期刊
TUMOR BIOLOGY
卷 37, 期 7, 页码 8503-8514出版社
SAGE PUBLICATIONS LTD
DOI: 10.1007/s13277-016-5049-3
关键词
Tumour microenvironment; Cancer associated fibroblast; Metabolism; Glycolysis
类别
资金
- Department of Science and Technology, Govt. of India [SB/YS/LS-248/2013]
- Department of Biotechnology, Govt. of India [6242-P5/RGCB/PMD/DBT/SMNB/2015]
Cancers have long being hallmarked as cells relying heavily on their glycolysis for energy generation in spite of having functional mitochondria. The metabolic status of the cancer cells have been revisited time and again to get better insight into the overall carcinogenesis process which revealed the apparent crosstalks between the cancer cells with the fibroblasts present in the tumour microenvironment. This review focuses on the mechanisms of transformations of normal fibroblasts to cancer-associated fibroblasts (CAF), the participation of the CAF in tumour progression with special interest to the role of CAF cellular glycolysis in the overall tumorigenesis. The fibroblasts, when undergoes the transformation process, distinctly switches to a more glycolytic phenotype in order to provide the metabolic intermediates necessary for carrying out the mitochondrial pathways of ATP generation in cancer cells. This review will also discuss the molecular mechanisms responsible for this metabolic make over promoting glycolysis in CAF cells. A thorough investigation of the pathways and molecules involved will not only help in understanding the process of activation and metabolic reprogramming in CAF cells but also might open up new targets for cancer therapy.
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