Article
Cell Biology
Ying Yang, Jiaxing He, Bo Zhang, Zhansheng Zhang, Guozhan Jia, Shiqi Liu, Tao Wu, Xianli He, Nan Wang
Summary: SLC25A1 is significantly upregulated in CRC, associated with poor survival in patients, and reprograms energy metabolism through two mechanisms to promote CRC growth. It serves as a potential diagnostic marker and therapeutic target in CRC.
CELL DEATH & DISEASE
(2021)
Review
Biochemistry & Molecular Biology
Dan Chen, Xuebing Zhou, PengYu Yan, Chunyu Yang, Yuan Li, Longzhe Han, Xiangshan Ren
Summary: Metabolic reprogramming, particularly lipid metabolism reprogramming, plays a significant role in the occurrence and development of colorectal cancer (CRC). Understanding the molecular mechanism of lipid metabolism reprogramming in CRC is crucial for the development of new treatment directions.
JOURNAL OF CELLULAR BIOCHEMISTRY
(2023)
Article
Medicine, Research & Experimental
Kun Zhang, Tao Zhang, Yuhan Yang, Wenling Tu, Hongbin Huang, Yujun Wang, Yuzhuo Chen, Kejian Pan, Zhuojia Chen
Summary: The study reveals that the METTL3/LDHA axis-induced glucose metabolism could be a potential therapeutic target to overcome 5-FU resistance in CRC cells.
Article
Chemistry, Multidisciplinary
Lizhen He, Jianfu Zhao, Hongjun Li, Bin Xie, Ligeng Xu, Guanning Huang, Ting Liu, Zhen Gu, Tianfeng Chen
Summary: This study found that human serum albumin-encapsulated black phosphorus quantum dots (BPQDs@HSA) can effectively enhance the antitumor efficacy of NK cell immunotherapy derived from clinical patients. By activating the PI3K-Akt and mTOR signaling pathways, BPQDs@HSA reprograms NK cell metabolism, promotes cellular viability and immunity, and inhibits tumor immune escape. This research not only provides a successful strategy for nanomedicine-potentiated immune-cancer therapy, but also contributes to the understanding of the interface between nanomedicine and immune cell activation.
Review
Medicine, Research & Experimental
Zhenzhen Li, Chanjun Sun, Zhihai Qin
Summary: Cancer cells adapt their metabolism to proliferate and survive in harsh environments, with a close relationship between tumor microenvironment and cancer-associated fibroblasts (CAFs) playing key roles in tumor growth and metastasis. CAFs act as major regulators in shaping tumor metabolism, especially through dysregulation of metabolic pathways, influencing cancer cell behavior and response to therapy. The interaction and crosstalk between cancer cells and CAFs contribute to metabolic reprogramming that impacts cancer cell growth and progression.
Article
Chemistry, Multidisciplinary
Shenshen Wu, Jiajia Wang, Zan Fu, Giuseppe Familiari, Michela Relucenti, Michael Aschner, Xiaobo Li, Rui Chen, Hanqing Chen
Summary: Comparing the metabolic profiles of colorectal cancer patients and healthy controls, it was found that downregulation of matairesinol was evident in CRC patients, and supplementation of matairesinol significantly suppressed tumor formation. Matairesinol rewired lipid metabolism by inducing mitochondrial and oxidative damage and blunting ATP production, improving the therapeutic efficacy in CRC. Furthermore, matairesinol-loaded liposomes enhanced the antitumor activity of the FOLFOX regimen in mouse models, restoring chemosensitivity.
Review
Biochemistry & Molecular Biology
Miljana Nenkov, Yunxia Ma, Nikolaus Gassler, Yuan Chen
Summary: Colorectal carcinoma is a common cancer characterized by metabolic reprogramming that provides tumor cells with energy and nutrients for malignant growth. The metabolic crosstalk between tumor cells, the tumor microenvironment, and gut microbiota facilitates the development and therapy resistance of colorectal carcinoma.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Huashan Liu, Zhenxing Liang, Chi Zhou, Ziwei Zeng, Fengwei Wang, Tuo Hu, Xiaowen He, Xiaojian Wu, Xianrui Wu, Ping Lan
Summary: This study reveals a cell-extrinsic role of KRAS in modulating the tumor microenvironment by reprogramming tumor-associated macrophages, promoting tumor progression and inducing resistance to cetuximab therapy. Mechanistically, mutant KRAS stabilizes HIF-1 alpha to drive the production of CSF2 and lactate in tumor cells, enhancing HIF-1 alpha stabilization and contributing to a permissive microenvironment for tumor malignancy.
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2021)
Review
Oncology
Roberto Corchado-Cobos, Natalia Garcia-Sancha, Marina Mendiburu-Elicabe, Aurora Gomez-Vecino, Alejandro Jimenez-Navas, Manuel Jesus Perez-Baena, Marina Holgado-Madruga, Jian-Hua Mao, Javier Canueto, Sonia Castillo-Lluva, Jesus Perez-Losada
Summary: Metabolic changes in tumor cells and their interactions with stromal cells play a crucial role in tumor growth and progression. Understanding these metabolic changes can help identify new treatment strategies. Breast cancer serves as a useful example to illustrate the metabolic alterations in cancer.
Article
Multidisciplinary Sciences
Lulu Sun, Yi Zhang, Jie Cai, Bipin Rimal, Edson R. Rocha, James P. Coleman, Chenran Zhang, Robert G. Nichols, Yuhong Luo, Bora Kim, Yaozong Chen, Kristopher W. Krausz, Curtis C. Harris, Andrew D. Patterson, Zhipeng Zhang, Shogo Takahashi, Frank J. Gonzalez
Summary: Bile salt hydrolase (BSH) in Bacteroides is associated with the development of colorectal cancer (CRC) by activating the beta-catenin/CCL28 pathway and promoting the generation of immunosuppressive T-reg cells. Inhibition of BSH activity could slow down CRC progression and serve as a potential target for CRC prevention and treatment.
NATURE COMMUNICATIONS
(2023)
Article
Biochemistry & Molecular Biology
Huan Zhang, Hongyuan Zhu, Jinteng Feng, Zheng Zhang, Simei Zhang, Zheng Wang, Lin Sun, Wencheng Zhang, Bin Gao, Ying Zhang, Min Lin
Summary: Cancer-associated fibroblasts (CAFs), derived from activated fibroblasts, are known to play a major role in promoting tumor metastasis. Reprogramming these CAFs into a quiescent state may have therapeutic potential in cancer treatment.
JOURNAL OF MOLECULAR BIOLOGY
(2023)
Article
Medicine, Research & Experimental
Qian Li, Xuejiao Lv, Chunyong Han, Yu Kong, Zhongye Dai, Dawei Huo, Ting Li, Dapeng Li, Wei Li, Xing Wang, Qian Zhao, Jie Ming, Wen Yang, Yang Chen, Xudong Wu
Summary: This study investigates the transcriptomic and epigenomic features of NFs and CAFs associated with breast cancer metastasis, and identifies signature genes and enhancers specific to CAFs. The study demonstrates the importance of activated JUN in remodeling enhancers and maintaining the activation of CAF-specific enhancers, leading to breast cancer invasiveness. These findings provide insights into stroma cell transformation and support the potential of stroma-targeting strategy in cancer treatment.
Article
Biology
Konstantin Drexler, Katharina M. Schmidt, Katrin Jordan, Marianne Federlin, Vladimir M. Milenkovic, Gerhard Liebisch, Anna Artati, Christian Schmidl, Gregor Madej, Janina Tokarz, Alexander Cecil, Wolfgang Jagla, Silke Haerteis, Thiha Aung, Christine Wagner, Maria Kolodziejczyk, Stefanie Heinke, Evan H. Stanton, Barbara Schwertner, Dania Riegel, Christian H. Wetzel, Wolfgang Buchalla, Martin Proescholdt, Christoph A. Klein, Mark Berneburg, Hans J. Schlitt, Thomas Brabletz, Christine Ziegler, Eric K. Parkinson, Andreas Gaumann, Edward K. Geissler, Jerzy Adamski, Sebastian Haferkamp, Maria E. Mycielska
Summary: Citrate is essential for cancer cell metabolism, supplied by cancer-associated stroma (CAS) and controlled by cancer cells for progression and invasion. Depriving cancer cells of citrate significantly reduces growth and metastasis, indicating the importance of citrate uptake in cancer progression.
LIFE SCIENCE ALLIANCE
(2021)
Article
Immunology
Suelen Silva Gomes Dias, Tamires Cunha-Fernandes, Luciana Souza-Moreira, Vinicius Cardoso Soares, Giselle Barbosa Lima, Isaclaudia G. Azevedo-Quintanilha, Julia Santos, Filipe Pereira-Dutra, Caroline Freitas, Patricia A. Reis, Stevens Kastrup Rehen, Fernando A. Bozza, Thiago M. Lopes Souza, Cecilia J. G. de Almeida, Patricia T. Bozza
Summary: Zika virus infection is associated with adult neurological disorders and congenital diseases. The virus regulates lipid metabolism pathways, leading to lipid droplet accumulation in neural cells. Inhibition of DGAT-1 reduces virus replication and inflammation, suggesting targeting lipid metabolism may be a potential anti-ZIKV treatment strategy.
JOURNAL OF NEUROINFLAMMATION
(2023)
Article
Multidisciplinary Sciences
Xian Zhang, Shun Li, Isha Malik, Mytrang H. Do, Liangliang Ji, Chun Chou, Wei Shi, Kristelle J. Capistrano, Jing Zhang, Ting-Wei Hsu, Briana G. Nixon, Ke Xu, Xinxin Wang, Andrea Ballabio, Laura S. Schmidt, W. Marston Linehan, Ming O. O. Li
Summary: In metazoan organisms, cell competition functions as a mechanism to eliminate unfit cells and promote the survival of more robust cells. However, little is known about how environmental factors affect cancer cell competition. This study reveals that tumour-associated macrophages (TAMs) can be reprogrammed through diet or genes to outcompete MYC-overexpressing cancer cells. This discovery highlights a novel innate immune tumour suppression pathway that could be targeted for cancer therapy.
Article
Cell Biology
Xiaojie Wang, Liang Wang, Mingyi Luo, Qian Bu, Chunqi Liu, Linhong Jiang, Rui Xu, Shaomin Wang, Haoluo Zhang, Jiamei Zhang, Xuemei Wan, Hongchun Li, Yonghai Wang, Bin Liu, Ying Zhao, Yuanyuan Chen, Yanping Dai, Min Li, Hongbo Wang, Jingwei Tian, Yinglan Zhao, Xiaobo Cen
Summary: Clarithromycin (CLA) treatment causes anxiety-like behaviors, possibly through altered glycerophospholipid metabolism.
CELL BIOLOGY AND TOXICOLOGY
(2023)
Article
Chemistry, Applied
Zhang-Yang Shen, Ying-Ying Zhao, Ze-Hua Qiao, Zhen Xie, Ruo-Qing Guan, Ze-Yu Liu, Yan-Ping Liu, Guang-Ying Chen, Yan-Hui Fu
Summary: A phytochemical investigation of the fruits of Morinda citrifolia resulted in the discovery of a new anthraquinone, moricitrifone, along with seven known anthraquinones. The antiproliferative activities of these compounds were evaluated against multiple human cancer cell lines, and they exhibited significant inhibition of cell proliferation.
NATURAL PRODUCT RESEARCH
(2023)
Article
Neurosciences
Yonghai Wang, Hongchun Li, Ying Zhao, Feng Qin, Liang Wang, Linhong Jiang, Xiaojie Wang, Rong Chen, Yuman He, Qinfan Wei, Shu Li, Yuanyuan Chen, Yuzhou Xiao, Yanping Dai, Qian Bu, Yinglan Zhao, Jingwei Tian, Hongbo Wang, Xiaobo Cen
Summary: Sevoflurane exposure in the neonatal period causes cognitive impairment and social behavior deficits in adolescent rats. Lipidomics and proteomics analysis revealed the remodeling of lipid metabolism and downregulation of LPCAT1 expression in the hippocampus, suggesting their involvement in neurobehavioral dysfunction.
Article
Environmental Sciences
Hongchuan Li, Rui Jin, Zhaowen Xu, Hongxiang Hu, Yusef Kianpoor Kalkhajeh, Yingying Zhao, Linchuan Zhan
Summary: In this study, the potential of chelate tetrasodium glutamate diacetate (GLDA) combined with Tagetes patula L. to remediate cadmium-contaminated soil was investigated. The results showed that GLDA application significantly increased the biomass and cadmium content of Tagetes patula, indicating the efficacy of GLDA for the remediation of cadmium-contaminated farmlands.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Engineering, Electrical & Electronic
Tongchuan Chen, Yingying Zhao, Qianqian Wang, Wenting Wang, Aimin An
Summary: This paper proposes a Distributed Secondary Compensation Control (DSCC) method to solve the problems of the transmission system controlled by traditional droop control. It improves the dynamic response of the system and its fault ride through capability.
JOURNAL OF ELECTRICAL ENGINEERING & TECHNOLOGY
(2023)
Article
Chemistry, Applied
Ying-Ying Zhao, Yu-Jie Li, Xiao-Mei Yu, Qin-Ting Su, Li-Wen Wang, Yu-Shu Zhu, Yan-Hui Fu, Guang-Ying Chen, Yan-Ping Liu
Summary: A new bisabolane-type sesquiterpenoid, morincitrinoid A (1), was isolated from the stems and leaves of Morinda citrifolia L., along with five known analogues (2-6), through phytochemical study. The chemical structure of 1 was determined by comprehensive spectral analysis. Compounds 1-6 exhibited significant anti-inflammatory and anti-HIV activities, inhibiting NO production and HIV-1 reverse transcriptase (RT) with comparable or better potency than hydrocortisone, indicating their potential therapeutic value.
NATURAL PRODUCT RESEARCH
(2023)
Article
Pharmacology & Pharmacy
Shuai-Bing Liu, Xia Yao, Jun Tao, Jian-Jun Yang, Ying-Ying Zhao, Dong-Wei Liu, Su-Yun Wang, Su-Ke Sun, Xu Wang, Pang-Ke Yan, Nan Wu, Xiao Liu, Xiao-Jian Zhang, Xin Tian, Zhang-Suo Liu
Summary: The aim of this study was to develop a population pharmacokinetic (PK) model for ciprofol and its major metabolite M4, and link it to the population pharmacodynamics (PD) model in subjects with different renal functions. The study found that the PK of ciprofol and M4 could be best described by three-compartment and two-compartment models, respectively. The concentrations of ciprofol and M4 were linked using a linear protein binding model. Hemoglobin and uric acid were identified as covariates affecting the clearance of ciprofol and M4. The developed model provides a comprehensive understanding of the PK and PD of ciprofol.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2023)
Article
Agriculture, Multidisciplinary
Xiao-Han Sun, Mei-Wei Lv, Ying-Xin Zhao, Hao Zhang, Muhammad Asmat Ullah Saleem, Yi Zhao, Jin-Long Li
Summary: This study determined the mechanism of nano-Se antagonism in Cd-induced hepatocyte pyroptosis by targeting the APJAMPK-PGC1 alpha pathway. The results showed that Cd activated the NLRP3 inflammasome and caused hepatocyte pyroptosis. Furthermore, Cd also increased hepatic fibrosis. However, the co-treatment of nano-Se and Cd significantly reduced the degree of fibrosis.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Environmental Sciences
Zirui Ye, Miao Qi, Yingming Zhao, Wei Wei, X. George Xu
Summary: This study estimated the fetal and pediatric doses from chest CT scans performed during the COVID-19 pandemic. Organ and effective doses were calculated using VirtualDose-CT software. The results showed that fetal absorbed doses ranged from 0.04 to 0.61 mGy depending on the gestational age, and extending the scan range to the abdominal region increased fetal doses by almost 4-fold. The findings provide valuable information for radiologists and patients to minimize unnecessary radiation exposure.
RADIATION PROTECTION DOSIMETRY
(2023)
Article
Chemistry, Physical
Liang Yan, Qiao Yuan, Hui Tian, Wanzhong Ren, Lei Wang, Yingchun Zhao
Summary: Mo-Bi based catalysts have attracted attention for the oxidation reaction of isobutene to methacrolein. Most studies focus on the reaction mechanism and catalytic active sites, but fail to reflect the real reaction process on commercial catalyst surfaces. This research demonstrates that fine-tuning the active phase structure can greatly enhance the catalytic performances, providing a new perspective for developing high-performance catalysts.
REACTION KINETICS MECHANISMS AND CATALYSIS
(2023)
Article
Environmental Sciences
Kaixin Zheng, Yufen Wang, Xiaomin Wang, Tingting Zhu, Xueming Chen, Yingxin Zhao, Peizhe Sun, Yindong Tong, Yiwen Liu
Summary: This survey investigated the influence of ultrasound (US) and potassium permanganate (KMnO4) co-pretreatment on anaerobic digestion of waste activated sludge (WAS). The results showed that the co-treatment significantly increased the cumulative methane yield and improved the biodegradability of soluble organics. The analysis also revealed that US + KMnO4 pretreatment enhanced the biochemical methane potential, hydrolysis rate, and relative abundance of functional microorganisms associated with anaerobic digestion.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Chemistry, Multidisciplinary
Sanjiang Pan, Renjie Li, Jin Wang, Qixing Zhang, Manjing Wang, Biao Shi, Pengyang Wang, Ying Zhao, Xiaodan Zhang
Summary: In this paper, a two-dimensional nanosheet quaternary metal hydroxide catalyst composed of Ni, Fe, Cr, and Mo elements was reported. By in situ electrochemical activation, the catalyst obtained higher metal valence states and many O vacancies, providing excellent catalytic activity and corrosion resistance in overall alkaline seawater electrolysis. The floating solar seawater splitting device showed an efficiency of solar energy to hydrogen of 20.61 +/- 0.77%.
Editorial Material
Cell Biology
Gaoxiang Zhao, Qian Lin, Zhaoyuan Meng, Xinlei Sheng, Leina Ma, Yingming Zhao
Article
Green & Sustainable Science & Technology
Zheng Ma, Zhen Xing, Yingying Zhao, Yiru Hu
Summary: This paper investigates the influence of freeze-thaw cycles on the dynamic strength properties of silty clay fillers before and after cement improvement, and quantifies the improvement effects of cement improvement. The results show that cement modification significantly improves the dynamic strength parameters of silty clay even after multiple freeze-thaw cycles, providing a useful reference for subgrade improvement along the silty clay railway in northern China.
Article
Materials Science, Multidisciplinary
Ying Zhao, Lian-Cai An, Kai Li, Yong-Ji Gong, Tian-Meng Guo, Fei-Fei Gao, Yang Lei, Quanwen Li, Wei Li, Xian-He Bu
Summary: Hybrid organic-inorganic piezoelectrics have gained attention for their fascinating performance, ease of synthesis, and mechanical flexibility. However, most reported systems contain toxic heavy metals or are unstable due to metal halide bonds. In this research, a stable zero-dimensional hybrid piezoelectric material based on an environmentally friendly anion of SCN- was synthesized. The resulting flexible composite films showed exceptional mechanical energy harvesting properties, outperforming state-of-the-art piezoelectric devices, with excellent durability and stability.
SCIENCE CHINA-MATERIALS
(2023)
