期刊
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
卷 23, 期 5, 页码 3603-3615出版社
WILEY
DOI: 10.1111/jcmm.14261
关键词
CRC; EMT; PMEPA1; TGF beta
资金
- National Science Foundation for Young Scientists of China [81602073]
- Science and Technology Planning Project of Zhejiang province, China [2016C33065]
- Medical and health science and technology project of Zhejiang province, China [201614296]
- National Natural Science Foundation of China [81572716, 8167110538]
Prostate transmembrane protein androgen induced 1 (PMEPA1) has been reported to promote cancer progression. Metastasis is the main factor leading to cancer progression and poor prognosis, and at the beginning of metastasis, epithelial-to-mesenchymal transition (EMT) is a crucial activation. However, the relationship between PMEPA1 and EMT in colorectal cancer metastasis is still poorly understood. In this study, we first testified that PMEPA1 expresses higher in tumour than normal tissue in Gene Expression Omnibus database, in the Cancer Genome Atlas (TCGA) as well as in the clinical data we collected. Moreover, the higher expression was associated with poor prognosis. We furthermore demonstrated PMEPA1 promotes colorectal cancer metastasis and EMT in vivo and in vitro. We found that PMEPA1 activates the bone morphogenetic proteins (BMP) signalling of TGF-beta signalling resulting in promoting EMT and accelerating the proliferation and metastasis of colorectal cancer.
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