Review
Immunology
Dongming Yan, Weicheng Li, Qibing Liu, Kun Yang
Summary: The tumor immune microenvironment and immunotherapy in IDH-mutant gliomas have been extensively studied. IDH mutations inhibit immune evasion and T-cell responses, making it a potential target for immunotherapy.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Feng-Min Liu, Yu-Fei Gao, Yanyan Kong, Yihui Guan, Jinsen Zhang, Shuai-Hong Li, Dan Ye, Wenyu Wen, Chuantao Zuo, Wei Hua
Summary: The SUVmax on PET can predict IDH1 mutation with high sensitivity and specificity, supported by reduced glucose consumption in IDH1 mutant gliomas, as evidenced by changes in glucose quantity and metabolic enzyme expression levels.
Article
Gastroenterology & Hepatology
Lynda Corrigan, Maeve Lowery
Summary: Cholangiocarcinomas (CCAs) have poor survival outcomes with limited treatment options. Ivosidenib, a selective inhibitor of mutant IDH1, presents a promising treatment option for patients with IDH1 mutant CCA. Future studies may explore the use of this targeted agent in combination with other anticancer treatments to improve survival outcomes in advanced CCA.
EXPERT REVIEW OF GASTROENTEROLOGY & HEPATOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Mengqiu Cao, Xiaoqing Wang, Fang Liu, Ke Xue, Yongming Dai, Yan Zhou
Summary: This study explored the performance of a three-component diffusion model in evaluating the degree of malignancy and IDH-1 gene type of gliomas. The results showed that the three-component DWI model can serve as a useful biomarker for detecting microstructural features in gliomas with different grades and IDH-1 mutation statuses.
EUROPEAN RADIOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Minjae Kim, Kai Tzu-iunn Ong, Seonah Choi, Jinyoung Yeo, Sooyon Kim, Kyunghwa Han, Ji Eun Park, Ho Sung Kim, Yoon Seong Choi, Sung Soo Ahn, Jinna Kim, Seung-Koo Lee, Beomseok Sohn
Summary: The study evaluated the performance of NLP models in predicting IDH mutation status in diffuse glioma, with BERT GCN showing the highest performance in external validation. BERT GCN was found to have superior performance compared to other NLP models and human readers in predicting IDH mutation status.
EUROPEAN RADIOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Felix Neumaier, Boris D. D. Zlatopolskiy, Bernd B. Neumaier
Summary: In this review titled "Prospects and challenges for the application of mutated IDH PET probes in gliomas", the authors summarize the rationale behind the development of mutated IDH PET probes, describe their potential applications beyond IDH status assessment, and highlight potential challenges in tracer development. The authors also compile the major chemical classes of mutated IDH-selective inhibitors that have been described to date, briefly consider possible strategies for radiolabeling of the most promising candidates, and assess the suitability of radiolabeled analogs of mutated IDH inhibitors for PET imaging in gliomas.
Article
Biochemistry & Molecular Biology
Shuai Wang, Jingheng Wu, Wujun Zhao, Miaomiao Li, Shaoyi Li
Summary: CEBPB and P4HA2 are upregulated in IDH1 wt gliomas and associated with poor prognosis. CEBPE promotes proliferation and TMZ resistance by inducing P4HA2 expression in glioma cells.
Article
Radiology, Nuclear Medicine & Medical Imaging
Xiaorui Su, Xibiao Yang, Huaiqiang Sun, Yanhui Liu, Ni Chen, Shuang Li, Zongyao Huang, Hanbing Shao, Simin Zhang, Qiyong Gong, Qiang Yue
Summary: This study aimed to evaluate the value of MRI biomarkers for the identification of IDH mutation and 1p/19q codeletion in adult patients with diffuse glioma. ADC and CBV models were built to determine the status of IDH mutation and 1p/19q codeletion, and the performance of these models was improved by incorporating metabolite concentrations. The results showed that the ADC model performed well in identifying IDH mutation status, while the CBV model outperformed in predicting 1p/19q codeletion.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2023)
Review
Radiology, Nuclear Medicine & Medical Imaging
Ziqin Han, Qiuying Chen, Lu Zhang, Xiaokai Mo, Jingjing You, Luyan Chen, Jin Fang, Fei Wang, Zhe Jin, Shuixing Zhang, Bin Zhang
Summary: This study revealed a radiogenomic correlation between the presence of the T2-FLAIR mismatch sign on MR images and isocitrate dehydrogenase (IDH) mutation status in adult patients with lower-grade gliomas (LGGs). The T2-FLAIR mismatch sign could potentially serve as a non-invasive imaging biomarker for the selection of patients with IDH-mutant LGGs.
EUROPEAN RADIOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Martha Foltyn-Dumitru, Marianne Schell, Aditya Rastogi, Felix Sahm, Tobias Kessler, Wolfgang Wick, Martin Bendszus, Gianluca Brugnara, Philipp Vollmuth
Summary: The intensity normalization of MRI data has a significant impact on the performance of radiomics-based models in predicting molecular glioma subtypes.
EUROPEAN RADIOLOGY
(2023)
Review
Oncology
Julie J. Miller, L. Nicolas Gonzalez Castro, Samuel McBrayer, Michael Weller, Timothy Cloughesy, Jana Portnow, Ovidiu Andronesi, Jill S. Barnholtz-Sloan, Brigitta G. Baumert, Mitchell S. Berger, Wenya Linda Bi, Ranjit Bindra, Daniel P. Cahill, Susan M. Chang, Joseph F. Costello, Craig Horbinski, Raymond Y. Huang, Robert B. Jenkins, Keith L. Ligon, Ingo K. Mellinghoff, L. Burt Nabors, Michael Platten, David A. Reardon, Diana D. Shi, David Schiff, Wolfgang Wick, Hai Yan, Andreas von Deimling, Martin van den Bent, William G. Kaelin, Patrick Y. Wen
Summary: This article discusses the diagnosis and management of IDH-mutant gliomas, as well as new treatment methods and future research directions.
Review
Oncology
M. Platten, L. Bunse, W. Wick
Summary: The development of anticancer vaccines has been hindered by a lack of suitable tumor-specific antigens, while IDH1R132H mutation generates a shared clonal neoepitope recognized by mutation-specific T-helper cells, providing new directions for certain cancer vaccines.
Review
Clinical Neurology
Macarena I. de la Fuente
Summary: Somatic mutations in IDH are commonly found in gliomas and play a key role in gliomagenesis. Various experimental therapeutic approaches, including direct inhibitors, immunotherapies, and epigenetic/metabolic drugs, have shown promising results. Ongoing studies aim to elucidate the precise role of these treatments and the optimal timing for their application.
CURRENT OPINION IN NEUROLOGY
(2022)
Article
Medicine, General & Internal
Pau Montesinos, Christian Recher, Susana Vives, Ewa Zarzycka, Jianxiang Wang, Giambattista Bertani, Michael Heuser, Rodrigo T. Calado, Andre C. Schuh, Su-Peng Yeh, Scott R. Daigle, Jianan Hui, Shuchi S. Pandya, Diego A. Gianolio, Stephane de Botton, Hartmut Dohner
Summary: This study demonstrated that the combination therapy of oral ivosidenib and azacitidine showed better event-free survival and longer overall survival in patients with newly diagnosed IDH1-mutated acute myeloid leukemia.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Article
Chemistry, Multidisciplinary
Raluca-Ioana Stefan-van Staden, Catalina Cioates Negut, Sorin Sebastian Gheorghe, Paula Sfirloaga
Summary: Two three-dimensional stochastic microsensors based on single-walled carbon nanotubes (SWCNT) and multi-walled carbon nanotubes (MWCNT) were designed to recognize and quantify IDH1 and IDH2 in biological samples. The microsensor using MWCNT demonstrated the highest sensitivity and recovery rate compared to the ELISA standard method.
Article
Surgery
Nina Byskosh, Vivek Pamulapati, Shujun Xu, Ashley K. Vavra, Andrew W. Hoel, Lu Tian, Mary M. McDermott, Zeeshan Butt, Karen J. Ho
Summary: Patients with PAD have deficits in their awareness of this diagnosis and general knowledge about PAD. Female sex and history of percutaneous leg revascularization are associated with better awareness of PAD diagnosis. The PAD knowledge scores are positively correlated with awareness of PAD diagnosis and negatively correlated with a history of hypertension.
JOURNAL OF VASCULAR SURGERY
(2022)
Article
Oncology
D. Jay Wieczorek, Rupesh Kotecha, Matthew D. Hall, Martin C. Tom, Stephen Davis, Manmeet S. Ahluwalia, Michael W. McDermott, Minesh P. Mehta, Alonso N. Gutierrez, Ranjini Tolakanahalli
Summary: This study compared the plan quality metrics of manual forward planning (MFP) and Elekta Fast Inverse Planning (FIP) for stereotactic radiosurgery (SRS) in patients treated with Gamma Knife (R). The results showed that FIP plans demonstrated a statistically significant improvement in target coverage, conformity index, and gradient index compared to MFP plans, while there was no significant difference in beam-on time and delivery parameters between the two planning methods.
Editorial Material
Oncology
Rifaquat Rahman, Raymond Y. Huang
Article
Medicine, General & Internal
Christopher P. Millward, Terri S. Armstrong, Heather Barrington, Sabrina Bell, Andrew R. Brodbelt, Helen Bulbeck, Anna Crofton, Linda Dirven, Theo Georgious, Paul L. Grundy, Abdurrahman I. Islim, Mohsen Javadpour, Sumirat M. Keshwara, Shelli D. Koszdin, Anthony G. Marson, Michael W. McDermott, Torstein R. Meling, Kathy Oliver, Puneet Plaha, Matthias Preusser, Thomas Santarius, Nisaharan Srikandarajah, Martin J. B. Taphoorn, Carole Turner, Colin Watts, Michael Weller, Paula R. Williamson, Gelareh Zadeh, Amir H. Zamanipoor Najafabadi, Michael D. Jenkinson
Summary: This study presents the development of two core outcome sets for meningioma. These outcome sets will be used in clinical effectiveness trials and clinical studies of meningioma. The study utilizes systematic literature reviews, surveys, and consensus meetings to ensure the reliability and widespread application of the outcomes.
Article
Cardiac & Cardiovascular Systems
Matt T. Oberdier, Majd AlGhatrif, Fatemeh Adelnia, Marta Zampino, Christopher H. Morrell, Eleanor Simonsick, Kenneth Fishbein, Edward G. Lakatta, Mary M. McDermott, Luigi Ferrucci
Summary: In individuals without peripheral arterial disease, a greater decline in ABI over time is associated with a faster decline in thigh muscle mitochondrial oxidative capacity in the ipsilateral leg.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Letter
Oncology
Alice Laurenge, Renata Ursu, Emeline Tabouret, Vincent Harlay, Guido Ahle, Sylvain Choquet, Carole Soussain, Cecile Molucon-Chabrot, Bertrand Mathon, Karima Mokhtari, Valerie Pourcher, Lucia Nichelli, Stephane Marot, Mehdi Touat, Khe Hoang-Xuan, Caroline Houillier
LEUKEMIA & LYMPHOMA
(2023)
Article
Clinical Neurology
Anna Luisa Di Stefano, Lucia Nichelli, Giulia Berzero, Romain Valabregue, Mehdi Touat, Laurent Capelle, Clement Pontoizeau, Franck Bielle, Julie Lerond, Marine Giry, Chiara Villa, Bertrand Baussart, Caroline Dehais, Damien Galanaud, Capucine Baldini, Julien Savatovsky, Frederic Dhermain, Dinesh K. Deelchand, Chris Ottolenghi, Stephane Lehericy, Malgorzata Marjanska, Francesca Branzoli, Marc Sanson
Summary: In this study, the levels of D-2-hydroxyglutarate (2HG) in glioma patients were detected and quantified using MEGA-PRESS technique. The study investigated the clinical, radiologic, and molecular parameters affecting the levels of 2HG. The results showed that the sensitivity of 2HG detection depends on tumor volume, voxel coverage, and tumor presentation, and the decrease in 2HG levels after IDH inhibition does not predict tumor response.
Article
Clinical Neurology
N. Valyraki, E. Maillart, V. Pourcher, N. Shor, S. Tran, M. Boudot de la Motte, C. Houillier, F. Domont, E. Morvan, M. Touat, M. Del Mar Amador, J. Aboab, B. Mathon, A. Hesters, C. Vignal-Clermont, C. Dehais, S. Bonnin, F. Lafitte, N. Villain, S. Varnous, O. Gout, M. Eloit, C. Rodriguez, R. Deschamps
Summary: This study reports 4 cases of patients with similar clinical, biological, and radiological characteristics, including a history of transplantation with long-term immunosuppression and a progressive course of severe myelitis, and in 3 cases, optic neuropathy causing blindness. Extensive workup was negative but pan-microorganism DNA- and RNA-based shotgun metagenomics analysis of the cerebrospinal fluid (CSF) was positive for Human pegivirus (HPgV). This case series further supports the hypothesis of HPgV CNS infection and highlights the utility of metagenomic next-generation sequencing of CSF in immuno-compromised patients.
REVUE NEUROLOGIQUE
(2023)
Editorial Material
Clinical Neurology
Mehdi Touat
CURRENT OPINION IN NEUROLOGY
(2022)
Article
Oncology
Isaias Hernandez-Verdin, Kadir C. Akdemir, Daniele Ramazzotti, Giulio Caravagna, Karim Labreche, Karima Mokhtari, Khe Hoang-Xuan, Matthieu Peyre, Franck Bielle, Mehdi Touat, Ahmed Idbaih, Alex Duval, Marc Sanson, Agusti Alentorn
Summary: This study reveals the presence of AID mutations at the pan-cancer level, with higher frequency in hematological cancers. AID mutational load is independently associated with a favorable outcome in immune-checkpoint inhibitors treated patients. Additionally, AID-related neoepitopes enhance immunogenicity and increase ICI sensitivity.
NPJ PRECISION ONCOLOGY
(2022)
Article
Oncology
Sana Abbasi, Helia Rivand, Fatemeh Eshaghi, Mohammad Amin Moosavi, Saeid Amanpour, Michael F. Mcdermott, Marveh Rahmati
Summary: This study aimed to sensitize colorectal cancer cells to chemotherapy by targeting the IRE1a/XBP1 pathway. The results showed that the IRE1a inhibitor 4 mu 8C inhibited CRC cell growth and enhanced the cytotoxicity of 5-FU. In vivo experiments demonstrated that 4 mu 8C inhibited tumor growth and significantly enhanced drug responses when combined with 5-FU.
Letter
Hematology
Adam Al-Hakim, Alyssa Cull, Joanna Topping, Fatima Nadat, Joanna Milek, Razan F. Alhefzi, Michael F. McDermott, Roger Owen, Catherine Cargo, James G. Poulter, David G. Kent, Sinisa Savic, ImmunAID Consortium
Meeting Abstract
Oncology
William Cheng Chen, Abrar Choudhury, Harish Vasudevan, Calixto-Hope C. Lucas, Minh P. Nguyen, Jacob S. Young, Theresa Yu, Jason Chan, Nancy Ann Oberheim Bush, Jessica Schulte, Javier Villanueva-Meyer, Steve E. Braunstein, Nicholas A. Butowski, Penny Sneed, Mitchell Berger, Arie Perry, David Solomon, Michael W. McDermott, Stephen T. Magill, David R. Raleigh
JOURNAL OF CLINICAL ONCOLOGY
(2022)
Review
Immunology
Samuel Lara-Reyna, Emily A. Caseley, Joanne Topping, Francois Rodrigues, Jorge Jimenez Macias, Sean E. Lawler, Michael F. McDermott
Summary: Inflammasomes are innate immune sensors assembled by cells to detect danger signals and initiate pro-inflammatory responses. They activate inflammatory caspases, leading to cellular damage and release of pro-inflammatory cytokines. Multiple molecular mechanisms regulate inflammasome activation to maintain a balance between inflammation and tissue integrity. Aberrant inflammasome activation can result in excessive production of pro-inflammatory cytokines and cell death, causing tissue damage.
CLINICAL & TRANSLATIONAL IMMUNOLOGY
(2022)
Letter
Clinical Neurology
Theodore H. Schwartz, Michael W. McDermott
JOURNAL OF NEUROSURGERY
(2022)