase (V-ATPase) Inhibition
- (2012) Karin von Schwarzenberg et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Semaphorin 3A overcomes cancer hypoxia and metastatic dissemination induced by antiangiogenic treatment in mice
- (2012) Federica Maione et al. JOURNAL OF CLINICAL INVESTIGATION
- Systemic Buffers Inhibit Carcinogenesis in TRAMP Mice
- (2012) Arig Ibrahim-Hashim et al. JOURNAL OF UROLOGY
- Metabolic symbiosis in cancer: Refocusing the Warburg lens
- (2012) Erica C. Nakajima et al. MOLECULAR CARCINOGENESIS
- Hypoxia-inducible factor-1 alpha-dependent induction of FoxP3 drives regulatory T-cell abundance and function during inflammatory hypoxia of the mucosa
- (2012) E. T. Clambey et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Tumor metabolism as modulator of immune response and tumor progression
- (2012) Eva Gottfried et al. SEMINARS IN CANCER BIOLOGY
- What are regulatory T cells (Treg) regulating in cancer and why?
- (2012) Theresa L. Whiteside SEMINARS IN CANCER BIOLOGY
- Indoleamine 2,3 dioxygenase and metabolic control of immune responses
- (2012) David H. Munn et al. TRENDS IN IMMUNOLOGY
- Metformin elicits anticancer effects through the sequential modulation of DICER and c-MYC
- (2012) Giovanni Blandino et al. Nature Communications
- Warburg Meets Autophagy: Cancer-Associated Fibroblasts Accelerate Tumor Growth and Metastasis via Oxidative Stress, Mitophagy, and Aerobic Glycolysis
- (2011) Stephanos Pavlides et al. ANTIOXIDANTS & REDOX SIGNALING
- Targeting Tumor Hypoxia: Suppression of Breast Tumor Growth and Metastasis by Novel Carbonic Anhydrase IX Inhibitors
- (2011) Y. Lou et al. CANCER RESEARCH
- Metformin, Independent of AMPK, Induces mTOR Inhibition and Cell-Cycle Arrest through REDD1
- (2011) I. Ben Sahra et al. CANCER RESEARCH
- Hypoxia Induces Escape from Innate Immunity in Cancer Cells via Increased Expression of ADAM10: Role of Nitric Oxide
- (2011) I. B. Barsoum et al. CANCER RESEARCH
- Control of TH17/Treg Balance by Hypoxia-Inducible Factor 1
- (2011) Eric V. Dang et al. CELL
- Hallmarks of Cancer: The Next Generation
- (2011) Douglas Hanahan et al. CELL
- The reverse Warburg effect: Aerobic glycolysis in cancer associated fibroblasts and the tumor stroma
- (2011) Stephanos Pavlides et al. CELL CYCLE
- Evidence for a stromal-epithelial “lactate shuttle” in human tumors
- (2011) Diana Whitaker-Menezes et al. CELL CYCLE
- Reduction of metastasis using a non-volatile buffer
- (2011) Arig Ibrahim Hashim et al. CLINICAL & EXPERIMENTAL METASTASIS
- Indoleamine 2,3-Dioxygenase Expression in Human Cancers: Clinical and Immunologic Perspectives
- (2011) J. Godin-Ethier et al. CLINICAL CANCER RESEARCH
- Modulation of human T-cell functions by reactive nitrogen species
- (2011) Tihana Kasic et al. EUROPEAN JOURNAL OF IMMUNOLOGY
- Coexpression of hypoxia-inducible factor-1α and glucose transporter-1 is associated with poor prognosis in oral squamous cell carcinoma patients
- (2011) Alexander W Eckert et al. HISTOPATHOLOGY
- Regulatory role of p53 in cancer metabolism via SCO2 and TIGAR in human breast cancer
- (2011) Kyu Yeoun Won et al. HUMAN PATHOLOGY
- The Transcription Factor Myc Controls Metabolic Reprogramming upon T Lymphocyte Activation
- (2011) Ruoning Wang et al. IMMUNITY
- Mitochondrial Respiratory Capacity Is a Critical Regulator of CD8+ T Cell Memory Development
- (2011) Gerritje J.W. van der Windt et al. IMMUNITY
- HIF1α–dependent glycolytic pathway orchestrates a metabolic checkpoint for the differentiation of TH17 and Tregcells
- (2011) Lewis Z. Shi et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Chemokine nitration prevents intratumoral infiltration of antigen-specific T cells
- (2011) Barbara Molon et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Cutting Edge: Distinct Glycolytic and Lipid Oxidative Metabolic Programs Are Essential for Effector and Regulatory CD4+ T Cell Subsets
- (2011) R. D. Michalek et al. JOURNAL OF IMMUNOLOGY
- Cyclin-dependent kinases 4 and 6 control tumor progression and direct glucose oxidation in the pentose cycle
- (2011) Miriam Zanuy et al. Metabolomics
- Imatinib potentiates antitumor T cell responses in gastrointestinal stromal tumor through the inhibition of Ido
- (2011) Vinod P Balachandran et al. NATURE MEDICINE
- Adipocytes promote ovarian cancer metastasis and provide energy for rapid tumor growth
- (2011) Kristin M Nieman et al. NATURE MEDICINE
- Principles and mechanisms of vessel normalization for cancer and other angiogenic diseases
- (2011) Peter Carmeliet et al. NATURE REVIEWS DRUG DISCOVERY
- Organ engineering based on decellularized matrix scaffolds
- (2011) Jeremy J. Song et al. TRENDS IN MOLECULAR MEDICINE
- Cell metabolism: An essential link between cell growth and apoptosis
- (2010) Emily F. Mason et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
- Selective inhibition of IDO1 effectively regulates mediators of antitumor immunity
- (2010) X. Liu et al. BLOOD
- Quality of life in patients with advanced renal cell carcinoma treated with temsirolimus or interferon-α
- (2010) S Yang et al. BRITISH JOURNAL OF CANCER
- The unique characteristics of tumor vasculature and preclinical evidence for its selective disruption by Tumor-Vascular Disrupting Agents
- (2010) Dietmar W. Siemann CANCER TREATMENT REVIEWS
- Oxidative stress in cancer associated fibroblasts drives tumor-stroma co-evolution
- (2010) Ubaldo E. Martinez-Outschoorn et al. CELL CYCLE
- mTOR signalling and metabolic regulation of T cell differentiation
- (2010) Christian Peter et al. CURRENT OPINION IN IMMUNOLOGY
- Hallmarks of cancer: Interactions with the tumor stroma
- (2010) Kristian Pietras et al. EXPERIMENTAL CELL RESEARCH
- Constitutively Active Lck Kinase in T Cells Drives Antigen Receptor Signal Transduction
- (2010) Konstantina Nika et al. IMMUNITY
- The Mammalian Target of Rapamycin: Linking T Cell Differentiation, Function, and Metabolism
- (2010) Jonathan D. Powell et al. IMMUNITY
- Alternative Activation of Macrophages: Mechanism and Functions
- (2010) Siamon Gordon et al. IMMUNITY
- The mTOR Kinase Determines Effector versus Memory CD8 + T Cell Fate by Regulating the Expression of Transcription Factors T-bet and Eomesodermin
- (2010) Rajesh R. Rao et al. IMMUNITY
- Prognostic significance of regulatory T cells in tumor
- (2010) Cailin Moira Wilke et al. INTERNATIONAL JOURNAL OF CANCER
- Tumour hypoxia induces a metabolic shift causing acidosis: a common feature in cancer
- (2010) Johanna Chiche et al. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
- Extracellular NAD+shapes the Foxp3+regulatory T cell compartment through the ART2–P2X7 pathway
- (2010) Sandra Hubert et al. JOURNAL OF EXPERIMENTAL MEDICINE
- HIF-1α regulates function and differentiation of myeloid-derived suppressor cells in the tumor microenvironment
- (2010) Cesar A. Corzo et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Glutamine Uptake and Metabolism Are Coordinately Regulated by ERK/MAPK during T Lymphocyte Activation
- (2010) E. L. Carr et al. JOURNAL OF IMMUNOLOGY
- New insights into the physiological role of carbonic anhydrase IX in tumour pH regulation
- (2010) P Swietach et al. ONCOGENE
- Induction of Glucose Metabolism in Stimulated T Lymphocytes Is Regulated by Mitogen-Activated Protein Kinase Signaling
- (2010) Aimee J. Marko et al. PLoS One
- Stability of the Regulatory T Cell Lineage in Vivo
- (2010) Y. P. Rubtsov et al. SCIENCE
- Autophagy and Metabolism
- (2010) J. D. Rabinowitz et al. SCIENCE
- Phosphorylation of ULK1 (hATG1) by AMP-Activated Protein Kinase Connects Energy Sensing to Mitophagy
- (2010) D. F. Egan et al. SCIENCE
- The Role of Regulatory T Cells in Cancer
- (2010) Tai-You Ha Immune Network
- Tumor antigen-specific CD8 T cells infiltrating the tumor express high levels of PD-1 and are functionally impaired
- (2009) M. Ahmadzadeh et al. BLOOD
- Why are tumour blood vessels abnormal and why is it important to know?
- (2009) J A Nagy et al. BRITISH JOURNAL OF CANCER
- Myeloid-Derived Suppressor Cells Inhibit T-Cell Activation by Depleting Cystine and Cysteine
- (2009) M. K. Srivastava et al. CANCER RESEARCH
- Targeting glucose metabolism with 2-deoxy-D-glucose for improving cancer therapy
- (2009) BS Dwarakanath et al. Future Oncology
- The Sodium-Hydrogen Exchanger NHE1 Is an Akt Substrate Necessary for Actin Filament Reorganization by Growth Factors
- (2009) Marcel E. Meima et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Clinical studies for improving radiotherapy with 2-deoxy-D-glucose: Present status and future prospects
- (2009) BS Dwarakanath et al. Journal of Cancer Research and Therapeutics
- Cytotoxicity,radiosensitization, and chemosensitization of tumor cells by 2-deoxy-D-glucoseIn vitro
- (2009) BS Dwarakanath Journal of Cancer Research and Therapeutics
- Anergic T Cells Are Metabolically Anergic
- (2009) Y. Zheng et al. JOURNAL OF IMMUNOLOGY
- Enhancing CD8 T-cell memory by modulating fatty acid metabolism
- (2009) Erika L. Pearce et al. NATURE
- A human colonic commensal promotes colon tumorigenesis via activation of T helper type 17 T cell responses
- (2009) Shaoguang Wu et al. NATURE MEDICINE
- PD-1+ memory phenotype CD4+ T cells expressing C/EBP underlie T cell immunodepression in senescence and leukemia
- (2009) K. Shimatani et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Acriflavine inhibits HIF-1 dimerization, tumor growth, and vascularization
- (2009) K. Lee et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Glycolytic metabolism and tumour response to fractionated irradiation
- (2009) Ulrike G.A. Sattler et al. RADIOTHERAPY AND ONCOLOGY
- Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation
- (2009) M. G. Vander Heiden et al. SCIENCE
- Development of small molecule carbonic anhydrase IX inhibitors
- (2008) Claudiu T. Supuran BJU INTERNATIONAL
- Augmented serum level of major histocompatibility complex class I-related chain A (MICA) protein and reduced NKG2D expression on NK and T cells in patients with cervical cancer and precursor lesions
- (2008) Naela A Arreygue-Garcia et al. BMC CANCER
- The Biology of Cancer: Metabolic Reprogramming Fuels Cell Growth and Proliferation
- (2008) Ralph J. DeBerardinis et al. Cell Metabolism
- Roles of p53, Myc and HIF-1 in Regulating Glycolysis — the Seventh Hallmark of Cancer
- (2008) S. J. Yeung et al. CELLULAR AND MOLECULAR LIFE SCIENCES
- Protein Kinase B/Akt Phosphorylates and Inhibits the Cardiac Na +/ H + Exchanger NHE1
- (2008) Andrew K. Snabaitis et al. CIRCULATION RESEARCH
- The tumor microenvironment and metastatic disease
- (2008) Sarah Jane Lunt et al. CLINICAL & EXPERIMENTAL METASTASIS
- Hypoxia controls CD4+CD25+ regulatory T-cell homeostasis via hypoxia-inducible factor-1α
- (2008) Jeremy Ben-Shoshan et al. EUROPEAN JOURNAL OF IMMUNOLOGY
- Glucose deprivation inhibits multiple key gene expression events and effector functions in CD8+ T cells
- (2008) Candace M. Cham et al. EUROPEAN JOURNAL OF IMMUNOLOGY
- Mitochondrial Autophagy Is an HIF-1-dependent Adaptive Metabolic Response to Hypoxia
- (2008) Huafeng Zhang et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Targeting lactate-fueled respiration selectively kills hypoxic tumor cells in mice
- (2008) Pierre Sonveaux et al. JOURNAL OF CLINICAL INVESTIGATION
- Efficacy of everolimus in advanced renal cell carcinoma: a double-blind, randomised, placebo-controlled phase III trial
- (2008) Robert J Motzer et al. LANCET
- Deletion of vascular endothelial growth factor in myeloid cells accelerates tumorigenesis
- (2008) Christian Stockmann et al. NATURE
- Triggering the succinate receptor GPR91 on dendritic cells enhances immunity
- (2008) Tina Rubic et al. NATURE IMMUNOLOGY
- Cancer as an overhealing wound: an old hypothesis revisited
- (2008) Matthias Schäfer et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- The proton pump inhibitor inhibits cell growth and induces apoptosis in human hepatoblastoma
- (2008) Toshiya Morimura et al. PEDIATRIC SURGERY INTERNATIONAL
- Digoxin and other cardiac glycosides inhibit HIF-1 synthesis and block tumor growth
- (2008) H. Zhang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Regulation of cancer cell metabolism by hypoxia-inducible factor 1
- (2008) Gregg L. Semenza SEMINARS IN CANCER BIOLOGY
- The Genomic Analysis of Lactic Acidosis and Acidosis Response in Human Cancers
- (2008) Julia Ling-Yu Chen et al. PLoS Genetics
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