Reprogramming of glucose, fatty acid and amino acid metabolism for cancer progression

Targeting Mitochondrial Citrate Transport in Breast Cancer Cell Lines

(2015) Ali Ozkaya et al.   Anti-Cancer Agents in Medicinal Chemistry

Secreted pyruvate kinase M2 facilitates cell migration via PI3K/Akt and Wnt/β-catenin pathway in colon cancer cells

(2015) Peng Yang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Pyruvate kinase M2 affects liver cancer cell behavior through up-regulation of HIF-1α and Bcl-xL in culture

(2015) Tianfu Dong et al.   BIOMEDICINE & PHARMACOTHERAPY

miR-22 as a prognostic factor targets glucose transporter protein type 1 in breast cancer

(2015) Bo Chen et al.   CANCER LETTERS

Pyruvate Kinase M2 Regulates Hif-1α Activity and IL-1β Induction and Is a Critical Determinant of the Warburg Effect in LPS-Activated Macrophages

(2015) Eva M. Palsson-McDermott et al.   Cell Metabolism

cMyc-mediated activation of serine biosynthesis pathway is critical for cancer progression under nutrient deprivation conditions

(2015) Linchong Sun et al.   CELL RESEARCH

Dysregulated glycolysis as an oncogenic event

(2015) Takumi Mikawa et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Targeting Glutamine Metabolism in Breast Cancer with Aminooxyacetate

(2015) P. Korangath et al.   CLINICAL CANCER RESEARCH

Sirtuins and the Metabolic Hurdles in Cancer

(2015) Natalie J. German et al.   CURRENT BIOLOGY

A nexus for cellular homeostasis: the interplay between metabolic and signal transduction pathways

(2015) Ana P Gomes et al.   CURRENT OPINION IN BIOTECHNOLOGY

Arginine deprivation in cancer therapy

(2015) Lynn G. Feun et al.   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

Proline metabolism and cancer

(2015) James M. Phang et al.   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

Aerobic glycolysis tunes YAP/TAZ transcriptional activity

(2015) E. Enzo et al.   EMBO JOURNAL

Alpha-enolase promotes cell glycolysis, growth, migration, and invasion in non-small cell lung cancer through FAK-mediated PI3K/AKT pathway

(2015) Qiao-Fen Fu et al.   Journal of Hematology & Oncology

Thyroid-stimulating hormone decreases HMG-CoA reductase phosphorylation via AMP-activated protein kinase in the liver

(2015) Xiujuan Zhang et al.   JOURNAL OF LIPID RESEARCH

Targeting ASCT2-mediated glutamine uptake blocks prostate cancer growth and tumour development

(2015) Qian Wang et al.   JOURNAL OF PATHOLOGY

RETRACTED ARTICLE: Decreased Warburg effect induced by ATP citrate lyase suppression inhibits tumor growth in pancreatic cancer

(2015) Haifeng Zong et al.   MEDICAL ONCOLOGY

Metabolic pathways promoting cancer cell survival and growth

(2015) Lindsey K. Boroughs et al.   NATURE CELL BIOLOGY

Targeting mitochondria metabolism for cancer therapy

(2015) Samuel E Weinberg et al.   Nature Chemical Biology

Glycolytic flux controls d-serine synthesis through glyceraldehyde-3-phosphate dehydrogenase in astrocytes

(2015) Masataka Suzuki et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

SREBP1 regulates tumorigenesis and prognosis of pancreatic cancer through targeting lipid metabolism

(2015) Yan Sun et al.   TUMOR BIOLOGY

Long-chain acyl-CoA synthetase in fatty acid metabolism involved in liver and other diseases: An update

(2015) Sheng Yan   WORLD JOURNAL OF GASTROENTEROLOGY

Pyruvate kinase M2 prevents apoptosis via modulating Bim stability and associates with poor outcome in hepatocellular carcinoma

(2015) Wen Hu et al.   Oncotarget

Targeted cellular metabolism for cancer chemotherapy with recombinant arginine-degrading enzymes

(2015)   Oncotarget

The mitochondrial citrate transporter, CIC, is essential for mitochondrial homeostasis.

(2015) Olga Catalina-Rodriguez et al.   Oncotarget

Frequent amplification of ORAOV1 gene in esophageal squamous cell cancer promotes an aggressive phenotype via proline metabolism and ROS production

(2015) Yosuke Togashi et al.   Oncotarget

Tumor suppressor p53 negatively regulates glycolysis stimulated by hypoxia through its target RRAD

(2015) Cen Zhang et al.   Oncotarget

Hypoxia and cancer cell metabolism

(2014) D. Huang et al.   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

2-Deoxy-D-glucose targeting of glucose metabolism in cancer cells as a potential therapy

(2014) Dongsheng Zhang et al.   CANCER LETTERS

Oxidative Stress Activates SIRT2 to Deacetylate and Stimulate Phosphoglycerate Mutase

(2014) Y. Xu et al.   CANCER RESEARCH

Long non-coding RNA UCA1 promotes glycolysis by upregulating hexokinase 2 through the mTOR-STAT3/microRNA143 pathway

(2014) Zhengkun Li et al.   CANCER SCIENCE

Acetate Is a Bioenergetic Substrate for Human Glioblastoma and Brain Metastases

(2014) Tomoyuki Mashimo et al.   CELL

Acetate Dependence of Tumors

(2014) Sarah A. Comerford et al.   CELL

Acetate Fuels the Cancer Engine

(2014) Costas A. Lyssiotis et al.   CELL

Hypoxic Regulation of Glutamine Metabolism through HIF1 and SIAH2 Supports Lipid Synthesis that Is Necessary for Tumor Growth

(2014) Ramon C. Sun et al.   Cell Metabolism

Hexokinase 2 regulates G1/S checkpoint through CDK2 in cancer-associated fibroblasts

(2014) Jun-wei Hu et al.   CELLULAR SIGNALLING

Pyruvate kinase M2 facilitates colon cancer cell migration via the modulation of STAT3 signalling

(2014) Peng Yang et al.   CELLULAR SIGNALLING

Phosphofructokinase: A mediator of glycolytic flux in cancer progression

(2014) Nada Al Hasawi et al.   CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY

Interplay between sirtuins, MYC and hypoxia-inducible factor in cancer-associated metabolic reprogramming

(2014) B. M. M. Zwaans et al.   Disease Models & Mechanisms

ATP-citrate lyase regulates cellular senescence via an AMPK- and p53-dependent pathway

(2014) Jong-Hyuk Lee et al.   FEBS Journal

Deacetylation of phosphoglycerate mutase in its distinct central region by SIRT2 down-regulates its enzymatic activity

(2014) Takeshi Tsusaka et al.   GENES TO CELLS

Senescence-inducing stress promotes proteolysis of phosphoglycerate mutase via ubiquitin ligase Mdm2

(2014) Takumi Mikawa et al.   JOURNAL OF CELL BIOLOGY

Repositioning Proton Pump Inhibitors as Anticancer Drugs by Targeting the Thioesterase Domain of Human Fatty Acid Synthase

(2014) Valerie E. Fako et al.   JOURNAL OF MEDICINAL CHEMISTRY

Recent Advances in the Development of Acetyl-CoA Carboxylase (ACC) Inhibitors for the Treatment of Metabolic Disease

(2014) Matthew P. Bourbeau et al.   JOURNAL OF MEDICINAL CHEMISTRY

PTEN regulates plasma membrane expression of glucose transporter 1 and glucose uptake in thyroid cancer cells

(2014) Federica Morani et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

Aldolase positively regulates of the canonical Wnt signaling pathway

(2014) Michal Caspi et al.   Molecular Cancer

Glutamine Oxidation Maintains the TCA Cycle and Cell Survival during Impaired Mitochondrial Pyruvate Transport

(2014) Chendong Yang et al.   MOLECULAR CELL

Fructose-Bisphosphate Aldolase A Is a Potential Metastasis-Associated Marker of Lung Squamous Cell Carcinoma and Promotes Lung Cell Tumorigenesis and Migration

(2014) Sha Du et al.   PLoS One

A long noncoding RNA connects c-Myc to tumor metabolism

(2014) Chiu-Lien Hung et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Loss of the tumor suppressor LKB1 promotes metabolic reprogramming of cancer cells via HIF-1 

(2014) B. Faubert et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Serine and glycine metabolism in cancer

(2014) Ivano Amelio et al.   TRENDS IN BIOCHEMICAL SCIENCES

The pentose phosphate pathway and cancer

(2014) Krushna C. Patra et al.   TRENDS IN BIOCHEMICAL SCIENCES

Role of abnormal lipid metabolism in development, progression, diagnosis and therapy of pancreatic cancer

(2014) Julian Swierczynski   WORLD JOURNAL OF GASTROENTEROLOGY

Lin28/let-7 axis regulates aerobic glycolysis and cancer progression via PDK1

(2014) Xiaoyu Ma et al.   Nature Communications

Hexokinase 2-Mediated Warburg Effect Is Required for PTEN- and p53-Deficiency-Driven Prostate Cancer Growth

(2014) Lei Wang et al.   Cell Reports

HIF-1-Mediated Suppression of Acyl-CoA Dehydrogenases and Fatty Acid Oxidation Is Critical for Cancer Progression

(2014) De Huang et al.   Cell Reports

Serine, but Not Glycine, Supports One-Carbon Metabolism and Proliferation of Cancer Cells

(2014) Christiaan F. Labuschagne et al.   Cell Reports

Regulation of the pentose phosphate pathway in cancer

(2014) Peng Jiang et al.   Protein & Cell

p53 regulates glucose metabolism by miR-34a

(2013) Hwa-Ryeon Kim et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Hexokinase 2 Is Required for Tumor Initiation and Maintenance and Its Systemic Deletion Is Therapeutic in Mouse Models of Cancer

(2013) Krushna C. Patra et al.   CANCER CELL

PKM2 Isoform-Specific Deletion Reveals a Differential Requirement for Pyruvate Kinase in Tumor Cells

(2013) William J. Israelsen et al.   CELL

Serine Metabolism: Some Tumors Take the Road Less Traveled

(2013) Ralph J. DeBerardinis   Cell Metabolism

Cellular Fatty Acid Metabolism and Cancer

(2013) Erin Currie et al.   Cell Metabolism

Molecular Pathways: Reactive Oxygen Species Homeostasis in Cancer Cells and Implications for Cancer Therapy

(2013) V. Nogueira et al.   CLINICAL CANCER RESEARCH

Glutaminase Isoenzymes as Key Regulators in Metabolic and Oxidative Stress Against Cancer

(2013) J.M. Mates et al.   CURRENT MOLECULAR MEDICINE

Fatty acid synthase plays a role in cancer metabolism beyond providing fatty acids for phospholipid synthesis or sustaining elevations in glycolytic activity

(2013) Kathryn E. Hopperton et al.   EXPERIMENTAL CELL RESEARCH

PTEN antagonises Tcl1/hnRNPK-mediated G6PD pre-mRNA splicing which contributes to hepatocarcinogenesis

(2013) Xuehui Hong et al.   GUT

The role of phosphoglycerate mutase 1 in tumor aerobic glycolysis and its potential therapeutic implications

(2013) Xiangli Jiang et al.   INTERNATIONAL JOURNAL OF CANCER

Glyceraldehyde-3-phosphate Dehydrogenase Is Activated by Lysine 254 Acetylation in Response to Glucose Signal

(2013) Tingting Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ATP Citrate Lyase Mediates Resistance of Colorectal Cancer Cells to SN38

(2013) Y. Zhou et al.   MOLECULAR CANCER THERAPEUTICS

Targeting 6-Phosphofructo-2-Kinase (PFKFB3) as a Therapeutic Strategy against Cancer

(2013) B. F. Clem et al.   MOLECULAR CANCER THERAPEUTICS

Acetylation Stabilizes ATP-Citrate Lyase to Promote Lipid Biosynthesis and Tumor Growth

(2013) Ruiting Lin et al.   MOLECULAR CELL

SIRT4 Coordinates the Balance between Lipid Synthesis and Catabolism by Repressing Malonyl CoA Decarboxylase

(2013) Gaëlle Laurent et al.   MOLECULAR CELL

Glutamine supports pancreatic cancer growth through a KRAS-regulated metabolic pathway

(2013) Jaekyoung Son et al.   NATURE

Metabolic targets for cancer therapy

(2013) Lorenzo Galluzzi et al.   NATURE REVIEWS DRUG DISCOVERY

Long Chain Fatty Acyl-CoA Synthetase 4 Is a Biomarker for and Mediator of Hormone Resistance in Human Breast Cancer

(2013) Xinyu Wu et al.   PLoS One

ATP citrate lyase knockdown impacts cancer stem cells in vitro

(2013) J-i Hanai et al.   Cell Death & Disease

Multiple Regulatory Layers of SREBP1/2 by SIRT6

(2013) Sivan Elhanati et al.   Cell Reports

Methyljasmonate displaysin vitroandin vivoactivity against multiple myeloma cells

(2012) Steffen Klippel et al.   BRITISH JOURNAL OF HAEMATOLOGY

Phosphoglycerate Mutase 1 Coordinates Glycolysis and Biosynthesis to Promote Tumor Growth

(2012) Taro Hitosugi et al.   CANCER CELL

An Integrated Genomic Screen Identifies LDHB as an Essential Gene for Triple-Negative Breast Cancer

(2012) M. L. McCleland et al.   CANCER RESEARCH

ATP-Citrate Lyase: A Key Player in Cancer Metabolism

(2012) N. Zaidi et al.   CANCER RESEARCH

Mutant p53 Disrupts Mammary Tissue Architecture via the Mevalonate Pathway

(2012) William A. Freed-Pastor et al.   CELL

Glucose-Independent Glutamine Metabolism via TCA Cycling for Proliferation and Survival in B Cells

(2012) Anne Le et al.   Cell Metabolism

Novel insight into the role of GAPDH playing in tumor

(2012) Chunmei Guo et al.   Clinical & Translational Oncology

SLC1A5 Mediates Glutamine Transport Required for Lung Cancer Cell Growth and Survival

(2012) M. Hassanein et al.   CLINICAL CANCER RESEARCH

MicroRNAs and the Warburg Effect: New Players in an Old Arena

(2012) Ping Gao et al.   CURRENT GENE THERAPY

Links between metabolism and cancer

(2012) C. V. Dang   GENES & DEVELOPMENT

Tumor regression with a combination of drugs interfering with the tumor metabolism: efficacy of hydroxycitrate, lipoic acid and capsaicin

(2012) Laurent Schwartz et al.   INVESTIGATIONAL NEW DRUGS

Targeting of Several Glycolytic Enzymes Using RNA Interference Reveals Aldolase Affects Cancer Cell Proliferation through a Non-glycolytic Mechanism

(2012) Carolyn Ritterson Lew et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Small-Molecule Inhibitor of Glucose Transporter 1 Downregulates Glycolysis, Induces Cell-Cycle Arrest, and Inhibits Cancer Cell Growth In Vitro and In Vivo

(2012) Y. Liu et al.   MOLECULAR CANCER THERAPEUTICS

Metabolic control of adult neural stem cell activity by Fasn-dependent lipogenesis

(2012) Marlen Knobloch et al.   NATURE

Serine is a natural ligand and allosteric activator of pyruvate kinase M2

(2012) Barbara Chaneton et al.   NATURE

Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis

(2012) Dimitrios Anastasiou et al.   Nature Chemical Biology

The many faces of insulin-like peptide signalling in the brain

(2012) Ana M. Fernandez et al.   NATURE REVIEWS NEUROSCIENCE

Metabolism of [U-13C]glucose in human brain tumorsin vivo

(2012) Elizabeth A. Maher et al.   NMR IN BIOMEDICINE

miR-143 regulates hexokinase 2 expression in cancer cells

(2012) A Peschiaroli et al.   ONCOGENE

Pyruvate kinase M2 promotes de novo serine synthesis to sustain mTORC1 activity and cell proliferation

(2012) J. Ye et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Anti-Cancer Drugs Targeting Fatty Acid Synthase (FAS)

(2012) Puspa R. Pandey et al.   Recent Patents on Anti-Cancer Drug Discovery

Phosphofructokinase 1 Glycosylation Regulates Cell Growth and Metabolism

(2012) W. Yi et al.   SCIENCE

Metabolite Profiling Identifies a Key Role for Glycine in Rapid Cancer Cell Proliferation

(2012) M. Jain et al.   SCIENCE

The Proline Regulatory Axis and Cancer

(2012) James Ming Phang et al.   Frontiers in Oncology

Aerobic Glycolysis: Meeting the Metabolic Requirements of Cell Proliferation

(2011) Sophia Y. Lunt et al.   Annual Review of Cell and Developmental Biology

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Regulation of Glycolytic Enzyme Phosphoglycerate Mutase-1 by Sirt1 Protein-mediated Deacetylation

(2011) William C. Hallows et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inhibition of lung cancer growth: ATP citrate lyase knockdown and statin treatment leads to dual blockade of mitogen-activated protein Kinase (MAPK) and Phosphatidylinositol-3-kinase (PI3K)/AKT pathways

(2011) Jun-ichi Hanai et al.   JOURNAL OF CELLULAR PHYSIOLOGY

p53 regulates biosynthesis through direct inactivation of glucose-6-phosphate dehydrogenase

(2011) Peng Jiang et al.   NATURE CELL BIOLOGY

Mammalian target of rapamycin up-regulation of pyruvate kinase isoenzyme type M2 is critical for aerobic glycolysis and tumor growth

(2011) Q. Sun et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inhibition of Pyruvate Kinase M2 by Reactive Oxygen Species Contributes to Cellular Antioxidant Responses

(2011) D. Anastasiou et al.   SCIENCE

Androgen stimulates glycolysis forde novolipid synthesis by increasing the activities of hexokinase 2 and 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2 in prostate cancer cells

(2010) Jong-Seok Moon et al.   BIOCHEMICAL JOURNAL

Targeting Mitochondrial Glutaminase Activity Inhibits Oncogenic Transformation

(2010) Jian-Bin Wang et al.   CANCER CELL

The hexosamine biosynthetic pathway couples growth factor-induced glutamine uptake to glucose metabolism

(2010) K. E. Wellen et al.   GENES & DEVELOPMENT

Silybin and dehydrosilybin decrease glucose uptake by inhibiting GLUT proteins

(2010) Tianzuo Zhan et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Phosphate-activated glutaminase (GLS2), a p53-inducible regulator of glutamine metabolism and reactive oxygen species

(2010) S. Suzuki et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inhibition of lactate dehydrogenase A induces oxidative stress and inhibits tumor progression

(2010) A. Le et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Evidence for an Alternative Glycolytic Pathway in Rapidly Proliferating Cells

(2010) M. G. Vander Heiden et al.   SCIENCE

Rb Regulates DNA Damage Response and Cellular Senescence through E2F-Dependent Suppression of N-Ras Isoprenylation

(2009) Awad Shamma et al.   CANCER CELL

c-Myc suppression of miR-23a/b enhances mitochondrial glutaminase expression and glutamine metabolism

(2009) Ping Gao et al.   NATURE

Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

(2009) M. G. Vander Heiden et al.   SCIENCE

ATP-Citrate Lyase Links Cellular Metabolism to Histone Acetylation

(2009) K. E. Wellen et al.   SCIENCE

SREBP Activity Is Regulated by mTORC1 and Contributes to Akt-Dependent Cell Growth

(2008) Thomas Porstmann et al.   Cell Metabolism

p53 regulates glucose metabolism through an IKK-NF-κB pathway and inhibits cell transformation

(2008) Keiko Kawauchi et al.   NATURE CELL BIOLOGY

Myc regulates a transcriptional program that stimulates mitochondrial glutaminolysis and leads to glutamine addiction

(2008) D. R. Wise et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA