TGFβ drives NK cell metabolic dysfunction in human metastatic breast cancer

Recent progress in and challenges in cellular therapy using NK cells for hematological malignancies

(2020) Junji Tanaka et al.   BLOOD REVIEWS

NK cell metabolism

(2019) Clair M. Gardiner   JOURNAL OF LEUKOCYTE BIOLOGY

Novel Transforming Growth Factor Beta Receptor I Kinase Inhibitor Galunisertib ( LY 2157299) in Advanced Hepatocellular Carcinoma

(2019) Sandrine Faivre et al.   LIVER INTERNATIONAL

Tumor-Derived Extracellular Vesicles Inhibit Natural Killer Cell Function in Pancreatic Cancer

(2019) Jiangang Zhao et al.   Cancers

Tumor-derived TGF-β inhibits mitochondrial respiration to suppress IFN-γ production by human CD4+ T cells

(2019) Sarah Dimeloe et al.   Science Signaling

Mitochondrial fragmentation limits NK cell-based tumor immunosurveillance

(2019) Xiaohu Zheng et al.   NATURE IMMUNOLOGY

Natural Killer Cells in Myeloid Malignancies: Immune Surveillance, NK Cell Dysfunction, and Pharmacological Opportunities to Bolster the Endogenous NK Cells

(2019) Mattias Carlsten et al.   Frontiers in Immunology

IL-10+ NK and TGF-β+ NK cells play negative regulatory roles in HIV infection

(2018) Yongjun Jiang et al.   BMC INFECTIOUS DISEASES

Human iPSC-Derived Natural Killer Cells Engineered with Chimeric Antigen Receptors Enhance Anti-tumor Activity

(2018) Ye Li et al.   Cell Stem Cell

Canonical TGF-β Signaling Pathway Represses Human NK Cell Metabolism

(2018) Vanessa Zaiatz-Bittencourt et al.   JOURNAL OF IMMUNOLOGY

Amino acid-dependent cMyc expression is essential for NK cell metabolic and functional responses in mice

(2018) Róisín M. Loftus et al.   Nature Communications

Tumor-Associated Macrophages Derived TGF-β‒Induced Epithelial to Mesenchymal Transition in Colorectal Cancer Cells through Smad2,3-4/Snail Signaling Pathway

(2018) Jianhui Cai et al.   Cancer Research and Treatment

Education-dependent activation of glycolysis promotes the cytolytic potency of licensed human natural killer cells

(2018) Jolie R. Schafer et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Galunisertib plus gemcitabine vs. gemcitabine for first-line treatment of patients with unresectable pancreatic cancer

(2018) Davide Melisi et al.   BRITISH JOURNAL OF CANCER

Natural Killer Cell Dysfunction in Hepatocellular Carcinoma: Pathogenesis and Clinical Implications

(2018) Pil Soo Sung et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Structural basis of latent TGF-β1 presentation and activation by GARP on human regulatory T cells

(2018) Stéphanie Liénart et al.   SCIENCE

Surface Expression of TGFβ Docking Receptor GARP Promotes Oncogenesis and Immune Tolerance in Breast Cancer

(2016) Alessandra Metelli et al.   CANCER RESEARCH

The Tumor Microenvironment Represses T Cell Mitochondrial Biogenesis to Drive Intratumoral T Cell Metabolic Insufficiency and Dysfunction

(2016) Nicole E. Scharping et al.   IMMUNITY

Bioenergetic Insufficiencies Due to Metabolic Alterations Regulated by the Inhibitory Receptor PD-1 Are an Early Driver of CD8 + T Cell Exhaustion

(2016) Bertram Bengsch et al.   IMMUNITY

Metabolic Reprogramming Supports IFN-γ Production by CD56brightNK Cells

(2016) Sinéad E. Keating et al.   JOURNAL OF IMMUNOLOGY

TGF-β inhibits the activation and functions of NK cells by repressing the mTOR pathway

(2016) Sébastien Viel et al.   Science Signaling

Distinct Metabolic Requirements of Exhausted and Functional Virus-Specific CD8 T Cells in the Same Host

(2016) Anna Schurich et al.   Cell Reports

TGF-β inhibits the activation and functions of NK cells by repressing the mTOR pathway

(2016) Sébastien Viel et al.   Science Signaling

Peripheral blood NK cells expressing HLA-G, IL-10 and TGF-β in healthy donors and breast cancer patients

(2015) Yekaterina O. Ostapchuk et al.   CELLULAR IMMUNOLOGY

Activation-Specific Metabolic Requirements for NK Cell IFN-γ Production

(2015) Molly P. Keppel et al.   JOURNAL OF IMMUNOLOGY

Monoclonal antibodies against GARP/TGF-β1 complexes inhibit the immunosuppressive activity of human regulatory T cells in vivo

(2015) Julia Cuende et al.   Science Translational Medicine

First-in-Human Dose Study of the Novel Transforming Growth Factor-β Receptor I Kinase Inhibitor LY2157299 Monohydrate in Patients with Advanced Cancer and Glioma

(2014) Jordi Rodon et al.   CLINICAL CANCER RESEARCH

Serum transforming growth factor-beta 1 (TGF-β1) levels have diagnostic, predictive, and possible prognostic roles in patients with melanoma

(2014) Faruk Tas et al.   TUMOR BIOLOGY

Fiji: an open-source platform for biological-image analysis

(2012) Johannes Schindelin et al.   NATURE METHODS

Blast-derived microvesicles in sera from patients with acute myeloid leukemia suppress natural killer cell function via membrane-associated transforming growth factor- 1

(2011) M. J. Szczepanski et al.   HAEMATOLOGICA

Human breast cancer cells enhance self tolerance by promoting evasion from NK cell antitumor immunity

(2011) Emilie Mamessier et al.   JOURNAL OF CLINICAL INVESTIGATION

TGF-β and immune cells: an important regulatory axis in the tumor microenvironment and progression

(2010) Li Yang et al.   TRENDS IN IMMUNOLOGY

GARP (LRRC32) is essential for the surface expression of latent TGF-  on platelets and activated FOXP3+ regulatory T cells

(2009) D. Q. Tran et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA